--- title: Anxiety and tension: 819 studies, explained | Niyora description: 819 studies on anxiety and tension and PMS or PMDD, each summarised in plain English: what was tested, who took part, what they found and what it means. url: https://niyora.com/research/topics/symptom-anxiety/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Anxiety and tension # Anxiety and tension: what the research says 819 studies on anxiety and tension in PMS and PMDD, each explained in plain English. 29 of them use the strongest designs: randomised trials and systematic reviews. Survey study 345 Randomised trial 116 Study 102 Cohort study 53 Review 50 Case-control study 48 Randomised trial, 2026 Does Kundalini Reiki help reduce PMS symptoms and improve quality of life? Yes, according to this rigorous double-blind study. Nursing students receiving Kundalini Reiki showed significantly greater improvements in PMS symptoms and quality of life compared to those who received placebo. Randomised trial, 2026 Does calcium and vitamin D supplementation reduce PMS symptoms? Yes. Women taking 1,000 mg calcium daily plus 50,000 IU vitamin D every two weeks for 12 weeks showed significantly greater improvements in anger, anxiety, food cravings, physical symptoms, and work efficiency compared to placebo. Randomised trial, 2026 Does aerobic or resistance exercise reduce anxiety in women with PMS? Both aerobic and resistance exercise reduced anxiety and improved emotional control in women with PMS. Resistance exercise was superior to aerobic exercise for reducing anxiety. Systematic review, 2026 Does vitamin D supplementation help PMS symptoms? Vitamin D reduced overall PMS severity and particularly helped with physical symptoms and depression, but the certainty of this evidence is very low. We cannot be confident in these findings yet and more high-quality research is needed. Systematic review, 2026 Do mindfulness and relaxation techniques help with PMS symptoms? Yes. These techniques reduced physical symptoms like pain and fatigue, and emotional symptoms like anxiety and depression. However, the evidence is still limited. Cohort study, 2025 Do women with PMS or PMDD report lower quality of life than women without these conditions? Yes. Women with PMS or PMDD reported significantly lower quality of life, particularly those with PMDD. These findings held even after accounting for mood and pain. Cohort study, 2025 How common is PMS in Chinese teenage girls, and what factors are linked to it? About 1 in 4 Chinese girls (24.6%) has PMS. Higher stress, anger, alcohol use, menstrual cycles of 24 days or less, and period pain are all linked to increased PMS likelihood. Cohort study, 2024 Does psychological distress in adolescence predict menstrual symptoms in adulthood? Yes. Women who had higher psychological distress at age 16 were significantly more likely to experience various menstrual symptoms at ages 16, 30, and 42. This is based on a large, long-term study. Randomised trial, 2024 Does curcumin reduce depression, anxiety, and stress in women with PMS and dysmenorrhea? Yes, curcumin significantly reduced depression, anxiety, and stress and improved mental health and quality of life compared to placebo. This was a larger, high-quality study. Guideline, 2024 How should Xiangshao Granules be prescribed for premenstrual tension syndrome? Experts from 29 major hospitals have created standardized guidelines on how to use Xiangshao Granules for premenstrual tension, including dosage and timing. These recommendations come from multidisciplinary experts' review of current evidence. Systematic review, 2024 Does yoga help reduce PMS symptoms? Yes, yoga appears to help reduce emotional, behavioral, and physical PMS symptoms and improve quality of life. The evidence comes from a systematic review of 14 randomized controlled trials. Review, 2024 What is premenstrual exacerbation and how does it affect different psychiatric illnesses? Premenstrual exacerbation is when psychiatric symptoms worsen during the premenstrual phase. Hormonal changes during the menstrual cycle create a vulnerable period for many psychiatric conditions, but premenstrual exacerbation remains poorly defined. Systematic review, 2022 Do mental health disorders get worse during the menstrual cycle? Yes, several mental health disorders like depression, panic attacks, eating disorders and borderline personality disorder clearly worsen around menstruation. The evidence is less clear for anxiety or bipolar disorder. Systematic review, 2021 Does damask rose help reduce menstrual pain, headache, fatigue, anxiety, and bloating? Damask rose significantly reduced menstrual-related headache, fatigue, and bloating, but did not clearly reduce menstrual pain or anxiety. More research on pain and anxiety is needed. Study, 2021 Does soy isoflavones help reduce PMS symptoms? Yes. A randomized controlled study found that soy isoflavones clearly helped reduce both mood symptoms and pain compared to a control group. Review, 2020 How do reproductive hormones affect the brain and behavior during the menstrual cycle? Reproductive hormones like estradiol and progesterone change significantly during the menstrual cycle and affect mood, thinking, perception, and behavior through effects on the brain. The same applies to hormones in oral contraceptives. Systematic review, 2019 Does psychotherapy reduce depression and anxiety in women with PMS? A review of 7 trials found a large decrease in depression levels (standardized mean difference -0.978), but the abstract is incomplete so we cannot know if this was statistically significant or what the full conclusions were. Review, 2018 Which women are most likely to experience hot flashes during menopause? Up to 80% of women experience hot flashes during menopause, lasting about 10 years on average. Black and Hispanic women are more likely to experience them, while Asian women are less likely. Randomised trial, 2017 Does the combined oral contraceptive pill affect mood? Yes, but effects vary by cycle phase. The pill causes small increases in anxiety and irritability between periods but improves depression in the days before menstruation. Non-randomised trial, 2008 Can the Sheehan Disability Scale measure whether treatments work? Yes. The scale was able to tell the difference between treatments that worked and treatments that didn't in clinical trials. Systematic review, 2008 What treatments work best for PMS and PMDD? Antidepressants called SSRIs are proven effective for severe PMDD and are the first medication to try. Lifestyle changes and exercise are recommended for all women with PMS or PMDD. Review, 2003 How do menstrual cycle hormones affect the brain and cause mood disorders like PMDD? A hormone called allopregnanolone acts on brain receptors. Changes in this hormone during the cycle may cause mood and behavioral symptoms in up to 20% of people through three mechanisms: direct effects, building tolerance, and withdrawal effects. Randomised trial, 2003 Are SSRI antidepressants effective for PMDD? Yes, SSRIs are effective first-line treatments for PMDD. Both continuous dosing and intermittent dosing during the luteal phase lead to rapid improvement in symptoms and functioning. Randomised trial, 1999 Does calcium reduce PMS symptoms? Yes, this large study of 497 women found that calcium supplementation reduced PMS symptoms during the luteal and menstrual phases. This is strong evidence from a well-designed trial. Randomised trial, 1999 Do SSRIs reduce premenstrual dysphoria symptoms? Yes. SSRIs work significantly better than placebo and faster than when used for depression or anxiety. Intermittent dosing (taking medication only before the period) may work even better than daily dosing. Randomised trial, 1997 Does Vitex agnus castus work better than vitamin B6 for premenstrual tension syndrome? Both reduced symptoms by similar amounts (47-48%), but more women on Vitex reported excellent results and had no remaining complaints, suggesting Vitex may work better for PMTS. Randomised trial, 1995 Does fluoxetine help premenstrual dysphoria? Yes. Fluoxetine at 20 mg or 60 mg per day significantly reduced tension, irritability, and dysphoria compared to placebo. The 20 mg dose had fewer side effects than the 60 mg dose. Survey study, 1994 How many different ways do researchers measure PMS in clinical trials? Researchers use many different measurement tools across studies. 65 different questionnaires were found in 350 trials of PMS drugs, making it hard to compare whether treatments actually work. Cohort study, 1993 How common are premenstrual and menstrual symptoms in women? Menstrual symptoms are very common in women in the community and increase with age. Women with anxiety are more likely to report menstrual problems. Survey study, 2026 Are menstrual characteristics linked to depression and anxiety in teenage girls? Yes. Girls with earlier periods, irregular cycles, long cycles, severe period pain, and worse premenstrual symptoms have higher depression and anxiety scores, and these links get stronger as girls get older. Survey study, 2026 How does PMS affect test anxiety in nursing students? PMS was linked to higher test anxiety both directly and indirectly through delaying sleep and reduced ability to pay attention. The indirect pathway through sleep delays and attention difficulties accounted for 50% of the link between PMS and test anxiety. Survey study, 2026 Are there different types or patterns of PMDD among Chinese college students? Yes. There are two patterns: one with severe emotional and physical symptoms, and another with milder symptoms. Women with painful periods were more likely to have the severe pattern. Survey study, 2026 What dietary, lifestyle, and psychological factors are associated with PMS in young women? Stress and sleep problems were independently associated with PMS. Diet and weight were not independently associated with PMS after accounting for other factors. This is a cross-sectional study, so these are associations, not proof of cause and effect. Randomised trial, 2026 Does online muscle relaxation training or lifestyle changes reduce PMS symptoms and improve work performance? Yes, both approaches significantly reduced PMS symptoms and improved work performance. Progressive muscle relaxation was slightly more effective for pain and overall symptom severity. Randomised trial, 2026 Does yoga or Pilates help manage PMS symptoms? Yes, both yoga and Pilates reduced depression, anxiety, stress, and improved quality of life over 6 weeks, with yoga producing slightly larger improvements. However, this was a very small pilot study. Randomised trial, 2026 Does education about PMS symptoms help reduce pain and stress? Yes. Women who received education about PMS symptoms had lower pain and stress levels than the control group, especially if their symptoms were more severe to begin with. Survey study, 2026 Does exercise help college women with period problems and mental health? Yes. College women who do moderate to vigorous exercise have less severe period problems, lower stress, fewer depression symptoms, and better sleep quality. Study, 2026 Does rimegepant help prevent migraines that happen around your period? Yes, in this study rimegepant worked well. Women who took it around their period had fewer, shorter, and less severe migraines, and their quality of life improved. However, this was a small study without a comparison group. Study, 2026 Does how women's body responds to stress change across their menstrual cycle? Yes. During the luteal phase (the second half of the cycle), women's blood pressure and anxiety rose more when they faced a stressor, compared to other phases. This suggests the luteal phase involves different stress reactivity. Survey study, 2026 What factors affect PMS in university students and does it impact schoolwork? About 15% of students had significant PMS. More than half said it affected their schoolwork. Strong family support reduced PMS, and students with PMS were less likely to have very dysfunctional families. Study, 2026 Do anxiety and depression get worse before your period if you already have a mental health condition? Yes. If you have depression, bipolar disorder, or other mental health conditions, symptoms often worsen before your period due to hormone changes. This can affect how well treatments work. Study, 2026 Does increased brain reward sensitivity protect mood during the premenstrual phase? Possibly. When estradiol levels drop before the period, some women's brains show increased sensitivity to rewards. Women who had bigger increases in reward sensitivity experienced smaller increases in depression symptoms. Study, 2026 How do mood, heart rate, and muscle strength change during the menstrual cycle? Heart rate patterns change across the cycle, especially during the mid-luteal phase when progesterone is highest. Muscle strength appears stable, but feeling energetic links with muscle activity. Depression increases during the early-cycle phase. Survey study, 2026 Is worry about climate change linked to worse PMS symptoms? Higher climate change anxiety was associated with worse PMS symptoms. Climate anxiety is just one of many factors affecting PMS severity. Survey study, 2026 What lifestyle and work factors are linked to PMDD symptoms in Chinese nurses? 42.4% of Chinese nurses have PMDD symptoms. Risk is higher in those who work night shifts, do not exercise, drink alcohol, are overweight in a certain range, or have depression, anxiety, or poor sleep. Case-control study, 2026 Does PMDD affect how the brain handles motivation when facing difficult choices? Women with PMDD showed less motivation in low-conflict situations and reduced brain activity in reward centers compared to healthy women. This suggests PMDD affects how the brain processes rewards and risks. Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? Between 5% and 8% of women have moderate-to-severe symptoms that cause significant problems with work, relationships, and daily life. These are called PMS or PMDD. PMDD is the most severe form. Survey study, 2026 Does the Chinese version of the PMS screening questionnaire work well? Yes. The Chinese version is reliable and valid for identifying PMS and PMDD in Chinese college students. Survey study, 2025 Do menstrual problems and poor sleep affect mood and thinking in teenage girls? Yes. Clear links exist between menstrual pain or PMS symptoms and anxiety, depression, and social problems in adolescent girls. Sleep also matters. Girls with later bedtimes or shorter sleep plus pain had worse mood and thinking problems. Survey study, 2025 Do women with PMS have higher anxiety, stress, and different personality traits? Yes. Women with PMS had significantly higher anxiety sensitivity and stress levels, higher neuroticism and psychoticism traits, and slightly lower extraversion than women without PMS. Systematic review, 2025 Does the menstrual cycle affect how your body and emotions respond to stress? There is modest evidence that during the luteal phase (the second half of your cycle), you show greater heart rate changes and emotional reactions to stressful situations. This may explain some PMS symptoms. Study, 2025 Do women have different symptom patterns before, during, and after menopause? Yes. Women have different symptom patterns depending on whether they are before, during, or after menopause. All women experience fatigue, headache, anxiety, and brain fog regardless of life stage. Randomised trial, 2025 Does relaxation training help women with PMDD? Yes. Relaxation training significantly reduced PMDD symptoms, anxiety, depression, and disability in women with PMDD, and improved their quality of life. Randomised trial, 2025 Can hypnosis ease anxiety, stress and low mood in women with PMS? Yes, in this small trial women who had hypnosis sessions ended up with lower depression, anxiety and stress scores than women who had no treatment, but the study was small and not blinded. Study, 2025 Does anger get worse before your period? Yes. Anger and irritability are clearly more severe before your period across reproductive ages. Randomised trial, 2025 How do leptin levels and combined medical treatments affect premenstrual symptoms in obese women? Obese women with premenstrual tension syndrome had higher leptin levels and nervousness than healthy women. Combined treatments including diet, exercise, and medication significantly reduced both leptin levels and nervousness. Case-control study, 2025 Does sleep quality affect brain activity and anxiety-depression symptoms in PMS? Yes. Poor sleep quality in PMS patients is linked to different brain activity patterns. The relationship between certain brain changes and anxiety-depression symptoms is partly explained by sleep quality. Survey study, 2025 How do personality traits like neuroticism affect PMS severity and sexual satisfaction? Yes, personality traits significantly predict both PMS severity and sexual satisfaction. Women with higher neuroticism had more severe PMS with anxiety, depression, and fatigue, while those with higher extraversion had milder PMS and better sexual satisfaction. Randomised trial, 2025 Does Nigella sativa reduce PMS symptoms in women? Yes, Nigella sativa supplements reduced PMS symptoms and increased estrogen levels in women with moderate to severe PMS. This is a well-designed study, but the sample size is not reported in the abstract. Survey study, 2025 How do premenstrual symptoms change with age? Physical symptoms vary with age. Acne and oily skin are most common at ages 20-29, and headache at 30-49. Emotional symptoms like irritability and anger are most severe at all ages. Survey study, 2025 Is the PSST a good screening tool for PMS in Bangladesh? Yes, the Bangladeshi version of the PSST was found to be valid and reliable for screening PMS, with strong correlations to depression, anxiety, and stress. Case-control study, 2025 Do women with eating disorders experience more menstrual distress, and does birth control help? Yes, women with eating disorders reported significantly more menstrual distress than healthy women across all symptoms measured. Birth control reduced distress only in those with milder eating disorder symptoms, not in those with more severe symptoms. Survey study, 2025 Can anxiety and depression predict how severe PMS will be? Yes. Depression and anxiety strongly predict PMS severity. When depression increased by one level, PMS risk went up 41%. When anxiety increased by one level, risk went up 51%. Case report, 2025 Does an online peer support community help women with PMDD? Yes, probably. Women who joined r/PMDD showed a clear decrease in linking PMDD to depression and anxiety. The community seems to help them understand PMDD separately. However, this is based on analyzing discussions, not a controlled study, so we cannot be certain it caused these changes. Survey study, 2025 How common is PMDD in Brazilian women and what are the most frequent symptoms? PMDD affects 3.57% of Brazilian women. Emotional symptoms like anxiety and irritability are much more common than physical symptoms like weight gain. Cohort study, 2025 What causes migraine in female college students who have PMS? Among college students with PMS, those with migraine have worse sleep quality and higher anxiety. Poor sleep and anxiety appear to predict migraine risk. Survey study, 2025 Is PMS connected to mental health problems and lifestyle choices? Yes, 64% of nursing students had PMS and it was strongly linked to depression, anxiety and stress. PMS was also more common in students who smoked, drank alcohol, drank coffee or reported psychological problems. Survey study, 2025 How common are PMS, anxiety, and depression in teenage girls, and are they related? PMS is very common (89.35%), as are anxiety (98.72%) and depression (75%). Depression is linked to PMS, but anxiety is not. Survey study, 2025 Can flexibility in managing difficult feelings help mothers with PMDD parent better? Mothers with higher psychological flexibility (ability to accept and work with difficult feelings) showed more positive parenting even when they had worse PMDD symptoms. Psychological flexibility also reduced depression and anxiety. Survey study, 2025 Does PMS make teenage girls more anxious and reduce their quality of life? Yes, PMS significantly increases social anxiety and reduces quality of life in teenage girls. The effect was stronger in urban areas and in school-going girls. Survey study, 2025 Do menstrual problems lower well-being through anxiety? Premenstrual symptoms and menstrual pain lower well-being both directly and through worry about the future. Other menstrual problems like irregular bleeding only affect well-being through causing worry. Survey study, 2025 Does physical activity help reduce PMS symptoms? Yes, there was a clear link between more exercise and less severe PMS symptoms. The improvement came both from exercise itself and partly from exercise reducing anxiety. Survey study, 2025 Is a Chinese version of a PMDD screening tool reliable and valid for identifying PMDD? Yes. The Chinese version is reliable and accurately identifies PMDD in college students. It can distinguish women with PMDD from those without. Case-control study, 2024 Do women with PMDD have a weaker stress response? Yes, women with PMDD showed significantly lower stress hormone (cortisol) levels 40 to 90 minutes after a stressful test, suggesting a blunted stress response. Survey study, 2024 Is PMS linked to mental health problems and stress in teenage girls? Yes, PMS was strongly linked to anxiety, depression, self-harm, and suicidal thoughts in Polish teenage girls, along with stress and risky behaviors. However, finding a link doesn't prove PMS causes these problems. Study, 2024 When women suspected of having PMDD are tracked for 3 months, how many actually meet the full criteria? About two-thirds (65.3%) of women with suspected PMDD actually met the full criteria for PMDD when their symptoms were tracked for 3 months. Randomised trial, 2024 Can stress inoculation training reduce anxiety, depression, and stress in students with PMS? Yes. Computer-based stress inoculation training significantly reduced PMS severity, anxiety, depression, and perceived stress in university students. Randomised trial, 2024 Does emotion-focused therapy help PMDD symptoms? Yes. Emotion-focused therapy significantly reduced PMDD symptoms, emotion regulation difficulties, and depression and stress over 16 weeks compared to a waiting list control. Randomised trial, 2024 Do hormonal changes in obese women cause worse PMS, and can medications help? Yes, obese women with PMS had significantly higher stress hormone levels than healthy women, and a combination treatment of medications, diet, and exercise significantly reduced these hormones and PMS symptoms. Cohort study, 2024 How does sleep change across your menstrual cycle? Sleep was best during the mid-to-late follicular phase (when estrogen is rising) compared to menstruation and the luteal phase. This is fairly clear evidence from 96 women. Survey study, 2024 What menstrual and mental health factors are linked to high-risk premenstrual dysphoric disorder? Heavy periods, irregular cycles, severe period pain, anxiety, depression, loneliness, and low resilience were all linked to higher PMDD risk. Resilience might help buffer the effects of anxiety and depression. About half of students studied had high-risk PMDD. Study, 2024 Does how women feel when exercising change across the menstrual cycle? Yes, clearly. Women experience worse pain, water retention, nausea, and dizziness before high-intensity exercise during menstruation versus other phases. They have lower motivation during menstruation and the luteal phase. However, exercise improves mood and motivation regardless of phase. Randomised trial, 2024 Do positive psychology and physical activity help PMS symptoms? Yes. Both positive psychology and physical activity significantly reduced depression, anxiety, and stress in students with PMS, with benefits appearing about two months after the interventions. Randomised trial, 2024 Can yoga or muscle relaxation exercises ease PMS symptoms? Yes, in this small trial, students who practiced yoga, or yoga plus progressive muscle relaxation, had lower PMS scores afterward than those who did only relaxation or nothing. Survey study, 2024 Are menstrual cycle symptoms related to sleep problems and mental health in female athletes? Yes. Women with more menstrual symptoms reported more depression, anxiety, stress problems, and sleep issues. Survey study, 2023 Can psychological immunity and coping skills reduce anxiety and depression in women with PMS? Psychological immunity and coping strategies were strongly linked to lower anxiety and depression in women with PMS. Self-regulation was the strongest protective factor. Cohort study, 2023 Is the mid-luteal phase a vulnerable time for mood problems? The study found weak evidence for this. Women had more depression-like symptoms in the mid-luteal phase, but stress was a stronger predictor of mood changes than menstrual cycle phase. Survey study, 2023 Which personality traits predict PMDD or severe PMS? Women with anxious or cyclothymic personality traits are more likely to have PMDD and severe PMS. About 13.2% of women studied had PMDD. Survey study, 2023 Do stomach and gut problems change during the menstrual cycle? Overall gut symptoms did not differ clearly across menstrual cycle phases. However, pain in the lower belly was higher during menstruation than in other cycle phases. Survey study, 2023 Is PMDD diagnosis associated with more severe depression and anxiety and lower well-being? Yes. Women with probable PMDD had significantly higher depression and anxiety symptoms and lower well-being compared to those without PMDD, regardless of their menstrual cycle phase. Cohort study, 2023 Are premenstrual disorders linked to depression, anxiety, and self-harm in teenage girls? Yes. Girls with premenstrual disorders have 4 to 7 times higher rates of depression, anxiety, self-injury, and suicide risk compared to boys and girls without the disorder. This suggests premenstrual disorders may cause much of the difference in mental health problems between teenage boys and girls. Review, 2023 Can herbs and supplements help with PMS symptoms? Herbs like chaste berry and supplements like calcium and magnesium may help with PMS. Evidence is strongest when combined with lifestyle changes and therapy, though more research is needed. Survey study, 2023 Is PMS related to depression, anxiety, and stress during the COVID-19 pandemic? Yes. A clear relationship was found between PMS and depression, anxiety, and stress. Most women experienced PMS (68.8%), anxiety (75.8%), and depression (63.8%). Survey study, 2023 How common are PMS, PMDD, anxiety, and depression in rural adolescent girls? In 430 rural girls, 8.8% had PMDD and 17.4% had PMS. PMDD was significantly linked to depression, anxiety, menstrual pain, irregular cycles, and family type. Case-control study, 2023 Do women with premenstrual syndrome respond differently to emotional stress? Yes. Women with PMS showed different brain wave patterns and lower stress hormone levels. These differences were moderately linked to how severe their PMS was. Survey study, 2022 How common are PMS and PMDD? Are stress, anxiety, depression, and sleep problems related to them? About 22.49% of women have PMS and 1.36% have PMDD. Women with these conditions have much higher stress, anxiety, and depression and worse sleep than women without them. Survey study, 2022 How common are PMS and menstrual problems in women on kidney dialysis? Very common. 