---
title: Does micronized progesterone treat severe PMS in women approaching menopause?
description: Yes. After three months of treatment, 86.5% of women had complete relief of their symptoms and 13.5% had decreased symptoms.
url: https://niyora.com/research/papers/using-micronized-progesterone-for-treatment-of-premenopausal-age-women-suffering-2017/
---

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- Does micronized progesterone treat severe PMS in women approaching menopause?

Study, 2017

# Does micronized progesterone treat severe PMS in women approaching menopause?

Yes. After three months of treatment, 86.5% of women had complete relief of their symptoms and 13.5% had decreased symptoms.

 Early or limited evidence

37 premenopausal women with severe PMS

## What they did

Researchers treated 37 women approaching menopause who had severe PMS with micronized progesterone (100 mg taken under the tongue from day 11 to day 25 of each menstrual cycle). They measured symptoms and hormone levels before treatment and again after three months.

## What they found

After three months, 86.5% of women had complete disappearance of their severe PMS symptoms, and 13.5% had decreased symptoms. Lab tests showed luteinizing hormone (LH) decreased 1.3 times and progesterone increased 1.3 times after treatment.

## What it means for you

Micronized progesterone appears to be highly effective for severe PMS in women approaching menopause, with most women improving significantly. The medication is natural and well tolerated. The main limitations are the small sample of 37 women and lack of a comparison group receiving a different treatment.

37

women treated

86.5%

had complete symptom relief

13.5%

had decreased symptoms

## About the study

Original title Using micronized progesterone for treatment of premenopausal age women suffering from severe premenstrual syndrome Authors О.H. Horbatiuk, Alla Binkovska, O.H. Gerych et al. Journal Current Issues in Pharmacy and Medical Sciences Year 2017 Study design Study Participants 37 What was tested Micronized progesterone, 100 mg under the tongue, days 11 to 25 of menstrual cycle Open access Yes Read the paper [doi.org/10.1515/cipms-2017-0025](https://doi.org/10.1515/cipms-2017-0025)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)

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