--- title: Cognition, concentration and memory: 614 studies, explained | Niyora description: 614 studies on cognition, concentration and memory and PMS or PMDD, each summarised in plain English: what was tested, who took part, what they found and what url: https://niyora.com/research/topics/symptom-cognition/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Cognition, concentration and memory # Cognition, concentration and memory: what the research says 614 studies on cognition, concentration and memory in PMS and PMDD, each explained in plain English. 34 of them use the strongest designs: randomised trials and systematic reviews. Survey study 189 Study 86 Randomised trial 78 Case-control study 65 Cohort study 50 Review 41 Systematic review, 2026 Do brain wave patterns change across the menstrual cycle? Yes. Brain wave patterns shift across the cycle. Certain waves decrease and others increase around ovulation in a pattern that suggests sharper thinking and better emotional well-being. These changes could help detect hormone-sensitive mood disorders. Systematic review, 2026 Can digital tools help diagnose PMDD? Digital tools show promise for diagnosing PMDD by helping you track symptoms, but most need more testing and better integration with healthcare systems before they're widely used. Systematic review, 2026 Does the menstrual cycle affect athletic performance and fatigue in female athletes? Lab tests showed stable athletic performance across the menstrual cycle, but the premenstrual phase linked to higher fatigue. In real games, athletes covered less distance during menstruation with separate thinking changes. Systematic review, 2025 Does zinc supplementation help with PMS symptoms? Yes. Zinc supplements significantly reduced physical symptoms, anger, anxiety, tearfulness, difficulty concentrating, insomnia, and overeating compared to placebo. Systematic review, 2025 How do cognition and behavior change across the menstrual cycle in people with PMDD? Evidence that cognitive abilities change is limited and inconsistent. A negative attention bias (focusing on negative things) appears central to PMDD. Cohort study, 2025 Are irregular menstrual cycles linked to lower thinking and memory skills in middle-aged women? Yes. Women with irregular cycles at ages 29-46 and women with very short cycles (25 days or less) at ages 18-22 both had slightly lower memory scores later in life. Systematic review, 2025 Does how well women think change throughout their menstrual cycle? No. Across 3,943 women in 102 studies with 730 comparisons, there was no clear evidence that thinking, memory, creativity, problem-solving, coordination, spatial ability, or verbal ability changed across the menstrual cycle. Randomised trial, 2025 Does the menstrual cycle phase affect how much alcohol impairs women's memory? Yes, women's working memory was less impaired by alcohol during the late follicular phase (when estradiol is high) compared to the early follicular phase (when estradiol is low), suggesting higher estradiol may protect against alcohol's cognitive effects. Systematic review, 2025 Does teaching adolescent girls about their menstrual cycle and health help reduce period pain and PMS? Yes. A systematic review of five good-quality studies shows that psychoeducation (structured teaching) significantly reduced period pain and PMS symptoms and improved emotional wellbeing in adolescent girls. Randomised trial, 2024 Does estradiol prevent thinking problems before the period in women with suicidal thoughts? Yes. Estradiol prevented drops in working memory and verbal fluency that otherwise happened before the period. Review, 2024 What are the most effective treatments for PMDD? According to this literature review, SSRIs (antidepressants) and cognitive-behavioral therapy are the most commonly recommended first-line treatments. Birth control pills with drospirenone are also effective. Systematic review, 2024 Do SSRI antidepressants help treat PMS and PMDD? Yes. SSRIs probably reduce premenstrual symptoms in women with PMS and PMDD based on moderate-certainty evidence from 34 studies. Daily continuous use appears more effective than taking SSRIs only before your period. Cohort study, 2023 Are PMS symptoms linked to genetic factors for psychiatric disorders? Yes. Women with PMS were more likely to have genetic factors for depression, bipolar disorder, ADHD, schizophrenia, and autism spectrum disorder. This was a large, well-designed study, so we can be confident in these findings. Cohort study, 2023 Is PMDD a valid medical diagnosis? Yes. PMDD is recognized by the World Health Organization and American Psychiatric Association as a distinct medical diagnosis. Evidence suggests it has real neurobiological basis, though more biological research is still needed to fully understand it. Systematic review, 2022 Does the stress hormone cortisol change across the menstrual cycle? Yes, but only slightly. Across many studies, cortisol was a little higher in the first half of the cycle (follicular phase) than the second half (luteal phase), and higher during a period than right before it, but most other phase comparisons showed no clear difference. Systematic review, 2022 Do athletes' feelings and performance change across the menstrual cycle? Some feelings change across the cycle, especially motivation and mood. However, the research methods vary a lot, so we cannot be very confident about most findings. Cohort study, 2021 Are low antioxidant vitamins or high oxidative stress linked to premenstrual syndrome? This study found that oxidative stress markers were linked to more depression and food cravings symptoms and more severe PMS, but antioxidant vitamin levels were mostly not associated with PMS symptoms. Systematic review, 2021 Can cognitive behavioral therapy treat PMS without medication? Yes, according to this review. All 32 studies found that cognitive behavioral therapy and other non-medication approaches significantly reduced or completely stopped PMS symptoms with no side effects reported. Survey study, 2020 What symptoms best predict whether PMDD will seriously affect daily life? Four premenstrual symptoms is the optimal number for predicting clinically significant impairment. Psychological symptoms like difficulty concentrating were the strongest predictors, more so than core mood symptoms. Systematic review, 2019 Do women take more health-related risks at certain times in their menstrual cycle? Women show higher sexual activity and better risk awareness during ovulation, but no consistent pattern for alcohol or cigarette smoking across the cycle. Randomised trial, 2019 Does online cognitive behavioral therapy help women with PMDD? Yes. Women who completed 8 weeks of online therapy had significantly greater improvements in functional impairment, mood, and everyday life. The improvements lasted for at least 6 months. Survey study, 2018 Does the menstrual cycle affect emotions and thinking ability? The menstrual cycle affects emotions consistently, especially in the luteal phase and stronger in women with PMDD. It has only small and inconsistent effects on cognitive tasks like memory and attention. Review, 2017 What causes PMDD and what are the best treatments? PMDD involves an abnormal response to normal hormone changes affecting the serotonin system and brain circuits that control emotion. SSRIs are the first-line treatment, with several other options available. Systematic review, 2016 What are the best treatments for PMDD without other mental health conditions? Selective serotonin reuptake inhibitors (especially paroxetine and fluoxetine) and low-dose oral contraceptives work best. Other options like light therapy, cognitive behavioral therapy, and supplements show promise but need more research. Review, 2015 What do we know about PMS and PMDD and how are they treated? PMS affects 30 to 40 percent of reproductive-age women and PMDD affects 3 to 8 percent. Serotonergic antidepressants are the most effective treatment, but oral contraceptives, lifestyle changes, cognitive behavioral therapy, and herbal supplements are also available options. Systematic review, 2014 Do estrogen and progesterone change how the brain processes emotions and decisions? Yes. These hormones affect which brain areas activate when women process emotions and make decisions, particularly in areas involved in mood and choice-making. The specific pattern varies by hormone level and person. Review, 2013 What treatments work best for PMDD? A combination of lifestyle changes, medicines, and cognitive behavioral therapy works best. This approach reduces symptoms and improves daily functioning and quality of life. Systematic review, 2012 How effective are cognitive-behavioral therapy and antidepressants for PMS and PMDD? Both cognitive-behavioral therapy and serotonergic antidepressants showed small to medium effects, but researchers concluded efficacy was not satisfactory and recommend combining both approaches for better results. Review, 2011 What are PMS and PMDD, and how common are they? PMS affects 20-32% of women before menopause with moderate mood and physical symptoms. PMDD is more severe and affects 3-8% of women, causing significant problems at work or socially. Randomised trial, 2010 What treatments work for premenstrual syndrome? Several treatments reduce PMS symptoms according to controlled studies: SSRIs, some birth control pills, hormone injections, calcium, chasteberry, and cognitive-behavioral therapy. However, about 40% of women don't respond to current treatments. Review, 2003 How do menstrual cycle hormones affect the brain and cause mood disorders like PMDD? A hormone called allopregnanolone acts on brain receptors. Changes in this hormone during the cycle may cause mood and behavioral symptoms in up to 20% of people through three mechanisms: direct effects, building tolerance, and withdrawal effects. Randomised trial, 2003 Are SSRI antidepressants effective for PMDD? Yes, SSRIs are effective first-line treatments for PMDD. Both continuous dosing and intermittent dosing during the luteal phase lead to rapid improvement in symptoms and functioning. Review, 2001 What are PMS and PMDD, and how are they treated? PMS is a cluster of symptoms occurring 7 to 14 days before menstruation. PMDD is the most severe form. Both should be treated first with lifestyle changes like exercise and stress management, with medication added if needed. Randomised trial, 1998 Does cognitive therapy help women with PMS? Yes. Cognitive therapy was significantly more effective than being on a waitlist, and women showed almost complete remission of symptoms. Survey study, 2026 Does childhood trauma cause worse PMS, and can social support help? In a study of 629 women in Iran, childhood trauma was associated with more severe PMS, while strong perceived social support was associated with less severe PMS. Social support appeared to reduce the negative effect of trauma on PMS. Survey study, 2026 Do people with ADHD traits have higher rates of PMDD than others? Yes, people with ADHD traits had significantly higher risk of PMDD. People with autism traits did not show a higher risk of PMDD. Survey study, 2026 How does PMS affect test anxiety in nursing students? PMS was linked to higher test anxiety both directly and indirectly through delaying sleep and reduced ability to pay attention. The indirect pathway through sleep delays and attention difficulties accounted for 50% of the link between PMS and test anxiety. Survey study, 2026 Are PMDD and ADHD linked in women with bipolar disorder? In women with bipolar disorder, 44.2% have PMDD, and those with PMDD also have higher ADHD symptom scores. Genetic risk for ADHD was linked to both PMDD severity and ADHD symptoms. Systematic review, 2026 What types of talking therapy have been studied for PMS and PMDD? Several cognitive behavioral therapies have been studied for PMS and PMDD, including CBT, mindfulness therapy, and acceptance therapy. The evidence is scattered and hasn't been systematically compared yet, so we don't know which approach works best. Randomised trial, 2026 Which works better for PMDD: cognitive-behavioral therapy or mindfulness-based cognitive therapy? Both therapies reduced stress and improved well-being in PMDD, with cognitive-behavioral therapy being more effective. However, neither significantly improved emotional well-being. Systematic review, 2026 Can mindfulness, yoga or qigong help with PMS symptoms? Yes, these practices seem to help with mood, stress, anxiety, physical symptoms and sleep in women with PMS, but the research quality is only moderate, so we cannot be fully certain yet. Systematic review, 2026 Do digital tools and apps help reduce PMS and PMDD symptoms? Yes, several digital programs help reduce symptoms, especially internet-based cognitive behavioral therapy and app-based mindfulness. Therapist-guided internet CBT for PMDD showed benefits lasting up to 6 months. Tracking apps helped with symptom awareness and engagement. Survey study, 2026 Do women with PMS have lasting problems with focus and impulse control throughout their cycle? Yes. Women with PMS have ongoing problems with focus and impulse control throughout their cycle, and these are not caused by hormone level changes. Interview study, 2026 Does the menstrual cycle affect how well therapy works? Yes. Women reported lower satisfaction with therapy and worse symptoms during the premenstrual and perimenstrual phases, but talking about their menstrual cycle in therapy helped. Case-control study, 2026 How do thinking, mood, and work change across the cycle in women with and without period pain? Women with period pain experienced challenges in mood, work performance, and self-esteem that extended beyond the pain itself. Thinking and memory skills did not show clear differences between women with and without period pain. Survey study, 2026 Do how you think about your period and how you manage emotions affect PMS and PMDD? Yes. How you view your period and whether you reframe difficult thoughts (cognitive reappraisal) matter. Women who reframe thoughts had less distress, while those who suppress feelings and deny menstrual impact had more. Survey study, 2026 Are PMS and PMDD the same condition or are they different? They are different. PMDD is more severe and causes significant distress and impairment in work and relationships, while PMS is broader and milder. PMDD requires more intensive treatment. Survey study, 2026 What menstrual cycle symptoms do people experience and how much do they interfere with daily life? Most symptoms cause modest interference with daily life, but distress is highest during menstruation. Pain and discomfort are the strongest predictors of difficulty with daily activities. Randomised trial, 2026 Does acceptance and commitment therapy help women with PMS manage emotions and unhelpful thoughts? Yes. Eight weeks of acceptance and commitment therapy improved emotional regulation and reduced unhelpful thought patterns in women with PMS, with benefits lasting at least 2 months after treatment. Survey study, 2026 Do women with ADHD and autism have more premenstrual problems than women without these conditions? Yes, women with ADHD and autism have significantly more premenstrual problems than women without these conditions, with equal severity in both groups. Premenstrual symptoms are linked to traits like inattention and social difficulties. Cohort study, 2026 How do beliefs about control and ways of handling emotions affect distress before your period? Women who believed their premenstrual period was uncontrollable experienced stronger increases in distress before their period. Their general ways of handling emotions were linked to overall distress throughout the cycle rather than specifically to increases before the period. Study, 2026 Does the menstrual cycle affect athletic performance, recovery, or sleep despite hormone changes? Hormone levels change significantly across the menstrual cycle and symptoms are higher at certain times, but athletic performance, recovery, and sleep remain consistent in trained women. This is a well-designed study. Review, 2026 How does the menstrual cycle affect concentration and work productivity? Reaction time slows and attention problems occur most during the luteal and premenstrual phases, particularly in people with PMS or PMDD. Overall evidence is mixed because studies use different methods. Survey study, 2025 Do menstrual problems and poor sleep affect mood and thinking in teenage girls? Yes. Clear links exist between menstrual pain or PMS symptoms and anxiety, depression, and social problems in adolescent girls. Sleep also matters. Girls with later bedtimes or shorter sleep plus pain had worse mood and thinking problems. Study, 2025 Do ADHD symptoms get worse in the week before your period? Yes. Women with ADHD had more symptoms, worse sleep, and higher stress in the late luteal phase (the week or so before their period), and they took more medication during this time. Survey study, 2025 Do mental abilities like reaction time and attention change across the menstrual cycle? Yes, some do. Women had faster reaction times and fewer mistakes during menstruation, but slower reactions and poorer timing skills during the luteal phase. Survey study, 2025 What behavioral symptoms of premenstrual syndrome are most common? Most women studied (519 out of 650) experienced at least one premenstrual symptom, with insomnia, confusion, difficulty concentrating, and avoiding social situations being most common. These behavioral symptoms were the top concerns for women with PMS. Study, 2025 Do women have different symptom patterns before, during, and after menopause? Yes. Women have different symptom patterns depending on whether they are before, during, or after menopause. All women experience fatigue, headache, anxiety, and brain fog regardless of life stage. Review, 2025 Does creatine supplementation help women's health? Creatine supplementation may improve muscle strength, exercise performance, mood, and cognitive function in women. However, most research so far is small and more studies are needed, especially in women approaching menopause. Review, 2025 How do hormone changes across the menstrual cycle affect mood and behavior in psychiatric disorders? This review proposes that fluctuations in estradiol and progesterone trigger different patterns of mood and behavior problems at different cycle phases through different biological mechanisms. Understanding individual differences in hormone sensitivity could help develop more precise treatments. Cohort study, 2025 Is the stress hormone cortisol different in women with PMDD? Yes. Women with PMDD had weaker cortisol peaks in the early cycle phase, and lower cortisol was linked to