--- title: Does vitamin D supplementation improve inflammation markers and PMS? description: Yes. Vitamin D supplementation improved inflammation markers and total PMS symptom scores in vitamin D-deficient women. url: https://niyora.com/research/papers/vitamin-d-supplementation-for-premenstrual-syndrome-related-inflammation-and-2019/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does vitamin D supplementation improve inflammation markers and PMS? Randomised trial, 2019 # Does vitamin D supplementation improve inflammation markers and PMS? Yes. Vitamin D supplementation improved inflammation markers and total PMS symptom scores in vitamin D-deficient women. Early or limited evidence 44 vitamin D-deficient women with PMS ## What they did 44 vitamin D-deficient women with PMS received vitamin D supplementation. Researchers measured inflammation markers (IL-10, IL-12) and antioxidant capacity (TAC) before and after treatment. ## What they found After vitamin D supplementation, IL-10 and IL-12 levels significantly decreased and total antioxidant capacity significantly increased. Overall PMS symptom scores significantly improved, with significant differences between groups for IL-12 and TAC. ## What it means for you Vitamin D may help PMS by reducing inflammation and improving the body's antioxidant system. This is a small study with limited detail about dosage and duration in the abstract, so findings need confirmation in larger studies. 44 Women in study IL-10, IL-12 Inflammation markers decreased TAC Antioxidant capacity increased ## About the study Original title Vitamin D Supplementation for Premenstrual Syndrome-Related inflammation and antioxidant markers in students with vitamin D deficient: a randomized clinical trial Authors Heidari H, Amani R, Feizi A et al. Journal Scientific reports Year 2019 Study design Randomised trial What was tested Vitamin D supplementation (dose and duration not specified) Open access Yes Read the paper [doi.org/10.1038/s41598-019-51498-x](https://doi.org/10.1038/s41598-019-51498-x) Original abstract Premenstrual syndrome (PMS) is a common disorder in the reproductive age that negatively significant impacts on women's quality of life. This randomized clinical trial study was undertaken to investigate the effect of vitamin D supplementation on inflammatory and antioxidant markers in 44 vitamin D deficient (25(OH)D 3 , Interleukin10 and 12 (IL-10, IL-12) and total antioxidant capacity (TAC). In vitamin D group, serum levels of IL-10 and IL-12 significantly decreased while TAC significantly increased post-intervention. There were significant differences regarding serum IL-12 and TAC levels between the two groups. Mean score of the total PMS symptoms showed significant improvement in 25(OH)D. Vitamin D supplementation seems to be an effective strategy to improve inflammation and antioxidant markers in vitamin D deficient women with PMS. This clinical trial was registered at Iranian Registry of Clinical Trials on 20/06/2018 (IRCT20180525039822N1). Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/)[Students and academic performance](https://niyora.com/research/topics/life-area-education/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2010 How do anxiety disorders differ across different life stages? Randomised trial, 2026 Does Kundalini Reiki help reduce PMS symptoms and improve quality of life? Randomised trial, 2026 Does calcium and vitamin D supplementation reduce PMS symptoms? Randomised trial, 2026 Does a warm footbath help PMS symptoms and sleep quality? Randomised trial, 2025 Which is more effective for PMS - Vitagnus, soy, or both together? Systematic review, 2025 Do nutritional interventions help with emotional symptoms of PMS? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