70% had PMS and 58% had dysmenorrhea. Several medical factors including hypertension, autoimmune disease, and hepatitis C infection increased risk. Cohort study, 2022 Do adverse childhood experiences increase risk of PMS and PMDD? Women who experienced adverse childhood events had significantly higher risk of PMS and PMDD. Those with 4 or more such experiences had 2.46 times higher risk than those with none. The link was stronger for PMDD than for PMS. Survey study, 2022 What diet, stress, and lifestyle factors are linked to PMS symptoms? High coffee intake, sugar, stress, smoking, and low physical activity were all linked to worse PMS symptoms, with stress showing the strongest association. These are associations only, not proven causes. Randomised trial, 2022 Does group counseling reduce PMS symptoms and depression, stress, and anxiety? Yes, group counseling significantly reduced PMS severity and depression, stress, and anxiety in women with PMS. Randomised trial, 2022 Does auriculotherapy reduce PMS symptoms? Both auriculotherapy and placebo auriculotherapy reduced PMS symptoms, pain, and anxiety. The benefits were similar between the two groups, suggesting placebo effect may play a role. Randomised trial, 2022 Does PMS50 supplementation reduce psychological symptoms of premenstrual syndrome? Yes, it helped several psychological symptoms like mood, anxiety, and irritability compared to placebo. The study was small, so we need larger trials to be sure. Survey study, 2022 What factors are associated with irregular menstrual cycles and how do irregular cycles affect other symptoms? Irregular cycles (varying by more than 7 days) affected 21% of nurses. Higher weight, lack of vigorous exercise, shift work, and heavy lifting were associated with irregular cycles. Women with irregular cycles also reported more depression, anxiety, stress, fatigue, and sleep problems. Survey study, 2022 Did the COVID-19 pandemic change women's periods and mental health? Yes. More than half of women reported changes in their menstrual cycle, including more heavy bleeding, painful periods, and missed periods. Rates of depression, anxiety, and poor sleep were more than double what is normal, and these were connected to menstrual changes. Cohort study, 2022 Does living in greener areas reduce PMS symptoms? Yes, women living in greener areas had lower rates of several PMS symptoms including anxiety, depression, sleep problems, and breast tenderness. The effect was modest but consistent. Case-control study, 2022 Does how women think about their period affect how their nervous system responds to stress? Yes. How women view their period (as bothersome or predictable) affects their nervous system response. Women with PMS also show delayed recovery from stress during the premenstrual period. Survey study, 2022 Does physical activity or anxiety affect PMS in young women? Anxiety is strongly linked to PMS, but physical activity is not. Girls with higher anxiety had more severe PMS symptoms. Survey study, 2022 How common are premenstrual symptoms, and do they change with age? Very common. Food cravings affect 85%, mood swings 64%, and fatigue 57%. Several symptoms got worse with age, but mood symptoms stayed the same across all age groups. Survey study, 2022 Do stress and rumination increase with PMS severity? Yes. Women with more severe PMS symptoms had higher levels of stress, anxiety, depression and rumination. Momentary stress and rumination also increased during the premenstrual phase of the cycle. Systematic review, 2022 Do anxiety disorders, PTSD and OCD get worse at certain points in the menstrual cycle? For some women, yes. A review of 14 studies found that symptoms of several anxiety-related disorders tend to flare around the days before and after the period starts, but this pattern doesn't happen in every woman. Study, 2022 Does having COVID-19 affect premenstrual syndrome symptoms? Yes. Women who recovered from COVID-19 within the previous 6 months reported more PMS symptoms than women who had never had COVID-19. Randomised trial, 2021 Does hypnotherapy reduce pain and emotional distress in women with PMDD? Yes. Hypnotherapy focusing on cognitive flexibility and ego strength reduced pain and emotional distress much more than no treatment. Cohort study, 2021 Does the menstrual cycle change how brain regions connect with each other? Yes. The menstrual cycle changes how brain regions connect, particularly around ovulation, and these changes relate to estradiol levels and well-being. This is a small study (24 women) so the findings need confirmation in larger groups. Survey study, 2021 What factors affect premenstrual syndrome in teenage girls? Multiple factors affect PMS. These include how active you are physically, what you eat (especially coffee), stress, and feelings of insecurity. Survey study, 2021 Does the menstrual cycle affect women's ability to train and compete? Yes. Women who experienced more frequent menstrual symptoms were significantly more likely to miss or change their training, miss competitions, miss work or school, and use pain medication. Randomised trial, 2021 Does ulipristal acetate help premenstrual dysphoric disorder? Yes. After 3 months, women taking ulipristal acetate had 41% improvement in symptoms versus 22% with placebo, and 50% achieved full remission versus 21% with placebo. Case-control study, 2021 Does sleep quality change across the menstrual cycle in women with anxiety disorders? Sleep quality remained mostly stable across menstrual cycle phases in both groups. The only link found was that larger increases in estradiol were associated with fewer nighttime awakenings. Survey study, 2021 Does the menstrual cycle affect how emotions and heart rate connect? In the luteal phase, women's sadness, stress, and anxiety were linked to increased heart rate and reduced heart rhythm variation, but this was not seen in the follicular phase. Women also showed larger heart rate increases with anger than men. Survey study, 2021 Does COVID-19 stress affect menstrual cycle regularity? Women healthcare workers with irregular periods reported significantly higher stress, anxiety, and depression linked to COVID-19 compared to women with regular periods. About 28.7% of the women in the study had irregular cycles during the pandemic. Case-control study, 2021 Does depression affect whether a screening tool accurately identifies PMS? Yes. A screening tool for PMS overidentified PMS in depressed women compared to tracking daily symptoms. Women with depression may report more PMS symptoms on a screening tool than they actually experience day-to-day. Cohort study, 2020 Are women with PMDD more likely to have generalized anxiety disorder? Yes, women with generalized anxiety disorder were 7.65 times more likely to have PMDD than those without it. The connection between the two conditions was explained by depression and partly by behavior inhibition and irritability. Case-control study, 2020 Is diet quality lower in teenagers with PMS? Yes. Teenagers with PMS have lower diet quality scores. Better diet quality was linked to less anxiety, depression, and sleep problems in girls with PMS. Lab study, 2020 Does anxiety sensitivity change during different parts of the menstrual cycle? No, not much. Anxiety sensitivity remained relatively stable across the menstrual cycle phases tested, even in women with PTSD. Randomised trial, 2020 Does an oxaloacetate and vitamin C combination reduce emotional symptoms of PMS? Yes. The supplement significantly improved depression, anxiety, stress, and aggression, with depression improving by 54.1% and suicidal ideation reduced by 47.9%. Case-control study, 2020 Does fatigue change across the menstrual cycle, especially in women with anxiety? Mental fatigue increases during the high-hormone phase in healthy women, rising to levels that women with anxiety disorder experience. Physical fatigue does not change, and hormone levels alone do not explain fatigue. Survey study, 2020 Is PMS common in female university students and linked to anxiety, depression, and stress? PMS is common, with most students having moderate symptoms and 8% experiencing severe PMS. PMS is significantly associated with anxiety, depression, and stress. Randomised trial, 2020 Does progesterone therapy help premenstrual syndrome in women with PCOS? Yes, progesterone significantly reduced multiple emotional PMS symptoms in women with PCOS, including depression, anxiety, and mood swings. Survey study, 2020 What topics are researchers most interested in studying about PMS and PMDD? Researchers have published 2,833 papers on PMS and PMDD from 1945 to 2018, with growing focus on depression, anxiety, and how these conditions affect young women. Cohort study, 2019 Do SSRIs help women who have both PMS and panic disorder? Yes. After six months of SSRI treatment, most symptoms improved though they persisted in reduced form. About 40 percent of women recovered completely. Survey study, 2019 Does the luteal phase worsen anxiety and checking behaviors? Checking behaviors and anxiety-related brain responses stay about the same between cycle phases, but they are more strongly linked during the luteal phase. Randomised trial, 2019 Does cooling the head during sleep improve sleep quality during the luteal phase? Yes, according to a small study. Young women with daytime sleepiness during the luteal phase showed improved sleep quality with head cooling, including fewer sleep interruptions and more deep sleep. Non-randomised trial, 2019 Does exercising before your period help with pain and anxiety? Yes, exercising 30 minutes a day for 5 days before your period significantly reduced both pain and anxiety. This was a controlled trial but not fully randomized. Survey study, 2019 How common is PMDD in teenage girls? Nearly 5% of teenage girls surveyed had PMDD. Girls with PMDD also had higher levels of stress, depression, and anxiety. Study, 2019 Can an educational health program reduce depression and anxiety in women with PMS? Yes. An 8-week program on healthy living and mental health reduced depression and anxiety in women with PMS. Depression dropped from 15 to 8.01 on average, and anxiety dropped from 9.1 to 4.73. Non-randomised trial, 2019 Does Benson's relaxation technique reduce oxidative stress and PMS symptoms? Yes. Women who used Benson's relaxation technique showed a clear change in oxidative stress markers compared to those who did not. This may help reduce both physical and mental PMS symptoms. Randomised trial, 2019 Does yoga reduce anxiety in women with PMS? Yes, yoga significantly reduced anxiety symptoms in women with PMS compared to no yoga. Diastolic blood pressure also improved. Randomised trial, 2018 Does inhaling lavender oil help with premenstrual syndrome? Yes. Inhalation of lavender oil reduces PMS symptoms compared with a control group, including anxiety, depression, nervousness, pain, and bloating. Randomised trial, 2018 Can a lemon balm (Melissa officinalis) capsule improve mental health symptoms in teenage girls with PMS? Yes, in this trial girls taking lemon balm capsules had significantly better scores for psychosomatic symptoms, anxiety, sleep problems and social functioning than girls taking a placebo. Randomised trial, 2018 Does swimming reduce premenstrual syndrome symptoms? Yes. Swimming significantly reduced anxiety, depression, cramps, headaches, and most other PMS symptoms, but it did not help irritability or food cravings. Cohort study, 2018 Does progesterone affect women's anxiety across the menstrual cycle? Yes. Women with higher average progesterone reported higher anxiety, and anxiety increased as progesterone rose during the cycle. Both studies showed this link. Case-control study, 2017 Does heart rate change across your menstrual cycle if you have insomnia during menopause? Yes. Women with insomnia in the menopausal transition have heart rates about 4 beats per minute higher than controls throughout both phases of the cycle. Case-control study, 2017 Are PMDD symptoms triggered by changes in hormone levels or by having high hormone levels? PMDD symptoms are triggered by the rapid increase in hormone levels after ovulation, not by having those hormones at steady high levels. Once hormone levels stay stable, symptoms improve. Randomised trial, 2017 Does acupressure at specific points reduce PMS symptoms? Yes, acupressure at points LIV3 and LI4 for 14 days before menstruation reduced PMS symptoms, anxiety, and depression, and improved quality of life compared to placebo acupressure. Study, 2017 Does menstrual cycle phase affect how much pain women feel when orthodontic treatment starts? Yes. Women in the follicular phase experienced less pain after the initial archwire was placed compared to women in the luteal phase. Cohort study, 2017 Are oxidation levels abnormal in women with PMDD? No. Women with PMDD did not differ from healthy controls in oxidant-antioxidant balance or paraoxonase-1 enzyme levels, despite having higher depression and anxiety symptoms. Randomised trial, 2017 Does Sepranolone reduce symptoms of severe premenstrual syndrome (PMDD)? Yes, Sepranolone reduced PMDD symptoms significantly more than placebo, with severe symptom scores dropping by 75% compared to 47% for placebo in women who completed treatment correctly. However, implementation challenges limit confidence in the results. Survey study, 2016 Does the menstrual cycle affect daily mood, and does anxiety or rumination change this effect? Calmness was higher during menstrual and luteal phases. Women with high anxiety and rumination experienced worse irritability before their period, while those with low anxiety were protected from mood worsening. Survey study, 2016 Do hormonal contraceptives reduce PMS symptoms? Hormonal contraceptives are linked to lower risk of some PMS symptoms, including cramps, fatigue, and depression, but not others like mood swings and bloating. Guideline, 2016 Can education improve understanding and management of PMS in blind teenage girls? Yes. After receiving an educational guideline about PMS, blind adolescent girls showed significant improvements in knowledge, daily care practices, and pain and anxiety relief. Randomised trial, 2016 Does foot reflexology with relaxation training reduce premenstrual symptoms in young women? Yes, adding foot reflexology to relaxation training significantly reduced PMS symptoms more than relaxation training alone. Survey study, 2016 Do relaxation exercises and meditation reduce PMS symptoms and anxiety in girls? Yes. Girls who did relaxation exercises had clear reductions in anxiety and PMS symptoms compared to girls who did not do the exercises. Survey study, 2016 Do paranoid thinking and self-esteem change across the menstrual cycle? Yes. During the paramenstrual phase (3 days before and after the period), women reported more feelings of persecution, lower positive self-esteem, higher negative self-esteem, and more anxiety and depression compared to mid-cycle. The difference was clear. Randomised trial, 2016 Does mindfulness-based cognitive therapy reduce PMS, depression and anxiety? Yes. Women who received mindfulness-based cognitive therapy showed significantly lower depression, anxiety, and PMS symptoms than those who received no treatment. Study, 2015 Where does swelling occur in women with premenstrual syndrome? Most women with PMS experience swelling in the face, breasts, abdomen, and limbs during the premenstrual period. Irritability, swelling, and anxiety were the most common symptoms. Study, 2015 Does premenstrual tension slow how quickly women react to sounds and lights? Yes. Women took longer to react to both sounds and lights during their premenstrual phase compared to the postmenstrual phase. Case-control study, 2015 Does the menstrual cycle affect psychological symptoms differently in women with PTSD? Psychological symptoms including depression and anxiety were worse during the early follicular phase compared to the midluteal phase. Women with PTSD showed worse phobic anxiety in the early follicular phase, while women without PTSD did not show this pattern. Study, 2015 How do women with PMS respond to stress compared to women without PMS? Women with PMS show a weaker stress response in their body than women without PMS, measured by cortisol (a stress hormone). This difference was consistent regardless of where they were in their menstrual cycle. Cohort study, 2015 What factors predict anxiety and depression during pregnancy and after birth? Women are at high risk for anxiety and depression around pregnancy and birth, especially those with prior mental health problems or poor social support, though symptoms vary widely between women. Review, 2014 Are mental health problems linked to gynecological conditions like PMS and PMDD? Yes. Anxiety and depression are common with PMS and PMDD and are frequently undetected and untreated, affecting women's work, social and personal lives. Case-control study, 2014 Are reward and punishment sensitivity different in women with PMDD and related to hormone levels? Yes. Women with PMDD show heightened reward sensitivity and increased sensitivity to negative stimuli during the premenstrual phase, which are related to progesterone levels. Survey study, 2014 Are depression and anxiety linked to period pain in teenage girls? Yes. Girls with painful periods had higher anxiety and depression scores than those without. Girls with the most severe form of PMS had much higher scores. Survey study, 2014 What psychological factors are linked to premenstrual syndrome? Psychological factors like difficulty identifying emotions, low social support, neurotic personality, and anxiety are associated with PMS. The strongest link was difficulty identifying emotions, which increased PMS risk 4.39 times. Cohort study, 2014 How common are PMDD, subthreshold PMDD, and PMS in adolescent girls, and how much do they affect their lives? About 20 percent of adolescent girls reported distressing premenstrual symptoms. Roughly 6.76 percent met criteria for full PMDD and 6.2 percent met criteria for subthreshold PMDD, which is a milder form. Study, 2014 Do women and men respond differently to sudden loud noises, and does the menstrual cycle matter? The menstrual cycle affects how women respond to sudden loud sounds, but being female versus male alone does not clearly affect this. Cohort study, 2013 Do depression, irritability, and anxiety get worse before the period in women with PMDD? Yes. Women with PMDD showed worsening depression, irritability, and anxiety in the days before their period, while women without PMDD did not. Randomised trial, 2013 Does yoga reduce PMS symptoms and physical stress markers? Yes. Women who did yoga for 3 months had significantly lower heart rate, blood pressure, anger, depression, and anxiety, and higher sense of wellbeing compared to controls. Randomised trial, 2013 Does acupuncture help anxiety and depression from PMDD? Real acupuncture reduced anxiety and depression significantly more than sham acupuncture, with anxiety scores dropping 58.9% versus 21.2% and depression scores dropping 52.0% versus 19.6%, suggesting a real treatment effect. Randomised trial, 2013 Does psychological education reduce PMS symptoms in teenagers? Yes. Psychological education significantly reduced overall PMS severity and reduced anxiety and physical symptoms. Effects on depression were minimal, and the intervention did not improve difficulty in relationships. Cohort study, 2013 Do women who are prone to anxiety experience more severe menstrual symptoms? Women with higher anxiety sensitivity reported greater menstrual symptoms regardless of which phase of their cycle they were in, compared to women with lower anxiety sensitivity. This suggests anxiety sensitivity may be an important factor in how severe menstrual symptoms feel. Randomised trial, 2013 Does progesterone reduce PMS symptoms in women with polycystic ovary syndrome? Yes. Women with PCOS and PMS who took progesterone had significant reductions in depression, anxiety, mood swings, bloating, and several other PMS symptoms compared to placebo. Study, 2012 Does stress affect your body differently during your luteal phase? Yes, women show greater heart rate and blood pressure increases to stress during their luteal phase compared to their follicular phase. Sleep and negative mood together affect how much anxiety stress causes during the luteal phase. Randomised trial, 2012 Do women with PMDD have different emotional brain responses across the menstrual cycle? Women with PMDD showed different emotional brain patterns during the follicular phase and links to anxiety and progesterone levels, rather than a simple luteal phase increase. Anxiety proneness and progesterone appear to modulate emotional reactivity in PMDD. Study, 2012 Do women with severe PMS have poor sleep quality? Women with severe PMS feel like they sleep poorly before menstruation, but measurements of their actual sleep don't show this. How they feel about sleep is strongly linked to anxiety. Survey study, 2012 What non-hormonal medications and therapies help severe PMS and PMDD? SSRIs (a type of antidepressant) are well-established for severe PMS and PMDD, taken either continuously or during the luteal phase. Cognitive-behaviour therapy, calcium, and chasteberry may also help, though the strength of evidence varies. Cohort study, 2012 How quickly does fluoxetine start working for PMDD symptoms? Very quickly. Fluoxetine improved irritability, sadness, anxiety, and mood swings within hours, with clear daily improvement by the second day. Survey study, 2012 Is severe PMS linked to psychiatric symptoms like depression and anxiety? Yes. Women with PMS have significantly higher depression, anxiety, aggression and interpersonal sensitivity than healthy women. These symptoms increase as PMS becomes more severe. Study, 2012 Does anxiety sensitivity affect panic symptoms differently at different menstrual cycle phases? Women with higher anxiety sensitivity had more panicked thoughts during the premenstrual phase compared to the follicular phase, and compared to women with lower anxiety sensitivity. Physical panic symptoms did not differ clearly. Survey study, 2011 Are premenstrual symptoms linked to health anxiety? Yes. Women with more PMS symptoms showed clear connections to health anxiety, and these symptoms often happened together with depression and panic. Cohort study, 2011 Which six symptoms best identify who has PMS? Six key symptoms identify PMS just as well as tracking 17 symptoms: anxiety or tension, mood swings, aches, appetite changes, cramps, and decreased interest in activities. They correctly classified 84 to 86 percent of cases. Review, 2010 How can doctors treat moderate to severe premenstrual symptoms? This review describes multiple treatments: lifestyle changes, cognitive behavioral therapy, birth control that suppresses ovulation, antidepressants, and anti-anxiety medications. Between 20-50% of women experience moderate to severe symptoms, and about 5% meet criteria for PMDD. Review, 2010 Can neurosteroids help with anxiety and brain disorders? The review suggests neurosteroids might help with anxiety, epilepsy, and depression, but clinical evidence is limited. Survey study, 2010 Do women with premenstrual asthma have more premenstrual symptoms overall? Yes. Women whose asthma worsens before their period had greater increases in most premenstrual symptoms, especially belly and breast tension, compared to women without this pattern. Study, 2010 Does how the body responds to stress change during the menstrual cycle? Partly. Stress response is slightly different in follicular and luteal phases, and the type of stress matters. Anxiety response to mental stress was higher in the follicular phase. Case-control study, 2010 Do lesbian and bisexual women have different reproductive health than heterosexual women? The study found that lesbian and bisexual women had less gynecological screening and more sexually transmitted infections, but response rate differences may have affected the findings. Randomised trial, 2010 Does St John's wort help women with mild PMS? St John's wort at 900 mg daily was more effective than placebo for physical and behavioral PMS symptoms, but the study was small. Survey study, 2009 What premenstrual and menstrual symptoms do Chinese women experience? About 18.6% to 34.2% of Chinese women reported 10 or more menstrual symptoms, showing that PMS is common in Chinese women at similar rates to Western populations. Cohort study, 2009 Does treating heavy periods with endometrial ablation help period pain and premenstrual mood symptoms? Yes. When women had endometrial ablation (a procedure that reduces menstrual bleeding), both period pain and premenstrual mood symptoms like irritability and depression improved over 3 and 6 months. Case-control study, 2009 How common is irritable bowel syndrome in Korean teenage girls and what causes it? One in four Korean teenage girls has IBS. Stress, anxiety, and depression were strongly linked to IBS, with depression showing the strongest connection. Study, 2008 Do women who are naturally anxious show bigger stress responses during certain parts of their menstrual cycle? Yes. Women who are naturally anxious showed the biggest stress response (more cortisol and higher blood pressure) during the early part of their menstrual cycle, but non-anxious women did not show this pattern. Cohort study, 2008 Does age at menarche affect how much premenstrual symptoms women have? Women who started their period before age 11 reported more symptoms and syndrome, but the difference was not strong enough to be certain it wasn't just chance. Case-control study, 2007 Does progesterone activate the part of the brain that handles fear and emotion? In 18 healthy women, taking progesterone doses that matched luteal phase levels significantly increased activity in the amygdala (the brain's emotion and fear center) when viewing emotional images. This may explain why progesterone could cause anxiety in women with PMDD. Survey study, 2007 Are diet and lifestyle factors associated with premenstrual symptoms? Most dietary factors were not related to PMS. Smoking increased symptoms, and alcohol was associated with fewer mood and headache symptoms. Lab study, 2007 Do women with PMDD show a stronger physical startle response during their cycle? Yes. Women with PMDD showed much stronger startle responses to a loud noise during the luteal phase (around their period) compared to the follicular phase, but healthy women did not show this pattern. Randomised trial, 2007 Does bromocriptine or pyridoxine help reduce PMS symptoms? Both bromocriptine and pyridoxine significantly reduced PMS symptoms over 3 months. Pyridoxine showed a higher response rate with fewer side effects. Randomised trial, 2006 Do women with a history of PMS react differently to hormone therapy after menopause? Yes. Women with a history of PMS had worse mood symptoms when progestin was added to estrogen, especially those with anxiety-related personality traits. Randomised trial, 2006 Do different types of PMS symptoms respond better to different medicines? Yes. Different medications work best for different symptoms. SSRIs help irritability and anxiety. Birth control works broadly. Other drugs target specific symptoms. However, current treatments help fewer than 60% of women. Study, 2006 Is the nerve system activity different in women with premenstrual symptoms? In women with increased premenstrual symptoms, the fight-or-flight part of the nerve system became more active and the calming part became less active during the late premenstrual phase. This change in nerve balance may contribute to premenstrual symptoms. Guideline, 2006 What is the best treatment for PMDD and severe PMS? SSRIs are first-line therapy for PMDD and severe PMS. They can be taken continuously throughout the month, only during the luteal phase, or with higher doses in the late luteal phase depending on each person. Review, 2006 How is PMDD diagnosed and what treatments are available? PMDD is the severe form of PMS, dominated by mood symptoms like depression, anxiety, and irritability. It occurs in the last week of the cycle and disappears after menstruation. Treatment is challenging because few options have been carefully tested and fewer still have proven effective. Study, 2005 Does paroxetine help premenstrual tension syndrome? Yes. Paroxetine greatly reduced depression, anxiety, and physical symptoms over 3 months, much more than vitamin B1 did. Randomised trial, 2005 Does acupuncture with herbal injection work better than medication for premenstrual tension syndrome? Acupuncture with herbal injection had a 92.6 percent success rate compared to 75 percent for standard medication over 3 menstrual cycles. However, the study could not be blinded, so expectations may have influenced results. Randomised trial, 2005 How do PMDD symptoms start, end, and vary from cycle to cycle? Very variably. Symptoms peak 2 days before the period on average, but timing and duration differ by 4 or more days between cycles in nearly half of women studied. Review, 2004 How well does alprazolam work for anxiety and panic attacks? Alprazolam is more effective than placebo and works as well as some other medications for anxiety. It works within the first week but can impair thinking and driving skills. Randomised trial, 2004 Does Qi-therapy help PMS symptoms? Yes. Qi-therapy significantly reduced pain and water retention. It also had short-term effects on pain, depression, and anxiety. Review, 2004 Is premenstrual dysphoria a variant of panic