more depression during the premenstrual phase. Survey study, 2025 Does thinking repeatedly about distressing thoughts make PMS worse, and can being mentally flexible help? Women who thought repeatedly about worrying thoughts had more severe PMS symptoms. Being mentally flexible did not reduce this effect, meaning the link between overthinking and PMS remained strong and direct. Cohort study, 2025 How has PMS burden changed worldwide from 1990 to 2021? The global burden of PMS increased from 1990 to 2021. The burden is heaviest in poorer regions, where the real numbers may be much higher than recorded. Randomised trial, 2025 Does Nigella sativa reduce PMS symptoms in women? Yes, Nigella sativa supplements reduced PMS symptoms and increased estrogen levels in women with moderate to severe PMS. This is a well-designed study, but the sample size is not reported in the abstract. Study, 2025 Does PMS change how much attention emotional faces grab? No clear difference was found. Angry faces grabbed attention more than neutral faces in all women, but PMS did not change this pattern. Study, 2025 Does menstrual cycle phase affect memory ability? Memory performance follows the menstrual cycle, with best performance in the late follicular phase when estradiol (estrogen) is high, and worst performance in the mid-luteal phase when progesterone is high. This is a large study. Review, 2025 How does the menstrual cycle affect ADHD symptoms and concentration? Women with ADHD experience worse attention and executive function during the mid-luteal and premenstrual phases, whereas women without ADHD show improved attention during these phases. Research is still limited. Cohort study, 2025 Do pain sensitivity and negative thinking explain how trauma and stress cause PMS or PMDD? Yes. Both heightened pain sensitivity and negative thinking patterns mediate the connection between past trauma or stress and premenstrual disorder symptoms. Survey study, 2025 Do women with PMS have thinking problems that change with the menstrual cycle or persist all month? Women with PMS had lasting problems with working memory and impulse control across the entire menstrual cycle, not just before their period. These problems correlated with symptom severity but not with hormone levels. Survey study, 2025 How are PMS and PMDD diagnosed and treated? PMS and PMDD are diagnosed by tracking symptoms for at least two cycles and noting if they occur in the luteal phase. SSRIs are first-line treatment. Cognitive behavior therapy, exercise, acupuncture, and the herb Vitex agnus castus may also help. Non-randomised trial, 2025 What treatments help PMS and PMDD? Both medications (SSRIs, hormonal therapy) and non-drug approaches (therapy, mindfulness, supplements, herbal medicine) show promise for PMS and PMDD. More research is needed to know which works best for whom. Review, 2025 How does progesterone affect mood and brain function? Progesterone influences how your brain processes emotions and manages stress. In women with PMDD, targeting progesterone receptors can improve mood symptoms before your period. Randomised trial, 2025 Does yoga help women with PMS reduce their focus on negative thoughts? Yes, 12 weeks of regular yoga reduced how much women with PMS focused on negative information and changed brain activity patterns involved in attention. Lab study, 2025 Does yogic pilates and breathing exercises help PMS symptoms? Yes. Women doing yogic pilates and breathing exercises (pranayama) for 24 days had a clear improvement in core strength and a clear reduction in stress. There was no clear change in memory function or AMH hormone levels. Study, 2025 Do women with PMDD who experienced childhood trauma have more trouble recognizing emotions? Yes. Women with PMDD who experienced childhood trauma, especially physical or sexual abuse, had significant difficulty recognizing emotions compared to women with PMDD who were not traumatized. Randomised trial, 2025 Does cognitive-behavioral hypnotherapy reduce period pain and PMS symptoms? Yes. Hypnotherapy significantly reduced period pain, PMS symptoms, and improved women's emotional regulation. Study, 2025 Does cognitive-behavioral therapy help girls with PMDD feel better about themselves? Yes. Girls who received cognitive-behavioral therapy showed clear improvements in well-being and self-compassion compared to girls who received no treatment. Randomised trial, 2025 Does escitalopram improve attention and reduce impulsivity in women with premenstrual irritability and anger? Escitalopram improved attention consistency in a lab test and women reported fewer impulsive urges when taking the drug. We can be moderately confident in this finding. Interview study, 2025 How does the menstrual cycle affect women's experience of therapy? Women reported less satisfaction with therapy during their premenstrual and perimenstrual phases compared to other phases of their cycle. When therapists discussed the menstrual cycle openly, women felt their treatment worked better. Review, 2025 What causes PMDD and why is it hard to function? PMDD is caused by the brain being too sensitive to hormonal changes. It leads to real and significant difficulty with work, school, or relationships that doctors often overlook. Case-control study, 2024 Do women with PMDD have more attention and memory problems than other women? Yes, women with PMDD show greater increases in memory and attention problems as they progress through their menstrual cycle toward their period. Women with PMDD are also more likely to have ADHD. Survey study, 2024 Does pranayama breathing training reduce PMS symptoms and improve brain function? Yes. Women with PMS who completed 8 weeks of pranayama training showed significant improvements in nerve function and cognitive performance compared to those who didn't train. The study is small, and we don't know if effects last after training stops. Case-control study, 2024 How does PMDD affect how women understand and feel what others are experiencing? Women with PMDD show unusual brain patterns related to empathy during the luteal phase: they have stronger emotional responses but have more difficulty understanding other people's perspectives. This may explain the severe social difficulties that women with PMDD report during this phase. Survey study, 2024 Does estrogen affect how well women recognize emotions in others? Women with higher overall estrogen levels were better at recognizing emotions. However, when a woman's estrogen was unusually high for her at a given time, it made emotion recognition worse. Case-control study, 2024 Are hormone and growth factor levels different in women with PMDD during the luteal phase? Yes. Women with PMDD have higher progesterone and cortisol during the late luteal phase, and these are linked to worse symptoms. Growth factors that may protect are lower in women with PMDD. Case-control study, 2024 Can short mindfulness or rumination exercises shift mood differently across the cycle in PMDD? Yes. Short mindfulness exercises boosted positive mood more in women with PMDD during the premenstrual (late luteal) phase than in women without PMDD, while short rumination exercises worsened mood and awareness for everyone, regardless of cycle phase or PMDD status. Survey study, 2024 Does learning mindfulness meditation help women with PMS feel happier? Yes, women with PMS who learned mindfulness meditation felt significantly happier immediately after the program and one month later (P=0.0001). This suggests mindfulness could be a helpful tool. Cohort study, 2024 Does the tendency to ruminate make PMS mood swings worse? No. This larger study found that trait rumination did not predict whether women experienced more mood changes across their cycle, contradicting some earlier smaller studies. Rumination may not be a useful treatment target for PMS mood disorders. Survey study, 2024 Does thinking style affect mood through the menstrual cycle in people with PMDD? Yes. People with PMDD who had less repetitive negative thinking and more present-moment awareness during the late luteal phase showed better mood. Long-term thinking habits didn't protect them from premenstrual mood worsening. Non-randomised trial, 2024 Does metacognitive therapy help women with PMDD reduce dysfunctional thinking? Yes, metacognitive therapy reduced dysfunctions in women with PMDD. The therapy accounted for approximately 24.3% of the improvement in dysfunctional attitudes. Survey study, 2024 Does PMS reduce how well nurses perform their clinical work? Yes. Nurses with more severe PMS had significantly lower clinical performance scores. PMS predicted 26.5% of differences in how well nurses performed. Case-control study, 2024 Does PMDD affect how women judge space and direction? Women with PMDD performed better on spatial thinking tests during the follicular phase, suggesting PMDD may involve different brain processing patterns. The practical meaning of this enhanced ability is not yet clear. Study, 2023 Do women with PMDD have different brain network patterns than women without PMDD? Yes. Using brain imaging, researchers found that women with PMDD have different patterns of connection between brain regions in three brain networks compared to women without PMDD. Study, 2023 What treatments help premenstrual dysphoric disorder (PMDD)? Several treatments work for PMDD. First-line treatments are lifestyle changes, SSRIs, combined hormonal birth control, and benzodiazepines. Studies also show benefits from exercise, cognitive behavioral therapy, supplements, relaxation, and herbs. Case-control study, 2023 Do emotion regulation strategies help women with PMDD manage mood and stress hormones? Women with PMDD use less helpful emotion regulation strategies. Using better strategies improves daily mood but does not fully prevent the premenstrual mood drop. Mindfulness may help maintain normal stress hormone levels. Randomised trial, 2023 Does curcumin improve memory and thinking in women with PMS and period pain? Yes. Women taking curcumin had significant improvements in memory, attention, and overall thinking abilities compared to placebo. Cohort study, 2023 Do women recognize emotions differently at different times of their menstrual cycle? No. Two independent studies found that women's ability to recognize emotions in faces did not change across their cycle, even though mood symptoms did change as expected. Study, 2023 Does the menstrual cycle affect how well women learn new information? Yes, clearly. Women learn exceptions to rules much faster when estradiol (a hormone that rises and falls with the cycle) is high than when it's low, and they learn faster than men do. Survey study, 2023 How do rumination and awareness affect mood and stress hormones during the menstrual cycle in PMDD? In women with PMDD, being aware of the present moment and thinking less about negative things predicted better mood during the premenstrual phase. Women with PMDD also lacked the normal stress hormone pattern that healthy women show, which may be a biological marker of PMDD. Cohort study, 2023 Does recreational physical exercise reduce premenstrual symptoms in teenage girls? Possibly. Girls who exercised 3 or more times per week had lower depression. However, older age and higher weight were linked to worse symptoms. Survey study, 2022 Does emotional processing change through the cycle if someone had postpartum depression? Yes. Women with a history of postpartum depression showed depression-like thinking patterns during the late luteal phase, like dwelling on negative self-views and remembering sad information better. Healthy women did not show this pattern. Survey study, 2022 Do women with premenstrual syndrome think differently than women without it? Women with PMS think differently in some ways than women without symptoms, but not as drastically as women with depression. Women with both PMS and depression have the most distorted thinking patterns. Case-control study, 2022 Do women with PMDD recognize emotions differently across their menstrual cycle than women without PMDD? Yes. Women with PMDD showed different emotion recognition responses during different cycle phases while women without PMDD did not. This suggests PMDD affects how the brain processes emotional faces. Survey study, 2022 Do women with PMDD have different brain function at different cycle phases? Yes. Women with PMDD have worse focus and decision-making during the week before their period, and they have more difficulty managing emotions throughout the cycle. Randomised trial, 2022 Does online counselling using cognitive-behavioral techniques help PMS symptoms? This abstract is a data description and does not report the study results. Randomised trial, 2022 Do hormone pills prevent suicidal thoughts from getting worse around menstruation? Yes. Giving women estradiol and progesterone during the time when their natural levels drop (around menstruation) significantly reduced suicidal thoughts, depression, and feelings of rejection and burden compared to placebo. Randomised trial, 2022 Does internet-based cognitive-behavioral therapy reduce PMS symptoms and improve quality of life? Yes. Internet-based cognitive-behavioral therapy significantly reduced PMS symptoms and improved quality of life during the period itself, though not during less-symptomatic phases. Case-control study, 2022 Does how women think about their period affect how their nervous system responds to stress? Yes. How women view their period (as bothersome or predictable) affects their nervous system response. Women with PMS also show delayed recovery from stress during the premenstrual period. Case-control study, 2022 Does the menstrual cycle affect how women without PMS pay attention to emotional faces? No, women without PMS show the same level of attention to emotional faces throughout their menstrual cycle. This suggests emotional changes during the cycle may be specific to people who have PMS. Cohort study, 2022 What are PMS and PMDD and how should they be diagnosed and treated? PMS involves 1-4 symptoms or 5 or more physical or behavioral symptoms. PMDD requires 5 or more symptoms with at least one mood symptom like irritability or mood swings. Treatments include exercise, cognitive behavioral therapy, and medications like SSRIs and hormonal contraceptives. Lab study, 2022 Does attention to other people's faces change during the menstrual cycle? Attention to faces changes during the cycle. In the late follicular phase, women's eyes showed more distraction by faces. In the mid-luteal phase, this pattern did not occur. Women also remembered targets better in the late follicular phase. Randomised trial, 2022 Does happiness training improve quality of life in women with PMS? Yes, happiness training based on Fordyce's approach significantly improved quality of life and reduced negative emotions and body pain in women with PMS. Randomised trial, 2021 Does blocking progesterone receptors help women with PMDD control anger and aggression? Yes, according to this study. Women taking the medication had a 93% response rate compared with 53.3% on placebo, and their brains showed stronger activity in emotion control regions. Randomised trial, 2021 Does cognitive behavioral therapy help PMDD? Yes. Cognitive behavioral therapy (CBT) significantly reduced PMDD symptom severity and improved women's quality of life compared to standard care. Randomised trial, 2021 Does hypnotherapy reduce pain and emotional distress in women with PMDD? Yes. Hypnotherapy focusing on cognitive flexibility and ego strength reduced pain and emotional distress much more than no treatment. Cohort study, 2021 Does the menstrual cycle change how the brain works during memory tasks? Yes. Brain activation and connectivity between different regions change across the menstrual cycle during working memory tasks, with the largest changes during the luteal phase when progesterone levels are high. Cohort study, 2021 Do women with PMDD have worse sleep, focus, and tiredness problems that get worse before their period? Yes, women with PMDD have more severe insomnia, attention problems, and fatigue than women without it, and these symptoms get significantly worse in the late luteal phase (the days before menstruation). Survey study, 2021 What is menstrual migraine and how common is it? Menstrual migraine is migraine linked to menstruation more often than by chance. It affects 20-25% of women with migraines in the general population and 22-70% of people seen at headache clinics. These migraines cause more disability than non-menstrual migraines. Survey study, 2021 How common is premenstrual syndrome in Saudi women and what symptoms do they experience? PMS is common in Saudi women. The most frequently reported symptoms were severe body aches (40.9%), severe mood swings (37.5%), and mild lack of concentration (36.2%). Survey study, 2021 How common is PMDD among high school girls? About 1 in 20 high school girls (4.89%, or 44 out of 900) had PMDD. The study included girls aged 12-16 in India. Case-control study, 2021 Does period pain only affect you during your period? No. Women with dysmenorrhea had worse balance and coordination problems both during menstruation and on days when they felt well, suggesting it affects them continuously. Case-control study, 2021 Do women with PMS have different stress hormone levels during their menstrual cycle? Women with PMS had higher evening aldosterone levels during the early luteal phase compared to women without PMS, and these levels correlated with symptom frequency. Cortisol levels did not differ between the groups. Survey study, 2021 Does cognitive-behavioral emotional regulation training help women with PMDD? Yes. Training significantly improved marital happiness and emotional regulation in women with PMDD. This was a small study with a control group, so the effect is promising but needs confirmation in larger studies. Cohort study, 2020 Are calcium and magnesium levels lower in women with PMS? Yes. Women with PMS had significantly lower calcium (8.3 vs 9.1 mg/dL) and magnesium (1.5 vs 1.9 mg/dL) levels compared to healthy women. Cohort study, 2020 Does air pollution increase the risk of premenstrual syndrome? Yes. Women exposed to higher levels of air pollution had significantly increased risk of PMS. Exposure to the highest levels of certain pollutants increased PMS risk by 3 to 7.77 times. Study, 2020 Does how the brain processes words change across the menstrual cycle? The pattern of how the brain is organized for word problems stayed the same across the cycle. However, performance actually improved during the high-hormone phase of the cycle. Non-randomised trial, 2020 What treatments help premenstrual syndrome? Both medications and non-drug treatments help PMS. Non-drug