--- title: Does vitamin D improve mood symptoms in girls with severe vitamin D deficiency and PMS? description: Yes. Girls with severe vitamin D deficiency and PMS who received vitamin D supplements showed significant improvements in anxiety, irritability, crying, and s url: https://niyora.com/research/papers/vitamin-d-improves-mood-disorders-in-d-deficient-girls-with-pms-2016/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does vitamin D improve mood symptoms in girls with severe vitamin D deficiency and PMS? Randomised trial, 2016 # Does vitamin D improve mood symptoms in girls with severe vitamin D deficiency and PMS? Yes. Girls with severe vitamin D deficiency and PMS who received vitamin D supplements showed significant improvements in anxiety, irritability, crying, and sadness by the fourth month of treatment. Moderate study design 158 girls aged 15-21 in Italy with severe PMS and severe vitamin D deficiency (≤10 ng/ml) ## What they did Randomized trial at 2 Italian academic centers from 2010-2012 with 158 girls aged 15-21 with severe PMS, severe vitamin D deficiency (≤10 ng/ml), and severe PMS symptoms. One group received vitamin D-3 (200,000 IU on day 1, then 25,000 IU every 2 weeks for 4 months); the other received placebo in the same pattern. Mood was assessed monthly. ## What they found By month 3, the vitamin D group showed improvements in emotional symptoms. By month 4, anxiety, irritability, crying, and sadness were all significantly reduced compared to baseline in the vitamin D group. ## What it means for you Vitamin D supplementation may help mood symptoms in girls with very low vitamin D levels and PMS. The study only included girls with extremely low vitamin D, so it's unclear if it works for those with moderate deficiency or normal levels. 158 Girls in study 4 Months of treatment ≤10 ng/ml Baseline vitamin D level ## About the study Original title Vitamin D Improves Mood Disorders in D-Deficient Girls With PMS Journal AAP Grand Rounds Year 2016 Study design Randomised trial Participants 158 What was tested Vitamin D-3 supplementation (200,000 IU day 1, then 25,000 IU every 2 weeks) for 4 months Read the paper [doi.org/10.1542/gr.35-4-42](https://doi.org/10.1542/gr.35-4-42) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Thyroid disorders](https://niyora.com/research/topics/comorbidity-thyroid/)[Students and academic performance](https://niyora.com/research/topics/life-area-education/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2012 Does vitamin D affect PMS symptoms? Case-control study, 2010 Does vitamin D intake reduce the risk of PMS? Randomised trial, 2026 Does calcium and vitamin D supplementation reduce PMS symptoms? Randomised trial, 2009 Is dydrogesterone or calcium plus vitamin D better for severe PMS? Non-randomised trial, 2026 Do dietary changes or sun exposure reduce PMS symptoms in adolescent girls? Randomised trial, 2021 Is low vitamin D linked to premenstrual symptoms? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