disorder? PMDD and panic disorder both trigger panic in lab tests, but scientists haven't identified the connection. This doesn't prove PMDD is a type of panic disorder. Case-control study, 2004 Does norepinephrine cycle with the menstrual cycle differently in women with PMS? Healthy women have a natural norepinephrine cycle that peaks at ovulation and early luteal phase, but women with PMS lack this cycling. Low norepinephrine is linked to mood swings, fatigue, and other symptoms. Study, 2004 How do work and time off affect women's moods during different phases of their menstrual cycle? Work days made women feel more anxious, stressed, and tired compared to days off. Menstrual cycle phase also affected mood, but the effect depended on whether it was a work or off day and on the woman's personality traits. Randomised trial, 2004 Does paroxetine controlled-release help PMDD symptoms? Yes, paroxetine CR was more effective than placebo for PMDD symptoms and caused less nausea than regular paroxetine in the first week. This summary reviews multiple well-designed trials. Cohort study, 2004 What risk factors cause PMDD to develop? Traumatic events, anxiety disorders, and high daily stress significantly increase the risk of developing PMDD. Women who already had subthreshold PMDD at the start were at highest risk. Randomised trial, 2004 Does St. John's wort help with premenstrual symptoms? There was a slight trend suggesting it might help, but the result was not statistically significant, so we cannot be sure it works. Review, 2003 Do GABA receptors and progesterone affect PMDD? The review suggests they may be important based on animal studies, but does not provide specific conclusions about their role in PMDD in humans. Case-control study, 2003 Are progesterone-related brain molecules different in women with panic disorder? Women with panic disorder had higher levels of progesterone-related brain molecules during different phases of their menstrual cycle compared to healthy women. This suggests the brain may be overproducing these molecules. Review, 2003 What is PMDD and what treats it? PMDD is a severe form of PMS affecting 3-8% of women of reproductive age. It is marked by depression, anxiety, emotional instability, and reduced activity during the luteal phase. SSRIs (selective serotonin reuptake inhibitors) are the most effective treatment. Randomised trial, 2002 Is fluoxetine or cognitive-behavioral therapy more effective for PMDD? Both work equally well after 6 months. Fluoxetine works faster and reduces anxiety more. Cognitive-behavioral therapy builds better coping skills and changes how women think about their symptoms. Review, 2002 What are the reproductive-related mood disorders and how are they connected? Mood and anxiety disorders are more common in women around menstruation, after childbirth, and during perimenopause. They all appear linked to changes in ovarian hormones. Review, 2001 What is the best treatment for depression and anxiety disorders, including PMDD? SSRIs (a type of antidepressant) are the first-line treatment for most depression and anxiety disorders, as well as for PMDD. Other newer antidepressants are options if SSRIs don't work or cause side effects. Study, 2001 Do women with PMDD panic as easily when breathing carbon dioxide as people with panic disorder? Yes. Women with PMDD showed panic attacks when breathing carbon dioxide at rates similar to people with panic disorder, and higher than people without these conditions. Cohort study, 2001 How common are premenstrual mood symptoms like irritability and tension in women? In this community study, about 1 in 5 women had moderate or severe perimenstrual psychological symptoms, and irritability, nervousness and tension stood out as the core symptoms, whether or not depressed mood was also present. Randomised trial, 2000 Does magnesium and vitamin B6 together help with anxiety-related premenstrual symptoms? A combination of 200 mg magnesium plus 50 mg vitamin B6 daily showed a small benefit for anxiety-related symptoms like nervousness and mood swings. Individual supplements alone did not work. Review, 2000 What conditions beyond depression can antidepressants treat? Newer antidepressants including SSRIs have FDA approval for several conditions including anxiety, obsessive-compulsive disorder, and panic disorder. Controlled studies also show they help premenstrual dysphoric disorder. Randomised trial, 2000 Does having used benzodiazepines before make withdrawal symptoms worse when stopping them? No. Analysis of data from three clinical trials found that prior benzodiazepine use did not increase symptoms when stopping the medication, either in people with PMS or anxiety disorder. Case-control study, 2000 Do women with panic disorder have different menstrual cycle patterns in anxiety and stress response? Yes. Women with panic disorder showed stronger physical stress responses during the premenstrual phase and higher anxiety-related symptoms overall compared to controls. Review, 2000 How should doctors diagnose and treat PMDD? Doctors should use self-report tools combined with diagnostic criteria and rule out other conditions. Treatment options include exercise, diet changes, antidepressants, anti-anxiety medications, and ovulation-suppressing drugs. Randomised trial, 1999 Is taking sertraline just during the premenstrual phase as effective as taking it year-round for severe PMS? Half-cycle dosing worked about as well as full-cycle dosing for overall symptoms. However, some mood symptoms like nervous tension and feeling out of control improved more with half-cycle dosing. Review, 1999 Is premenstrual dysphoric disorder a distinct clinical disorder? Yes, according to expert consensus. PMDD has distinct characteristics, clear symptoms linked to the menstrual cycle, and responds differently to treatment than other mood disorders. Review, 1999 How should severe premenstrual dysphoric disorder be diagnosed and treated? Diagnosis requires ruling out other conditions and tracking daily symptoms. Treatment with serotonin-blocking antidepressants or alprazolam during the luteal phase provides substantial relief. Case-control study, 1999 What are the main symptom patterns in PMDD? PMDD has five distinct symptom groups: anger and irritability, depressed mood, anxiety and tension, decreased energy with physical symptoms, and eating problems. These patterns were identified through analysis of 99 women's symptoms. Randomised trial, 1999 Does the drop in progesterone or stress during the menstrual cycle cause chocolate and sweets cravings? This study found no clear evidence either way. Neither progesterone nor a tranquilizer reduced chocolate or sweets craving in women with severe PMS. Cohort study, 1997 Are premenstrual mood changes linked to depression and anxiety during pregnancy and after childbirth? Yes. Women with premenstrual irritability before pregnancy had higher depression scores throughout pregnancy and after birth, plus greater anxiety about pregnancy, delivery, and their babies. Randomised trial, 1996 Does oral progesterone work better than vaginal progesterone for PMS? No. Both oral and vaginal progesterone were no better than placebo for PMS symptoms, even though oral progesterone created higher levels of potentially calming metabolites. Survey study, 1996 Is the Daily Symptom Report a reliable way to diagnose PMS? Yes, the Daily Symptom Report is a reliable way to diagnose PMS, with very high internal consistency of 0.92. It measures mood, behavior, pain, and physical symptoms separately. Randomised trial, 1995 Does danazol help severe PMS? Yes, danazol significantly reduced severe PMS symptoms compared to placebo, with 43.8 percent of women becoming symptom-free versus 8.3 percent on placebo. Randomised trial, 1995 Do vaginal progesterone suppositories relieve PMS symptoms? Overall PMS scores were not significantly better with progesterone than placebo, but a specific group of 'nervous' symptoms, tension, mood swings, irritability, anxiety and lack of control, did improve significantly. Randomised trial, 1995 Is paroxetine better than other antidepressants for treating severe PMS? Yes. Paroxetine reduced symptoms much more than placebo. It also worked better than maprotiline for most symptoms. Randomised trial, 1994 Does alprazolam help women with late luteal phase dysphoric disorder? Yes, but only for women whose symptoms happen only in the luteal phase. It reduced tension, irritability, and anxiety in that group but not in women who also had anxiety or depression at other times of the month. Study, 1994 Do women with PMS cope with stress differently than other women? Women with PMS who have higher depression scores tend to use avoidant coping (avoiding stressful situations rather than dealing with them). This pattern is consistent throughout their menstrual cycle, not just during the premenstrual phase. Randomised trial, 1994 Does stopping ovulation help severe premenstrual tension? Yes, a drug that stops ovulation (goserelin) reduced breast discomfort and swelling significantly. It also reduced mood swings, though the effect on mood was weaker and had a strong placebo component. Randomised trial, 1993 Does the point in your menstrual cycle change your mood, or change how alcohol affects your mood? No. This study found no evidence that mood or alcohol's effects on mood differed across menstrual cycle phases, suggesting cycle-linked mood swings may be more about expectations than biology, at least in this drinking context. Randomised trial, 1992 Does a triphasic birth control pill help premenstrual symptoms? It reduced breast pain and bloating but did not help mood symptoms. Women also experienced decreased sexual interest as a side effect. Study, 1992 What is the psychological profile of women who experience premenstrual dysphoria? Women with premenstrual dysphoria tend to have higher anxiety and mood problems before their period, and many have a history of mood disorders or feel they have little control over their lives. Randomised trial, 1992 Does bromocriptine help premenstrual syndrome? Bromocriptine helped significantly with physical symptoms like abdominal tension, water retention, weight gain, and breast tenderness. It was less clear whether it helped with mood symptoms like depression and irritability. Study, 1992 Do women trying to get pregnant report more premenstrual symptoms? Yes. Women in fertility treatment reported more premenstrual symptoms than medical students, and over half of them met criteria for severe premenstrual disorder compared to 42% of students. Non-randomised trial, 1991 Does mefenamic acid help PMS symptoms? Yes. A randomized double blind trial of 15 women found that mefenamic acid 500 mg three times daily reduced irritability, anxiety, abdominal swelling, and headaches compared with placebo. Study, 1991 Does exposure to DES before birth affect period symptoms in adult women? Mostly no. Women exposed to DES in the womb reported similar period symptoms to unexposed women. The only possible difference was slightly more water retention symptoms in the exposed group. Randomised trial, 1991 Do spironolactone and medroxyprogesterone acetate help premenstrual tension? Yes, both medications significantly reduced symptoms compared to placebo. However, placebo itself also significantly improved symptoms, which is important to know. Study, 1991 Do women with premenstrual syndrome have different symptom severity in different menstrual cycles? Symptoms were mostly stable between cycles. However, women with different PMS patterns behaved differently: those with symptoms only before menstruation had worse symptoms during the first cycle, while those with symptoms at other times felt better in the first cycle. Survey study, 1991 Does how your brain responds to images change during your menstrual cycle? A specific type of brain wave activity changed based on hormone levels: it was strongest for babies and male faces when progesterone was high, and women found all images more pleasant when estrogen was high. Review, 1990 Is buspirone an effective treatment for anxiety? Yes, buspirone works as well as benzodiazepine anxiety medications and significantly better than placebo for generalized anxiety disorder and chronic anxiety. It also has antidepressant effects, and it is safer because it does not cause dependence, though it works more slowly. Randomised trial, 1990 Does education about PMS help reduce premenstrual symptoms? Yes. Women who received education had fewer anxiety and appetite symptoms, fewer severe depression and water retention symptoms, and fewer days with any symptoms. Cohort study, 1990 What PMS symptoms do women experience even when not seeking treatment? Most women have some premenstrual symptoms. The most common are depressive symptoms (65%), physical discomfort (61.7%), and fluid retention (53.4%). Only 20.3% had no negative symptoms. Study, 1989 Can premenstrual mood changes be reliably measured and how common are they? A mathematical method was developed that reliably detected premenstrual mood changes. About 7 out of 10 menstrual cycles from women with PMS showed clear premenstrual mood worsening, compared to just 1 out of 12 cycles from women without PMS. Study, 1989 What's the best way to measure premenstrual tension using mood diaries? Six of seven tested methods gave similar results. Methods using bipolar mood scales (with both positive and negative options) and based on known symptom patterns worked best, though some complex cases showed discrepancies of 9-23%. Survey study, 1989 Can daily symptom tracking help doctors diagnose different types of PMS? Yes. Daily symptom tracking separated women into three groups: those with symptoms only before their period (30%), those with ongoing symptoms that worsen before the period (56%), and those with no menstrual pattern (14%). This helps doctors understand each woman's specific pattern. Survey study, 1989 Do anxiety, anger, and depression increase before a woman's period? Yes, clearly. Women with PMS had clear increases in anxiety, anger, and depression at different parts of their cycle. Those with the most obvious PMS had the strongest increases. Survey study, 1989 Is a history of bad premenstrual tension linked to low mood after giving birth? Yes. Women who reported having bad premenstrual tension in the past were more likely to have low mood scores in the days after giving birth. Cohort study, 1989 Does anxiety from panic disorder get worse before a woman's period? No. Women with panic disorder did not have more anxiety before their period, unlike women with PMS. This suggests panic disorder is not affected by the menstrual cycle. Randomised trial, 1989 Does vitamin B6 reduce PMS mood symptoms? Yes, vitamin B6 at 50 mg per day significantly improved mood-related symptoms like depression, irritability, and tiredness. It did not help other PMS symptoms. Only about half the women finished the study. Study, 1989 Do women with anxiety report more premenstrual symptoms? Women with anxiety reported more total symptoms before their period than women without anxiety, though both groups reported similar amounts of PMS overall. The difference was in their beliefs and attitudes rather than in the actual severity of symptoms. Survey study, 1988 Do depressive symptoms cluster into patterns including a premenstrual syndrome pattern? Yes. Statistical analysis identified five symptom patterns: one matching major depression and another in younger women as premenstrual syndrome. This explains the gap between reported depression symptoms and diagnoses. Randomised trial, 1988 Does stopping ovulation with buserelin help premenstrual tension syndrome? Yes, buserelin (which stops ovulation) worked significantly better than placebo and eliminated the monthly symptom pattern. This shows the menstrual cycle is the cause of these symptoms. Survey study, 1988 Do women with PMS have higher rates of postpartum depression and birth control side effects? Yes. Among women who had given birth, 62.6% of those with PMS had experienced postpartum depression compared to 41.4% without PMS. Among those with postpartum depression, 69.8% of PMS patients reported birth control side effects compared to 38.9% of controls. Survey study, 1988 How do birth control methods and smoking affect menstrual periods? Women taking oral contraceptives report fewer menstrual problems like heavy or painful periods. Women using IUCDs report heavier and more frequent periods. Smokers report more menstrual problems than non-smokers, with current smokers reporting the worst. Randomised trial, 1987 Does vitamin B6 help premenstrual tension symptoms? No. Vitamin B6 did not significantly improve PMS symptoms in this small study, even though it increased a blood marker of serotonin activity. Randomised trial, 1987 Does alprazolam help premenstrual syndrome? Yes, according to this study, alprazolam was significantly more effective than placebo at relieving many PMS symptoms including mood and physical symptoms. Side effects were uncommon, making it potentially acceptable for women who don't respond to other treatments. Survey study, 1986 How common are premenstrual symptoms in women? Very common. About 70% of women reported mental symptoms in combination with body swelling. Premenstrual anxiety increased with age. Randomised trial, 1985 Does vitamin B-6 help premenstrual tension? No. Vitamin B-6 at 100 mg daily was no better than placebo for relieving premenstrual tension. Study, 1985 Do women get worse grades on exams during the premenstrual phase? No. All 26 women in the study earned similar exam marks during the premenstrual phase compared to other times of their cycle. Cohort study, 1985 Do mood and physical symptoms really change across the menstrual cycle, and does anxiety make this worse? Yes, women reported more symptoms before and during their period and fewer in the days after, though the exact pattern differed a lot between women. Anxious women reported more symptoms overall, but anxiety did not explain the cyclical ups and downs themselves. Study, 1984 Do women with premenstrual tension have different hormone patterns? Yes. Women with premenstrual tension had measurable differences in their hormone patterns compared to women without the condition. Randomised trial, 1984 Does mefenamic acid help premenstrual tension? Yes. 86 percent of women reported significant relief of premenstrual tension with mefenamic acid, and the drug appears to work by lowering prostaglandin levels. Study, 1983 Does menstrual cycle affect how much alcohol women drink? For women not on birth control, yes. They reported more negative moods before their period and drank alcohol more often to help with stress and sadness, particularly drinking alone. Women on birth control pills did not show this pattern. Review, 1983 What causes PMS symptoms and how should it be treated? The four days before a period are when most PMS happens, causing irritability, depression, anxiety and fatigue. Treatments include vitamin B6, antidepressants, anti-anxiety medication and therapy, though evidence is mixed. Randomised trial, 1982 Does lowering prolactin with bromocriptine help premenstrual syndrome? No. Although bromocriptine lowered prolactin, it was not significantly more effective than placebo. This suggests prolactin alone doesn't cause premenstrual syndrome. Survey study, 1982 How common are premenstrual symptoms in American women, and what factors affect them? Premenstrual symptoms are very common in American women, with over 30% experiencing weight gain, headache, mood changes, and other symptoms, though only 2% to 8% found them severe. Randomised trial, 1980 Does bromocriptine help premenstrual tension? Bromocriptine improved breast tenderness, bloating, and depression, but placebo also helped with many other symptoms, so the true effect may be smaller than it appears. Study, 1979 What factors are linked to having prolonged menstrual periods? Prolonged periods are more common in women with irregular menstrual cycles, menstrual pain, high number of pregnancies, and IUD use. Psychological factors, smoking, and drinking are not more common in women with prolonged periods. Survey study, 1979 How common is painful periods and premenstrual tension in teenage girls? Very common and worsens with age. Painful periods ranged from 7.2% in the first menstrual year to 26% five years later, reaching 56.5% by ages 17 to 20. Painful periods run in families. Study, 1978 Do women with premenstrual tension have too much water in their bodies? Women with premenstrual tension had normal total body water, but showed an imbalance between water and potassium during the late menstrual phase. Diuretics and bromocriptine did not help. Study, 1976 How much higher do anxiety and depression get before your period? Anxiety and depression are noticeably higher before your period than in the middle of your cycle, but they are still much lower than in people with depression or anxiety disorders. Randomised trial, 1975 Does a combination of isoxsuprine, acetaminophen and caffeine help period pain and premenstrual tension? The drug combination was effective in 95 percent of women with premenstrual tension and 92.5 percent with period pain. This is an older study that doesn't clearly show placebo comparison. Case report, 2026 Can anxiety and PMDD trigger binge drinking, and can medication help? This single case shows that a woman whose binge drinking episodes were triggered by anxiety and linked to her PMDD improved with medication: her anxiety and drinking urges decreased, and she had no new drinking episodes at 12 weeks. Interview study, 2026 Does acceptance and commitment therapy help people with anxiety and PMDD? One woman showed meaningful improvement in anxiety and psychological flexibility after 37 therapy sessions, and no longer met criteria for PMDD, though some period-related symptoms remained. This is just one person's experience. Survey study, 2026 Is anxiety linked to irregular menstrual cycles in teenage girls? Yes. Among 65 high school students in Indonesia, those with higher anxiety levels were significantly more likely to have irregular menstrual cycles. The relationship was strong and statistically significant. Survey study, 2026 Are PMDD, anxiety, and internet use linked to cognitive problems in women? In this study of women aged 19-45 with anxiety, those who also had PMDD, severe anxiety lasting 5 or more years, or problematic internet use showed associations with cognitive problems including memory and concentration difficulties. Survey study, 2026 Do girls who experienced childhood abuse or neglect have higher PMDD symptoms? Yes. Girls who experienced childhood abuse or neglect reported higher PMDD symptoms compared to girls with limited abuse or neglect. This is a cross-sectional study, so we cannot know if maltreatment causes PMDD. Survey study, 2026 Does climate change stress and anxiety increase premenstrual syndrome symptoms in nursing students? Nursing students who felt stressed and anxious about climate change were more likely to have premenstrual symptoms. The eco-anxiety appeared to play a connecting role. Case report, 2026 Can antidepressants cause stomach problems that only happen during menstruation? One woman taking antidepressants developed nausea, vomiting, and diarrhea only during her menstrual period. The problem improved when her dose was lowered. Randomised trial, 2026 Can deep breathing exercises help with PMS pain and mood symptoms? Based on a review of existing studies, deep breathing exercises may ease both the physical pain and the mood symptoms of PMS, but the evidence is not yet strong enough to be fully certain. Survey study, 2026 Do emotional regulation and resilience change during the menstrual cycle in women with PMDD? Women with PMDD have much higher depression and anxiety than other women, especially before their period. Their ability to handle emotions and bounce back from stress is significantly lower during that time. Review, 2026 Is premenstrual dysphoric disorder now recognized in the international diagnosis system? Yes. ICD-11 now officially recognizes premenstrual dysphoric disorder as a depressive disorder, with seven new specifiers to describe depressive disorders. Specific guidance for children and adolescents still needs more research. Interview study, 2026 How do eating behavior and mood change during the menstrual cycle in women using birth control? Women not using birth control showed more emotional and compulsive eating in the early cycle phase, while women using birth control pills showed less change. This is a small study of 84 university students. Survey study, 2026 Are there differences in brain activity and connectivity in women with PMDD? Yes, women with PMDD show increased activity in the brain's waste-clearing system (glymphatic system) and increased connections between the hypothalamus and multiple emotion-processing brain regions compared to women without PMDD. Review, 2026 Can the brain's perception of internal body signals explain premenstrual syndrome? This is a new theoretical idea that PMS may involve abnormal brain perception of internal signals like heartbeat and hormones. The theory has not yet been tested through research. Non-randomised trial, 2026 Are the most bothersome premenstrual symptoms physical or emotional? Emotional symptoms like stress, anxiety, and depression are reported at much higher levels than physical symptoms. Married women experience significantly more emotional distress than unmarried women. Case-control study, 2026 What role do brain chemicals called neurosteroids play in PMDD? A key brain chemical called allopregnanolone likely triggers PMDD symptoms in vulnerable women. It acts as a sedative at high levels but can cause anxiety and irritability at lower levels in some people. Survey study, 2026 Can changing your diet help with period and PMS symptoms like fatigue, mood swings and bloating? This paper suggests certain foods may help, but it is not a real study on people, it is a write-up of general nutrition advice based on a newspaper health article, so it does not prove anything. Survey study, 2026 Is obesity linked to worse PMS symptoms and menstrual problems? Yes, obese women had much more PMS (113.83 vs. 62.5 severity score) and more depression and anxiety (97.5% vs. 47.5%). However, this small hospital study in Bangladesh can't tell us if weight loss would reduce PMS. Survey study, 2026 Do premenstrual symptoms affect athletic performance? Yes, women with premenstrual symptoms showed higher stress and anxiety, and athletic performance was best during ovulation. However, this is a small feasibility study with only 18 women who had actual performance testing. Survey study, 2026 How common is premenstrual tension and does it affect university students' studies? 