options including herbs, supplements, exercise, and therapy are recommended as they have fewer side effects. Lab study, 2020 Does anxiety sensitivity change during different parts of the menstrual cycle? No, not much. Anxiety sensitivity remained relatively stable across the menstrual cycle phases tested, even in women with PTSD. Lab study, 2020 Does progesterone affect how women pay attention to social information? Higher progesterone levels, which occur in the luteal phase of the cycle, made women pay more attention to social information and process it more accurately. However, this heightened sensitivity might contribute to mood problems in some women. Study, 2020 Does how often you blink change across your menstrual cycle? No. Eye blink rate stayed the same no matter where women were in their menstrual cycle, even when hormone levels changed dramatically. Case-control study, 2020 Do appetite hormones and eating behaviors change differently across the luteal phase in women with PMDD? Women with PMDD have higher leptin levels throughout the luteal phase and show increased sweet cravings and uncontrolled eating, but changes in leptin are not linked to eating changes while depression and impulsivity are more important. Study, 2020 Does the menstrual cycle affect how well you learn new physical skills? Yes. Women learn new physical skills more slowly during the week before their period compared to around ovulation. Systematic review, 2020 What brain changes happen in PMDD? Women with PMDD show several brain differences on imaging: more grey matter in the cerebellum, changes in serotonin and GABA chemicals, and different patterns of activity in emotion-related brain regions. Case-control study, 2020 Do negative thoughts affect mood more strongly in women with PMDD? Yes. In women with PMDD, negative thoughts had stronger effects on later negative mood, especially in the late luteal phase. This suggests mindfulness-based approaches could help. Randomised trial, 2020 Can a short course of CBT-based psychoeducation ease PMS symptoms like irritability and fatigue? Yes, in this trial, women who went through five sessions of CBT-based psychoeducation reported fewer depressive thoughts, less irritability, and less fatigue than the control group. Cohort study, 2020 Does sleep duration and sleep timing affect reproductive hormones and ovulation? Yes, but the effects are modest. For every extra hour of sleep, estradiol increased 3.9% and progesterone increased 9.4%. Less than 7 hours of sleep was linked to earlier hormone peaks, and shift work was linked to lower testosterone. Study, 2019 Do muscles get tired at different times during the menstrual cycle? Yes. Muscles take much longer to get tired around ovulation than at other times of the cycle, showing that menstrual hormones affect muscle strength. Case-control study, 2019 Does multiple sclerosis get worse before your period? Yes. Both cognitive function and physical ability appear to worsen in the premenstrual phase compared to ovulation in people with MS, more so than in healthy people. Survey study, 2019 Do women feel worse after social rejection during the luteal phase, and does progesterone protect against it? Women felt worse mood after being socially excluded, and this effect was stronger during the luteal phase than the late follicular phase. Higher progesterone levels were linked with less distress from exclusion, suggesting progesterone may buffer against the pain of rejection. Case-control study, 2019 Do negative thinking patterns increase the risk of PMS or PMDD? Yes. Women with PMS and PMDD have more negative thinking patterns and process information differently than other women, especially during the luteal phase. Randomised trial, 2019 Does aromatherapy with rose and citrus essential oils help PMS symptoms? Yes, both rose and citrus essential oils reduced mental symptoms of PMS. Rose oil was more effective overall, significantly improving physical symptoms and social function as well. Lab study, 2018 Does menstrual cycle phase affect how sleep loss impacts attention? Women in the follicular phase had the worst attention during sleep deprivation, especially at night, while women in the luteal phase performed as well as or better than men. This suggests women are more vulnerable to attention problems at certain cycle points. Case-control study, 2018 Does PMS affect thinking and memory? Women with PMS showed slower brain responses to sounds compared to women without PMS, suggesting possible cognitive effects, though memory itself was not directly tested. Study, 2018 Do irregular periods and menopause affect thinking and memory in women with schizophrenia? Yes. Women with schizophrenia who had irregular periods performed worse on tests of processing speed, word fluency, and word memory compared to women with regular periods. Women past menopause had worse performance on visual-spatial thinking. Survey study, 2018 Does vitamin D or calcium level affect PMS symptoms and menstrual bleeding? Calcium level is linked to heavier menstrual bleeding and irritability, but vitamin D level does not appear linked to PMS symptoms overall. Randomised trial, 2018 Does mindfulness-based cognitive-behavioral therapy reduce premenstrual syndrome symptoms? Yes. Mindfulness-based cognitive-behavioral therapy significantly reduced PMS symptoms immediately after treatment and the improvements lasted at least one month. Study, 2018 What treatments work best for premenstrual syndrome? Many treatments reduce PMS. Most helpful were nutrition and exercise, followed by medication, stretching, massage, acupuncture, and cognitive-behavioral therapy. Cost and access are major barriers. Case-control study, 2017 Is the pattern of progesterone drop related to developing premenstrual symptoms? Yes. How fast progesterone falls appears linked to symptoms. Women with symptoms had stable progesterone that dropped sharply, while symptom-free women had a gradual decline. Randomised trial, 2017 Does cognitive-behavioral therapy reduce premenstrual syndrome symptoms? Yes, cognitive-behavioral therapy significantly reduced PMS symptoms, especially for women who completed the full treatment. Lab study, 2017 Do women with PMS process emotions differently? Yes. Women with PMS are slower to respond to emotional pictures and faces during their premenstrual phase, compared to women without PMS. Randomised trial, 2017 Can couples therapy help with severe PMS or PMDD more than individual therapy alone? Yes. Both one-to-one and couple-based CBT reduced premenstrual symptoms and distress compared to a wait-list control, and couple-based CBT added extra benefits for coping skills and relationship quality. This comes from a moderate-sized randomised trial, so results are promising but not definitive. Survey study, 2017 Does painful menstruation affect adolescent girls' mood, emotions, sleep, and thinking? Yes. Girls with painful periods had higher depression, aggression, and sleep problems compared to girls without painful periods. However, thinking ability was not affected. Girls with only PMS (without pain) were similar to girls without either condition. Cohort study, 2017 Do birth control pills affect mood in healthy women without PMS? In healthy women without PMS, birth control pills did not change overall positive or negative mood. However, pill users had fewer mood swings and fewer ruminating negative thoughts. Cohort study, 2017 Which PMS symptoms best predict that PMS will interfere with work, relationships, and activities? Psychological and emotional symptoms are the strongest predictors of how much PMS interferes with daily life. Having at least four cyclical symptoms best predicts significant impairment. Randomised trial, 2017 Does a single bright light therapy session improve mood in women with PMS? A single 30-minute bright light session reduced negative mood in women not using hormonal birth control, but had no effect in women using contraceptives. This was a small study testing only one session. Survey study, 2017 Can finger length ratio predict how severe premenstrual symptoms will be? Women whose finger length ratios suggested higher exposure to testosterone before birth tended to have less severe premenstrual symptoms in certain areas. This suggests that prenatal hormone exposure may influence symptom severity, though the connection applied to only some symptoms. Systematic review, 2017 Does vitamin D status change during the menstrual cycle and is it linked to PMS or PMDD? The active form of vitamin D rises 13 to 26 percent across the menstrual cycle, but the basic form does not change much. Whether vitamin D is linked to PMS or PMDD remains unclear, with some studies finding a link and most finding none. Randomised trial, 2016 Does cognitive-behavioral therapy improve quality of life in women with premenstrual syndrome? Yes. Group cognitive-behavioral therapy significantly improved quality of life in women with PMS, and the benefits lasted for 2 months after treatment ended. Review, 2016 How common are PMS and PMDD, and what are the best treatments? Up to 12% of women are affected by premenstrual disorders that significantly affect their lives. SSRIs are the most evidence-based treatment; oral contraceptives and calcium may also help, but vitamin D and herbal remedies have weak evidence. Randomised trial, 2016 Does mindfulness-based cognitive therapy reduce PMS, depression and anxiety? Yes. Women who received mindfulness-based cognitive therapy showed significantly lower depression, anxiety, and PMS symptoms than those who received no treatment. Study, 2015 Does how your brain processes visual information change during your menstrual cycle? Yes. During the second half of your cycle, your brain responds more strongly to visual images compared to men. Randomised trial, 2015 Does aerobic exercise reduce premenstrual syndrome symptoms in young women? Yes. Three months of aerobic exercise combined with vitamin B6 and calcium supplements significantly reduced all PMS symptoms. Review, 2015 Does a progesterone metabolite called allopregnanolone cause mood problems in PMDD? In some women with PMDD, the progesterone metabolite allopregnanolone is linked to negative mood during the luteal phase, despite being expected to be calming. A preliminary clinical trial of a blocking agent called isoallopregnanolone showed good effects in treating PMDD symptoms. Randomised trial, 2015 Does menstrual cycle change stress effects on cortisol and memory? Yes. When hormones are low (follicular), stress triggers strong cortisol responses that impair emotional memory, but when hormones are high (luteal), stress does not produce this cortisol response. Lab study, 2015 Does the menstrual cycle affect how our brains learn and forget things? Yes. Women in the luteal phase (second half) of their cycle showed stronger brain responses related to learning compared to men. Women in the menses phase also showed stronger learning responses than men, but not when trying to forget. Randomised trial, 2014 Does alcohol change brain activity during the menstrual cycle? Yes. Alcohol changed how the brain worked during thinking tasks, with effects varying by menstrual cycle phase, though the study was small. Review, 2014 How does the menstrual cycle affect thinking, memory, and emotions? The evidence for how the menstrual cycle affects thinking and memory is weak and inconsistent. However, emotional changes are more consistently related to the cycle, with high progesterone levels linked to stronger emotional processing in the brain. Case-control study, 2014 Does past abuse affect pain sensitivity differently in women with menstrual mood disorders? Yes. Women with menstrual mood disorders who experienced abuse showed greater pain sensitivity and lower stress hormone levels, suggesting abuse affects this group differently. Survey study, 2014 Do women who had PMS develop more hot flashes in menopause? No. Women with a history of premenstrual symptoms did not have more or worse hot flashes after menopause. However, those with a PMS history did report more problems with memory, mood, sleep, and feeling less attractive during the menopause transition. Study, 2014 Does the menstrual cycle phase affect how women respond to nicotine? Yes. Women in the luteal phase showed reduced sensitivity to nicotine's effects and performed better on thinking tasks compared to women in the follicular phase, suggesting the luteal phase may reduce nicotine's rewarding effects. Study, 2014 What does brain activity show us about PMDD? Women with PMDD show more activity in brain areas that control emotions. This might help explain mood symptoms, but scientists are still working out what this activity means. Survey study, 2013 Does stress before learning affect memory differently based on sex and menstrual cycle phase? Yes. Without stress, women remembered more words than men, but when exposed to stress, men's performance improved to match women's. In the luteal phase, higher stress hormones were linked to worse memory. Case-control study, 2013 Are stress hormones different in women with PMDD? Overall stress hormone patterns are similar in PMDD and healthy women, but those with high allopregnanolone (a progesterone derivative) show blunted nighttime cortisol levels. Survey study, 2013 Does how well you recognize emotions change depending on where you are in your menstrual cycle? Yes, slightly. Women in the follicular phase recognized emotions more accurately. Women in the luteal phase reacted faster to sad and angry emotions, linked to progesterone levels. Case-control study, 2013 Does the prefrontal cortex function differently in women with PMDD? Brain scans showed that women with PMDD have greater activity in a part of the brain called the dorsolateral prefrontal cortex during thinking tasks, regardless of hormone levels. Higher activity was linked with more severe symptoms. Lab study, 2013 Does the menstrual cycle affect how well women remember emotional stories? Women in the high-hormone luteal phase remember more extra details from emotional stories, while women in the low-hormone follicular phase show no difference between emotional and neutral stories. Men remember the main plot better from emotional stories. Randomised trial, 2013 Does psychological education reduce PMS symptoms in teenagers? Yes. Psychological education significantly reduced overall PMS severity and reduced anxiety and physical symptoms. Effects on depression were minimal, and the intervention did not improve difficulty in relationships. Case-control study, 2012 Do women with mood symptoms linked to their menstrual cycle have different thyroid hormone levels? Yes. Women with menstrually related mood symptoms had different thyroid hormone patterns, including faster conversion of one hormone and lower levels of another. These patterns were linked to worse premenstrual symptoms. Randomised trial, 2012 Does estradiol improve women's attention and cognitive control? Yes. Women's attention control was best during the high-estradiol follicular phase, with the effect linked to estradiol levels. Review, 2012 How does the menstrual cycle affect thinking and memory skills? Healthy women show small changes in cognitive performance across the menstrual cycle, with worse performance in the luteal phase. Women with PMS or PMDD show even greater decline, but the difference is small. Survey study, 2012 What non-hormonal medications and therapies help severe PMS and PMDD? SSRIs (a type of antidepressant) are well-established for severe PMS and PMDD, taken either continuously or during the luteal phase. Cognitive-behaviour therapy, calcium, and chasteberry may also help, though the strength of evidence varies. Randomised trial, 2012 Do sleep benefits for memory vary by sex and menstrual cycle phase? Yes. Men's memory improved after napping, but women's did so only during mid-luteal phase, with female hormones playing a role. Study, 2012 Does anxiety sensitivity affect panic symptoms differently at different menstrual cycle phases? Women with higher anxiety sensitivity had more panicked thoughts during the premenstrual phase compared to the follicular phase, and compared to women with lower anxiety sensitivity. Physical panic symptoms did not differ clearly. Case-control study, 2012 Do women with PMDD have working memory problems linked to concentration and irritability? Yes. Women with PMDD perform worse on working memory tasks during the luteal phase, and this decline is linked to difficulty concentrating, irritability, and reduced daily functioning. Case-control study, 2011 Do women with PMS have different BDNF levels during their menstrual cycle than women without PMS? Yes. Unlike healthy women, women with PMS have decreasing BDNF (a brain chemical) as they enter the luteal phase instead of increasing levels, and their luteal BDNF is significantly lower. This could be related to symptom onset. Survey study, 2011 Do smoking habits affect premenstrual and menstrual symptoms? Smokers had significantly more severe premenstrual and menstrual symptoms than non-smokers, especially pain, concentration problems, water retention, and mood changes. Worse symptoms were linked to higher nicotine dependence. Systematic review, 2009 Does psychological treatment help women with premenstrual syndrome? Cognitive behavioral therapy may reduce anxiety and depression in women with PMS, but the quality of evidence is low. For every five women treated, one additional woman may benefit. Non-randomised trial, 2008 Do mood, memory, and food cravings worsen during the luteal phase in women with PMDD? Yes. During the luteal phase, women with PMDD showed significantly worse mood, impaired memory and concentration, and increased cravings for fatty foods compared to their follicular phase and compared to women without PMDD. Cohort study, 2008 Do women with PMDD have different hormone levels than women without it? The total amount of estradiol is not different, but women with PMDD have less free estradiol available (the active form) and higher levels of a hormone-binding protein. These are significant findings but cannot prove they cause PMDD. Study, 2008 Do women who are naturally anxious show bigger stress responses during certain parts of their menstrual cycle? Yes. Women who are naturally anxious showed the biggest stress response (more cortisol and higher blood pressure) during the early part of their menstrual cycle, but non-anxious women did not show this pattern. Case-control study, 2007 Do women with PMDD see emotions in faces differently during the luteal phase? Women with PMDD showed more negative bias during the luteal phase, seeing neutral faces as sadder than they were. The statistical effect was modest and might not hold up with stricter