---
title: How are GnRH agonists used to treat PMDD that doesn't respond to standard medications?
description: GnRH agonists combined with hormone replacement are effective for severe PMDD that doesn't respond to first-line treatments, but many doctors don't know how t
url: https://niyora.com/research/papers/what-s-stopping-us-using-gnrh-analogs-with-stable-hormone-addback-in-treatment-2023/
---

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- How are GnRH agonists used to treat PMDD that doesn't respond to standard medications?

Guideline, 2023

# How are GnRH agonists used to treat PMDD that doesn't respond to standard medications?

GnRH agonists combined with hormone replacement are effective for severe PMDD that doesn't respond to first-line treatments, but many doctors don't know how to use this option.

 Strong study design

Women with treatment-resistant PMDD.

## What they did

This is a clinical guideline, not a research study. Experts reviewed evidence for GnRH agonist treatment in severe PMDD and created practical guidance, screening tools, and treatment algorithms for doctors.

## What they found

GnRH agonists with hormone addback are established treatments for treatment-resistant PMDD. The main barrier is that many gynecologists and general psychiatrists lack knowledge about PMDD or training to prescribe this treatment. The guideline provides tools to help providers implement it.

## What it means for you

GnRH agonists are an option when standard medications fail. The challenge is finding doctors trained to use them. This guideline aims to educate more providers. Cost can be a barrier depending on insurance coverage.

2021

Latest evidence cited

## About the study

Original title What's Stopping Us? Using GnRH Analogs With Stable Hormone Addback in Treatment-Resistant Premenstrual Dysphoric Disorder: Practical Guidelines and Risk-Benefit Analysis for Long-term Therapy Authors Wagner-Schuman M, Kania A, Barone JC et al. Journal The Journal of clinical psychiatry Year 2023 Study design Guideline What was tested GnRH agonists with hormone addback. Read the paper [doi.org/10.4088/jcp.22r14614](https://doi.org/10.4088/jcp.22r14614)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Economic burden](https://niyora.com/research/topics/life-area-economic-burden/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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Review, 2008

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