65.2% had premenstrual symptoms and 8.1% met PMDD criteria. Those with symptoms had more difficulty concentrating, worse exam performance, and less participation in activities. Survey study, 2026 Among women with bipolar I disorder, who is more likely to also have PMDD? About one-third (36.5%) of women with bipolar I disorder have PMDD. Those at higher risk have seasonal mood patterns, a history of suicide attempts, and a family history of mental illness. Survey study, 2026 Does eating foods that cause inflammation link to worse food cravings and mood problems in women with PMS? The study found that eating more fat and saturated fat linked to more food cravings. The abstract cuts off before showing complete results about mood and inflammation. Survey study, 2026 Are PMS symptoms and injuries common in teen girls who play competitive badminton? Yes, in this small study most of the young badminton players had at least one PMS symptom, and about one in seven had a knee or back injury linked to the sport. Playing badminton for longer was linked to more PMS symptoms, but this study cannot prove that badminton causes PMS. Study, 2026 Does replacing gut bacteria help with menstrual problems, depression, and anxiety? In this study, transplanting healthy gut bacteria improved quality of life, reduced depression and anxiety, and improved menstrual conditions. However, this is an early study and larger research is needed. Survey study, 2026 Does physical activity reduce the effect of climate anxiety on PMS? Yes. Climate anxiety increases PMS symptoms, but physical activity has a protective effect that reduces this relationship. Survey study, 2026 Is climate change worry linked to worse PMS and lower quality of life? Yes. Women more worried about climate change have worse PMS symptoms and lower quality of life, both physically and mentally, though the study cannot prove anxiety causes PMS. Survey study, 2026 Is there a link between PMS symptom severity and daily stress hormone levels? Women who reported worse PMS symptoms had lower cortisol (stress hormone) levels during the day. Cortisol patterns varied slightly across cycle phases, suggesting stress hormones may play a role in PMS, though this was a very small study. Study, 2026 Could early stress or past trauma make PMDD symptoms worse later in the cycle? This research offers a possible explanation for why PMDD symptoms vary so much, and why related conditions can worsen before a period. It is only a theory, not tested on patients, so we don't yet know if it is true. Survey study, 2026 Does eating more ultra-processed food make PMS symptoms worse? Yes, this study found that eating more ultra-processed food was linked to worse PMS symptoms, but it cannot prove that the food caused the symptoms. Survey study, 2026 How common is PMDD in Russian medical students, and what are its symptoms? About 14.3% of medical students had PMDD, or 25.4% including mild forms. Most common symptoms were depression (87.9%), anxiety (48.3%), and sleep problems (31.0%). Systematic review, 2026 Has osteopathic manual therapy been studied as a treatment for PMDD? This scoping review protocol plans to search for studies on osteopathic manual therapy for PMDD. Since no reviews of OMT for PMDD exist, it will examine indirect evidence from related conditions like PMS and dysmenorrhea. Survey study, 2025 What are the most common premenstrual symptoms among adolescent girls in Chandigarh? The most common premenstrual symptoms were headaches (67%), breast pain (62%), and anxiety or tension (59%). These findings are from one city in India with 100 girls, so they may not represent all adolescent girls. Survey study, 2025 Is there a link between premenstrual syndrome and obsessive-compulsive symptoms? Yes, 74.2% of young women had PMS and showed significantly higher obsessive-compulsive symptoms than those without PMS, particularly in rumination. The link suggests PMS and psychological symptoms are connected. Study, 2025 Does your personality type affect how much emotional PMS symptoms you have? Yes. Your temperament or personality type is a strong predictor of emotional PMS symptoms like irritability and mood swings. Survey study, 2025 Do PMS symptoms ease once your period starts, and does diet make them worse? Yes, many PMS symptoms were significantly less severe after menstruation began, and eating more sugar or fat was linked to worse irritability and tension, while multi-nutrient supplements and higher education seemed to help, in this Bangladeshi study of 400 women. Interview study, 2025 Does sleep quality affect how severe PMS symptoms are? Yes. Poor sleep was linked to more severe PMS symptoms, including anger, anxiety, mood changes, and fatigue. Survey study, 2025 Are PMDD symptoms linked to depression and anxiety? Yes. Women with higher PMDD-type symptom scores were much more likely to have depression and anxiety, and most women with PMDD had severe depression and moderate-to-high anxiety. Survey study, 2025 How common is premenstrual syndrome and what are its main symptoms in female medical students? 77.6% of female medical students have PMS, with the most common symptoms being decreased mood, anxiety, muscle tension, and breast pain. Most women notice symptoms 7-10 days before their period. Survey study, 2025 Does your menstrual cycle or hormonal contraceptive affect how your brain responds to scary situations? Yes. Women in the luteal phase and women using hormonal IUDs showed less ability to distinguish between threatening and safe situations compared to women in the follicular phase or using the pill. Women with high PMS symptoms showed more fear overall regardless of cycle phase. Survey study, 2025 What causes premenstrual syndrome and premenstrual dysphoric disorder, and how common are they? This review article explains the known biological, genetic and lifestyle factors behind premenstrual disorders rather than testing a treatment; it reports that any premenstrual disorder may affect up to 87% of women. Cohort study, 2025 How do stress, anxiety, and depression relate to premenstrual symptoms? Stress was associated with most premenstrual symptoms, but anxiety and depression were not independently linked to premenstrual symptoms. Study, 2025 Does difficulty managing emotions make menstrual mood symptoms worse? Yes. Women who struggled to manage their emotions had higher anxiety and sadness during the days right before and at the start of their period, and experienced stronger urges to smoke when they felt sadder during this time. Non-randomised trial, 2025 Does an educational video help teenagers with PMS knowledge and anxiety? Yes. The study found the video was effective at increasing knowledge and improving behavior and reducing anxiety in teenagers with PMS (p = 0.0001). However, there was no control group so we cannot be certain the video caused the changes. Non-randomised trial, 2025 Does aerobic exercise reduce anxiety and depression in students with PMS? Yes, female students who did aerobic exercise showed large reductions in both anxiety and depression. However, there was no control group that did not exercise, so we cannot be certain the exercise caused the improvement rather than placebo or natural variation. Survey study, 2025 Can a plant-based supplement reduce PMS symptoms? Yes, a multi-ingredient plant-based supplement taken daily for three months significantly reduced anger, irritability, mood problems, and other PMS symptoms in most women. Without a control group, some improvement might be due to placebo effect or natural changes over time. Survey study, 2025 What factors are linked to PMS in female graduate students? 40% experienced PMS. Stress, period pain, use of menstrual delaying medicine, and earlier menarche were significantly linked to higher PMS risk. Survey study, 2025 What factors increase suicide risk in young women with PMDD? About 28% of young women with PMDD have current suicide risk, with risk higher in those with panic disorder, depression, childhood trauma, or non-white skin color. The evidence is limited because only 128 women were assessed in one location. Survey study, 2025 Are specific genetic variations linked to PMS and PMDD? Yes, specific genetic variations in the estrogen receptor 1 gene were linked to different PMS symptoms like anxiety and sleep problems, suggesting genetics may affect how sensitive women are to hormones. Sample size is not provided in the abstract. Lab study, 2025 Can genistein reduce anxiety in the premenstrual phase without raising estrogen? Yes. In rats, genistein reduced anxiety during the premenstrual phase as well as the hormone estradiol did, but without increasing estrogen levels in the blood. Survey study, 2025 What is the link between stress hormones, psychological distress, and resilience in women with PMDD and PMS? Women with PMDD have higher stress and anxiety than others. In the PMDD group, women with stronger resilience had lower levels of cortisol, the stress hormone, in their hair. Survey study, 2025 How does premenstrual syndrome change in women during wartime compared to peacetime? During wartime, women with PMS had much worse symptoms: 2.1 times more anxiety and sleep problems, plus greater loss of emotional control and lower working capacity. The study is limited to one war region. Non-randomised trial, 2025 Does yoga practice reduce PMS symptoms and improve heart function? Twelve weeks of regular yoga improved heart rate variability and stress response measures, with decreases in blood pressure and heart rate. Survey study, 2025 Are women with ADHD more likely to have PMDD? Yes. Women with ADHD had PMDD at rates of 31.4% to 41.1%, compared to 9.8% without ADHD. We cannot be completely certain because this study relied on self-reported diagnoses. Randomised trial, 2025 Can nutrients help PMS by regulating multiple body systems? The paper proposes a theoretical framework suggesting nutrients could work across brain, hormone, blood vessel, and metabolic systems to help PMS. No evidence is presented. This is a conceptual proposal requiring clinical trials. Survey study, 2025 Does anxiety and emotion regulation change across the menstrual cycle in women with PMS and PMDD? Yes, women with PMS and PMDD showed higher anxiety sensitivity and worse emotion regulation during the luteal phase compared to those without these conditions. Survey study, 2025 Are mental health problems linked to period pain and lack of support? Yes. About 29% of girls experienced anxiety, 14% stress, and 32% depression. Those with moderate or severe period pain or without support during menstruation were more likely to experience these mental health problems. Case-control study, 2025 Do certain hormone-related brain chemicals predict how bad premenstrual depression and anxiety will be? In this small study, women with a PMDD-like condition had higher levels of a calming hormone (allopregnanolone) early in the cycle, and higher levels of it predicted worse later depression and anxiety. The sample is small, so this is an early finding, not a proven cause. Survey study, 2025 What do women with PMDD want in a mental health program? Women want programs that address serious mental health impacts like suicidal thoughts, hopelessness, and anxiety, plus effects on relationships. They also want evidence-based information and techniques for managing difficult emotions. Survey study, 2025 Do brain chemistry genes shift across the menstrual cycle in women with mood changes? Yes, genes that control a brain chemical called GABA do change across the menstrual cycle in women with mood disorders. However, the relationship is complex: both unusually high and unusually low gene activity can be linked to worsening mood symptoms like anxiety and suicidal thoughts. Survey study, 2025 How aware are medical students of PMDD, and how common is it among female medical students? Female medical students recognised PMDD as a mental disorder much more than male students. About 9% of female medical students tested positive for PMDD on screening. Survey study, 2025 Does PMDD increase the risk of suicidal thoughts or attempts? Yes, women with PMDD had much higher rates of suicidal thoughts (38.8%) and suicide attempts (28.6%), with depression, anxiety, and stress playing key roles in this risk. Survey study, 2025 How common is PMS among reproductive-aged women, and what are the main symptoms? About 46% had PMS. Anxiety and bloating were the most common symptoms, affecting most of those with PMS. Survey study, 2025 What is premenstrual syndrome and how can it be managed in adolescent girls? PMS is a combination of physical, emotional, and behavioral symptoms affecting 70-90% of women of reproductive age in Indonesia. It can be managed with medications like NSAIDs and antidepressants, or non-medication approaches like exercise and lifestyle changes. Survey study, 2025 Does dental anxiety change depending on where women are in their cycle? Yes. Women in their menstrual and secretory phases reported higher dental anxiety than men. Physical measures of anxiety, like blood pressure, showed no differences. Survey study, 2025 Does a new Turkish questionnaire work well to screen for PMDD? Yes, in this study the questionnaire showed strong reliability and was very good at telling apart people with and without PMDD. Survey study, 2025 Does menstruation affect how well women sleep? Yes. Women who were menstruating had lower sleep efficiency (81%) compared to non-menstruating women (84.2%). No other major differences were found in symptoms or blood inflammation markers. Survey study, 2025 How common is PMS in high school girls, and which non-drug methods help reduce anxiety and stress? About 25% of high school girls had PMS. The most common non-drug methods used were yoga (58%), prayer (17.5%), and exercise. Study, 2025 Could taking a combination of vitamins and minerals help with PMS and PMDD symptoms? This paper proposes a theoretical framework linking low or borderline vitamin and mineral intake to many health problems, including PMS and PMDD, but it is not a new study testing a supplement in women, so it cannot tell us how well any particular combination actually works. Study, 2025 Does the menstrual cycle affect balance and dizziness? Objective balance tests showed no clear change during the menstrual cycle. However, women reported more dizziness and anxiety before menstruation. Survey study, 2025 Does climate change anxiety affect premenstrual syndrome? Women with PMS had higher climate change anxiety scores. Women who felt affected by climate change were 2.1 times more likely to have PMS, though the study design doesn't show whether anxiety causes PMS or vice versa. Survey study, 2025 How do estrogen and progesterone affect anxiety and cigarette craving during the menstrual cycle? Anxiety and cigarette craving are highest during the 7 days before your period starts and the first 3 days after, regardless of hormone levels. At other times, higher progesterone and lower estrogen are linked to lower anxiety and craving. Survey study, 2025 Is there a relationship between anxiety and PMS in female adolescents? Yes. Adolescents with severe anxiety had 1.6 times higher risk of PMS than those with mild anxiety. Most adolescents in the study had mild anxiety and no PMS. Cohort study, 2025 Does PMS affect mental health and sleep-wake cycles? Yes. Women with PMS have significantly higher depression and anxiety than those without PMS. Sleep-wake timing irregularities may also play a role, though the relationship is unclear. Survey study, 2025 Are violent tendencies linked to premenstrual symptoms? Students with higher PMS symptoms, especially anxiety, irritability, and sleep problems, had higher violence tendency scores. This shows a link in the data but doesn't prove that PMS causes violence. Survey study, 2025 What level of anxiety do adolescent girls experience when they have PMS? Most adolescent girls with PMS have low anxiety (76.7%), even though many have moderate to severe PMS symptoms. Certainty is low because this is a small study. Review, 2025 How does the menstrual cycle affect psychiatric symptoms like depression and anxiety? Many women experience worsening psychiatric symptoms during the premenstrual and menstrual phases due to hormonal changes in estrogen and progesterone. Treatment should monitor symptoms across the menstrual cycle and may include lifestyle changes, therapy, antidepressants, or hormonal therapies. Survey study, 2025 Do women with PMS sense their body signals differently from women without PMS? Yes. Women with PMS are very good at detecting their own heartbeat but less aware of what those sensations mean. They also take longer to calm down after stressful situations. Survey study, 2024 Can a smartphone app that teaches heart rate control help with premenstrual symptoms? Yes, people using the app for 4 weeks showed clear improvements in premenstrual symptoms, depression, and anxiety, while those who waited did not improve. Survey study, 2024 What premenstrual symptoms do martial arts athletes experience? Martial arts athletes experience both disturbing and non-disturbing PMS symptoms with regular 35-day menstrual cycles, and they have no significant difference in PMS compared to non-athletes. Survey study, 2024 Does PMS or PMDD affect teenage girls' heart rhythm signals? This small study found that teens with premenstrual disorder had some different ECG (heart electrical) measurements than those without it, but it does not prove PMD causes dangerous heart rhythm problems. Survey study, 2024 What factors are associated with PMS and PMDD in adolescent and young women? The study found that mood symptoms (anger, anxiety, irritability), physical symptoms (headache, weight gain), and higher BMI were significantly associated with PMS and PMDD. However, the study had very few cases of PMDD. Survey study, 2024 Are anxiety and depression linked to PMS in female athletes? Yes, the study found strong links between anxiety and depression with PMS in female athletes. However, this is a small study from one location, so findings may not apply everywhere, and showing a link doesn't prove one causes the other. Survey study, 2024 Can mood early in the cycle predict who will have PMS symptoms? Possibly. Women with lower mood scores during the follicular phase showed reduced automatic nervous system activity as they moved toward their period, which may indicate PMS symptoms. The study is small and early-stage. Survey study, 2024 Is suicidal thinking more common in women with premenstrual disorders? Yes. Women with premenstrual disorders have higher rates of suicidal thinking and attempts, especially if they are young (18-25), unemployed, have low income, or have depression or anxiety. Survey study, 2024 Does menstruation increase anxiety, stress, and depression? Yes, women had significantly higher anxiety, stress, and depression during menstruation compared to non-menstruating days. Survey study, 2024 Do daughters' premenstrual symptoms match their mothers' previous premenstrual symptoms? Some symptoms like anxiety and bloating were similar between mothers and daughters. Daughters' anxiety and fatigue were linked to their mothers' psychological menopausal symptoms. Survey study, 2024 How common is PMS in different groups of women and is it linked to depression, anxiety, and stress? 58.2% had mild PMS, 39.9% moderate, and 8% severe. PMS was most common in medical professionals and housewives, and was strongly correlated with depression, anxiety, and stress. Survey study, 2024 Does musculoskeletal pain affect quality of life and mood in women with PMS? Yes. Women with more severe musculoskeletal pain had worse quality of life, less physical activity, and worse mood during the luteal phase, though this study cannot prove pain causes these effects. Non-randomised trial, 2024 Does lavender aromatherapy reduce anxiety during premenstrual syndrome in teenage girls? Yes, lavender aromatherapy significantly reduced anxiety levels during PMS. Most girls shifted from moderate to mild anxiety after treatment. Study, 2024 Does PMS affect how well women can think and concentrate? Yes. Women with PMS had difficulty concentrating in the week before their period. Having a baby did not change how women think long-term. Survey study, 2024 Is diabetes linked to PMS, and could diabetes drugs affect it? This is a review of ideas, not a study with new data, so it cannot prove a link. It suggests diabetes and some diabetes drugs could plausibly worsen or trigger PMS-like symptoms, but this needs to be tested properly. Survey study, 2024 Can researchers create a better animal model to study premenstrual syndrome? Yes. Researchers developed a rat model combining stress and hormonal changes that produced greater biological changes than hormonal changes alone. Survey study, 2024 How common are premenstrual symptoms in university students and do they affect academic performance? 78.9% of female university students had premenstrual symptoms and 90% reported that it negatively affected their academic performance, especially their ability to pay attention in class. Randomised trial, 2024 Does individualized homeopathic medicine reduce PMS symptoms? Yes. Women who received individualized homeopathic medicines showed significant reductions in PMS symptoms compared to placebo by month 2, with benefits continuing through month 3. The study was very small and needs larger follow-up studies. Survey study, 2024 Is mental health different in premenstrual exacerbation versus core premenstrual disorder? Women with premenstrual exacerbation, where an existing mental health condition worsens before menstruation, had higher anxiety and depression and lower quality of life than women with core premenstrual disorder. This was a very small study. Survey study, 2024 What symptoms and life factors are most closely linked to PMS in young women? Anxiety showed up as the symptom most tightly connected to everything else in PMS, closely tied to low mood, and PMS was also linked to a history of painful periods and a neurotic personality type. This comes from one pattern-mapping study, not a trial, so it cannot prove what causes what. Survey study, 2024 Do women with PMDD have more depression and anxiety than those without PMDD? Yes. Women with PMDD had significantly higher depression and anxiety symptoms and lower well-being compared to women without PMDD. Cohort study, 2024 What are the symptoms of PMDD and how common is it? PMDD appears fairly common in this Hungarian sample. Women with probable PMDD reported significantly higher depression and anxiety and lower well-being than those without PMDD. Survey study, 2024 How common is dysmenorrhea related to PMS in university students, and how do they treat it? About 54% of 320 university students in Karachi experienced PMS-related dysmenorrhea. Most women (93%) used plant-based remedies, while only 7% used standard medications. Survey study, 2024 Does Vitex agnus castus help PMS, and what causes PMS? Risk factors for PMS include delayed menarche (2.5 times increased risk) and painful periods (2.1 times increased risk). Treatment with Vitex agnus castus extract showed 2.8 times higher symptom remission than no treatment. Case-control study, 2024 Are vitamin D and calcium deficiency linked to severe PMS symptoms? Women with lower vitamin D levels and calcium intake had more severe PMS symptoms including fatigue, headache, and mood swings. The study is small and shows a link but doesn't prove supplements would help. Survey study, 2024 How do hormonal changes during the menstrual cycle affect gut health and mood? Hormonal changes during the menstrual cycle affect the bacteria in the gut and mood. Higher progesterone levels in the premenstrual phase are linked with worse bloating, constipation, and mood swings. Approximately 50% to 80% of women experience premenstrual symptoms that affect daily life. Cohort study, 2024 Does menstrual cycle phase affect anxiety and complications during tooth extraction surgery? Yes. Women had significantly higher anxiety and more complications during the secretory phase (second half) of their cycle compared to other phases. Women also had higher anxiety than men overall. Survey study, 2024 Are PMS or PMDD linked to different features of bipolar disorder in women? Yes. Women with bipolar disorder and PMS or PMDD became ill at younger ages, had worse depression symptoms with more anxiety and thinking problems, and were more likely to have OCD or family history of mental illness. This is observational, so we cannot prove cause and effect. Survey study, 2024 Does anxiety change at different times during the menstrual cycle in teenage girls? Yes. Girls had higher anxiety overall than boys. Among girls, those in the luteal phase before their period had higher anxiety than those in the menstrual phase. Survey study, 2023 How many women have PMS and what strategies do they use to cope with it? About 53% of women had mild PMS symptoms, 40% had moderate symptoms, and 7% had severe symptoms. Age, family type, and remedies used were linked to how women coped. Lab study, 2023 Can agmatine help prevent anxiety and depression when progesterone drops? Yes. When female rats had their progesterone suddenly withdrawn, they showed anxiety and depression-like behavior, but agmatine and related compounds prevented most of these symptoms. Case-control study, 2023 Does allopregnanolone affect how women with PMDD respond to stress? Women with PMDD had a much larger drop in heart rate variability during stress than healthy women, and recovered more slowly. Baseline allopregnanolone levels predicted the heart response only in women with PMDD. Lab study, 2023 How does allopregnanolone help with PMDD symptoms? In rats with PMDD-like symptoms, allopregnanolone reduced anxiety and improved how brain receptors work in areas that control emotions. Survey study, 2023 Does physical activity reduce premenstrual tension symptoms? Yes, physical activity was significantly associated with less severe premenstrual tension symptoms, particularly pain and concentration problems, though the study was small. Survey study, 2023 Does attachment style affect how severe premenstrual symptoms are? For women not on hormonal birth control, yes. Women with anxious attachment (being very worried in relationships) had more severe premenstrual symptoms through difficulty controlling emotions. Women on hormonal contraception did not show this pattern. Survey study, 2023 Does childhood trauma increase the risk of PMDD? Yes. Women who experienced childhood trauma were about three times more likely to have PMDD symptoms than those who did not experience childhood trauma. Survey study, 2023 Do women with PMS have slower reaction times and mood changes than others? Women with PMS had slower reaction times and higher anxiety, depression, and stress levels. As PMS severity increased, these effects worsened. Survey study, 2023 Do psychological patterns change across the menstrual cycle? This study found certain psychological patterns were lower on day 15 compared to day 1 of the cycle. Anxiety, depression, and stress were linked to more pronounced psychological challenges. However, this was small and done in one country, so findings may not apply broadly. Survey study, 2023 Did COVID-19 stress affect menstrual cycles and mental health? Yes, during the pandemic women had longer cycles, more heavy bleeding days, and more mental health problems like depression and anxiety. The proportion of women with heavy bleeding more than doubled. Cohort study, 2023 Are premenstrual symptoms linked to psychotic-like experiences? Yes. Women with more intense premenstrual symptoms reported more psychotic-like experiences. Depression and anxiety partially explained this link for negative psychotic-like experiences but not positive ones. Survey study, 2023 Does PMS cause changes to the automatic nervous system? No. The study found only a weak connection between PMS and nervous system changes. All women had nervous system changes during their cycle, regardless of whether they had PMS. Randomised trial, 2023 Does chronic stress make progesterone withdrawal anxiety worse in a rat model of PMDD? In stress-prone rats, yes. Chronic stress made anxiety from progesterone withdrawal more severe and changed how the brain's stress system responded. However, this is an animal study, so we cannot be certain the same happens in humans. Survey study, 2023 Does knowing about PMS help reduce anxiety about it in young girls? Yes, the study found that girls with better knowledge about PMS experienced less anxiety (p=0.003). However, attitudes about menstruation alone did not significantly affect anxiety levels (p=0.303). Randomised trial, 2023 What does research show about PMDD neurochemistry? The provided text does not include results from a PMDD neurochemistry study. It discusses unrelated research on other topics. Survey study, 2023 Does connective tissue manipulation help dysmenorrhea pain and other symptoms? Yes, connective tissue manipulation reduced pain and fatigue significantly. Longer treatment appeared to have longer-lasting benefits through 12 months. Survey study, 2023 Does paeonol, a compound from traditional Chinese medicine, help with PMDD symptoms in rats? Yes, in rats. Paeonol reduced irritability, anxiety, and social withdrawal, and it improved brain structure and reduced nerve cell death. However, this has only been tested in rats, not humans. Survey study, 2023 Does peer group education reduce anxiety about PMS in teenage students? Yes, peer group education reduced anxiety about PMS in these teenagers. Most had no anxiety after the program (72.7%) compared to 37.7% before. Survey study, 2023 How common is PMS among nursing students in Sudan, and how much does it affect daily life? In this study, about 4 in 10 nursing students had PMS, and it affected things like eating, recreation, and social life, with mood swings and nervous tension being the most noticeable symptoms. Because this was a small, one-time survey, the result tells us about this group only, not women in general. Survey study, 2023 How common is PMS among female nursing students and how does it affect their lives? 