testing. Randomised trial, 2006 Do women with PMDD and depression process progesterone differently than others? Yes. Women with prior depression convert progesterone to its active form less efficiently. Women with PMDD and no depression history show unusual patterns of this conversion, suggesting altered metabolic pathways. Case-control study, 2006 Are hormone-related chemicals different in women with mood disorders during the menstrual cycle? Women with bipolar disorder and major depression had higher levels of progesterone and a related chemical (3alpha,5alpha-THPROG) during the luteal phase compared to healthy women. This difference was present whether or not they were taking medication. Review, 2006 What treatments work for premenstrual disorders? Several treatments work. Three SSRIs are FDA-approved for PMDD. Exercise, diet changes, and therapy also help some women, but no single treatment works for everyone. Randomised trial, 2005 Does stress hormone affect women's memory differently depending on menstrual cycle or birth control use? Cortisol impaired memory in naturally cycling women but not in women on oral contraceptives, suggesting birth control pills may protect the brain from stress hormone effects on memory. Study, 2005 Can women recognize fear in faces better at certain times of their menstrual cycle? Yes. Women recognized fear expressions significantly better during the preovulatory phase when estrogen is highest, compared to during menstruation when estrogen is lowest. This pattern was not as strong for other emotions. Review, 2005 Can controlling hormones during the luteal phase improve fertility treatment outcomes? Yes. Lowering the hormone FSH during the luteal phase reduced size variation among egg follicles and improved their coordination during fertility treatment. Randomised trial, 2005 Does step aerobic exercise improve fitness and cholesterol in college women? Yes. Both continuous and interval step training improved fitness and reduced body fat. Interval training also increased good cholesterol (HDL). Randomised trial, 2005 Does a low dose of alcohol change allopregnanolone, a brain chemical linked to PMDD? During the late cycle phase, a small dose of intravenous alcohol decreased allopregnanolone levels in both women with severe PMS and control women, but this did not happen during the early cycle phase. This is moderate evidence, but the study is small and used an unnatural way of giving alcohol. Review, 2004 How well does alprazolam work for anxiety and panic attacks? Alprazolam is more effective than placebo and works as well as some other medications for anxiety. It works within the first week but can impair thinking and driving skills. Randomised trial, 2004 Does the luteal phase of the menstrual cycle affect mood and brain function? Yes. In the luteal phase, women showed slower word-finding, lower mood scores, and changes in stress hormone levels, though reaction times were faster. Non-randomised trial, 2004 Are reproductive hormones abnormal in chronic fatigue syndrome? Reproductive hormones FSH, LH, estradiol, and progesterone were normal in women with chronic fatigue syndrome. However, cortisol (the stress hormone) was significantly lower than in healthy women. Study, 2003 Does cognitive behavioral therapy help premenstrual symptoms as well as medication? Possibly. Growing evidence suggests cognitive behavioral therapy may work as well as medication for premenstrual symptoms and is a good option for women who prefer not to take medicine. Randomised trial, 2003 Does leptin explain why women develop PMS symptoms? Probably not. Leptin levels did not change with successful PMS treatment, so leptin may not be the cause of PMS. Case-control study, 2003 Do IBS symptoms change across the menstrual cycle and vary by contraceptive use? Women with IBS have higher symptom severity than controls, and symptoms vary by menstrual cycle phase and bowel pattern type. Oral contraceptive use did not significantly change most IBS symptoms. Randomised trial, 2002 Does therapy work as well as an antidepressant for PMDD, and does combining them work better? Both therapy and antidepressant work well for PMDD with no difference in results after 6 months. Therapy maintains its effects better after treatment ends. Combining them does not help more than either one alone. Case-control study, 2002 Does mercury exposure at work affect period pain and menstrual symptoms? Yes, women exposed to mercury vapor at work have significantly higher rates of period pain and cramping. Since this is observational research, it shows association but not definite causation. Study, 2002 Does a protein called IL-6 in the uterus change throughout the menstrual cycle? Yes. IL-6 levels in the uterus are low in the first half of the cycle and increase 5 to 10 times in the second half, especially around the time for pregnancy implantation and before the period. Study, 2002 Does memory performance change at different times during the menstrual cycle? Some types of memory and thinking skills changed across the menstrual cycle, particularly during the high-hormone phase, though the pattern varied by task type. Estrogen appears responsible for these changes, not progesterone. Randomised trial, 2002 Is fluoxetine or cognitive-behavioral therapy more effective for PMDD? Both work equally well after 6 months. Fluoxetine works faster and reduces anxiety more. Cognitive-behavioral therapy builds better coping skills and changes how women think about their symptoms. Study, 2002 Does how women perceive men change during the menstrual cycle? Yes. During the high-fertility phase of the cycle, women showed an enhanced ability to notice male characteristics and remember stereotypical information about men. Non-randomised trial, 2001 Does a new birth control pill reduce PMS symptoms? Yes. In 322 women, after 6 cycles of this pill, negative mood and water retention during the premenstrual phase dropped significantly. However, this study had no control group, so we cannot be certain the pill itself caused the improvement rather than a placebo effect. Case-control study, 2000 Do women with PMS have different hormone levels than women without PMS? Yes. Women with PMS have significantly lower levels of allopregnanolone and progesterone, especially during the second half of the menstrual cycle. Their bodies also showed a weaker response to a hormone stimulation test. Randomised trial, 2000 Does a low-fat vegetarian diet reduce period pain and premenstrual symptoms? Yes. The diet increased a hormone-binding protein that reduces active estrogen, lowered body weight, and decreased both period pain duration and premenstrual symptoms. Cohort study, 2000 What causes irregular periods in women with bulimia, and do they improve with treatment? Irregular periods in bulimia were linked to vomiting, low thyroid hormone, and low dietary fat. After 12 months of treatment, 56.8 percent of women with irregular cycles became regular. This study concerns eating disorders, not PMS or PMDD. Randomised trial, 2000 What non-antidepressant treatments might help PMS? A study of 466 women found calcium was effective at reducing emotional, behavioral, and physical PMS symptoms. Cognitive therapy, light therapy, and tryptophan also showed promise in early trials. Case-control study, 1998 Do women with PMDD have changes in memory or thinking speed across the menstrual cycle? Women with PMDD showed subtle slowing on motor speed tasks during the late luteal phase, but scores remained within the normal range. Memory and attention were not affected. Review, 1998 Does women's performance on cognitive and motor tasks change across the menstrual cycle? No. Women's performance did not differ between menstruation and the midluteal phase, even though men and women scored differently on 5 of the 6 tasks tested. Randomised trial, 1998 Does supplementing progesterone during the luteal phase increase progesterone levels? Yes, both dydrogesterone alone and dydrogesterone with HCG injections increased progesterone in the middle of the luteal phase compared to placebo. However, progesterone returned to placebo levels by day 11 and did not affect the premenstrual period if pregnancy did not occur. Randomised trial, 1997 Does light therapy affect melatonin in women with PMDD? Bright light affected melatonin timing and levels in women with PMDD depending on when the light was given, with morning light shifting it earlier and evening light shifting it later. The evidence is moderate because it comes from a controlled study, but only 21 women with PMDD were studied. Cohort study, 1996 Does premenstrual syndrome affect how well women think and remember? The study found no clear differences in thinking, memory, or attention between women with PMS and those without, though women with PMS felt more depressed. Cohort study, 1996 Can inhibin testing diagnose luteal phase deficiency? No. In this study, inhibin levels were similar in infertile women with luteal phase defects and fertile women, so inhibin testing does not accurately identify luteal phase problems. Non-randomised trial, 1995 Do women with PMS have memory or attention problems? Women with PMS showed difficulty retrieving information from memory compared to controls, independent of which phase of the cycle they were tested in. The effect was mild and the sample was small. Case-control study, 1995 Do women with PMS have weaker bones due to calcium deficiency? Yes. Women with PMS have lower bone density in the spine and hip compared to women without PMS, and they also have lower vitamin D levels. Randomised trial, 1995 Does a special carbohydrate drink help mood and thinking problems in PMS? Yes, the carbohydrate beverage significantly reduced depression, anger, confusion, and food cravings 90 to 180 minutes after drinking it, and improved memory performance. Study, 1994 Do women's heart and cardiovascular responses to stress change during the menstrual cycle? Yes. Women's heart rate responses to stress were consistently stronger than men's during both cycle phases, and some heart responses in women changed between follicular and luteal phases. Study, 1994 Does skin sensitivity to nickel change during your menstrual cycle? No. Skin sensitivity to nickel did not increase before the period. However, repeated nickel testing itself made the skin more sensitive. Case-control study, 1992 Does PMS affect learning and memory? Yes. Women with PMS have significant difficulty learning new material, and this problem persists throughout their menstrual cycle regardless of mood. Cohort study, 1992 Is hormone control by the brain different in women with PMS? No. The pattern of hormone changes across the menstrual cycle was similar in women with PMS and controls, with only a minor difference in FSH during the mid-luteal phase. Lab study, 1992 Do serotonin levels change across the menstrual cycle? In healthy women tracked through their menstrual cycles, serotonin levels in the blood were higher during the periovulatory phase (around ovulation) and the premenstrual phase compared to serotonin at the start of menstruation. Study, 1992 How do sex hormones affect memory during the menstrual cycle? Some types of memory change across the menstrual cycle, related to hormone levels. Visual memory is lower during the menstrual phase, particularly in about half of women. Other types of memory show less change. Case-control study, 1990 Do women with PMS have different ANP hormone levels during their cycle? Yes. Women with PMS have consistently lower ANP levels throughout their cycle, especially during the luteal phase, while women without PMS show no cycle-related changes. Survey study, 1989 What kinds of PMS symptoms tend to occur together? PMS symptoms cluster into two groups: mood and behavior symptoms (which are most common) and physical and thinking symptoms (which are less common). These groups stay the same throughout the entire menstrual cycle. Survey study, 1989 Does PMS get worse with higher hormone levels? Yes, women with PMS have worse symptoms in months when their estradiol and progesterone levels are high. This contradicts the theory that PMS is caused by low progesterone. Survey study, 1989 How can we diagnose PMS and what causes it? Ovulation and the hormone progestagen appear necessary for PMS. A GnRH agonist drug helped relieve symptoms better than placebo, with most patients no longer showing cyclic symptoms on the active drug. Study, 1985 Do women get worse grades on exams during the premenstrual phase? No. All 26 women in the study earned similar exam marks during the premenstrual phase compared to other times of their cycle. Randomised trial, 1984 Does vitamin E help premenstrual syndrome symptoms? Yes. Vitamin E significantly improved symptoms in three of the four classes of PMS, though it did not change hormone levels directly. Randomised trial, 1984 Does mefenamic acid help premenstrual tension? Yes. 86 percent of women reported significant relief of premenstrual tension with mefenamic acid, and the drug appears to work by lowering prostaglandin levels. Case-control study, 1981 Is sex hormone-binding globulin (SHBG) different in women with severe PMS? Yes. Women with severe PMS have significantly lower SHBG binding capacity. This suggests low SHBG may help explain PMS and could be useful for diagnosis. Survey study, 1980 Do thinking and mood symptoms change across the menstrual cycle? Yes. Women report worse concentration, mood, pain, and water retention before and during their period. Patterns vary between individuals. Study, 1976 Do mood and body changes happen at the same time in the menstrual cycle? Women experience more pain and water retention during their period and just before it, but their mood problems and stress responses are more strongly tied to what's happening in their lives than to their cycle. Men have more stable emotions and less pain throughout. Randomised trial, 2026 Is Pilates exercise more effective than stretching for reducing PMS symptoms? Yes. In this small randomized trial of 20 college students with PMS, Pilates was significantly better than stretching exercises at reducing symptoms. Survey study, 2026 Are PMDD, anxiety, and internet use linked to cognitive problems in women? In this study of women aged 19-45 with anxiety, those who also had PMDD, severe anxiety lasting 5 or more years, or problematic internet use showed associations with cognitive problems including memory and concentration difficulties. Cohort study, 2026 Does brain structure differ between women with PMDD and healthy controls? Cannot be answered. The provided abstract contains only background information and cuts off mid-sentence, with no results presented from this study. Study, 2026 Does evening primrose oil help teenage girls and young women with menstrual cycle problems? 86.79% had improvements. Girls with PMS reported better sleep and memory. Those with PCOS reported better mood and appearance. Survey study, 2026 Is there a good way to measure menstrual symptoms in teenage girls? Yes. Researchers developed a 12-item scale to measure menstrual symptoms in teenage girls. When different people used it to rate responses, they showed very strong agreement. Randomised trial, 2026 Does individualized nutrition therapy help women with PMS improve symptoms and health? This small exploratory study found improvements in PMS symptoms, mood, and other health measures. However, because there was no control group, we cannot be certain that nutrition therapy caused these improvements rather than other factors. Randomised trial, 2026 Does caffeine improve athletic performance differently at different times in the menstrual cycle? Caffeine (400 mg) improved alertness and reaction time across all menstrual cycle phases, but effects on muscle and power were less consistent and didn't clearly depend on cycle phase. This was a small pilot study in 12 trained women. Interview study, 2026 How does PMDD change how women feel about themselves in their relationships? This study interviewed 20 women with PMDD to understand how the condition affects their sense of self as partners, mothers, and friends. The abstract does not include what the researchers actually found. Survey study, 2026 How aware are female students of PMDD and how does it affect their schoolwork? Most female students have low awareness of PMDD and rarely discuss it with teachers. PMDD symptoms make it hard to concentrate in class. This was only a survey in Nigeria, so results may not apply elsewhere. Review, 2026 Do men experience premenstrual syndrome? No. Men do not experience PMS in the strict sense because PMS is defined in relation to the menstrual cycle, which men do not have. However, men may experience recurrent mood, energy, and behavior changes from different biological and social causes. Review, 2026 What causes PMDD? PMDD happens when the brain is too sensitive to hormonal changes during the menstrual cycle. Many brain systems are involved, but most of the mechanisms still need direct testing. Systematic review, 2026 What do we know about PMDD in autistic people and those with ADHD? Very little research exists on PMDD specifically in autistic people and those with ADHD. Early evidence suggests they may experience more severe symptoms and face barriers to diagnosis, but we cannot yet say for certain. Survey study, 2026 Should PMDD be recognized in Indian law as affecting criminal responsibility? The analysis concludes that PMDD should be legally recognized in India as affecting judgment and behavior. Modern medicine recognizes PMDD as serious, but Indian criminal law currently does not acknowledge it. Cohort study, 2026 Does estradiol level affect mood and how we relate to others during the menstrual cycle? Yes. Higher estradiol in the late follicular phase improved mood and self-esteem, while lower estradiol in the early follicular phase increased irritability. This small study of 23 women provides initial evidence, but more research is needed. Non-randomised trial, 2026 Does group counseling reduce PMS symptoms in school students? Yes. Group counseling significantly reduced PMS symptoms across all types (emotional, behavioral, thinking-related, physical) and functional problems. Quality of life improved substantially, and severe school interference dropped from 15.9% to 2.3%. Study, 2026 Does menstrual cycle phase affect how the brain reacts to heading a ball in female footballers? Menstrual cycle phase does not change how the physical force of heading affects the brain, but the brain's thinking ability does change across the menstrual cycle. This was a small proof-of-concept study. Survey study, 2026 Does a brain chemical relate to depression that worsens before periods in women with major depression? Yes, during the premenstrual phase. Women with worse depression had lower levels of GABA (a brain chemical) in a specific brain region, but only when tested just before their period. Review, 2026 What should doctors know about PMS and PMDD in teenagers? PMS and PMDD are common in teenagers and affect school, friendships, and mental health because the body is overly sensitive to normal hormone changes. SSRIs (antidepressants), birth control pills, exercise, therapy, and lifestyle changes can help, though most evidence comes from adult studies. Study, 2026 How does PMDD affect women's work and careers? PMDD causes major challenges at work. Women struggle with concentration, relationships with coworkers, and confidence during the two weeks before their period. They may continue working but do not perform at their usual level, affecting long-term career development. Review, 2026 What should doctors know about PMDD across gynecology and psychiatry? PMDD is a serious mood disorder linked to the menstrual cycle that requires care from both gynecology and psychiatry specialists working together. Case report, 2026 Does psychotherapy help with premenstrual increases in sexual desire and thoughts? Yes. Psychotherapy reduced sexual distress in three women with cyclical increases in sexual desire before menstruation. Survey study, 2026 How common is premenstrual tension and does it affect university students' studies? 