--- title: Autism: 20 studies, explained | Niyora description: 20 studies on autism and PMS or PMDD, each summarised in plain English: what was tested, who took part, what they found and what it means. url: https://niyora.com/research/topics/comorbidity-autism/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Autism # Autism: what the research says 20 studies on autism in PMS and PMDD, each explained in plain English. 1 of them use the strongest designs: randomised trials and systematic reviews. Survey study 11 Study 3 Cohort study 2 Randomised trial 2 Systematic review 1 Review 1 Cohort study, 2023 Are PMS symptoms linked to genetic factors for psychiatric disorders? Yes. Women with PMS were more likely to have genetic factors for depression, bipolar disorder, ADHD, schizophrenia, and autism spectrum disorder. This was a large, well-designed study, so we can be confident in these findings. Survey study, 2026 Do people with ADHD traits have higher rates of PMDD than others? Yes, people with ADHD traits had significantly higher risk of PMDD. People with autism traits did not show a higher risk of PMDD. Survey study, 2026 Do women with ADHD and autism have more premenstrual problems than women without these conditions? Yes, women with ADHD and autism have significantly more premenstrual problems than women without these conditions, with equal severity in both groups. Premenstrual symptoms are linked to traits like inattention and social difficulties. Cohort study, 2008 Do women with autism have PMS more often than women without autism? Yes, women with autism had much higher rates of PMS compared to women without autism. In the autism group, 92% showed PMS symptoms, while only 11% of the control group did. Study, 2005 Can women recognize fear in faces better at certain times of their menstrual cycle? Yes. Women recognized fear expressions significantly better during the preovulatory phase when estrogen is highest, compared to during menstruation when estrogen is lowest. This pattern was not as strong for other emotions. Survey study, 2026 Could hormonal changes and immune problems explain menstrual issues in autistic women? This paper proposes that autistic women may experience severe menstrual and reproductive health problems because their immune cells react strongly to hormonal changes during menstruation and pregnancy. This proposed connection has not yet been tested. Survey study, 2026 Do teen girls with ADHD have more suicidal thoughts when angry before their period? Teen girls with ADHD are more likely to have PMDD and premenstrual anger. However, overall depression appears to be the main driver of suicide risk, not premenstrual anger alone. Systematic review, 2026 What do we know about PMDD in autistic people and those with ADHD? Very little research exists on PMDD specifically in autistic people and those with ADHD. Early evidence suggests they may experience more severe symptoms and face barriers to diagnosis, but we cannot yet say for certain. Survey study, 2025 Are girls with ADHD or autism more likely to have severe PMS or PMDD? Yes, girls with ADHD were 2.43 times more likely to have moderate to severe PMS, and girls with both autism and ADHD were 3.27 times more likely. Girls with only autism did not show this link. Survey study, 2024 Do blood flow changes during menstruation worsen PMDD differently in autistic women? This article discusses existing theory rather than reporting new research. It suggests blood flow redirects to the uterus during menstruation, which may reduce blood flow to the brain's prefrontal cortex and worsen mood dysregulation in autistic women, especially combined with sensory sensitivities. Randomised trial, 2023 Does matching your running training to your menstrual cycle phase improve performance, recovery and wellbeing? This pilot study was designed to test that question, but the text available here stops before the results section, so no answer can be given yet. Randomised trial, 2023 What does research show about PMDD neurochemistry? The provided text does not include results from a PMDD neurochemistry study. It discusses unrelated research on other topics. Survey study, 2022 Do autistic women experience more PMDD and worse menopausal symptoms than non-autistic women? Autistic women did not have more PMDD than non-autistic women (14.3% vs 9.5%), but they reported worse menopausal symptoms linked to depression. Survey study, 2018 Do autistic women experience menstruation differently from non-autistic women? Yes. Autistic women reported that menstruation made autistic challenges worse, especially sensory sensitivity and difficulty controlling emotions and behavior. This seriously affected their lives. Survey study, 2016 What menstrual health problems do young women with Angelman syndrome experience? Menstrual and premenstrual symptoms were common but infrequently caused problems at home or school. Girls with AS had significant challenges with menstrual hygiene and needed full assistance managing it. Survey study, 2012 What menstrual and premenstrual symptoms do girls with Rett syndrome experience and how are they treated? Girls with Rett syndrome commonly experience painful periods and PMS symptoms similar to other women, plus some autism-specific symptoms. Hormonal contraception, especially birth control pills, is commonly used to manage them. Study, 2011 How do women with autism experience menstruation and its symptoms? Women with autism (ages 10-25) commonly experience severe menstrual pain and PMS, but these conditions are often undertreated. Study, 2010 What gynecologic problems do girls with Down syndrome, autism, and cerebral palsy experience? Girls with these developmental disabilities commonly have irregular periods and mood or behavioral changes when they start menstruating. Girls with autism are especially likely to develop behavioral problems related to their periods. Review, 2005 How does acute tryptophan depletion help us understand mood disorders? Acute tryptophan depletion is a research method that temporarily lowers serotonin levels in the brain to study its role in depression, anxiety, sleep problems, and psychiatric conditions. Survey study, 2005 Do women with intellectual disabilities experience more period pain and PMS? Women with Down syndrome or autism spectrum disorder reported more period pain than is typical. However, the sample was very small and relied on parent reports, so firm conclusions are difficult. Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