61.4% of nursing students had PMS. Most had physical symptoms, anger, anxiety, and sensitivity. These symptoms interfered significantly with family relationships, social life, and academic work. Survey study, 2023 How common are PMS and PMDD among college girls, and what are their symptoms? Among 318 college students in India, 44 had PMDD and 89 had PMS. Symptoms differed, with PMDD including more severe mood changes like anger, tearfulness, and anxiety than PMS. Survey study, 2023 How common are period pain, PMS, and premenstrual symptoms in physiotherapy students? Most physiotherapy students report premenstrual symptoms affecting their daily lives, with the most common being impact on social activities (49%), work relationships (43%), food cravings (43%), bloating (41%), and headaches (41%). Systematic review, 2023 Do different racial and ethnic groups experience depression, anxiety, and PMDD differently? The review found inconsistent results. Women of color generally reported lower depression rates than White women, but they may experience different or more severe symptom patterns. Survey study, 2023 Does menstrual distress affect how well female basketball players perform? No. Menstrual distress did not appear to affect basketball performance. However, women with more menstrual distress were more likely to also have depression. Randomised trial, 2023 Does a smartphone app for heart rate variability biofeedback reduce premenstrual and depressive symptoms? Yes, the app reduced premenstrual, depressive, and stress symptoms over 4 weeks. However, it did not change the underlying heart rate patterns it was designed to improve. Systematic review, 2023 Can relaxation methods like yoga help with the anxiety that comes with PMS? This review suggests relaxation therapy, including yoga, may help lower anxiety linked to premenstrual syndrome, but it mostly draws on older studies rather than new data, so confidence in this is limited. Survey study, 2023 Does PMS affect school performance and relationships in female medical students? Yes, significantly. 73.6% of the 2080 students studied had premenstrual symptoms, and those with symptoms did worse in school and had more problems with relationships. The study shows a clear link, but only studied medical students. Survey study, 2023 Did COVID-19 infection and vaccination affect women's menstrual cycles and mental health? Yes, temporarily. 48.2% of women reported menstrual changes after COVID and 58.8% after vaccination, with more period pain and PMS. Mental health worsened with more anxiety and poor sleep. Most changes improved by 6 months. Lab study, 2023 Does menstrual cycle phase affect anxiety differently after becoming a mother? Menstrual cycle phase changed anxiety in women without children but made no difference in mothers. Motherhood appears to reduce how hormones affect anxiety. Survey study, 2023 Does learning more about PMS help reduce anxiety in teenage girls? The review suggests that teenage girls with PMS can reduce anxiety by learning more about their symptoms and getting appropriate treatment, though this conclusion comes from reviewing existing studies rather than new research. Lab study, 2023 Does Xiangshao granules reduce irritability and anxiety in PMDD? In rats with PMDD-like symptoms, Xiangshao granules reduced aggressive and anxiety-like behaviors and improved social skills. This was only tested in animals, not in women. Randomised trial, 2022 Does a B6 supplement with herbs help sleep and anxiety in PMS and menopause? Yes, the supplement improved sleep problems by 46.6% and anxiety by 23.2% in women with PMS and those in menopause transition. Case report, 2022 Does sertraline help women with severe premenstrual dysphoric disorder? In this case, a 44-year-old woman with severe PMDD symptoms showed complete recovery after taking sertraline for two menstrual cycles, and was able to continue taking it just during the week before menstruation. Non-randomised trial, 2022 Does eating papaya help premenstrual tension syndrome? We cannot tell if papaya helps because the abstract does not report the actual results. The study was small and not properly randomized. Survey study, 2022 Do women with PMS have increased risk of suicidal thoughts? Yes. Nearly one-third of women with PMS symptoms reported new or worsening suicidal thoughts in the week before their period. Women with depression history, current depression, and childhood trauma were at highest risk. Survey study, 2022 What are the differences in mood between PMDD, PMS, and no or mild PMS? Women with PMDD had significantly higher anxiety and depression than those with PMS or no/mild PMS. This is a cross-sectional study, so it shows differences but cannot prove what causes them. Survey study, 2022 Did COVID-19 stress worsen period pain and PMS symptoms in female medical students? Yes. Severe period pain increased from 36.9% before COVID-19 to 49.9% during the pandemic, and period symptoms were closely linked to depression and anxiety. Survey study, 2022 Is reduced thinking ability linked to nervous system changes in women with PMS? Yes. Women with PMS showed increased activity in the part of the nervous system that speeds up the heart and body, and had reduced thinking and memory ability compared to women without PMS. Survey study, 2022 How common is PMS in medical students and what are the main symptoms? 18.9% of medical students had PMS. Anxiety before the period (78.8%) and stomach pain during the period (72.2%) were the most common complaints. Students who started menstruating earlier were more likely to have PMS. Survey study, 2022 What factors are associated with PMS in emergency room nurses? PMS was common in ED nurses at 67.47%. Women with higher occupational stress, higher anxiety, lower education level, younger age, and higher BMI were more likely to have PMS. Survey study, 2022 Does physical activity and stress affect which type of PMS a teenager gets? Yes. Stress was linked to different types of PMS, but physical activity was not. However, the study only looked at one moment in time, so we cannot be sure stress causes different PMS types. Lab study, 2022 Can Kamishoyosan, a traditional Japanese medicine, help with anxiety from hormone changes? In a rat model, Kamishoyosan reduced anxiety-like behavior caused by stopping progesterone. The effect appeared to work through a brain chemical called serotonin, but we don't yet know if it would work the same way in women. Survey study, 2022 Can peer health education help young women manage PMS? Yes. Peer education using counseling techniques reduced anxiety about PMS in high school students, with 54.5% very satisfied and 41.6% satisfied with the education. Interview study, 2022 Are doctors correctly diagnosing PMDD or mistaking it for depression or anxiety? All four women interviewed were initially misdiagnosed with depression or anxiety rather than PMDD. The key to accurate diagnosis was recognizing that symptoms followed the menstrual cycle. Review, 2022 Can blocking a natural brain steroid help PMDD? Maybe. An early study showed that blocking a steroid called allopregnanolone improved negative mood in women with PMDD compared with placebo, but more research is needed. Survey study, 2022 Is there a link between premenstrual syndrome and fear of childbirth? Yes, women with more PMS symptoms tend to have more fear of childbirth, though the connection is weak. This finding comes from university students only, so we should be cautious about whether it applies to all women. Survey study, 2022 How common is premenstrual tension in adolescent girls? Most adolescent girls experience mild to moderate premenstrual tension syndrome. Family background like mother's education and father's job appear to be related to symptom levels. Survey study, 2022 How common are premenstrual syndrome and PMDD among college students in Mongolia? 23.8% had moderate to severe PMS and 4.7% had PMDD. The most common symptoms were fatigue (86.7%), anger or irritability (80.9%), and tearfulness (76.2%). Survey study, 2022 Is stress about puberty and menstruation linked to depression and anxiety in adolescent girls? Yes. Stress related to menstruation and puberty was linked to depression, anxiety, and reproductive tract infections in adolescent girls in Tanzania. Non-randomised trial, 2022 Does a young women's class reduce PMS anxiety in teenage girls? Yes. Teenage girls who attended a young women's class with stress management and yoga exercises showed a mean anxiety reduction of 5.94 compared to 0.97 in the control group. Survey study, 2022 Did COVID-19 increase PMS symptoms in female doctors? Yes. Female doctors showed more PMS and PMDD symptoms during the pandemic, linked to psychological stress. Front-line workers had worse symptoms. Study, 2022 What is the difference between PMS and PMDD? PMDD is more serious than PMS, with stronger depression, anxiety, and irritability that happens in the week or two before a period when hormones drop. Survey study, 2022 Does depression or panic disorder increase the risk of severe PMS? Yes. Women with panic disorder had much higher rates of severe PMS (43%) than women with depression (16%) or no mental health conditions (10%). Lab study, 2021 Does a Japanese herbal medicine help reduce anxiety before a period? An ethanol extract of a Japanese herbal medicine called Inochinohaha White reduced anxiety-like behavior in rats when hormone levels dropped sharply, suggesting it might help premenstrual anxiety. This was an animal study. Survey study, 2021 What blood markers can help identify menstrual cycle-related symptoms? Several blood markers including hormones and immune markers showed links to menstrual cycle symptoms. This is a theory paper, not a new study testing whether these markers work in practice. Survey study, 2021 Does what elite young female athletes eat affect their menstrual cycles? Yes. Athletes who ate enough carbohydrates did not have menstrual problems. This suggests that adequate calories and carbohydrates may help maintain regular periods. Interview study, 2021 How does the female reproductive cycle affect anxiety in rodent studies? Female rodents show more anxiety responses during the late phase of their reproductive cycle, similar to the premenstrual phase in women. This is animal research, not human research, so findings may not directly apply to women. Survey study, 2021 Does fluoxetine reduce panic-like behavior during the premenstrual phase? In female rats, low-dose fluoxetine prevented an increase in panic-like behavior during late diestrus (the phase equivalent to the human premenstrual phase). A higher dose of fluoxetine did not have this effect. Survey study, 2021 Do ovarian hormones affect how worry impacts working memory? Yes. Higher worry was linked to worse working memory performance, especially when estradiol or progesterone levels were high. Survey study, 2021 Is anxiety about PMS related to how much girls know about reproductive health? Yes. There is a relationship between girls' knowledge about reproductive health and their anxiety about premenstrual syndrome. Survey study, 2021 Do medical students with premenstrual syndrome have higher anxiety and depression? Yes. Medical students with PMS had significantly higher depression and anxiety scores than those without PMS. Survey study, 2021 Does anxiety change during different phases of the menstrual cycle? Yes, significantly. Most women reported anxiety before menstruation, much fewer reported it during and after menstruation. Review, 2021 What symptoms and health impacts do women experience from menstrual distress? Women with menstrual distress experience physical symptoms like cramping, tiredness, and breast pain, plus emotional symptoms like sadness and anxiety. These affect their ability to work, attend school, and maintain mental health. Randomised trial, 2021 Does a nomegestrol acetate oral contraceptive help mood symptoms in PMDD? Most women (74.5%) reported improved mood, and depression, anxiety, and stress scores improved significantly. This was an early feasibility study without a control group, so we need stronger evidence. Survey study, 2021 Does premenstrual tension syndrome affect how well a woman's family functions? Yes, in this study premenstrual tension syndrome was very common among female university students, and the more severe it was, the more likely their family was to be dysfunctional. Survey study, 2021 Does the menstrual cycle affect women's social behavior and anxiety? Women in the luteal phase (when progesterone is high) reported being more sensitive to others' feedback, feeling more anxious with other people, and preferring to cooperate. These changes did not appear in the follicular phase. Survey study, 2021 Do girls with PMS have different estrogen levels than those without? Girls with PMS had higher estrogen levels than those without. Girls with severe PMS had the highest levels. This is a one-time measurement, so we cannot tell if high estrogen causes PMS. Study, 2021 Does the point in the menstrual cycle change mood, anxiety and exercise performance in active women? It made a small difference to aerobic fitness and to how exercise affected depression, but most other measures of mood, anxiety and performance did not clearly differ between cycle phases. Review, 2021 How does the menstrual cycle affect anxiety and PTSD symptoms? The menstrual cycle and its hormones affect anxiety and PTSD symptoms. The clearest finding is premenstrual worsening of anxiety, and estradiol may help with trauma memory processing. Survey study, 2021 How do coping strategies affect mood across the menstrual cycle in women trying to conceive? Active coping and behavioral engagement reduced evening depression during menstruation. But seeking social support increased anxiety and reduced emotional quality of life, and using fertility monitoring techniques also increased anxiety. Survey study, 2021 What are the research trends in PMS and PMDD studies from 1945 to 2018? Research on PMS and PMDD has grown over time. Recent research increasingly focuses on prevalence in young women and how anxiety and depression relate to menstrual cycle phases. Cohort study, 2021 Did the COVID-19 pandemic affect women's periods and anxiety levels? Yes. During the pandemic in May 2020, women reported shorter periods with fewer pads needed. Higher anxiety scores were linked to worse menstrual symptoms. Survey study, 2020 What attitudes do teenage girls have about premenstrual syndrome, and what affects them? Most girls had positive attitudes about PMS (50.3%) and good knowledge about it (74.2%). Knowledge, physical activity, anxiety levels, and health education all related to how they felt about managing PMS. Survey study, 2020 Can teaching about yoga techniques improve girls' knowledge about managing PMS? Yes. After the teaching program, girls' knowledge about using yoga for PMS increased significantly, with post-test scores more than double the pre-test scores. Lab study, 2020 Can Paeonia lactiflora extract reduce anxiety in rats with PMS-like symptoms? Yes. In rats with PMS-like anxiety, Paeonia lactiflora extract reduced anxious behavior and changed three brain chemicals involved in stress and mood. However, this is a rat study, so it does not directly show whether it would help people. Lab study, 2020 Can an estrogen and gene variant cause PMDD-like mood symptoms? Mice carrying a BDNF gene variant developed anxiety and depression-like behavior when given estrogen, similar to PMDD symptoms. Survey study, 2020 Do women with IBS and period problems have worse psychological symptoms? Yes. Women with IBS alongside period pain and PMS show more depression, sleep problems, and worse quality of life than those without IBS. Lab study, 2020 Can a natural compound called paeonol ease anxiety and aggression in animal models of PMDD? In mouse and rat studies, paeonol reduced anxiety-like and aggressive behaviour at certain doses, but the effective dose differed between models, so this is early animal evidence, not proof it works in women. Survey study, 2020 What are the most common PMS symptoms and how much do they disrupt daily life? Painful periods affected 63% of women and 40% said their routine was disrupted during their period. However, the study was in one community in Pakistan and only recorded current symptoms, not tracked changes over time. Survey study, 2020 Do negative attitudes about menstruation and suggestibility predict worse PMS pain and distress? Yes. Women with more negative attitudes about menstruation and higher suggestibility had significantly greater pain intensity and higher levels of stress, anxiety, and depression. Randomised trial, 2020 How should premenstrual syndrome be diagnosed and treated? PMS is diagnosed by tracking cyclical symptoms that appear 2-14 days before menstruation and disappear when menstruation starts. Both hormonal treatments like birth control pills and non-hormonal treatments like Vitex extract have been shown in research to be effective. Survey study, 2020 How common are PMS and PMDD in women with mood and anxiety disorders? PMS affected 47.5% and PMDD affected 13.0% of women with mood or anxiety disorders. Both were significantly linked to diet, menstrual patterns, and medication use. Survey study, 2020 How common are PMS and PMDD in Bulgaria, and what are the main symptoms? PMS affects 32.1% of Bulgarian women and PMDD (the more severe form) affects 3.3%. Most symptoms are mild or moderate, with mood symptoms like irritability about as common as physical symptoms like bloating. Survey study, 2020 How common is PMS in elite female athletes, and do training or lifestyle factors cause it? 14.55% of elite female athletes have moderate to severe PMS. No specific modifiable risk factors were found. 76.6% of athletes felt their symptoms interfered with performance, but only 5 out of 18 athletes with PMS saw a doctor. Randomised trial, 2020 Can learning coping strategies reduce anxiety in girls with PMS? In this small study, a 10-session coping skills training program lowered anxiety scores in girls with PMS more than in a comparison group, but the study was small so this is not strong proof. Survey study, 2020 Does penguin exercise reduce anxiety in girls with premenstrual syndrome? Girls who did penguin exercise showed a clear difference in anxiety levels, while girls in the control group showed no change. This suggests penguin exercise may help reduce anxiety during PMS. Survey study, 2020 Does menstruation trigger symptoms in people with Behçet's disease? Menstruation was rarely reported as a trigger. An irregular menstrual cycle triggered mouth ulcers in only 2 out of 60 patients. Food items like eggplant and walnut, as well as psychological stress, were much more commonly reported as triggers. Survey study, 2020 Does menstrual cycle affect balance and position sense in women with multiple sclerosis? In the early follicular phase, pain was linked to how well women could sense their knee position. The study was very small and had no comparison group, so results are uncertain. Survey study, 2020 Does worry about health change how stressed women feel at different times in their menstrual cycle? Women with higher worry about health reported more stress during the late luteal phase. This worry did not change whether they experienced more premenstrual symptoms overall. Cohort study, 2020 Are immune and oxidative stress markers linked to menstrual cycle symptoms? Certain markers related to antioxidant defenses and immune function may play a role in menstrual cycle symptoms, though this isn't due to general inflammation. However, this is a small study with no control group, so the findings need confirmation. Survey study, 2020 Are anxiety, depression, and coping styles linked to PMS symptoms? Yes. Mental health problems and coping strategies are significantly linked to PMS symptoms in the premenstrual phase. Study, 2020 What is premenstrual syndrome and what causes it? PMS is a group of physical and emotional symptoms caused by the body's abnormal response to hormone changes during the menstrual cycle. Symptoms always go away when the period starts. Survey study, 2019 Does allopregnanolone, a hormone made from progesterone, affect premenstrual mood? Growing evidence suggests allopregnanolone may influence mood during the premenstrual phase and other reproductive times, but exactly how it works is not yet clear. Review, 2019 Does yoga help women with premenstrual syndrome? A review found that yoga may help PMS by reducing inflammation and decreasing heart rate, blood pressure, and anxiety. Non-randomised trial, 2019 Does an education program help nursing students with PMS improve knowledge and reduce symptoms? Yes. The education program clearly increased knowledge and reduced PMS symptoms. Students also lost weight, dropping from an average of 77.4 kg to 68.89 kg. Non-randomised trial, 2019 Does Raja Yoga meditation reduce depression, anxiety, and stress in women with PMS? In this small study, 8 women who practiced Raja Yoga meditation once daily for 8 weeks showed lower depression, anxiety, and stress scores during the premenstrual period. But without a control group, we cannot be sure the improvement came from meditation. Survey study, 2019 Why might depression develop when women stop breastfeeding? This review proposes that hormonal changes during weaning may trigger depression in some women. A brain chemical normally calming anxiety may work differently during weaning, worsening mood instead. Survey study, 2019 Do low progesterone levels cause PMS symptoms? Yes. Women with lower progesterone levels overall, and those whose progesterone dropped more during the two weeks after ovulation, had worse PMS symptoms. Estradiol was also linked to PMS but this effect was largely explained by progesterone levels. Study, 2019 What are the different ways to treat PMS and PMDD? There are two main treatment approaches: medications that reduce hormone changes during the menstrual cycle and medications that affect the brain and nervous system. Some alternative therapies also have supporting evidence. Case-control study, 2019 Does premenstrual dysphoric disorder affect the heart's electrical patterns? Women with PMDD had higher P wave dispersion measurements than healthy women. The study is small, so we cannot be certain how important this is for real life. Case-control study, 2019 Does inflammation affect mood in women with PMS? In female soccer players, those with PMS had higher levels of inflammatory markers and reported more depression and tension at certain cycle phases compared to those without PMS. Cohort study, 2019 Is there a link between menstrual symptoms and anxiety, depression, and stress in teenage girls? Yes. There was a strong correlation between menstrual distress and depression, anxiety, and stress, with distress significantly higher before, during, and after menstruation (p=0.000). Survey study, 2019 How common is premenstrual syndrome among medical students? About 3 out of 4 medical students in this study had PMS. Mood swings and anxiety were most common. Survey study, 2019 Does the menstrual cycle affect gut bacteria and immune response related to PMS? Yes. Antibody levels to gut bacteria change throughout the cycle, peaking at day 28, and these changes are linked to physical symptoms like bloating, anxiety, and breast swelling but not depression. Progesterone appears to drive these changes. Survey study, 2019 How common is PMS in female operating room technologists? The study aimed to find how common PMS is in female operating room technologists and what factors influence it, but the results are not provided in this abstract. Survey study, 2019 Can birth control pills treat PMDD? Yes. Birth control pills with drospirenone significantly reduced emotional symptoms like depression and anxiety by 50% at 6 months, while physical symptoms like pain improved by 70%. Without a placebo control, we cannot be certain the medication caused all the improvement. Survey study, 2018 What signs of premenstrual tension syndrome do female college students experience? Most female college students experience signs of premenstrual tension syndrome, and they typically manage these symptoms at home without seeing a doctor. Case-control study, 2018 Is the stress response system overactive in women with premenstrual syndrome? No. Women with PMS actually had lower stress hormone levels and less stress response activity than women without PMS during the late phase of the menstrual cycle. Randomised trial, 2018 How do progesterone metabolites affect PMDD symptoms? Women with PMDD respond differently to these natural brain chemicals. Blocking one type may reduce negative mood symptoms, but this summary is incomplete. Survey study, 2018 Does estrogen affect anxiety and mood problems in PMDD, and does a woman's genes play a role? In women with PMDD, higher estrogen before the period was linked to lower anxiety and stress, but only in women carrying a specific genetic variant. This shows correlation in this subset and cannot confirm cause and effect. Survey study, 2018 How does PMS affect self-esteem in girls? Girls with PMS showed lower self-esteem compared to expected levels. The link may be because PMS mood changes lead girls to feel worse about themselves. Case report, 2018 Can severe head injury lead to PMDD? Yes. A 17-year-old girl developed PMDD months after a severe traumatic brain injury. She needed antipsychotic medication to manage her symptoms. Review, 2018 Is PMDD properly recognized and treated in Denmark? No. PMDD is often overlooked in Denmark despite being common. SSRIs (antidepressants) can treat PMDD when used only during the luteal phase rather than continuously, which differs from how they are typically prescribed for depression. Survey study, 2018 Is a girl's temperament linked to how much premenstrual symptoms bother her? Girls with irritable, mood-varying, or sad-leaning personality types had more premenstrual symptoms. This suggests that personality type may influence how much premenstrual symptoms affect a girl. Lab study, 2017 Do physical changes happen before menstruation? Yes. Before menstruation compared to after, women showed increased perceived stress, faster heart rate, higher blood pressure, weight gain, and slower reaction times. Case report, 2017 Can a combined oral contraceptive pill help PMDD in women who also have depression or anxiety? One 34-year-old woman with PMDD along with depression, anxiety, and other psychiatric conditions improved on a combined oral contraceptive pill. Her mood, anxiety, menstrual cramps, and ability to handle stress all got better. Randomised trial, 2017 Can smelling yuzu citrus scent ease premenstrual mood symptoms? In this small study, a short sniff of yuzu scent reduced tension, anger and fatigue in the days before a period, working about as well as lavender. The study is very small, so this is an early, low-certainty finding rather than proof. Survey study, 2017 Does the body's immune response to tryptophan relate to PMS? Women with PMS had higher immune responses to certain tryptophan byproducts. This suggests PMS involves the immune system, though more research is needed to understand what this means. Survey study, 2017 What is the impact of having both bipolar disorder and premenstrual dysphoric disorder? Women with both conditions experience significantly worse bipolar illness: earlier onset, more rapid cycling, more mood episodes, and higher rates of anxiety disorders and other conditions. They also experience more severe symptoms during pregnancy and while taking oral contraceptives. Survey study, 2017 Are PMS symptoms linked to mood disorders and personality? This study found significant relationships between PMS symptoms and lifelong mania or hypomania symptoms, and between PMS and personality traits. Because it was cross-sectional, we cannot know if hormonal changes in PMS cause mood and personality changes. Survey study, 2017 Can we detect differences in how women's brains work during different parts of the menstrual cycle? Yes. Brain activity patterns are different during menstruation, the follicular phase, and the luteal phase, with 72-93% accuracy in detecting these differences depending on which phases are compared. Survey study, 2017 How common is PMS in adolescents with psychiatric problems and does it affect their quality of life? PMS was present in nearly 4 out of 5 adolescents in a psychiatric clinic and significantly lowered their quality of life. The more severe their PMS, the worse their quality of life became. Survey study, 2017 Are dietary and lifestyle habits like alcohol consumption linked to PMS in college students? The study examined alcohol consumption in college students and found females drink much less than males. The connection to PMS specifically is not clearly described. Study, 2017 Does what women