65.2% had premenstrual symptoms and 8.1% met PMDD criteria. Those with symptoms had more difficulty concentrating, worse exam performance, and less participation in activities. Interview study, 2026 What do female employees and high school girls understand about PMDD? High school girls were more aware of PMDD than working women, though both groups understood roughly the same amount. Being more aware did not necessarily mean understanding the condition better. Randomised trial, 2026 How should PMS and PMDD be understood and treated differently based on how severe they are? PMS and PMDD are complex conditions needing personalized, stepped treatment. Start with lifestyle and behavioral changes, then add medication based on severity and individual response. Survey study, 2026 Do women with PMDD and PMS have worse attention and decision-making than healthy women? Yes. Women with PMDD show the poorest performance on attention and decision-making tasks, followed by women with PMS, then healthy women. The differences appear linked to how severe symptoms are. Cohort study, 2026 How do motivation and emotion control change across the menstrual cycle? This abstract describes a research study design but ends abruptly and provides no results, so no answer can be given. Survey study, 2025 Does PMS affect thinking ability, sleep quality, and attention in teenage girls? Yes. Teenage girls with PMS had lower scores on thinking tests, worse sleep quality, and a shorter Stroop effect duration than girls without PMS. Survey study, 2025 Does a mother's overprotection affect whether someone develops premenstrual disorder? Maternal overprotection was among the top factors the machine learning model identified as associated with moderate-to-severe PMS or PMDD. This suggests parenting style may play a role, but this is exploratory research that needs follow-up studies. Cohort study, 2025 Does worse PMS pain and concentration problems affect a woman's balance during her cycle? Yes. Women with more pain and concentration problems during menstruation had poorer balance. Women with worse overall symptoms before their period also had poorer balance, though the study was very small with no comparison group. Survey study, 2025 Are girls with ADHD or autism more likely to have severe PMS or PMDD? Yes, girls with ADHD were 2.43 times more likely to have moderate to severe PMS, and girls with both autism and ADHD were 3.27 times more likely. Girls with only autism did not show this link. Cohort study, 2025 Does working memory change during different phases of the menstrual cycle? Yes. Working memory for both visual and hearing tasks was significantly better during the secretory phase (days 21-25) than during the proliferative phase (days 10-14). Survey study, 2025 Does the menstrual cycle affect how women think of words? The menstrual cycle affects the thinking strategies women use to find words, especially in younger women, but does not clearly change how many words they produce. Survey study, 2025 What causes premenstrual syndrome and premenstrual dysphoric disorder, and how common are they? This review article explains the known biological, genetic and lifestyle factors behind premenstrual disorders rather than testing a treatment; it reports that any premenstrual disorder may affect up to 87% of women. Randomised trial, 2025 Does dark chocolate help exercise performance and muscle pain during the premenstrual phase? Dark chocolate significantly improved exercise performance and reduced muscle soreness during the premenstrual phase in female CrossFit athletes. The study was very small and limited to trained athletes, so results may not apply broadly. Randomised trial, 2025 Can combined therapy reduce emotional effects of PMS in teenage girls? Yes. Teenage girls who received 10 sessions of combined cognitive behavioral therapy and narrative therapy showed significant reductions in rumination and catastrophic thinking about pain. Improvements lasted at follow-up. Randomised trial, 2025 Does psychoeducation with psychodrama techniques reduce PMS symptoms? Yes. Women who participated in 7 sessions of psychoeducation and psychodrama had significantly lower PMS symptom scores, especially for depression, fatigue, irritability, and sleep problems. Survey study, 2025 Can a plant-based supplement reduce PMS symptoms? Yes, a multi-ingredient plant-based supplement taken daily for three months significantly reduced anger, irritability, mood problems, and other PMS symptoms in most women. Without a control group, some improvement might be due to placebo effect or natural changes over time. Survey study, 2025 Do hormone levels during the menstrual cycle affect visual memory? Hormone levels do not clearly affect how well women remember visual information. Age was more important than hormones. Study, 2025 Does taking more ADHD medication during the premenstrual week help women with ADHD? Yes. All 9 women with ADHD who took a higher medication dose during the premenstrual week experienced better focus, mood, and energy during those weeks. Lab study, 2025 Can genistein reduce anxiety in the premenstrual phase without raising estrogen? Yes. In rats, genistein reduced anxiety during the premenstrual phase as well as the hormone estradiol did, but without increasing estrogen levels in the blood. Survey study, 2025 What is the link between stress hormones, psychological distress, and resilience in women with PMDD and PMS? Women with PMDD have higher stress and anxiety than others. In the PMDD group, women with stronger resilience had lower levels of cortisol, the stress hormone, in their hair. Survey study, 2025 How do hormone changes during the menstrual cycle affect mood and emotions? Estrogen and progesterone affect brain chemicals and structures that control mood, but scientists still cannot fully explain why some women experience severe symptoms like PMS or PMDD. Survey study, 2025 Are women with ADHD more likely to have PMDD? Yes. Women with ADHD had PMDD at rates of 31.4% to 41.1%, compared to 9.8% without ADHD. We cannot be completely certain because this study relied on self-reported diagnoses. Survey study, 2025 Do hormone levels during the menstrual cycle affect sleep in female athletes? Hormone levels (estradiol and progesterone) themselves do not affect sleep. But having more menstrual symptoms was linked to worse sleep in naturally cycling athletes. Study, 2025 Could ginkgo biloba, soy, and other nutrients help hormone-related mood problems like PMS and PMDD? This paper presents a theoretical model suggesting ginkgo biloba, soy isoflavones, and supporting nutrients might together support hormone, blood vessel, and brain chemical balance in conditions such as PMS and PMDD. It is not a new study in women, so we cannot know how well it works. Survey study, 2025 How do hormonal changes affect ADHD symptoms in women? Hormonal changes significantly impact women with ADHD. Symptoms may get worse during certain parts of the menstrual cycle and after childbirth, often with mood and sleep problems. Case-control study, 2025 How does PMDD and PMS affect thinking skills across the menstrual cycle? Women with PMDD had larger changes in thinking skills between cycle phases than those with PMS. Language and abstract thinking improved during the follicular phase in all groups. Cohort study, 2025 Does migraine affect your ability to think clearly? Women with migraine performed as well as healthy women on a memory task, but their brains showed lower activity in a deep brain region after an attack. Results are from a small group, so we should be cautious. Survey study, 2025 How common are painful periods, PMS, and heavy bleeding in teenage girls in Sudan? Painful periods were most common at 56.8%, followed by PMS at 30.2% and heavy bleeding at 21%. However, these numbers come from Sudan only, so they may not apply elsewhere. Case report, 2025 How common are premenstrual symptoms in women during COVID-19 quarantine? In a survey of 109 Italian women in May 2020, 77% reported premenstrual symptoms and approximately 36.7% reported at least five symptoms including mood symptoms. Survey study, 2025 Does period pain affect memory and thinking? Yes. Women with period pain showed clear decreases in memory and thinking abilities on the worst day of their period and on day 3 of menstruation. Survey study, 2025 Is PMS linked to changes in eating behavior? Yes. Women with PMS had more uncontrolled eating and emotional eating compared to women without PMS. However, this only shows the behaviors go together, not that PMS causes them. Review, 2025 Can self-guided online therapy help premenstrual mood symptoms? A review suggests that self-guided online cognitive behavior therapy shows promise for premenstrual mood symptoms and could be integrated into menstrual tracking apps. However, more research is needed. Study, 2025 Could taking a combination of vitamins and minerals help with PMS and PMDD symptoms? This paper proposes a theoretical framework linking low or borderline vitamin and mineral intake to many health problems, including PMS and PMDD, but it is not a new study testing a supplement in women, so it cannot tell us how well any particular combination actually works. Case report, 2025 Can whey protein help premenstrual dysphoric disorder symptoms? In one case study, a woman with PMDD perceived substantial relief of her symptoms (approximately 80-95% improvement) when she took whey protein concentrate daily for 8 days before her period. Case-control study, 2025 How does PMS affect how women process emotions under stress? Women with PMS make more mistakes when trying to ignore emotional faces while completing a task. They also tend to focus more on internal body sensations when processing emotions, which may affect how they handle emotional information under stress. Survey study, 2024 How common is PMS among female students in Bangladesh and how does it affect daily life? Very common; 94% experienced PMS. It significantly disrupted academic concentration in 65.85% and caused difficulty with work and activities in 59.56%. Interview study, 2024 Do women with ADHD benefit from a group focused on the menstrual cycle? Women with ADHD who attended a group program focused on the menstrual cycle said it was helpful and made them more aware of their symptoms. We do not know if ADHD symptoms actually improved. Survey study, 2024 Can a smartphone app that teaches heart rate control help with premenstrual symptoms? Yes, people using the app for 4 weeks showed clear improvements in premenstrual symptoms, depression, and anxiety, while those who waited did not improve. Survey study, 2024 What premenstrual symptoms do martial arts athletes experience? Martial arts athletes experience both disturbing and non-disturbing PMS symptoms with regular 35-day menstrual cycles, and they have no significant difference in PMS compared to non-athletes. Survey study, 2024 How does the menstrual cycle affect ADHD symptoms in women? This paper proposes that estrogen drops during the cycle may worsen ADHD symptoms, but this theory is untested and so we cannot yet know if it is true. Non-randomised trial, 2024 Does caffeine improve cognitive function in women with PMS? No. Caffeine did not improve attention or working memory in women with PMS after they stopped consuming caffeine, regardless of how quickly they metabolize caffeine. Non-randomised trial, 2024 Does cognitive-behavioral or mindfulness stress management help reduce PMS in high school girls? The study compared cognitive-behavioral and mindfulness stress management for PMS in high school girls, but the results section of the abstract was not provided, so the effectiveness is unknown. Case report, 2024 Can maca, an herbal supplement, help with PCOS, PMS, dysmenorrhea, and hormone imbalances? In this one woman with PCOS, yes - after three months of taking maca, her PMS symptoms, dysmenorrhea, and hormone levels improved, and these improvements lasted over two years. But this is one person's story, so we can't be sure it works for others. Study, 2024 Does menstrual cycle phase affect how exercise changes stress hormones, energy use, or thinking ability? Menstrual cycle phase does not change how exercise affects thinking ability, but it does change how the body uses energy and stress hormones in response to exercise. This is a small study. Study, 2024 Does PMS affect how well women can think and concentrate? Yes. Women with PMS had difficulty concentrating in the week before their period. Having a baby did not change how women think long-term. Study, 2024 Can fluoxetine help someone with both bulimia and PMDD? In this one case, yes. A woman's binge and purge behaviors almost completely stopped after switching to fluoxetine, and her pre-menstrual mood and cognitive symptoms improved, though some mood symptoms continued. Survey study, 2024 Does PMS affect heart rate variability and attention? Yes. Women with higher PMS symptoms showed decreased heart rate variability and reduced attention performance during the premenstrual phase. The study was small and more research is needed. Survey study, 2024 Does a Chinese herbal medicine called ShuYu capsule help PMDD symptoms? In rats with PMDD-like symptoms, ShuYu capsules improved mood and reduced pain sensitivity. This is early animal research that hasn't been tested in women yet. Non-randomised trial, 2024 Does cognitive behavioral therapy help reduce PMDD symptoms in teenage girls? Yes. Adolescents with PMDD who received cognitive behavioral therapy showed significant symptom reduction compared to a no-treatment group. Survey study, 2024 Are PMS or PMDD linked to different features of bipolar disorder in women? Yes. Women with bipolar disorder and PMS or PMDD became ill at younger ages, had worse depression symptoms with more anxiety and thinking problems, and were more likely to have OCD or family history of mental illness. This is observational, so we cannot prove cause and effect. Lab study, 2024 Can the natural compound rutin help with depression from PMDD? In laboratory studies with rats, rutin reduced depression symptoms, improved memory, and reduced brain cell damage. It is unknown whether rutin would help women with PMDD because this was not tested in people. Survey study, 2023 Are there differences in brain activity and structure between women with PMS and without? Yes. Women with PMS showed different brain activity and lower gray matter volume in regions related to emotion, thinking, and movement. This doesn't prove what causes the differences. Survey study, 2023 Do women with PMDD have problems with attention and impulse control during the luteal phase? Yes. Women with PMDD show worse attention and weaker impulse control during the luteal phase, with problems getting worse in the late luteal phase right before their period. These problems are linked to impulsivity. Survey study, 2023 Does reaction time change during the menstrual cycle? Reaction time was slower during the luteal phase compared to other cycle phases, but the difference was very small and not clearly seen. Survey study, 2023 Do women with PMS have slower reaction times and mood changes than others? Women with PMS had slower reaction times and higher anxiety, depression, and stress levels. As PMS severity increased, these effects worsened. Interview study, 2023 Are women overestimating their PMDD symptoms or do they actually have PMDD? Women significantly overestimate PMDD. When women self-assessed their symptoms, 51.76% thought they had PMDD, but when clinically evaluated by a doctor, only 5.88% actually met the clinical criteria for PMDD. Survey study, 2023 Do personality traits and hormone changes affect how well women recognize emotions? Women who score high in neuroticism recognized emotions less well when progesterone was high. Personality traits did not significantly affect emotion recognition across different cycle phases. Study, 2023 Does the hormone LH affect whether young women get PMS? Young women with PMS had different LH hormone levels compared to those without PMS, showing a link between this hormone and PMS. LH levels also differed between mild and severe PMS. Study, 2023 How do stress and menstrual cycle phase affect memory and brain activity? Stress reduced memory performance in all cycle phases. Memory was somewhat better protected in the late follicular phase than in the early follicular and luteal phases. Survey study, 2023 Does pelvic alignment exercise help with period pain and PMS symptoms? Yes, for some symptoms. The exercise program reduced period pain and improved mood-related PMS symptoms, and also improved pelvic positioning. Randomised trial, 2023 What does research show about PMDD neurochemistry? The provided text does not include results from a PMDD neurochemistry study. It discusses unrelated research on other topics. Survey study, 2023 What causes PMS and how is it treated? PMS is caused by hormone changes during the menstrual cycle, combined with stress and changes in brain chemistry. Main medical treatments are SSRIs (antidepressants) and hormonal pills, but lifestyle changes, therapy, and surgery also help. Survey study, 2023 How common are PMS and PMDD among college girls, and what are their symptoms? Among 318 college students in India, 44 had PMDD and 89 had PMS. Symptoms differed, with PMDD including more severe mood changes like anger, tearfulness, and anxiety than PMS. Case report, 2023 Should doctors check whether mood symptoms are linked to the menstrual cycle before treating them? This paper says yes. It argues doctors treating women of childbearing age for mood symptoms should always consider whether the menstrual cycle plays a role, using one woman's case as an example. Randomised trial, 2023 Does a smartphone app for heart rate variability biofeedback reduce premenstrual and depressive symptoms? Yes, the app reduced premenstrual, depressive, and stress symptoms over 4 weeks. However, it did not change the underlying heart rate patterns it was designed to improve. Survey study, 2023 Does psychological capital and marital satisfaction help women with PMS manage their emotions better? Yes. Women with stronger psychological capital (more hope and confidence) managed their emotions better, and this connection worked both directly and through marital satisfaction. Randomised trial, 2023 Does cognitive-behavioral counseling help adolescent girls with PMS build resilience? The abstract does not provide the study results, so we cannot tell if the counseling helped. Randomised trial, 2023 Does cognitive-behavioral hypnotherapy help women with severe PMS control anger and distress? Yes. In 30 women with severe PMS, those who received cognitive-behavioral hypnotherapy showed significant improvements in distress tolerance and aggression after treatment and at 3-month follow-up. However this is a very small study so results are preliminary. Survey study, 2023 Does taking hormone contraceptives change how well women remember or think in 3D? Women taking hormone contraceptives were better at remembering objects than naturally cycling women. There was no difference in 3D spatial thinking between the groups. Survey study, 2023 Is low vitamin D linked to depression and irregular periods in women with premenstrual syndrome? Yes. Among 250 women with PMS, 61.2% had vitamin D deficiency. Those with deficiency were much more likely to have depression, with 28.8% having severe depression. The link was statistically strong (P=0.001). Review, 2023 Could orexin be a new treatment for PMS symptoms? This review suggests orexin, a brain chemical, might help treat PMS by addressing sleep problems, mood changes, and thinking difficulties. Current medications like SSRIs don't work well for everyone, making new treatment targets important. Review, 2022 What causes PMDD and what are the best treatments? PMDD is caused by hormonal changes in estrogen and progesterone that lower serotonin levels. Antidepressants called SSRIs are the most effective treatment, working faster for PMDD than for depression, and women don't necessarily need to take them daily. Survey study, 2022 What factors affect premenstrual syndrome in teenage girls? Diet and physical activity were connected with having PMS, but age at first period was not. This was a very small study in one location, so results may not apply to other girls. Survey study, 2022 Which premenstrual symptoms are linked to the personality trait neuroticism? Only difficulty concentrating and loss of interest were significantly associated with neuroticism. Mood symptoms like depression, anxiety, anger, and mood swings were not significantly associated. Case-control study, 2022 Do women with PMS show different brain activity when viewing sad images compared to women without PMS? Yes, a clear difference. Women with PMS showed stronger activation in visual processing and cerebellum areas but weaker activation in emotion regulation and decision-making areas compared to controls. Study, 2022 Do pain and thinking use the same brain regions, and does this change across the menstrual cycle? Pain and cognitive tasks activate overlapping brain regions. The interaction between these two does not change across different cycle phases. Case-control study, 2022 Does cognitive function decline in women with PMS, and can brain imaging detect it? Women with PMS showed significantly lower correct responses on harder cognitive tasks and reduced brain activation during the luteal phase compared to women without PMS, which could be detected with brain imaging. The decline was linked to worsening mood. Survey study, 2022 What are the differences in mood between PMDD, PMS, and no or mild PMS? Women with PMDD had significantly higher anxiety and depression than those with PMS or no/mild PMS. This is a cross-sectional study, so it shows differences but cannot prove what causes them. Survey study, 2022 Is reduced thinking ability linked to nervous system changes in women with PMS? Yes. Women with PMS showed increased activity in the part of the nervous system that speeds up the heart and body, and had reduced thinking and memory ability compared to women without PMS. Randomised trial, 2022 Does cognitive-behavioral hypnotherapy reduce menstrual pain in women with severe PMS? Yes. In 24 women with menstrual pain and severe PMS, those who received 8 sessions of cognitive-behavioral hypnotherapy showed significant improvements in pain intensity and quality of life. This is a very small study so results are preliminary. Survey study, 2022 Do women with high PMS symptoms pay attention differently to emotional images? Women with high PMS symptoms showed different attention patterns. They looked more at negative images initially and had trouble looking away from them, while women with low PMS symptoms did not show these patterns. Survey study, 2022 Are there differences in brain structure in women with PMDD? Yes, women with PMDD show differences in brain structure in emotion-related regions. Smaller brain volume was found in the amygdala, and symptom severity correlated with changes in brain surface thickness and shape. Survey study, 2022 How do female elite athletes cope with premenstrual symptoms? Strategies that help include being aware of symptoms, practicing self-care, and communicating with others. Strategies that don't help include trying to avoid harm and adjusting energy. Premenstrual symptoms reduced physical ability and well-being. Study, 2022 Can changes in emotion recognition predict PMDD risk? Yes. Women who showed changes in how they recognized emotions at different cycle phases were more likely to have PMDD. Of 16 women with emotion recognition changes, 7 had PMDD. Of 22 women without emotion changes, only 2 had PMDD. Non-randomised trial, 2022 Can a simple taste test identify women with ADHD and severe PMS? A simple taste test showed women with both ADHD and severe PMS (PMDD) did not respond to lidocaine as expected. This might point to a physical difference in how their nerve cells work. Review, 2022 Can melatonin help with premenstrual syndrome symptoms? Melatonin appears safe and might help with PMS symptoms like sleep problems and low mood, but researchers say more rigorous studies are needed before it can be recommended. Survey study, 2022 Do autistic women experience more PMDD and worse menopausal symptoms than non-autistic women? Autistic women did not have more PMDD than non-autistic women (14.3% vs 9.5%), but they reported worse menopausal symptoms linked to depression. Review, 2022 Can blocking a natural brain steroid help PMDD? Maybe. An early study showed that blocking a steroid called allopregnanolone improved negative mood in women with PMDD compared with placebo, but more research is needed. Survey study, 2022 How common is PMS in university students and what helps them cope with symptoms? PMS was very common in this group. Most students coped by resting (67.6%) or sleeping (60.7%). Several menstrual and personal factors were linked to higher PMS risk, including family history, heavy periods, and starting menstruation early. Interview study, 2022 Can a smile-recognition smart mirror help women with PMS feel better? In a small 10-day study, 4 women with PMS used the mirror and reported that smiling prompted positive emotions and reduced the anger and depression related to their PMS. Study, 2022 Is there higher DNA damage from oxidative stress before your period if you have PMS or PMDD? Yes. Women with moderate-to-severe PMS or PMDD showed higher DNA damage markers before their period than after, and had higher levels compared to women without or with mild PMS symptoms. Survey study, 2021 Do ovarian hormones affect how worry impacts working memory? Yes. Higher worry was linked to worse working memory performance, especially when estradiol or progesterone levels were high. Survey study, 2021 Is aerobic exercise performance worse during the luteal phase compared to the follicular phase? Yes. Women completed a cycling time trial more slowly and reported higher fatigue during the luteal phase compared to the follicular phase. Survey study, 2021 Does the menstrual cycle or birth control affect sleep and memory? All women improved their memory overnight. Women on birth control and in the luteal phase had more of a certain type of sleep brain wave compared to women in the follicular phase, and this brain wave was linked to higher progesterone levels. Survey study, 2021 Does moderate physical activity during menstruation reduce PMS symptoms? Women who stay moderately active throughout their menstrual cycle, including during menstruation, have fewer PMS symptoms than inactive women. Activity does not affect cycle regularity, how long you bleed, or menstrual pain. Survey study, 2021 Are carotenoids linked to less severe premenstrual symptoms? Only one carotenoid showed a link. Higher beta-cryptoxanthin was linked to more appetite as a symptom, not less. No other carotenoids were linked to any symptoms. Survey study, 2021 Do women with PMS have real trouble with focus and memory, or just feel like they do? Women with PMS report problems with focus, memory, and organization, and these self-reported problems are strongly linked to PMS symptoms. However, when tested on actual focus and memory tasks, they do not perform noticeably worse. Systematic review, 2021 Are women with PMDD more likely to think about or attempt suicide? Yes. This review found that suicidal thoughts, plans and attempts were strongly linked to PMDD, even when other mental health conditions were taken into account. Survey study, 2021 Do PMS and PMDD affect attention and short-term memory in teenage girls? Yes, somewhat. Teenage girls with PMS/PMDD did worse on a test of attention and interference control than girls without it, and their performance dropped further in the luteal (premenstrual) phase. Study, 2021 Does the point in the menstrual cycle change mood, anxiety and exercise performance in active women? It made a small difference to aerobic fitness and to how exercise affected depression, but most other measures of mood, anxiety and performance did not clearly differ between cycle phases. Case report, 2020 Does Ayurvedic medicine help women with PMS? One 18-year-old woman with PMS was treated with Ayurvedic herbs and lifestyle advice for 15 days. Survey study, 2020 Does the menstrual cycle affect thinking, memory, or concentration, especially in women with PMS or PMDD? Research has produced mixed results with no clear consistent findings. It remains unclear whether any cognitive changes come from hormonal changes or from mood and psychological symptoms of PMS and PMDD. Survey study, 2020 Is a gene that controls how the body responds to estrogen linked to PMS? Possibly. A particular version of the estrogen receptor gene (ESR1) was more common in women with severe PMS, and it was linked to a bigger rise in estradiol before their period, but the study was small. Survey study, 2020 Do past trauma and emotions predict PMS severity? Yes. How women cope emotionally, particularly catastrophizing (assuming the worst), predicted about one-third of PMS severity. Past trauma involving life threat also predicted about one-third of PMS severity. Randomised trial, 2020 Does hormone change across the menstrual cycle affect how a woman's voice sounds? Yes. Hormone changes across the menstrual cycle affect the pitch and qualities of the voice. Oral contraceptive pills appear to stabilize these changes. Survey study, 2020 Do women with IBS and period problems have worse psychological symptoms? Yes. Women with IBS alongside period pain and PMS show more depression, sleep problems, and worse quality of life than those without IBS. Case report, 2020 How do psychotic symptoms connected to the menstrual cycle look in different parts of the world? In a study of 4 women in Oman with menstrual psychosis, all had psychotic and mood symptoms timed to their menstrual cycle. All had normal intelligence but had problems with thinking speed, memory, and planning skills. Interview study, 2019 Do spiny mice show behavioral changes before menstruation? This is the first study showing that female spiny mice have behavioral changes similar to PMS. However, the findings are only in mice, not humans, so we cannot be sure the same mechanisms apply to people. Lab study, 2019 Does menstrual cycle phase affect how women look at emotional images? During the luteal phase, women's eyes were drawn to important parts of emotional images faster than during the follicular phase. Women in the luteal phase also looked away from disgusting images sooner, suggesting heightened disgust sensitivity. Case-control study, 2019 Does PMS affect a woman's ability to concentrate and think clearly? Women with PMS performed just as accurately as women without PMS on thinking and attention tasks during all phases of their cycle. Women with PMS worked more slowly on one task but made no more mistakes. Review, 2019 What causes PMDD and which treatments actually help? This review explains that PMDD likely comes from an unusual brain response to normal hormone changes, involving serotonin and a brain receptor called GABA-A, and it says serotonin reuptake inhibitors (SSRIs) are the first choice of treatment, with other options available if those do not work. Case-control study, 2019 Does inflammation affect mood in women with PMS? In female soccer players, those with PMS had higher levels of inflammatory markers and reported more depression and tension at certain cycle phases compared to those without PMS. Study, 2019 Does brain activity at rest change across the menstrual cycle in women? Yes. In women, brain activity in thinking and planning areas changed across menstrual cycle phases, while this activity stayed stable in men across testing sessions. Brain activity in hearing areas stayed stable in both. Study, 2019 Does the brain work differently at different points in the menstrual cycle? Yes, brain activity patterns shift across the menstrual cycle even though task performance stays the same. Estradiol seems to boost activity in a memory-related brain area before ovulation, while progesterone boosts activity in planning-related areas in the second half of the cycle. Non-randomised trial, 2019 Does cinnamon and ginger combined with exercise help reduce PMS and period pain symptoms? The provided abstract does not include the results section, so this study cannot be properly summarized. Survey study, 2018 Does stress and thinking ability change during different phases of the menstrual cycle? Stress was higher in the premenstrual phase and thinking ability was lower in the premenstrual phase compared to the proliferative phase, but these differences were not statistically significant and may have happened by chance. Survey study, 2018 How aware are men of what PMS is and how it affects their partners? This abstract only describes the background and purpose of the study; it does not give the actual results on men's awareness, attitude, or behavior regarding PMS. Case-control study, 2018 Is the stress response system overactive in women with premenstrual syndrome? No. Women with PMS actually had lower stress hormone levels and less stress response activity than women without PMS during the late phase of the menstrual cycle. Randomised trial, 2018 Does cognitive-behavioral therapy or relaxation work better for PMS? Both cognitive-behavioral therapy and relaxation reduced PMS symptoms, but relaxation was more effective. Survey study, 2018 How does sleep quality affect thinking and physical coordination in women with PMS? As PMS severity increases, sleep quality worsens and reaction time becomes slower, suggesting worse thinking and coordination. Women with moderate PMS showed the most significant problems. Randomised trial, 2018 How do progesterone metabolites affect PMDD symptoms? Women with PMDD respond differently to these natural brain chemicals. Blocking one type may reduce negative mood symptoms, but this summary is incomplete. Survey study, 2018 Do difficulties handling emotions affect premenstrual symptom severity? Yes. Women who act impulsively when upset had worse premenstrual symptoms. Women who ruminate (think repetitively about problems) had symptoms that increased faster before their period and improved more slowly afterward. Non-randomised trial, 2018 Does estradiol hormone level affect how the brain responds to sexual content? Higher estradiol during fertile phases may make the brain more responsive to erotic words, but this very small study cannot confirm this effect. Lab study, 2018 Does ovarian cycle stage affect Alzheimer's disease features in female mice? During estrogen-dominant stages of the cycle, female mice with Alzheimer's features showed worse cognitive problems and brain network dysfunction. During progesterone-dominant stages and after ovary removal, the Alzheimer's features improved. Survey study, 2018 Does exercise change how the brain responds to sad emotions in women with severe PMS? Yes, in women with more severe PMS only. A single aerobic exercise session caused measurable changes in brain wave activity when viewing sad faces, especially in areas that process emotions. Case-control study, 2018 How does progesterone affect metabolism differently in women with PMDD? Progesterone reduces amino acid levels in the blood, and this reduction appears to be different in women with PMDD compared to controls. However, the sample is very small and findings are preliminary. Study, 2018 Do depressed adolescents respond differently to angry faces than non-depressed adolescents? Yes. Depressed adolescents found it harder to ignore angry faces compared to non-depressed adolescents. Happy faces did not create this difference in either group. Survey study, 2018 Does cognitive behavioral therapy with calcium and vitamin D help PMS symptoms? Yes, women who received cognitive behavioral therapy with calcium and vitamin D showed significant improvements in PMS symptoms compared to those who did not receive treatment. Interview study, 2017 What is the experience of living with PMDD and how well do doctors understand it? Women with PMDD reported severe suffering