eat affect how severe their premenstrual symptoms are? Yes. Women with severe premenstrual tension symptoms ate different amounts of certain nutrients compared to women with mild symptoms. Women with severe symptoms ate significantly more fat and vitamin C. Case-control study, 2017 Do anxiety levels differ in soccer players with and without PMS? Yes. Players with PMS had significantly higher anxiety levels than those without (p = 0.002). A chemical called IL-10 may help protect against anxiety, but this protection didn't work the same way in players with PMS. Survey study, 2017 Do women with moderate PMS have more depression, anxiety, stress, and sleep problems than those with mild PMS? Yes. Women with moderate PMS had significantly higher levels of depression, anxiety, and stress, and significantly worse sleep quality compared to those with mild PMS. Randomised trial, 2017 Does yoga help with PMS symptoms? This text only gives the background and reasoning for a yoga trial. It does not include the trial's actual methods or results, so no answer about whether yoga worked can be given from this excerpt. Survey study, 2017 Does the menstrual cycle affect heart rate variability independent of diet, activity, and sleep? Heart rate does change across the menstrual cycle, but this change appears to be driven by differences in diet, activity, and sleep rather than by the cycle itself. Case-control study, 2017 Do women with PMS panic more during a breathing test, and does cycle timing matter? Yes. Women with PMS felt more intense panic symptoms during a CO2 breathing challenge, but only in the days just before their period, not earlier in the cycle. Survey study, 2017 Is premenstrual syndrome linked to anxiety, digestive problems, and food choices? Women with PMS were more likely to have anxiety and digestive problems like IBS and constipation, and to eat more meat and fast food but less carbohydrates. However, this study only shows associations, so we cannot know whether these factors cause PMS or result from it. Survey study, 2017 Does fear of period pain affect mood and thinking during the menstrual cycle? Yes. Women expecting severe period pain showed increased anxiety and depression and slower thinking response during the premenstrual phase, suggesting that fear of pain affects emotions and cognition. Randomised trial, 2016 Does blocking progesterone conversion help PMDD symptoms? A high dose of dutasteride reduced several PMDD symptoms by blocking conversion of progesterone to a hormone compound. However, only the high dose worked and the study was small. Survey study, 2016 Is eating behavior in the luteal phase related to anxiety in women with PMDD? The provided abstract does not include results or findings from this study, so no answer can be determined. Randomised trial, 2016 Does Gung massage reduce PMS symptoms better than other treatments? Gung massage reduced more PMS symptoms than heat or regular massage. All treatments reduced pain, but Gung massage had the largest improvements in pain, emotions, water retention, and body temperature after 8 weeks. Study, 2016 Does balance or stability change across the menstrual cycle in active women? Balance that involves moving (dynamic stability) was worse during the middle of the luteal phase and best during the period itself. Anxiety, spinal posture, and balance while standing still did not change across the cycle. Survey study, 2016 Do women with PMDD also have postpartum depression? Rarely. Only about 11.7% of women with PMDD had a history of postpartum depression, suggesting these are separate conditions even though both involve mood changes. Survey study, 2016 Can noofen help with painful periods and anxiety symptoms? Girls with painful periods and anxiety symptoms who took noofen showed improvement in their symptoms over 30 days. The study found noofen was effective for treating these problems. Non-randomised trial, 2016 Does a birth control pill improve quality of life in women with moderate to severe PMS? Yes, this pill significantly improved quality of life in multiple areas after 3 months, with 88.4% of women reporting satisfaction with treatment. However, this was a small study with no comparison to other treatments. Survey study, 2016 Does difficulty controlling emotions affect how PMS and anxiety change during your cycle? Partially. Emotion regulation affected how much anxiety control changed between cycle phases, but did not clearly affect physical PMS symptoms. Case-control study, 2016 Do women with PMDD respond differently to allopregnanolone across the menstrual cycle? Yes, women with PMDD show an opposite pattern of brain response to injected allopregnanolone across the cycle compared to healthy women, with stronger effects in the luteal phase, suggesting altered sensitivity to this hormone. Survey study, 2015 Does a chemical in your body change before menstruation, and does smelling it affect your feelings? A chemical called 2-heptanone increases to about twice the level before menstruation. When people smelled this chemical for longer periods (180 seconds), they were less interested in smelling it again compared to shorter exposures. The connection to PMS or mood is unclear. Survey study, 2015 Does the ability to recognize emotions in faces change with menstrual cycle hormones? No clear difference in overall emotion recognition across menstrual cycle phases was found. However, estradiol levels were specifically linked to better disgust recognition, and progesterone levels were linked to slower responses to facial expressions in general. Case-control study, 2015 Are brain connections different in women with PMS? Yes. Women with PMS had decreased connectivity in some brain regions involved in emotion and memory, and increased connectivity in other regions. They also reported higher anxiety and depression. Survey study, 2015 Are menstrual problems linked to mental health issues? Yes. Girls with menstrual problems were clearly more likely to have stress and anxiety. Survey study, 2015 Does PMDD affect mood and quality of life more than PMS? Yes, women with PMDD had higher anxiety and depression scores and lower quality of life than women with PMS in every area measured. Randomised trial, 2015 Does quetiapine help women with PMS/PMDD who don't respond well to antidepressants? This very small pilot study suggests quetiapine as an add-on to antidepressants may help reduce mood-related symptoms like anxiety and irritability, but the evidence is weak because only 20 women were studied. Randomised trial, 2015 Does laser acupuncture with relaxation technique help premenstrual tension? Yes. Laser acupuncture combined with a relaxation technique reduced muscle tension, heart rate, and breathing rate in women with premenstrual tension. Interview study, 2015 What are the symptoms of PMDD and how many women have it? PMDD is a severe form of premenstrual syndrome. About 90% of women experience premenstrual symptoms, but only 4.6% to 6.4% meet criteria for PMDD, and about 5% experience severe symptoms. Case report, 2015 Do hormones from the menstrual cycle affect schizophrenia symptoms? Yes. Women with schizophrenia often have worsening psychotic symptoms and depression or anxiety at certain times in their menstrual cycle. Doctors can manage this by adjusting medications. Survey study, 2015 Which screening tool is best for diagnosing PMDD and menstrual-related psychiatric conditions? There is no agreed-upon best tool. Different studies use different definitions and methods, making it hard to compare research and provide consistent care. Survey study, 2015 Does sweet taste preference change with depression during the menstrual cycle? In women during their luteal phase, those with higher depression symptoms needed more sugar to taste sweetness. This connection happened only in the luteal phase, not at other times. Survey study, 2015 Does lower estrogen during menopause cause depression and anxiety? Women going through menopause who had depression had lower estrogen levels than those without depression, suggesting a link. The very small sample means we cannot prove this causes depression. Case-control study, 2015 Does feeling in control of anxiety affect how severe PMS symptoms feel? Possibly yes. Women who felt they had less control over anxiety reported worse PMS symptoms, regardless of which cycle phase they were in. This link was stronger than another anxiety measure studied. Survey study, 2014 What factors cause PMS in teenage girls? Daily hassles had the biggest effect on PMS in teenage girls. Other factors included age at first period, body weight, menstrual flow amount, test anxiety, social support, attitudes about menstruation, and femininity, but not school stress. Survey study, 2014 Does allopregnanolone, a progesterone metabolite, cause mood problems in PMDD? Theory suggests it might. In women with PMDD, allopregnanolone levels increase during the menstrual cycle and appear linked to mood changes. Paradoxically, this brain chemical normally calms the brain. Survey study, 2014 Do premenstrual symptoms make PTSD symptoms worse? Yes. Women with worse premenstrual symptoms had noticeably worse PTSD symptoms, especially if they were sensitive to anxiety. Survey study, 2014 Which PMS symptoms tend to occur together? Different PMS symptoms commonly occur together. Women who have mood symptoms like anxiety and irritability also tend to have appetite changes, depression, and sleep problems, and these associations were found to be statistically significant. Survey study, 2014 Does progressive muscle relaxation help reduce anxiety and depression in women with PMS? Progressive muscle relaxation reduced both anxiety and depression in women with PMS. Women who did the technique for one month showed clear improvement. Survey study, 2014 Which stomach and digestive symptoms occur around the time of menstruation? Most healthy women get stomach symptoms before or during their period, especially stomach pain and diarrhea. Women who have mood symptoms like depression or anxiety are more likely to have multiple stomach symptoms. Study, 2014 Does combining medication and therapy help PMDD? In one teenage girl with PMDD and anxiety, combining medication and therapy led to a good outcome. Combined treatment appeared to work better than either one alone. Interview study, 2014 What PMS symptoms affect women's daily lives? Women with premenstrual tension syndrome experience different combinations of physical and mental symptoms that interfere with daily activities. Better healthcare support and education can help. Survey study, 2013 What role do neurosteroids play in women's health? Neurosteroids are chemicals in the brain and nervous system that control how nerve cells work. They may be useful for treating health issues related to aging and reproductive hormones. Survey study, 2013 Do women with OCD experience worse symptoms before their period? About half (49.7%) do experience premenstrual worsening of OCD symptoms. These women show higher rates of depression, anxiety, suicidal thinking, and specific obsessions about sex or religion. Survey study, 2013 Is PMDD common in women with lupus and linked to depression? Yes. 32% of women with lupus had PMDD, and this was significantly associated with major depression (p=0.010). Survey study, 2013 Is a daily symptom tracker reliable for measuring PMS in Chinese women? Yes. The Daily Record of Severity of Problems showed good reliability and validity for tracking PMS symptoms in Chinese women, with stable measurements across two cycles. Survey study, 2013 How does emotional tension and thinking ability change across the menstrual cycle? Emotional tension is lowest and thinking ability is highest during the luteal phase. This is connected to progesterone levels. Randomised trial, 2013 Does lavender scent help premenstrual mood symptoms? A 10-minute inhalation of lavender scent reduced symptoms of sadness and confusion during the premenstrual phase compared to water. The effect lasted about 35 minutes. Review, 2013 Does exercise help or hurt women's menstrual health? Moderate exercise improves menstrual regularity and reproductive health. But excessive exercise without enough nutrition can cause loss of periods, weak bones, and eating disorders. Randomised trial, 2013 Does homeopathic treatment reduce PMS symptoms? In this small study, homeopathic treatment was associated with symptom reduction and improved quality of life. However, there was no control group, so we cannot be certain the improvement was due to the treatment rather than placebo effect or natural improvement. Case report, 2013 Can severe mood changes around a period be an early sign of bipolar disorder? In one teenage girl, a psychotic episode tied to her period turned out to be the first sign of bipolar disorder. This is a single case, so it cannot tell us how common this is. Survey study, 2013 Can headaches happen in the middle of a woman's cycle? Yes. About half of women get headaches before their period, but one in six experience headaches around the middle of their cycle instead. Headache timing often matches when mood symptoms occur. Survey study, 2013 Is health anxiety connected to PMS and PMDD? Yes, women with PMS and PMDD reported significantly more health anxiety and anxiety sensitivity than those with mild or no PMS. These links remained even after accounting for general anxiety, and both groups reported worse quality of life overall. Survey study, 2013 Does a bitter taste receptor gene affect PMS risk? This is the first study to link the TAS2R38 bitter taste gene to PMS. Women with higher sensitivity to bitter taste had more PMS symptoms, but the evidence is limited because this is a small study in one community. Survey study, 2013 Is PMS linked to perfectionism and anxiety in college students? Yes, but the link differs by student type. In nursing students, PMS is linked to both perfectionism and anxiety. In general students, it is only linked to anxiety. Randomised trial, 2013 Are low calcium and other minerals related to PMS symptoms? Yes, very low calcium is extremely common in women with PMS, and weak associations were found between low sodium or magnesium and some PMS symptoms like anxiety and depression. However, this study only shows association, not proof of causation. Lab study, 2013 Could antidepressants help prevent PMS by keeping brain chemicals stable? This is a theory based on how antidepressants work and animal research, but it has not yet been tested in women. Survey study, 2013 What do Brazilian men understand about premenstrual syndrome? Most Brazilian men (86%) have heard of PMS, but awareness and understanding are significantly higher in more educated men and those with higher income. Case-control study, 2012 Do PMDD and generalized anxiety disorder affect memory and thinking in the same way during the cycle? No. In this study, women with generalized anxiety disorder had worse memory, attention and psychomotor function in the late luteal phase than women with PMDD, and both groups did worse than healthy women. Study, 2012 How do thinking abilities change during the menstrual cycle? Women performed best on mental rotation tasks during menstrual and early follicular phases (low hormone times), best on word fluency during menstrual and mid-luteal phases. Anxiety and masculine/feminine feelings stayed the same. Survey study, 2011 Do overweight or obese women have worse PMS than normal weight women? Yes. Overweight and obese women reported significantly more pain and mood-related PMS symptoms compared to normal weight women. Survey study, 2011 Why do women get panic disorder more often than men? This review proposes that women with anxiety sensitivity may be more vulnerable to panic disorder because progesterone and its brain chemical allopregnanolone interact differently during the premenstrual phase. The evidence is preliminary. Review, 2011 How do the hormones estrogen and progesterone affect the brain's activity, and could this explain PMS or PMDD? Estrogen tends to make brain cells more excitable, while progesterone and a substance it breaks down into tend to calm them. This balance may help explain PMS and PMDD, but this is a summary of existing research, not a new experiment. Survey study, 2011 Do all women experience mood changes the same way across their menstrual cycle? No. About 61% of women follow the classic PMS pattern, 13% show mood peaking mid-cycle instead, and 26% have no regular pattern. Survey study, 2011 Why do some women experience negative mood with hormone changes? The paper proposes that negative mood in PMDD may result from how a brain chemical reacts to receptors. This is a theoretical explanation based on research patterns, not a definitive finding from a new study. Survey study, 2011 Do hormones affect types of headaches other than migraines? This review suggests that hormones and menstruation do affect various types of headaches besides migraines. However, the evidence is not as clear or strong as the evidence for hormone-related migraines. Survey study, 2011 Can premenstrual symptom rating scales be simplified and made easier to use? Yes. Researchers updated the rating scales and created a new visual scale that women found easier to use, especially those with severe PMS or PMDD. Cohort study, 2010 How do anxiety disorders differ across different life stages? The provided summary focuses on anxiety in children and risk factors. The section about women and hormones is cut off in the provided text, so no conclusion about menstrual-related anxiety can be drawn. Review, 2010 Is the menopause transition a risky time for depression to develop? Yes, some women are at higher risk of depression during the transition to menopause, and women with a history of severe PMS may be especially vulnerable. Survey study, 2010 Is lower blood serotonin linked to worse mood before menstruation? Yes, women with lower blood serotonin during the premenstrual phase had worse tension, anxiety, and fatigue. However, the study is very small and only looked at healthy women, so results may not apply to women with PMS or PMDD. Study, 2010 Do herbal plant capsules help with depression and anxiety in PMS? Women who took Elsholtzia splendens capsules had lower depression and anxiety scores than women who took Cirsium japonicum capsules. This suggests Elsholtzia splendens may help reduce these PMS symptoms. Case-control study, 2010 Are personality traits different in women with PMDD? Yes. Women with PMDD showed higher levels of neuroticism-related traits including anxiety, stress susceptibility, embitterment, and mistrust than healthy women. These traits were stronger in women with more severe symptoms and linked to a genetic variation in the serotonin transporter gene. Study, 2010 Do fine motor skills and spatial reasoning change during the menstrual cycle? Yes. Performance is best during the mid-luteal phase when hormones are highest and worst during menstruation when hormones are lowest. Survey study, 2010 Is headache during the period caused by migraine or PMS? Most women (76%) met migraine criteria, but many also had PMS. There was no clear difference in PMS severity between those with different types of headache. Survey study, 2010 Does premenstrual distress predict how women respond to challenges that trigger panic? Women with higher premenstrual distress had significantly greater panic symptoms when breathing CO2-enriched air, but this is preliminary evidence in a small study. Survey study, 2010 What do Brazilian women believe about PMS and what symptoms do they report? Most Brazilian women (96.1%) had heard of PMS, and 60.3% thought they had it. The most commonly reported symptoms were nervousness and anxiety (76.4%) and mood swings (55.7%). Survey study, 2010 How common is premenstrual syndrome in female university students? PMS is very common: 85.5% of students experienced symptoms regularly. We have low confidence since this is one study from one university in Nigeria. Survey study, 2010 How common are premenstrual symptoms in women around age 40? About 38% of women around age 40 had three or more premenstrual symptoms, and about 4.7% reported them as severe. Randomised trial, 2009 Does a hormone called allopregnanolone calm the body's startle reaction in PMDD? No. Giving this hormone by injection made women feel more sedated but did not change their physical startle response, in either women with PMDD or healthy women. Cohort study, 2009 What types of headaches do women with PMS experience? Migraine without aura is most common, occurring in 60 percent of women with PMS headaches, followed by tension-type headache in 30 percent. The type remained consistent for most women over time. Randomised trial, 2009 Does a combination of St. John's Wort and Chaste Tree help PMS-like symptoms in perimenopausal women? The herbal combination significantly improved PMS symptoms, especially depression and food cravings, compared to placebo. The study was very small with only 14 women. Survey study, 2009 Does brain activity change across the menstrual cycle? Yes, brain activity in the prefrontal cortex shifts between different phases, with different sides of the brain being more active at different times. This is based on a small study. Review, 2009 How common are PMS and PMDD, and how much do they disrupt women's lives? PMS causes distress in up to 20% of women and severe work or relationship problems in 3-8%. Women with PMDD experience about 3000 days of severe symptoms over their reproductive years. Survey study, 2009 Are women who have mood problems from birth control pills more likely to have psychiatric disorders? Yes. Women who experienced mood-related side effects from combination birth control pills had higher rates of mood and anxiety disorders compared to women who had no mood problems from the pills. Lab study, 2009 Does a stress-reducing hormone work differently at puberty? Yes. In female mice, pregnanolone (a hormone that normally reduces anxiety) actually increases anxiety at puberty because the brain develops new receptors that respond to it differently. Survey study, 2009 Why do some women feel depressed or anxious when progesterone increases before their period? A literature review suggests progesterone is converted to chemicals that affect the brain's GABA system. At levels before the period, these chemicals paradoxically cause anxiety instead of calming it. Women with PMDD have changes in their GABA system that make them more sensitive. Survey study, 2009 Does menstrual cycle phase affect how well women follow drug treatment? The study found relationships between menstrual cycle phase and treatment compliance through anxiety levels, but the exact connection needs more research. Non-randomised trial, 2009 Does the menstrual cycle affect pain relief from exercise? No, the menstrual cycle phase does not affect how much pain relief women get from exercise. Pain relief and other physical responses were similar in both the follicular and luteal phases. Non-randomised trial, 2008 Does duloxetine help PMDD symptoms? In this small study, 78% of women had at least half their symptoms improve. But there was no comparison group, so we cannot be sure the improvement came from the drug rather than from attention or expectation. Survey study, 2008 Do genes related to mood and stress change during the menstrual cycle? One stress-related gene (FKBP5) showed lower activity in the follicular phase compared to other phases. Anxiety scores also changed during the cycle, but these two changes were not connected to each other. Lab study, 2008 Does progesterone withdrawal affect anxiety in female brains? When progesterone levels drop, specific changes happen in a brain region involved in anxiety. This research is in rats, not humans, so we do not know if the findings apply to women. Case report, 2008 How do doctors diagnose and treat migraines linked to menstruation? Two case examples show that menstrual migraines are often diagnosed and managed together with other conditions like PMDD or depression. Treatment combines migraine prevention medication, management of mood disorders, and acute migraine treatments. Survey study, 2008 Do healthy women without PMDD have mood changes during their menstrual cycle? Yes, but the changes are small. Healthy women without PMDD showed small increases in anxiety, depression, and other negative mood symptoms from late follicular to late luteal phase. Survey study, 2008 How common is PMDD in African women and what factors are linked to it? 6.1% of Nigerian university students had PMDD. It was strongly linked to depression (17 times more likely), anxiety, panic disorder, painful periods, and a personality trait called neuroticism. Study, 2008 What causes severe PMS and how is it treated? Severe PMS is caused by the body's reaction to normal hormone changes during the menstrual cycle. It is treatable with hormonal methods or antidepressants. Survey study, 2008 Do women with PMS have higher blood pressure, and could PMS predict future high blood pressure? Yes. Women with PMS have higher blood pressure in the late premenstrual phase compared to the early phase, and this may put them at risk for developing high blood pressure later. The connection may be related to stress and anxiety. Randomised trial, 2008 Do brain glutamate levels change during the menstrual cycle in women with PMDD? Brain glutamate levels decrease during the luteal phase in both women with PMDD and healthy women. Women with PMDD may experience symptoms because they are more sensitive to these brain changes, though the reason is not yet clear. Survey study, 2008 Are sex hormones different in women with PMS? Women with PMS had more cells that respond to progesterone in their leg vein tissue compared to women without PMS. Cells responding to estrogen were the same in both groups. Survey study, 2007 Does the nervous system work differently during the menstrual cycle in women with PMS or PMDD? Yes. Women with PMS showed decreased automatic body control in the second half of their cycle, and women with PMDD showed decreased body control throughout their cycle compared to women without PMS. Case-control study, 2007 Does serotonin function change differently in PMDD versus PMS versus healthy women? Women with PMDD show unusually high serotonin function in the follicular phase but low function in the luteal phase, different from women with PMS and healthy women. This suggests PMDD involves an unstable serotonin system. Survey study, 2007 Does cycle-related anger connect to depression? In a rat study, females showing more anger during certain parts of their cycle also showed depression-like behavior at the same stage, suggesting these traits may share similar biological roots. Survey study, 2007 Is depression common in people with PMS? About 40% of people with PMS or anxiety had recurrent brief depression, even though most weren't being treated for it. Randomised trial, 2006 Does a five-day gradual reduction of chlormadinone help PMDD symptoms? Yes, significantly reducing anxiety and depression and some other symptoms by the third month of treatment. This is a small pilot study, so larger trials are needed to confirm. Review, 2006 When mood changes seem tied to your cycle, is it actually PMDD? No. Many mood and anxiety symptoms tied to the menstrual cycle are not genuine PMDD. When true PMDD occurs, its impact on quality of life is similar to major depressive disorder. Review, 2006 Could changes in brain receptors explain premenstrual anxiety? Possibly, based on animal studies. When progesterone drops (like before a period), rat brains show changes in GABA receptors in regions that control panic and anxiety, though whether this happens in women's brains is unknown. Lab study, 2006 Can a hormone that usually reduces anxiety instead cause anxiety after your body adapts to its being blocked? Yes. When a hormone precursor was blocked, the hormone THP (which normally calms anxiety) instead increased anxiety in female mice. This effect involved changes to specific brain receptors. Randomised trial, 2005 Does pain during dental treatment change depending on where a woman is in her menstrual cycle? Yes. Women experienced significantly more pain during the peri-menstrual phase (menstruation or pre-menstruation) than during the post-menstrual phase (mid-cycle). Randomised trial, 2005 Does a history of sexual abuse change how women with PMDD respond to the drug clonidine? In this very small study, yes: women with PMDD who had been sexually abused showed different heart rate, blood pressure and stress-hormone responses to clonidine than those without that history, though the