including suicidal thoughts and felt misunderstood by both doctors and family members. Case report, 2017 Does Ayurvedic medicine help PMS? Yes. One 18-year-old woman's mood swings, irritability, and concentration problems were completely relieved after one month of Ayurvedic herbs and weekly therapy sessions. Cohort study, 2017 Why does asthma worsen at certain times of the menstrual cycle? Women with perimenstrual asthma have higher airway sensitivity and allergic-type immune markers that increase during the luteal phase, which may explain worsening asthma. Survey study, 2017 Does cognitive-behavioral therapy or cognitive hypnosis help reduce depression in students with PMS? Both therapies reduced depression in students with PMS. Cognitive-behavioral therapy and cognitive hypnosis worked about equally well. Survey study, 2017 Are prolactin and beta-arrestin1 different in PMDD versus PMS? In women with PMDD and depression, beta-arrestin1 protein was reduced and prolactin was increased compared to those with PMS. These two changes were correlated. This is a tiny study and much more research is needed. Non-randomised trial, 2017 Does self-foot reflexology help reduce PMS symptoms? Yes, self-foot reflexology significantly reduced pain, concentration problems, mood changes, and other PMS symptoms. Improvements continued after treatment ended. Cohort study, 2017 Is acceptance therapy (ACT) more effective than other treatments for PMS? Yes, for stress. ACT reduced emotional PMS symptoms and perceived stress more than cognitive behavioral therapy or no treatment, with stress improvements lasting at follow-up. Study, 2017 Do women with PMDD experience emotions differently than other women? Only women with PMDD showed important changes in how they experienced unpleasant emotions and anxiety. The ability to recognize emotions in faces also depended on whether the face was male or female. Interview study, 2017 What is it like to live with PMDD and how do you experience healthcare? Women with PMDD reported severe suffering including suicidal thoughts and inability to do daily tasks premenstrually. Most felt misunderstood by family and healthcare providers, and many waited a long time for diagnosis. Case-control study, 2017 Do hormones and inflammation change during the menstrual cycle in women whose asthma worsens during periods? Yes. During the second half of the cycle, women with asthma that worsens around their period had higher estradiol levels in the blood, a higher estradiol-to-progesterone ratio, and higher inflammation markers in fluid from the lungs. Study, 2017 Do women with moderate to severe PMS have problems with attention and memory? Yes. Women with moderate to severe PMS made more mistakes and had lower accuracy on attention and memory tests even though tests were done when they didn't have symptoms. Case-control study, 2017 Do women with PMS recognize facial emotions differently depending on their menstrual cycle? Women with PMS struggle more to recognize sad and surprised faces during the luteal phase. However, women without PMS also had trouble recognizing sad faces then, so this pattern is not unique to PMS. Survey study, 2017 Does your menstrual phase affect how well you remember things after sleep? Women remembered faces and names better than men before a nap. After the nap, women forgot more during their period week than during other times of their cycle. Survey study, 2017 Does your menstrual cycle change how you recognize emotions on faces? Yes. In the late luteal phase before your period, women react more slowly to all emotional faces and show less brain response to happy faces. Survey study, 2017 Can women in the midluteal phase suppress their response to negative emotions as well as men? No. Women in the midluteal phase showed greater difficulty suppressing brain responses to negative emotions compared to men, and also reported more distress and effort when trying to suppress their responses. Survey study, 2016 How common are PMS and PMDD among women in Myanmar? 37.3% of the women met criteria for PMS, and 54.4% of those had PMDD. The study included only women in medicine, so these numbers may not represent all women. Case-control study, 2016 Is low zinc or low antioxidant levels connected to PMS? Yes. Women with PMS had lower zinc and antioxidant levels in their blood than healthy women, and these levels were linked to how severe their symptoms were. Non-randomised trial, 2016 Does group cognitive-behavioral therapy help reduce PMS symptoms? Yes, women who attended 8 sessions of therapy had significant improvements in psychological symptoms and less social problems from PMS (p=0.012). Cohort study, 2016 Does genetic variation affect how women process emotions at different cycle phases? Yes. Women with certain gene variants showed different emotional responses depending on cycle phase and oral contraceptive use, though results varied by which variant they had. Survey study, 2016 How common is PMS in female health science students and how does it affect their academic and social life? PMS affected 17.5% of students. Among those with PMS, 78.6% had concentration problems, 90.5% stopped studying, and most had poor social interactions. Survey study, 2015 Does the ability to recognize emotions in faces change with menstrual cycle hormones? No clear difference in overall emotion recognition across menstrual cycle phases was found. However, estradiol levels were specifically linked to better disgust recognition, and progesterone levels were linked to slower responses to facial expressions in general. Cohort study, 2015 Is there a measurable body stress marker linked to PMS? Yes, women with PMS had lower levels of a saliva immune marker (S-IgA) after their period and higher stress scores than women without PMS, but their cortisol levels were no different, suggesting S-IgA may track PMS-related stress better than cortisol does. Cohort study, 2015 Does muscle strength change during the menstrual cycle in female athletes? Yes, in this very small study. Muscle strength declined during the premenstrual week in 10 young athletes, though mood didn't change. Survey study, 2015 Do blood glucose levels change across the menstrual cycle? Blood glucose levels were significantly different between the follicular and luteal phases, though the abstract does not provide the specific values or describe differences between women with PMS and healthy controls. Survey study, 2015 Does a brain chemical involved in mood change during the menstrual cycle? In women with natural cycles, GABA (a calming brain chemical) increased at ovulation. In women on hormonal contraceptives, GABA levels did not change between pill phases. GABA levels were not linked to premenstrual symptom severity. Case-control study, 2015 Do women with PMS focus more on themselves when stressed? Women with PMS and PMDD report using more self-focused attention when stressed, even when their level of negative emotion is similar to women without PMS. This inward focus may increase their distress during the menstrual cycle. Survey study, 2015 Does sweet taste preference change with depression during the menstrual cycle? In women during their luteal phase, those with higher depression symptoms needed more sugar to taste sweetness. This connection happened only in the luteal phase, not at other times. Case-control study, 2015 Does yoga help attention and mental state in women with PMS? Possibly yes, according to this very small study. Women with PMS showed more relaxed brain patterns and better attention performance immediately after yoga, especially in the luteal phase (before their period). Case-control study, 2015 Are vitamin D, calcium, and magnesium linked to PMS? Lower calcium and magnesium levels were linked to having PMS. Vitamin D was also low in both groups, and more than one-third of women with PMS were deficient in magnesium. Interview study, 2015 Does childhood sexual abuse affect hormone levels and premenstrual symptoms? Women with menstrually-related mood disorders who experienced childhood sexual abuse had higher oxytocin levels than those without this history. In women with abuse history, higher oxytocin was linked with fewer premenstrual symptoms. Survey study, 2014 Does allopregnanolone, a progesterone metabolite, cause mood problems in PMDD? Theory suggests it might. In women with PMDD, allopregnanolone levels increase during the menstrual cycle and appear linked to mood changes. Paradoxically, this brain chemical normally calms the brain. Cohort study, 2014 Do sex hormones affect women's cognitive functions across the menstrual cycle? No. Changes in estrogen and progesterone did not affect memory, learning, or thinking abilities. Cognitive performance remained stable across the cycle. Study, 2014 Does soy extract containing isoflavones help with premenstrual symptoms? Soy isoflavone supplements improved some symptoms during menstruation but made mood symptoms worse during the luteal phase. Different treatments may work better at different times of the cycle. Survey study, 2014 Do brain wave patterns change at different times of the menstrual cycle? Yes, brain wave patterns changed significantly across the menstrual cycle. The luteal phase (second half) showed the strongest overall brain wave activity, while the follicular phase (first half) showed a different type of brain activation. Survey study, 2014 Do brain wave patterns change at different times of the menstrual cycle? Yes, brain wave patterns changed significantly across the menstrual cycle. The luteal phase (second half) showed the strongest overall brain wave activity, while the follicular phase (first half) showed a different type of brain activation. Survey study, 2014 Does how women pay attention to space change during the menstrual cycle? Slight changes were found in some attention tasks during different cycle phases, but the menstrual cycle affected performance less than biological sex did. Brain stimulation did not improve women's attention performance. Case-control study, 2014 Are appetite-regulating hormones ghrelin and leptin different in women with PMS? Leptin levels were higher in women with PMS before their period, but ghrelin showed no difference. The meaning is unclear because these hormones normally work together to control hunger. Lab study, 2014 How do changes in brain chemistry during the menstrual cycle affect memory and thinking? In mice, certain brain receptors change levels during the ovarian cycle, affecting brain wave patterns in a way that may explain memory and thinking problems in women with PMS or PMDD. Study, 2014 Does brain activity at rest change during different phases of the menstrual cycle? No. Women's resting brain activity did not change across menstrual cycle phases in this study. Brain differences between men and women appear to be permanent structural differences rather than changes caused by hormone fluctuations. Survey study, 2014 Does a genetic difference in the serotonin system make thinking and memory problems worse in PMDD? Yes. Women with PMDD who carry the G/G genotype of a serotonin gene (HTR1A rs6295) showed greater decline in working memory and cognitive control before their period. Cohort study, 2013 Are brain abnormalities in PMDD related to how severe the condition is? Yes, women with PMDD show abnormal activation in a thinking and emotion brain region, and the degree of abnormality correlated with how severe their symptoms and disability were. Survey study, 2013 Does smoking behavior change across the menstrual cycle and is it linked to mood and period symptoms? Yes. Young women smokers smoked more cigarettes and had stronger cravings during the luteal phase (second half of the cycle). Smoking was linked to higher depression and menstrual symptoms, but the study cannot prove smoking causes these or vice versa. Survey study, 2013 Do women with PMS have different blood sugar and insulin levels than healthy women? Yes, women with PMS had significantly lower blood glucose and lower insulin resistance during both menstrual phases compared to healthy women, but this was a small study with unclear practical importance. Survey study, 2013 How does emotional tension and thinking ability change across the menstrual cycle? Emotional tension is lowest and thinking ability is highest during the luteal phase. This is connected to progesterone levels. Survey study, 2013 Does the menstrual cycle change how the brain responds to emotional faces? Yes, brain electrical activity in response to emotional faces is stronger during ovulation than during the premenstrual phase, suggesting hormone changes affect emotional processing. Case-control study, 2013 How does the menstrual cycle affect processing emotions and thinking in women with and without PMS? All women took longer to resolve conflicts between emotions and thinking during the luteal phase. Only women with PMS showed increased stress levels during the luteal phase, suggesting an additional stress response. Randomised trial, 2013 Does the menstrual cycle affect cortisol (stress hormone) levels? No. The menstrual cycle phase does not affect cortisol levels. However, birth control pills are associated with higher resting cortisol levels and a weaker stress response. Survey study, 2013 Are premenstrual symptoms linked to how women experience their body? Yes. Women with premenstrual symptoms tend to focus more on physical sensations in their body, and this may contribute to how severe their symptoms become. Survey study, 2013 Does a bitter taste receptor gene affect PMS risk? This is the first study to link the TAS2R38 bitter taste gene to PMS. Women with higher sensitivity to bitter taste had more PMS symptoms, but the evidence is limited because this is a small study in one community. Lab study, 2013 Could antidepressants help prevent PMS by keeping brain chemicals stable? This is a theory based on how antidepressants work and animal research, but it has not yet been tested in women. Survey study, 2013 Do stress-sensitive women respond to stress differently across the menstrual cycle? Women with high stress sensitivity show stronger stress responses during menstruation than women with low stress sensitivity, but not at other cycle phases. Study, 2012 Does thinking ability change during the menstrual cycle? Seventy young women showed better thinking ability during the postmenstrual phase than during the premenstrual phase. There was no evidence of thinking problems in either phase. Case-control study, 2012 Do PMDD and generalized anxiety disorder affect memory and thinking in the same way during the cycle? No. In this study, women with generalized anxiety disorder had worse memory, attention and psychomotor function in the late luteal phase than women with PMDD, and both groups did worse than healthy women. Study, 2012 Does breathing pattern change during the menstrual cycle in women with PMS? Yes. During the luteal phase (the second half of the cycle, before the period), women with PMS had faster breathing and heart rate and lower carbon dioxide levels than during other phases of their cycle. Randomised trial, 2012 Does alcohol affect brain activity and thinking differently at different times in the menstrual cycle? Yes, alcohol had a stronger harmful effect on thinking during the follicular phase (first part of cycle) when progesterone is low. This was shown through brain wave patterns. Study, 2012 Does mugwort help with premenstrual syndrome? Mugwort is used traditionally for PMS and contains a compound that may work through serotonin. However, there is no clinical research evidence presented here, only historical uses. Non-randomised trial, 2012 Does brain activity during response inhibition differ in women with PMDD? Yes. Women with PMDD showed reduced activity in brain areas involved in attention and movement control compared to healthy women, and the insula showed different activation patterns across menstrual cycle phases. Study, 2012 How do thinking abilities change during the menstrual cycle? Women performed best on mental rotation tasks during menstrual and early follicular phases (low hormone times), best on word fluency during menstrual and mid-luteal phases. Anxiety and masculine/feminine feelings stayed the same. Survey study, 2011 Do overweight or obese women have worse PMS than normal weight women? Yes. Overweight and obese women reported significantly more pain and mood-related PMS symptoms compared to normal weight women. Survey study, 2011 Does quitting caffeine cause different withdrawal symptoms in different menstrual cycle phases? Caffeine withdrawal caused some symptoms in both phases, but the pattern was similar. Menstrual cycle phase did not change the severity of withdrawal symptoms or thinking and motor performance. Survey study, 2011 Does the menstrual cycle affect a chimpanzee's ability to do cognitive tasks? Yes. During the hormone surge at ovulation, the chimpanzee's accuracy decreased and she took longer to complete tasks, but only on difficult tasks that required attention and memory. Study, 2011 Does how your brain works on spatial tasks change during your menstrual cycle? Yes. Brain activity during a shape-matching task shifted across menstrual cycle phases, showing changes in how the brain's two sides coordinate during this task. Survey study, 2011 Are girls in Egypt exposed to chemicals from plastic food storage? Girls in Egypt, especially in cities, had chemical exposures similar to girls in the US. The study suggests this is likely from food stored in plastic containers. Study, 2011 Does your menstrual cycle affect how often you have unwanted memories of emotional events? Yes. Women in the luteal phase reported significantly more unwanted memories of emotional films than women in the follicular phase, and the number of memories correlated with progesterone levels. Survey study, 2011 Why do some women experience negative mood with hormone changes? The paper proposes that negative mood in PMDD may result from how a brain chemical reacts to receptors. This is a theoretical explanation based on research patterns, not a definitive finding from a new study. Cohort study, 2010 How do anxiety disorders differ across different life stages? The provided summary focuses on anxiety in children and risk factors. The section about women and hormones is cut off in the provided text, so no conclusion about menstrual-related anxiety can be drawn. Survey study, 2010 Is lower blood serotonin linked to worse mood before menstruation? Yes, women with lower blood serotonin during the premenstrual phase had worse tension, anxiety, and fatigue. However, the study is very small and only looked at healthy women, so results may not apply to women with PMS or PMDD. Survey study, 2010 How common is period