sample was too small to be confident. Lab study, 2005 How do changes in brain chemistry during the menstrual cycle affect anxiety and seizures? During the high-progesterone phase of the cycle, specific brain chemicals increase the brain's ability to calm down, which reduces seizure risk and anxiety. Some women with PMDD or epilepsy may not have normal cycling of these chemicals, which could explain their symptoms. Cohort study, 2005 How common is PMS and how severe is it in young college women? More than half of college women (53%) met PMS diagnostic criteria, with 31.7% having severe symptoms. About 18% met criteria for PMDD, the most severe form. This is a high prevalence, though the study used convenience sampling in one country. Survey study, 2005 How common are PMS and PMDD in female students, and what mental health problems go with them? PMS affected 15.3% and PMDD affected 4% of female hostel students. Psychiatric illness was present in 58.62% of these women. Lab study, 2005 When progesterone drops during the menstrual cycle, do brain changes occur that could explain anxiety in PMDD? Yes, according to this rat study. When progesterone was withdrawn, a specific type of brain receptor involved in anxiety control increased dramatically in numbers in key brain regions. Survey study, 2004 Does menstrual cycle aggression in rats relate to breathing changes? Female rats that showed aggression during their menstrual-like cycle had higher variation in their breathing depth, which may help explain why women with premenstrual dysphoria show increased breathing variability. Survey study, 2004 Does the body's stress response change during the menstrual cycle? Yes. The body's stress response changes at different times in the menstrual cycle, with stronger responses during the second half of the cycle. Women show a different overall pattern than men. Review, 2004 Could a brain hormone called allopregnanolone explain mood problems like PMDD in women? This review suggests that changes in allopregnanolone, a hormone-like substance in the brain, may be linked to mood problems including premenstrual dysphoria (PMDD), but this is a theory based on existing animal and human research, not new proof. Lab study, 2004 Does very low-dose alcohol reduce anxiety differently after progesterone is removed? Yes. Very low doses of alcohol (0.2-0.4 mg/kg) reduced anxiety by 60-70% after progesterone withdrawal, but higher doses (0.8-1.2 g/kg) did not work. Non-randomised trial, 2004 Does taking venlafaxine only during the premenstrual phase help PMDD? Nine out of 11 women showed good improvement in their PMDD symptoms, and the medication was well tolerated. This is a very small study, so we should be cautious about how much it proves. Non-randomised trial, 2004 Does premenstrual dysphoric disorder affect how the heart's nervous system regulates itself? Women with PMDD showed reduced activity in the vagus nerve, which helps regulate the heart. The difference from women without PMDD was most clear during the non-symptom phase of the cycle. Non-randomised trial, 2004 Does serotonin activity change across the menstrual cycle? Yes. Serotonin transporter binding was highest in the late follicular phase (right before ovulation), while serotonin receptor binding was highest in the early follicular and early luteal phases. These changes correlated with estradiol and progesterone levels. Interview study, 2004 What causes premenstrual syndrome and PMDD, and how should they be treated? Dysregulation of serotonin and GABA neurotransmitter systems combined with hormone changes causes these conditions. SSRIs, GnRH agonists, Yasmin birth control, cognitive-behavior therapy, lifestyle changes, and placebo all help. Survey study, 2004 How does serotonin function change during the menstrual cycle in women with PMS? Serotonin function varies throughout the menstrual cycle linked to hormone levels. This variation may contribute to PMS, but we don't yet know why only some women develop the condition. Non-randomised trial, 2004 Are depression and anxiety linked to estrogen and progesterone levels in women with PMDD? No. This study found no significant correlations between depression or anxiety ratings and either hormone. Survey study, 2004 What other mental health conditions often happen alongside PMDD? PMDD commonly occurs together with mood and anxiety disorders. This review does not report specific rates of how often this happens. Survey study, 2004 How common is PMS and premenstrual worsening of psychiatric symptoms in women with mental health disorders? Very common. Between 52% and 80% of women with anxiety, depression, or panic disorder reported PMS symptoms, and between 36% and 52% experienced worsening of their psychiatric symptoms before their period. Cohort study, 2004 Do anxiety levels and coping styles affect premenstrual distress? Yes. Women with high anxiety sensitivity used less helpful coping strategies and reported more premenstrual distress, especially when using avoidance coping. Randomised trial, 2003 Does Qi therapy reduce PMS symptoms? Yes. Women who received Qi therapy had significant reductions in pain, depression, and anxiety compared to controls, though this was a small pilot study. Survey study, 2003 Is cycle-related aggression linked to changes in breathing during the menstrual cycle? In rats prone to cycle-related aggression, breathing rate was higher during one phase of the cycle, whereas non-aggressive rats showed no breathing changes. This may help explain similar patterns in humans with PMDD. Non-randomised trial, 2003 Does venlafaxine help women with PMDD? Yes. This small study found venlafaxine significantly improved PMDD symptoms in Asian women. Survey study, 2003 Do hormone levels change during the menstrual cycle in women with depression? Yes. Women with depression had higher levels of a chemical called homocysteine in the early cycle compared to the late cycle, and overall higher levels than healthy women. Survey study, 2003 Is PMDD a form of depression, a form of anxiety, or something completely different? PMDD is a distinct condition, separate from both depression and anxiety. It is characterized more by irritability and mood swings than by depressed mood or anxiety. Survey study, 2003 Is how much control women feel over their life linked to premenstrual symptoms? Yes. Women who felt they had less control over their circumstances were more likely to have premenstrual symptoms, anxiety, and depression. Women felt especially out of control during the premenstrual phase compared to other times in their cycle. Study, 2003 What happens in the brain when progesterone drops that causes premenstrual anxiety? A laboratory study in animals found that specific brain receptors increase when progesterone drops, which may explain why anxiety increases before the period. This is animal research; much more study is needed to see if this applies to humans. Review, 2002 Do antidepressants help with PMDD symptoms? Some antidepressants appear to help relieve PMDD symptoms in controlled studies. The evidence comes from reviews of existing research rather than new data. Study, 2002 What did older research teach us about the causes of premenstrual tension? Research from before 1972 suggested several possible causes for premenstrual tension, including personality factors, stress, culture, hormones, and chemicals in the brain. Survey study, 2002 Does menstrual cycle phase affect asthma or anxiety symptoms? No. This study found no significant connection between menstrual cycle phase and these symptoms. The sample size was not reported in the abstract. Study, 2002 What causes PMS and how is it treated? The exact cause of PMS is not known, but it is linked to changes in brain chemicals like serotonin and to how the body handles sex hormones. Because the cause is unclear, treatment is tailored to each person's main symptoms rather than following one fixed approach. Review, 2002 Does noticing bodily changes cause PMS symptoms? Women who pay close attention to bodily sensations experienced mood changes with their cycle, while women who do not notice bodily cues showed no cycle effects. Reminding cycle-aware women of their cycle stage prevented symptoms. Survey study, 2002 Does the menstrual cycle change gut sensitivity in women with IBS? Yes. Women with IBS have more sensitive bowels during their period compared to other times, which may explain why their IBS gets worse. Women without IBS do not show this change. Randomised trial, 2001 Do women with PMDD have a different panic response than other women? No. Two stress hormones (vasopressin and oxytocin) increased similarly during a panic test in women with PMDD and in women without PMDD, regardless of where they were in their menstrual cycle. Cohort study, 2001 Do psychiatric symptoms get worse before the period in women with schizophrenia? Yes, overall psychiatric symptoms were worse in the premenstrual phase. However, the psychotic symptoms like hallucinations barely changed, while mood and behavioral symptoms worsened significantly. Review, 2001 Can citalopram, an antidepressant, help premenstrual dysphoria? Yes, citalopram is an antidepressant shown in controlled trials to help premenstrual dysphoria, depression, anxiety, and other conditions. This review focuses on the drug's general benefits, not specifically on PMS. Survey study, 2001 How do steroid hormones affect the brain and cause symptoms? Steroid hormones can rapidly change brain activity and behavior within seconds to minutes. This review discusses these fast effects in relation to premenstrual syndrome and other conditions. Case-control study, 2001 Does breathing carbon dioxide trigger panic attacks in people with PMDD like it does in panic disorder? Yes, people with PMDD had panic attacks during CO2 breathing at similar rates to people with panic disorder. However, this was a very small study with only 10 PMDD participants, so results need confirmation in larger studies. Survey study, 2001 How common is premenstrual dysphoric disorder and how is it related to other psychiatric conditions? About 75-85% of women report some premenstrual symptoms, but only 10-15% seek care and 2-5% experience serious disruption to work or social life. PMS may worsen other psychiatric conditions. Non-randomised trial, 2001 Do people with PMDD have different breathing patterns? Yes. PMDD patients showed greater variation in their breathing patterns than women without PMDD. Survey study, 2001 Does short-term progesterone exposure change anxiety and brain chemistry in female rats? Yes. Even 2-3 days of progesterone exposure changed brain cell receptors in a way linked to increased anxiety, and rats showed more anxiety-like behavior. Survey study, 2000 Why do women get more anxious when hormone levels drop? Falling estrogen and progesterone levels may trigger anxiety and mood disorders by affecting how brain receptors that control anxiety and mood work. The exact mechanism is not yet fully understood. Review, 2000 Can SSRI antidepressants treat premenstrual syndrome? Yes, SSRIs are particularly effective for treating premenstrual syndrome symptoms. Survey study, 2000 Does premenstrual worsening of panic disorder increase suicide risk in women? Yes. Women with panic disorder who experienced premenstrual worsening had higher suicide risk scores and were more likely to be considered suicidal than women whose panic did not worsen premenstrually. This was independent of depression. Randomised trial, 2000 Does massage therapy help premenstrual dysphoric disorder symptoms? Massage therapy reduced anxiety, depressed mood, and pain right after sessions. Over 5 weeks, it reduced pain and water retention but did not improve mood or activity level long-term. Survey study, 2000 Are women with PMDD more likely to have had mental health problems? This review questions the common belief that women with PMDD have higher rates of past psychiatric disorders. It suggests this assumption may be premature, but does not provide new research to confirm either way. Study, 1999 What causes PMS and how should different symptoms be treated? PMS involves hormone problems and disruptions in brain chemical systems (GABA, serotonin, endorphins). Different symptoms may respond to different treatments: mood symptoms to medication, physical symptoms to progesterone or diuretics. Non-randomised trial, 1999 Do women seeking PMS treatment actually have underlying mood or anxiety disorders? About 39% of women seeking PMS treatment meet criteria for mood or anxiety disorders. Mood disorders were about twice as common as anxiety disorders. Review, 1999 Do SSRI antidepressants work for PMDD? Yes, SSRIs are the treatment of choice for PMDD because they are effective, have acceptable side effects, and are well tolerated. Randomised trial, 1999 Are women with PMDD more sensitive to anxiety and panic from CCK-4 injection? Yes, women with PMDD showed a greater anxiety and panic response to CCK-4 than normal women, suggesting the CCK system may be involved in PMDD. The results are preliminary and specific outcome numbers were not reported. Randomised trial, 1999 Which symptom rating scales best measure PMDD? Three simple rating scales reliably measure PMDD symptoms and track treatment effects. They work well together, with strong agreement between them (correlations 0.70 to 0.82). Interview study, 1999 How do healthy women perceive and understand their premenstrual symptoms? Women view premenstrual symptoms as normal, everyday experiences rather than a medical problem. They explain these experiences through a mix of biological, psychological, and social factors and manage them with regular strategies. Non-randomised trial, 1998 Is there a brain chemistry abnormality in PMDD? The study found some differences in brain chemistry related to mood in PMDD, with early-cycle levels predicting worse symptoms later in the cycle. The sample was very small and the clinical meaning is unclear. Case-control study, 1998 Do stress receptors on immune cells function differently in women with PMDD? Women with PMDD have higher beta2-adrenergic receptor density compared to healthy women. Measurements in the follicular phase predict how severe luteal phase symptoms will be. Case report, 1998 Does how women manage anger affect how bad their PMS gets? No, not significantly. Women who coped with anger differently had similar PMS severity. But stress from work and family life was linked to worse PMS. Survey study, 1998 Does exercise help PMS? Exercise was not linked to having less PMS. However, women with PMS who exercised regularly had significantly less anxiety than sedentary women with PMS. Lab study, 1998 How does progesterone dropping affect the brain's anxiety-control system? When progesterone suddenly drops, the brain's anxiety-calming system becomes much less effective. This might explain anxiety symptoms that some women experience before their period. Case report, 1998 What treatments help when PMS becomes very severe? Several treatments can help severe PMS, including antidepressants, anxiety medications, and hormones that stop ovulation. The right choice depends on each woman's specific symptoms. Lab study, 1998 Do women prone to anxiety have different brain chemistry changes during the menstrual cycle? This rat study suggests anxious individuals have different patterns of mood-related brain chemicals throughout their cycle compared to calm individuals. This is an animal model and cannot prove the same happens in women. Review, 1998 What are neurosteroids and how do they work in the brain? Neurosteroids are hormones made in the brain that affect brain function through a special mechanism and are important in both normal and abnormal brain conditions. Survey study, 1998 Is anxiety related to premenstrual tension symptoms? Yes. Schoolgirls with high anxiety had more premenstrual tension symptoms. Non-randomised trial, 1997 Does paroxetine help severe PMS? Yes, paroxetine reduced mood and anxiety symptoms significantly. However, about 50 percent of women experienced sexual side effects that persisted, and the lack of a control group limits certainty. Survey study, 1997 Does exercise reduce mood problems during the menstrual cycle? Exercise did not reduce negative moods like tension and depression before menstruation. However, exercise improved mood (vigor) during the mid-cycle phase and produced better overall mood stability. Survey study, 1997 How are anxiety symptoms and anxiety disorders linked to PMDD? PMDD appears linked to anxiety disorders. Women with PMDD often have anxiety histories, and treatments that work for anxiety also help PMDD, though this is a review of existing research rather than new original findings. Survey study, 1997 How is premenstrual dysphoric disorder treated? Multiple treatments help PMDD, including antidepressants (particularly SSRIs), psychotherapy, sleep deprivation, and light therapy. SSRIs showed the best results among medications. Review, 1997 What causes PMDD and how can it be treated? The review suggests PMDD is caused by problems with how the brain's serotonin system works. Medications called serotonin reuptake inhibitors appear effective for treatment. Cohort study, 1997 Are PMS symptoms the same from cycle to cycle? Yes. Mood symptoms like anxiety and irritability are the most stable. These mood symptoms, not physical symptoms, cause most of the impact on daily life. Case-control study, 1997 Is a specific progesterone hormone lower in women with PMS? Yes. Women with PMS had lower levels of allopregnanolone (a calming hormone made from progesterone) in the luteal phase compared to women without PMS. Review, 1996 Do PMS, postpartum depression, and menopause share a common cause related to the brain? The hypothesis suggests that when brain estrogen levels fall below a critical threshold, mood and neurological symptoms develop. This could explain why PMS, postpartum depression, and menopause involve similar symptoms, though the mechanism remains unproven. Review, 1996 What does typical PMS research look like and what do studies generally find? Most PMS studies include 20 to 80 people and track the same women over time. They consistently find that negative mood and body symptoms get worse before or during the period, especially in women who say they have PMS. Cohort study, 1996 Does lisuride maleate, a dopamine medication, reduce PMS symptoms? Symptoms improved significantly, with headaches dropping from 85.7% to 20% and other symptoms also improving. However, this was a small study with no control group, so we cannot be sure how much improvement came from the drug versus placebo. Survey study, 1995 What's different about women who seek treatment for premenstrual mood changes? Women seeking treatment reported significantly more depression, anxiety, and unwanted negative thoughts than those not seeking treatment. Both groups had similar physical symptoms. The commonly used 30% improvement rule did not distinguish the two groups well. Survey study, 1995 Do women with premenstrual symptoms have ongoing psychological problems? In the time between periods, women with premenstrual symptoms were psychologically similar to women without symptoms. When recalling periods that included the premenstrual phase, they reported worse mood than they actually experienced. Randomised trial, 1995 Does menstrual cycle phase affect anxiety response to CO2 in women with panic disorder? Yes. Women with panic disorder showed significantly stronger anxiety during the early follicular phase than the luteal phase after breathing a CO2 mixture. Controls showed no anxiety response. Survey study, 1995 Do women crave salty and fatty foods more during certain phases of their menstrual cycle? No. Women's preferences for salty and fatty foods did not change across their menstrual cycle. What mattered instead was whether women restricted their eating and how much they exercised. Survey study, 1995 Does the uterus cause premenstrual symptoms? Women who had their uterus removed showed large improvements in premenstrual symptoms. This suggests the uterus may play a role, though the study cannot prove this. Case-control study, 1994 Is the stress hormone system different in women with severe PMS? Yes. Women with severe PMS have altered control of their stress hormone system, with cortisol responding differently to hormonal stimuli, suggesting reduced opioid receptor sensitivity. Non-randomised trial, 1994 Are progesterone and its related hormones different in women with PMS? No. Hormone levels were the same in women with PMS and healthy women. Symptom severity did not depend on these hormone levels. Study, 1994 Do women with both PMS and anxiety who have family alcoholism drink more before their period? Yes. 74% of women with family history of alcoholism on their father's side reported drinking more before their period, compared to only 22% without this family history. Study, 1994 Do women with irregular periods have different premenstrual mood changes than women with regular periods? No. Both women with irregular and regular periods showed similar increases in anxiety, depression, physical symptoms, and feelings of inadequacy before their period, suggesting the mood changes are not caused by negative expectations. Case-control study, 1994 Do women with PMS have different mineral levels in their blood? Yes. Women with PMS had significantly lower magnesium levels (0.70 versus 0.87 mmol/l) and a lower zinc-to-copper ratio (1.40 versus 1.51) than women without PMS. Non-randomised trial, 1994 Does bright light therapy reduce depression and anxiety before the period? Evening bright light significantly reduced depression symptoms. It tended to reduce anxiety and sluggishness, but these improvements were not statistically significant. More research is needed. Cohort study, 1994 Who finds cervical laser surgery painful? Young women who have never given birth, are anxious, or have a history of painful periods experience more pain during cervical surgery. Premenstrual syndrome scores did not predict surgical pain. Survey study, 1993 Can an anxiety questionnaire help identify PMS in high school girls? The study tested whether an anxiety questionnaire could distinguish girls with and without PMS, but the abstract does not report the actual results. Survey study, 1993 How common is seizure worsening with the menstrual cycle in women with epilepsy? Only 12.5% of women met the strict definition of seizures worsening with menstruation. However, 78% of women reported afterward that their seizures got worse during their period, showing that women's memories may not match their actual tracking. Survey study, 1993 How common is premenstrual tension among nurses in Kenya? Very common. 95.5 percent of 400 nurses studied reported premenstrual tension, with breast tenderness and bloating being the most frequent symptoms. Lab study, 1993 What does stopping progesterone do to anxiety in rats? In rats, withdrawal from progesterone increased anxiety-like behaviors including faster and longer defensive responses. This effect appeared to be caused by a progesterone breakdown product rather than progesterone itself. Non-randomised trial, 1993 Do women with PMDD react more strongly to lactate challenge? Yes. 58% of women with PMDD had panic responses to sodium lactate injection, compared to 0% of control women. Case-control study, 1993 Do women with both anxiety disorder and PMS have worse anxiety, and does the menstrual cycle affect it? Women with both anxiety disorder and PMS had worse symptoms in both menstrual phases, with clear worsening premenstrually. Even when assessed once, their ratings were influenced by how bad they felt premenstrually. Study, 1993 Why do some women with PMS have problems controlling their body temperature? Changes in certain brain chemical systems connected to hormones may cause temperature control problems. Different women showed different patterns of temperature disturbance. Study, 1992 What physical and emotional symptoms happen at different times of the menstrual cycle, and why? A study of 79 women found that physical and emotional symptoms happen throughout the entire menstrual cycle. These symptoms are connected to how the brain works. Study, 1992 Can a chemical called lactate trigger panic attacks in women with PMS? Yes. In this study, infusing lactate triggered panic attacks much more often in women with PMS than in women without PMS, suggesting people with PMS may be more sensitive to this trigger, though this extra sensitivity was not mainly explained by also having panic disorder. Survey study, 1992 Do women with more premenstrual symptoms have unhelpful thinking patterns? Women reporting more premenstrual symptoms had higher scores on the 'need for comfort' thinking pattern, indicating they struggled more with stress. We don't know if unhelpful thinking causes symptoms or symptoms cause unhelpful thinking. Case report, 1992 Can premenstrual tension affect a court sentence? In this court case, a woman's sentence for traffic offences was reduced because she had premenstrual tension at the time. The court agreed the original 6-month disqualification from driving was not necessary or appropriate. Case report, 1992 Is severe overeating linked to the premenstrual period in women with PMS? Yes. This woman experienced uncontrollable binge eating only during her premenstrual period, especially in the 3 to 5 days before her period. Survey study, 1992 Why do women with severe PMS have worse symptoms? Women with severe PMS have more active nervous systems and lower brain activity during the premenstrual phase. This may explain why their symptoms are worse, though it's unclear which causes which. Cohort study, 1992 Does premenstrual tension change as women age? In 9 women followed for 8 years, premenstrual symptoms showed little change in how common they were or how severe they were. Review, 1992 What role does molimina play in PMS? This is a review of PMS research. The author defines molimina (hormonal involuntary contractions) and its manifestations in PMS but doesn't provide specific research findings about its role. Randomised trial, 1992 Does fluoxetine (Prozac) help severe PMS? Yes. Fluoxetine significantly improved behavioral symptoms by 75%, physical symptoms by 40%, and total symptoms by 62% compared to placebo, with no significant side effects. Lab study, 1991 Does the central nervous system work differently in women with PMS? Yes. Women with PMS showed clear differences in brain wave patterns compared to healthy women, with abnormal patterns in the brain stem (46%), hypothalamus (37%), or both (17%). Survey study, 1991 How common are menstrual symptoms in working women? The most common symptoms were weight gain and swelling (over 60% of women), followed by anxiety, tension, irritability, fatigue, cramps, breast pain, mood swings, and food cravings. Symptoms were more common in younger women. Review, 1991 Can serotonin drugs treat PMS? The abstract mentions that tryptophan, a serotonin precursor, has been used to self-treat PMS, but doesn't provide evidence that serotonin drugs work for PMS specifically. Survey study, 1991 What mental health and social problems do women with PMS have? Most women seeking PMS treatment (67 percent) had a psychiatric disorder, with depression and anxiety being most common. Sexual dysfunction and social problems were also frequent. Cohort study, 1990 Does anxiety get worse before the period in women with panic disorder? Women with panic disorder reported afterward that their anxiety was worse before their period, but their daily diary records did not consistently show this pattern. The answer depends on how you ask the question. Case-control study, 1990 Are brain chemistry changes linked to missing periods in women with eating disorders? The study found that women with bulimia who stop bingeing have changes in a brain chemical called noradrenaline, and those who stopped menstruating showed the lowest levels. However, this is a very small study that does not prove whether the chemistry change causes period loss. Survey study, 1990 Do women's skin responses change during their menstrual cycle? Yes. Women's skin responded more strongly to sounds during ovulation compared to the luteal and premenstrual phases, but their emotional experience didn't change. Survey study, 1990 Do women who had pre-eclampsia in pregnancy experience more premenstrual symptoms? Mostly no. Women who had severe pre-eclampsia actually had fewer premenstrual symptoms than average. Only women with current high blood pressure reported more premenstrual sadness. Survey study, 1990 Can premenstrual anxiety and depression be confirmed with objective tests? Yes, women with reported premenstrual anxiety and depression had higher objective test scores in the premenstrual phase. Results suggest two populations: one with pure PMS and another with underlying depression that worsens premenstrually. Survey study, 1990 Is anxiety related to premenstrual syndrome? Yes. Women with higher levels of anxiety trait are significantly more likely to have premenstrual syndrome, especially psychological symptoms like mood changes. Study, 1989 Does heart rhythm change through the menstrual cycle? In women without premenstrual syndrome, there's no clear difference in heart rhythm variation across different phases of the menstrual cycle. But in women with PMS, heart rhythm variation is lower during the middle and end of the cycle, which might reflect different nerve function. Cohort study, 1989 What psychological factors are connected to confirmed premenstrual dysphoria? Women who tracked their mood every day and reported PMS symptoms had significantly higher anxiety, depression, and negative self-talk than others. But women who only remembered having PMS after the fact did NOT differ from controls, showing memory is unreliable. Lab study, 1989 Do women with severe premenstrual symptoms respond to stress differently? During mental tasks, women with mild or no severe symptoms showed smaller heart rate responses in the premenstrual phase than the postmenstrual phase, but women with severe symptoms did not. Survey study, 1989 Do anxiety and brain activity change with the menstrual cycle in healthy women? Brain wave frequencies decreased before menstruation, but anxiety and reaction time did not change significantly across the cycle in most women. Only women with high baseline anxiety showed premenstrual anxiety increases. Survey study, 1989 What nutrients help with anxiety and mood changes before your period? Yes, certain nutrients are linked to relief from premenstrual anxiety and mood changes. However, the review doesn't identify which specific nutrients are most beneficial. Randomised trial, 1988 Do hormones respond differently in women with PMDD? Two hormones (AVP and OT) increased similarly after an injection in women with and without PMDD, with no difference between groups or across menstrual cycle phases. This is a very small preliminary study. Cohort study, 1988 Do anxiety and depression relate to menstrual symptoms in healthy women? Yes, there was an association between anxiety and depression scores and menstrual symptoms. Nearly half of the women reported menstrual symptoms. However, this does not prove whether mood causes symptoms, symptoms cause mood, or both stem from another cause. Randomised trial, 1988 Does atenolol, a blood pressure medication, help PMDD symptoms? Atenolol improved some symptoms including irritability and mood, but not all symptoms. Women who had PMDD for more than 5 years showed more improvement. The study was very small with only 16 women. Case-control study, 1988 Can women with PMS read facial expressions during their menstrual cycle? Women with PMS had significantly impaired ability to interpret facial expressions during the premenstrual phase compared to healthy women. Study, 1988 Do panic attacks get worse before menstruation? The answer is unclear. When women looked back on their whole month, they said symptoms were worst in the week before menstruation. But when they rated symptoms every day or week, the changes were much smaller than expected. Review, 1988 Does caffeine make PMS worse? Yes. Caffeine may aggravate premenstrual syndrome symptoms, especially in people who are caffeine-sensitive or who consume heavy amounts chronically. Survey study, 1988 When do different PMS symptoms happen during the menstrual cycle? Physical symptoms peaked every 28 days in most women. About half showed this pattern for depression, behaviour, tension and concentration symptoms. Physical and tension symptoms tended to come 1-2 days before depression peaked. Randomised trial, 1987 Does danazol help premenstrual tension symptoms? Danazol may help some symptoms better than placebo, particularly breast pain, lethargy, anxiety and increased appetite by the third month. However, 13 of 40 women dropped out during the study, mostly because they felt the treatment was not helping. Survey study, 1987 What psychiatric conditions are associated with premenstrual tension syndrome? Depression is the main psychiatric condition. Other conditions like anxiety, psychosis, alcoholism, and bulimia may also occur. Treating the psychiatric illness does not necessarily treat the premenstrual symptoms. Case-control study, 1987 Do women with premenstrual tension have lower beta-endorphin? Yes. Women with symptoms had lower blood beta-endorphin during the early luteal phase (10.7 vs 14.6 pg/ml). This suggests a hormonal difference but doesn't prove it causes symptoms. Study, 1987 Does the menstrual cycle change how the brain processes sound? No. The brain's processing of sound did not change between the day before menstruation and 9 days after cycle start, despite significant mood changes. Cohort study, 1987 Does PMS cause behavior problems in women with mental disabilities? In this study, 27.5% of women with mental disabilities showed behavior worsening linked to their menstrual cycle, along with physical symptoms and hormone changes. This was a very small, old study, so we can't be sure how general this finding is. Study, 1987 What groups of symptoms come together in severe PMS? Women with severe PMS tend to have symptoms that form distinct patterns: two types of emotional and behavioral symptoms and two types of physical symptoms that go together. Review, 1987 Does a dietary program with supplements help premenstrual tension symptoms? Yes, according to both open trials and double-blind studies. A daily supplement of six tablets significantly reduced symptoms compared to placebo over three to six months. Study, 1987 How do job stress and teamwork affect cycle length, regularity, and cycle synchrony? Women in jobs where teamwork was high or moderate had synchronized cycles. Women with high job stress and anxiety had longer, less regular cycles. Women in high-stress, low-teamwork jobs did not sync with coworkers. Survey study, 1987 Do women with severe PMS have different personality and brain chemistry than healthy women? Yes, women with severe PMS have significantly lower levels of an enzyme in their blood (platelet MAO) and higher levels of anxiety, aggression, and emotional instability than healthy women. This enzyme does not change across the menstrual cycle. Cohort study, 1986 Is PMS mainly about symptoms worsening before your period, or is there more? Women with PMS have higher depression, anxiety, and tension even in the early part of their cycle. Some symptoms do worsen premenstrually, but baseline mood appears to be the bigger issue. Study, 1986 Do women with agoraphobia experience worse anxiety before their period? Yes, just over half of the women with agoraphobia in this study experienced worse anxiety before their period. Survey study, 1986 Do severely depressed women experience different PMS symptoms than women without depression? No, not in symptom type. Depressed women reported the same symptoms as non-depressed women with PMS but rated them as more severe, suggesting depression influences how severe symptoms feel rather than changing what they are. Case report, 1986 How should doctors identify premenstrual tension syndrome? Doctors should look for the timing pattern: symptoms that appear before the period and disappear when it starts. PMS can exist alone or alongside other mental health conditions. Non-randomised trial, 1986 Does what a woman is told about PMS change how severe her symptoms feel? Women told PMS comes from societal myths reported less negative mood and fewer symptoms compared to other groups. All women actually showed better task persistence and more positive interactions with their children during the premenstrual phase compared to mid-cycle. Survey study, 1986 Do women with rapid-cycling bipolar disorder have worse PMS symptoms? Yes. Women with rapid-cycling bipolar disorder had more severe forms of PMS. Those with both conditions also tended to cycle more frequently. Survey study, 1986 Does the nervous system work differently before your period and does this affect your mood? Yes. Before your period, women had lower brain alertness and higher nervous system activity, which were linked to more negative moods. Study, 1985 Does adding progestagen to estrogen cause PMS-like symptoms? Yes. Women who took estrogen plus progestagen developed cyclical mood and physical symptoms similar to PMS, while women on estrogen alone did not. Symptoms appeared 1 to 3 days after progestagen was added. Case-control study, 1985 Are hormone levels and ovulation timing different in women with premenstrual tension? Yes. Women with premenstrual tension tend to ovulate earlier in their cycle and have higher stress hormone (cortisol) levels than women without symptoms. Survey study, 1985 Do women with PMS eat more food before their period? Yes. Women with more severe PMS symptoms ate significantly more calories in the 10 days before their period. Survey study, 1985 Do personality and anxiety traits change across the menstrual cycle? Women reporting premenstrual symptoms had higher scores on personality and anxiety measures throughout their entire cycle, not just before their period. During the luteal phase (before the period), their anxiety scores were even higher than in the follicular phase. Non-randomised trial, 1985 Does progesterone reduce premenstrual symptoms? Progesterone treatment improved symptoms, but placebo improved them equally, so we cannot say progesterone works better than placebo. Case-control study, 1985 Do women with PMS show different hormone patterns and ovulation timing after the corpus luteum is removed? Yes. Women with PMS took longer to ovulate after corpus luteum removal (21 days versus 19 days in controls) and had lower FSH levels, suggesting their hormonal feedback system is more sensitive. Non-randomised trial, 1984 Does lithium help with premenstrual tension? Case reports suggested it might help, but well-designed research studies found no benefit. Study, 1984 Does a sudden drop in beta-endorphin cause PMS? Beta-endorphin levels did drop during the menstrual cycle, but the relationship between how much they dropped and symptom severity was opposite to what you would expect if withdrawal caused PMS. Case-control study, 1984 Do women with severe PMS have different hormone patterns than women without PMS? No. There was no relationship between the hormone patterns tested and PMS symptoms. Hormone levels followed similar patterns in both groups. Survey study, 1984 Do moods change during different phases of the menstrual cycle? In this study, most university women aged 18-30 did not experience clear changes in mood or psychological distress during different cycle phases. Even women who attended a psychiatric clinic showed no clear changes. Survey study, 1984 How do pain sensitivity and anxiety change through the menstrual cycle? Anxiety and a brain chemical were only linked during the menstrual phase. Pain sensitivity did not clearly change through the cycle. Non-randomised trial, 1984 Does elevated prolactin cause premenstrual tension? No. Prolactin levels were normal in women with severe PMS. When a drug that lowers prolactin was given, hormone levels changed but symptoms did not improve. Survey study, 1984 Does serotonin uptake change during the menstrual cycle in women with premenstrual tension? Yes, serotonin uptake capacity and serotonin levels were significantly lower during the premenstrual phase. Only 16 women were studied, so results need confirmation in larger groups. Survey study, 1983 Do the treatments doctors use for premenstrual tension actually work? Doctors have tried many treatments for PMS including hormones, vitamins, and psychotherapy, but the results are mixed and conflicting. Without understanding the cause of PMS, there is no single universally accepted effective treatment. Survey study, 1983 Does the nutritional supplement Optivite reduce premenstrual tension symptoms? In this small study of 31 women, Optivite reduced PMS symptoms significantly. However, without a control group, we cannot be sure the improvement was from the supplement rather than placebo effect or natural changes. Study, 1983 Does muscle tension increase during the premenstrual phase of the cycle? Yes. Women had higher muscle tension in their forehead during the premenstrual phase. Women with more forehead tension predicted they would have more premenstrual symptoms. Study, 1983 Does nutrition affect premenstrual symptoms? Yes. Different types of premenstrual symptoms may respond to different nutritional approaches: vitamin B6 (200-800 mg per day) for anxiety and water retention, magnesium for appetite and cravings, and limiting salt (to 3 grams per day), caffeine, and nicotine. Survey study, 1983 How do women with premenstrual tension differ psychologically? Women with premenstrual tension have lower self-esteem, more negative attitudes to menstruation, and feel less control over their lives than women without it. Study, 1983 Do women with premenstrual syndrome have different psychological patterns than other women? A small study found that women with diagnosed premenstrual syndrome had anxiety and depression appearing only in the second half of their menstrual cycle, while women without PMS did not. This suggests true PMS may differ from other menstrual symptoms. Survey study, 1983 What conditions are commonly found together with PMS? Endometriosis was most common (found in 66 women), followed by dysmenorrhea (31). Women also showed hormone changes, with lower progesterone and higher estrogen in the second half of the cycle. Non-randomised trial, 1983 Do drugs that block prostaglandins help PMS? This paper proposes that prostaglandin-blocking drugs might help PMS based on a theory, but it does not present results from a clinical trial. Non-randomised trial, 1982 Does alcohol affect anxiety differently in women versus men, and does menstrual cycle phase matter? Yes. For women at the premenstruum, expecting alcohol increased reported anxiety, but actual alcohol appeared to reduce tension. Men showed increased physical stress responses but no reduction in negative emotions. The study suggests menstrual cycle phase may influence how women respond to alcohol. Survey study, 1982 Do women without mental health problems experience mood and anxiety changes during their cycle? Women without current or past mental health issues experienced only minor cycle-related mood changes. Water retention was the only symptom that reached statistical significance. Survey study, 1982 Does mood change during the menstrual cycle? Group data showed some mood changes across the cycle, with fatigue and depression lower before menstruation and anger lower during menstruation. But individual tracking showed few changes, and women's memories of their moods did not match their daily recordings. Non-randomised trial, 1982 Does your menstrual cycle affect how your brain works and how well you do on mental tasks? Yes, brain activity and task performance change across the cycle, with performance best around ovulation and worst in the late luteal phase. Oral contraceptives eliminate these changes. This is a very small study with no control group. Survey study, 1982 Do different parts of the nervous system change at different times in the menstrual cycle? Yes. Brain activity was higher during the middle of the cycle, while the automatic nervous system was more active before your period. The two systems appear to change independently. Survey study, 1982 What percentage of women have premenstrual tension symptoms? Half the women in the study had at least one type of premenstrual tension symptom. Anxiety and mood changes, and swelling and bloating, were the most common types. Survey study, 1982 Are premenstrual and menstrual symptoms separate problems or part of one larger problem? They appear to be part of one larger problem. Although some symptoms are worse before your period and others during it, the symptoms largely overlap. Study, 1981 Does alcohol affect anxiety differently depending on where you are in your menstrual cycle? Yes. Anxiety increased more with alcohol during the luteal phase (before your period) than during the follicular phase (first half of cycle). However, this was a very small study, so results may not apply widely. Study, 1981 Do premenstrual tension symptoms go away after hysterectomy? No, cyclical mood and physical changes linked to the menstrual cycle continue after hysterectomy in women who had premenstrual tension syndrome, which suggests the cause is hormonal rather than related to the uterus itself. Survey study, 1981 Do teenage girls experience mood changes around their period? No. Teenage girls tested just before or during their period did not show different anxiety or depression levels compared to times tested at other parts of their cycle. A control group of teenage boys also showed no mood changes across time. Survey study, 1981 Is premenstrual syndrome linked to personality traits? Among 110 pregnant women, those with more severe PMS had more extreme personality traits, suggesting psychological factors may be involved. However, the study cannot prove personality causes PMS. Case report, 1981 How do hormonal birth control and progesterone affect mood? Hormonal birth control affects mood differently in different women. In some, it causes depression and loss of sexual desire. In others, it has mood-stabilizing effects and can reduce PMS. How progesterone and hormonal birth control affect mood varies from person to person. Study, 1981 Is low magnesium linked to premenstrual tension? Yes. Women with premenstrual tension had lower magnesium levels in their red blood cells compared to women without premenstrual tension. Study, 1980 Does personality type affect whether women develop premenstrual tension? Standard personality tests did not show that personality type predicts premenstrual tension, but women did report higher anxiety and more symptoms during the menstrual phase. Review, 1980 Why do women's moods change during their menstrual cycle? Mood changes during the cycle are linked to changing levels of estrogen and progesterone, which affect brain chemistry. Both hormones and psychology likely play a role. Survey study, 1980 What are the best tools to measure premenstrual tension syndrome? Researchers developed two new diagnostic rating scales that could help standardize how doctors and researchers diagnose and measure PMS severity. Interview study, 1980 What are the main symptoms of severe premenstrual tension and how do they differ from depression or anxiety? In 42 women with severe PMS, the main symptoms were irritability, mood swings, tension, and restlessness that appear and disappear with the cycle. These don't match patterns of depression or anxiety alone. Study, 1980 Do women with PMS have different personality traits than women without it? Yes. Women with PMS show higher levels of anxiety and neuroticism, and more negative feelings about their bodies and sexuality than women without PMS. Study, 1980 Does lithium carbonate help women with severe premenstrual tension? Lithium did not reduce physical symptoms and did not work for most women's behavioral symptoms. Measurement tools showed improvement, but this benefit had no real practical value, and side effects were common. Cohort study, 1979 Do women's moods change with the menstrual cycle? Many women report cyclical mood changes across their menstrual cycle with irritability and depression in the premenstrual and menstrual phases and better moods mid-cycle, but scientists do not know whether hormones, psychology, or social factors cause these changes. Study, 1979 How do brain waves change after giving birth compared to pregnancy? Brain wave patterns become stronger and show more activity after delivery compared to late pregnancy at week 32. Anxiety and irritability improve after delivery, and these changes do not appear in women who are not pregnant or postpartum. Randomised trial, 1979 Are hormone levels abnormal in women with premenstrual tension, and can bromocriptine help? Women with premenstrual tension showed different prolactin patterns across the cycle. Bromocriptine lowered prolactin but did not change other hormone levels. Study, 1979 What are normal menstrual patterns? Normal cycles last 21-35 days with 1-7 days of bleeding. About 43% of women experience menstrual pain and 75% experience premenstrual tension. Survey study, 1979 What social and psychological factors are linked to premenstrual tension and menstrual pain? Many factors are linked including age, country of birth, marital status, work attitudes, smoking, drinking, childbearing, sex life, and psychological factors. The study cannot determine if these factors cause PMS. Cohort study, 1978 Do women experience more symptoms at certain times in their menstrual cycle? Yes. A study of 30 healthy young women found symptoms peaked in the first few days of menstruation, with gradual buildup in the days before the period. Non-randomised trial, 1978 Does anxiety increase during menstruation? According to this study, yes. State anxiety (how anxious someone feels right now) was raised during menstruation, and the amount of increase depended on each woman's baseline anxiety tendency. However, the study is small, from 1978, and notes that women may have exaggerated their symptoms. Study, 1978 What happens to activity and alertness before your period? A review of studies found that women show increased activity and alertness during the premenstrual phase, but it's unclear what changes happen in the brain. Case report, 1978 Can psychosis come back regularly with the menstrual cycle? Yes, in these 7 women, psychosis came back regularly with their menstrual cycle. A change in brain chemicals linked to the menstrual cycle might be involved, possibly triggered by emotional stress or other causes. Survey study, 1977 What are the effects of premenstrual tension on women's lives? Premenstrual tension causes distressing physical and psychological symptoms in many women and can have a significant impact on their work, personality, and relationships. Study, 1977 What hormone levels are abnormal in women with severe premenstrual tension? Women with severe PMS had lower progesterone levels about 8 days before their period. In a larger study, approximately 30% had higher prolactin and lower progesterone during the second half of their cycle. Survey study, 1977 Do women perceive more tension and pressure just before their period? Yes, women not taking birth control pills perceived significantly more pressure just before and during menstruation compared to mid-cycle. Women on birth control pills had stable perceptions throughout their cycle. Study, 1977 Does vitamin B6 (pyridoxine) help treat PMS symptoms? Yes, vitamin B6 appears to help. Over half of the 70 women studied showed considerable benefit, especially for headaches, bloating, and mood changes. Study, 1977 What causes premenstrual tension? Researchers believe several hormone-related factors are involved, though the exact cause is still uncertain. These include progesterone deficiency in about 30% of women and changes in brain chemicals. Randomised trial, 1977 Does dydrogesterone help premenstrual tension symptoms? Yes, over 70% of women reported cure or marked improvement. Fluid retention improved almost completely, but mental symptoms and breast pain improved less. This was early evidence needing confirmation with a controlled study. Study, 1976 What types of headaches are related to the menstrual cycle? A clinical description categorizes types of headaches including those linked to menstrual hormones, but provides no data about how common they are or how well treatments work. Lab study, 1976 Does understanding where your arousal comes from help you perform better on difficult tasks? Yes, according to this study. When people could clearly attribute their feelings to an external source rather than worrying about the task itself, they performed significantly better. Randomised trial, 1976 Does bromocriptine help premenstrual syndrome and infertility? Yes, bromocriptine improved PMS symptoms and was associated with pregnancies in women treated for infertility, likely by lowering the hormone prolactin. Study, 1976 Does anxiety before your period affect how clearly you speak? No. Women spoke equally clearly at ovulation and before their period, even though anxiety is typically higher before menstruation. Survey study, 1976 Does premenstrual anxiety and depression affect how well women think? Women reported more anxiety and depression before their period, but this mood change did not affect how well they performed on thinking tests. Survey study, 1975 Is there a link between estrogen and progesterone levels and PMS symptoms? There was a significant link between estrogen levels and anxiety, irritability, and depression symptoms, but no clear link with progesterone levels. This is a very small early study, so we cannot be very sure. Study, 1973 Do opipramol and chlorthalidone help treat PMS? Yes, both treatments showed improvement in PMS symptoms. The combination of opipramol and chlorthalidone worked better than opipramol alone, particularly for breast swelling and ankle swelling. Survey study, 1972 How does the menstrual cycle affect mood and sexual arousal? The menstrual cycle affects mood in women. The strongest effects occur before the period, when some women become depressed or irritable. Physical symptoms also accompany these mood changes. Survey study, 1964 How common are mood and physical changes around menstruation? Very common. One in nine women reported severe pain, irritability or headache, and one in four had moderate to severe premenstrual tension. Psychological symptoms were linked to personality traits related to anxiety. Study, 1964 How can we measure premenstrual tension syndrome more accurately? Researchers developed two rating tools based on 42 women with severe premenstrual tension syndrome: a 36-item questionnaire women fill out and a 10-item scale for doctors and researchers to use. Study, 1962 Can hoarseness be a symptom of PMS? This clinical report describes hoarseness and loss of vocal control as symptoms of premenstrual tension, though the cause is not yet understood. Case report, 1961 What are the main symptoms of premenstrual tension? Premenstrual tension includes mainly anxiety and depression. Some women also have fluid retention, weight gain, and bloating. Most women feel much better once their period starts. Study, 1959 Does oxanamide help with premenstrual tension? Among 45 patients treated, 37 benefited from the medication, and 4 had mild side effects. Study, 1945 What symptoms do women experience with premenstrual tension? Premenstrual tension causes many different physical and emotional symptoms ranging from mild to severe, including nervousness, irritability, depression, headaches, nausea, and bloating. Lab study, 1943 Can vitamin B deficiency play a role in causing premenstrual symptoms? This work suggests that vitamin B deficiency could contribute to premenstrual symptoms and menstrual bleeding problems by affecting how the liver breaks down estrogen, based on review of existing evidence rather than a new study. Study, 1941 Is premenstrual tension caused by electrolyte and water imbalances? The researchers propose that premenstrual distress and tension are both caused by changes in electrolyte and water balance due to ovarian hormones, but the abstract does not describe whether this treatment worked. Study, 1940 What is the range of severity for premenstrual distress symptoms? Premenstrual distress affects women very differently, from mild symptoms that are easy to tolerate to severe symptoms that cause depression, suicidal thoughts, or extreme irritability. Study, 1938 How effective is a management plan for premenstrual tension? A management plan for premenstrual tension produced excellent results in ten women, though the abstract does not explain what the plan included or what the results were. Study, 1931 What types of health problems happen before menstruation? Women experience a range of premenstrual problems from mild discomfort including fatigue and difficulty concentrating to severe pain requiring bed rest to serious symptoms like convulsions. Show more studies Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