pain in adolescent Asian girls and what does it affect? Three-quarters of adolescent girls in Malaysia had period pain. It affected their concentration in class for over half, limited their social activities for half, caused about one in five to miss school, and caused poor school performance in one in eight. Survey study, 2010 Does sexual interest change across the cycle and what role do pain, sleep and hormones play? Overall sexual interest does not change across the cycle, but women not using oral contraceptives show a slight mid-cycle increase in attraction while those using them report greater overall attraction. Pain and sleep disturbances peak during menstruation. Randomised trial, 2009 Does a hormone called allopregnanolone calm the body's startle reaction in PMDD? No. Giving this hormone by injection made women feel more sedated but did not change their physical startle response, in either women with PMDD or healthy women. Systematic review, 2009 Does cognitive-behavioral therapy help PMS or PMDD? There is not enough good evidence that cognitive-behavioral therapy works for PMS or PMDD at this time. Lab study, 2009 Does the menstrual cycle affect how well women recognize emotions on people's faces? Yes. Women in the low-hormone early follicular phase recognize angry, sad, and fearful faces better than women in other menstrual phases or men. Higher estrogen levels are linked to lower accuracy recognizing angry faces. Randomised trial, 2009 Does the menstrual cycle phase affect how well you do memory tasks? No, memory task performance was equally good in all cycle phases. However, the luteal phase involved higher mental stress, and the menstruation phase had more complaints. Study, 2009 Does the menstrual cycle phase affect how well women can focus and remember things? The menstrual cycle affects how well women focus but not memory. Lower estradiol levels seem to reduce your ability to focus. Study, 2009 Does your body handle mental stress differently depending on your menstrual cycle phase? No. The study found no clear differences in how the cardiovascular system or blood responded to mental stress between the follicular and luteal phases. Study, 2009 What causes PMDD? PMDD is caused by multiple problems in how the brain and body handle hormones and brain chemicals, not by hormone levels being too high or low. It involves changes in serotonin, GABA, how the brain responds to estrogen, and possibly genetics. Survey study, 2009 Why do some women feel depressed or anxious when progesterone increases before their period? A literature review suggests progesterone is converted to chemicals that affect the brain's GABA system. At levels before the period, these chemicals paradoxically cause anxiety instead of calming it. Women with PMDD have changes in their GABA system that make them more sensitive. Review, 2008 How does the menstrual cycle affect thinking, mood, and sensation? Hormones that change during the menstrual cycle directly affect thinking, mood, sensation, appetite, and other brain functions. Evidence shows PMS is a real biological condition, likely involving the immune system. Survey study, 2008 Does eating lower glycemic index carbohydrates help reduce PMS symptoms? Yes. Lower glycemic index diet was associated with fewer overall PMS symptoms and specifically with fewer concentration problems, autonomic reactions, and water retention. Non-randomised trial, 2008 Does verbal memory change during different phases of the menstrual cycle or with oral contraceptives? Verbal memory did not change across the natural menstrual cycle, but women taking oral contraceptives showed better verbal memory during the active pill phase. The effect on memory does not match how natural estrogen levels change. Lab study, 2008 Does the premenstrual phase affect how well your brain can hold and work with information? Working memory was actually better during the premenstrual phase than after the period, with fewer errors. Mild PMS symptoms did not interfere with this improvement. Survey study, 2008 Does how well women recognize emotions change during the menstrual cycle? Women recognized emotions better during the follicular phase when progesterone levels were lower. This suggests progesterone may affect how well women read emotions in faces. Randomised trial, 2008 Does the menstrual cycle affect how well women recognize emotions in faces? Yes. Women were better at recognizing emotions and had stronger brain activity in response to emotional faces during their follicular phase compared to their luteal phase. Survey study, 2008 Do women's personality traits change across their menstrual cycle? According to related studies, femininity stays the same across the cycle, but women are more assertive and dominant during their fertile period. This might relate to hormones. Survey study, 2008 Does the brain's structure change during the menstrual cycle? Yes, parts of the brain were larger in the early menstrual phase than before the period, and memory performance was also better at this time. Survey study, 2008 Do women with PMDD have different growth factors than other women? Yes, women with PMDD had significantly lower insulin-like growth factor-1 levels throughout their menstrual cycle (205.7 vs 240.2 ng/mL, P=.01). Non-randomised trial, 2008 Does stress affect memory differently depending on menstrual cycle phase? Stress had no clear effect on how well women remembered information at any menstrual cycle phase. However, in the mid-luteal phase when progesterone is highest, there was a stronger relationship between stress hormone levels and memory. Study, 2008 Does the menstrual cycle affect how well women can control their responses to attractive men? During the early part of the menstrual cycle when pregnancy is possible, women's brains showed better control when viewing attractive male faces. This pattern did not appear with female faces. Non-randomised trial, 2008 Do the hormones in birth control pills affect thinking and mood? Yes. The type of hormone affects spatial thinking. Second generation pills improve this performance, while Yasmin reduces it. Effects on mood were not clearly reported. Survey study, 2008 Does estradiol hormone level affect memory across the menstrual cycle? No clear relationship was found between estradiol level and how well women remembered words. However, estradiol level did relate to brain activity in a memory region. Case-control study, 2008 Do women with seizures that worsen around their period have different hormone levels? Yes. Women whose seizures get worse before their period have lower THDOC levels and a lower DHEAS/cortisol ratio throughout their cycle (p < 0.05), which might explain their worsening seizures. Randomised trial, 2008 How do different menstrual cycle phases affect attention, memory, and thinking skills? Yes. Sustained attention improved during the early luteal phase when progesterone is high, and spatial memory improved during ovulation when estrogen is high. Survey study, 2008 Do hormone changes during the premenstrual phase relate to mood symptoms in women with mood disorders? In women with bipolar disorder and major depression, progesterone and allopregnanolone levels during the premenstrual phase are linked to mixed mood features and suicidal ideas, particularly in those with bipolar disorder. We cannot be certain because the study is very small. Randomised trial, 2007 Is a brain hormone called allopregnanolone linked to how PMS symptoms improve with treatment? Possibly yes: in this very small study, women whose PMS symptoms improved, whether on real treatment or placebo, also had a drop in allopregnanolone levels. But with only 6 women per group, this is far from proven. Lab study, 2007 Do female monkeys prefer to look at male faces during fertile times of the menstrual cycle? Yes, but only for rhesus monkey faces. During the fertile period, female monkeys looked longer at male rhesus monkey faces compared to female faces, but not at human or chimpanzee faces. Non-randomised trial, 2007 Does the contraceptive pill Yasmin ease premenstrual symptoms? In this study, women reported fewer premenstrual symptoms like low mood, poor concentration and water retention after six months on Yasmin, but because there was no comparison group, we cannot be fully sure the pill itself caused the improvement. Survey study, 2007 Does menstrual cycle affect how the brain works during spatial thinking? Brain activation patterns during spatial thinking tasks changed across the menstrual cycle and were linked to hormone levels. It is unclear whether these brain changes affect how well people actually perform. Review, 2007 Can birth control pills be tailored to help PMS while reducing side effects? Newer low-dose pills may reduce water retention and weight gain. The right choice depends on each woman's body type and symptoms. Case report, 2007 How does sertraline affect thinking in women with PMDD? One female aviator with PMDD received sertraline 25 mg daily for 5-7 days per month and had her thinking and attention assessed while on and off the medication. The report interprets her neuropsychological performance and discusses potential cognitive effects. Survey study, 2006 Could hormone-driven changes in brain chemistry explain mood problems during the menstrual cycle? This is a proposed explanation, not proven by research. The authors suggest that changes in specific brain-made chemicals called neurosteroids, triggered by shifting estrogen levels during the menstrual cycle, might cause depression and other mood problems. Cohort study, 2006 How should severe period pain in teenagers be treated? Regular pain relief medication (NSAIDs) started before periods begin may help. In one teenager, severe pain improved from 8 out of 10 to 5 out of 10. Study, 2006 Do men and women use different brain areas for mental rotation and word generation tasks? Yes. During mental rotation tasks, men and women showed activation in different brain areas. Gender differences were more prominent in mental rotation tasks than in word generation tasks. Women were tested during the mid-luteal phase of their menstrual cycle. Case-control study, 2006 Do women with IBS and period pain have worse symptoms? Yes. Women with IBS who also have dysmenorrhea and premenstrual distress report significantly more cramping, depression, anger, and cognitive problems than women with IBS alone. This group may need complex, multicomponent treatment. Cohort study, 2006 Are menstrual symptoms linked to inflammation in the body? Yes. A marker of low-grade inflammation in the blood correlated with mood, behavior, and physical symptoms during the menstrual cycle, independent of body weight and hormone levels. Review, 2006 How do birth control pills affect brain chemicals that control mood? Birth control pills reduce neuroactive steroid levels in the brain. Since these chemicals help regulate mood, lower levels might explain why some women experience negative mood symptoms on the pill. Survey study, 2006 What is premenstrual dysphoric disorder and how common is it? PMDD is now officially recognized as a distinct mood disorder linked to the menstrual cycle, affecting an important minority of women, and should be distinguished from regular PMS and depression. Survey study, 2006 Does estrogen replacement improve thinking abilities after menopause? Women after menopause who used estrogen replacement significantly outperformed women who did not on a test of complex thinking, even after accounting for age and education. This small study (48 women) with a single snapshot in time suggests benefits, but findings should be tested in larger studies. Review, 2005 How does acute tryptophan depletion help us understand mood disorders? Acute tryptophan depletion is a research method that temporarily lowers serotonin levels in the brain to study its role in depression, anxiety, sleep problems, and psychiatric conditions. Case-control study, 2005 Does the menstrual cycle affect how the brain's two hemispheres work together for attention? Yes, high estradiol levels during the midluteal phase decreased asymmetry in spatial attention, suggesting hormonal changes affect how brain hemispheres interact. Randomised trial, 2005 Does a history of sexual abuse change how women with PMDD respond to the drug clonidine? In this very small study, yes: women with PMDD who had been sexually abused showed different heart rate, blood pressure and stress-hormone responses to clonidine than those without that history, though the sample was too small to be confident. Randomised trial, 2005 Does clonidine help PMDD symptoms? No. Clonidine showed no benefit compared to placebo for mood or PMDD symptoms in this small study and caused more side effects. Randomised trial, 2005 Does a protein supplement that boosts serotonin help with memory problems before your period? The supplement improved memory for shapes but not for words. This suggests serotonin plays a partial role in premenstrual memory decline, but other factors are also involved. Study, 2005 Does the menstrual cycle phase affect how well women recognize objects shown partially? Yes, women in the low-estrogen phase were able to recognize objects from more incomplete images than women in the high-estrogen phase. Interview study, 2005 Can doctors correctly diagnose PMDD and depression in gynecology clinics? Gynecologists diagnosed PMDD correctly 80% of the time but depression only 48% of the time. Ironically, they were more confident about their depression diagnoses despite being less accurate. Review, 2004 Could a brain hormone called allopregnanolone explain mood problems like PMDD in women? This review suggests that changes in allopregnanolone, a hormone-like substance in the brain, may be linked to mood problems including premenstrual dysphoria (PMDD), but this is a theory based on existing animal and human research, not new proof. Case-control study, 2004 Do women with PMDD who experienced sexual abuse have different thyroid hormone levels? Yes. Women with PMDD and sexual abuse history had abnormal thyroid hormone patterns, including higher T3 levels, compared to other groups. Non-randomised trial, 2004 Does serotonin activity change across the menstrual cycle? Yes. Serotonin transporter binding was highest in the late follicular phase (right before ovulation), while serotonin receptor binding was highest in the early follicular and early luteal phases. These changes correlated with estradiol and progesterone levels. Survey study, 2004 How does serotonin function change during the menstrual cycle in women with PMS? Serotonin function varies throughout the menstrual cycle linked to hormone levels. This variation may contribute to PMS, but we don't yet know why only some women develop the condition. Non-randomised trial, 2004 Are depression and anxiety linked to estrogen and progesterone levels in women with PMDD? No. This study found no significant correlations between depression or anxiety ratings and either hormone. Non-randomised trial, 2004 Does the menstrual cycle affect brain activity related to memory and attention? Yes. Brain electrical activity related to attention (the P300 response) was significantly stronger during menstruation than during ovulation. Memory effects were similar at both cycle phases. Survey study, 2003 Do hormone levels change during the menstrual cycle in women with depression? Yes. Women with depression had higher levels of a chemical called homocysteine in the early cycle compared to the late cycle, and overall higher levels than healthy women. Non-randomised trial, 2003 Do menstrual cycle hormones change how the brain works during language tasks? Yes. Progesterone and estradiol levels correlated with the amount and pattern of brain activity during language tasks but not during simpler perception tasks. This shows hormones affect specific brain regions in specific ways. Survey study, 2003 How common is PMDD in women in Bosnia and Herzegovina and what are the most common symptoms? 52% of women in Bosnia and Herzegovina met diagnostic criteria for PMDD. The most common symptoms were depressed mood (68%) and breast swelling or weight gain (81.8%). Survey study, 2003 What hormone changes happen during the transition to menopause? A study of 40 women aged 43–52 transitioning to menopause found that inhibin-A hormone levels were lower than in younger women, with the largest decreases in those who had stopped ovulating. Study, 2002 Can talking therapy help premenstrual symptoms? A talking therapy combining techniques to change negative thought patterns and explore personal stories has been found to work as well as SSRI medication for moderate to severe premenstrual symptoms. Two case examples show symptom improvement. Case-control study, 2002 Do women with PMDD have worse cognitive function during their menstrual cycle? Tests found no significant differences in cognitive function between women with PMDD and controls, despite the PMDD group reporting cognitive problems. The researchers suggest these complaints may come from how women perceive things rather than actual cognitive deficits. Case-control study, 2002 Does brain GABA change differently in women with PMDD during the menstrual cycle? Yes. GABA levels dropped across the cycle in healthy women but rose in women with PMDD. This is a very small study, so results need confirmation. Survey study, 2002 Do women think and solve math problems differently depending on their menstrual cycle phase? Overall performance on math tasks did not clearly differ between menstrual cycle phases. However, how much individual women's performance varied from day to day did change with the cycle phase, and this pattern was different for each woman. Non-randomised trial, 2002 Do verbal and spatial abilities change during the menstrual cycle? Spatial ability did not change across the cycle. Verbal working memory improved during periods of high estrogen, suggesting estrogen may enhance this type of verbal ability. Lab study, 2001 Does spatial memory change across the menstrual cycle? Yes. In female rhesus monkeys, spatial memory is better during low-estrogen phases (follicular and luteal) compared to high-estrogen phases (around ovulation). Survey study, 2001 Does the menstrual cycle affect how alcohol impacts flying ability? No clear difference. Women pilots' flight performance after drinking was the same during their menstrual phase and luteal phase, even though hormone levels were much higher in the luteal phase. Survey study, 2001 Does the menstrual cycle phase affect spatial ability? Yes. Women in the luteal phase scored lower on spatial reasoning tests than women in other menstrual phases, but hormone levels didn't explain why. Case-control study, 2001 Do women with PMS respond differently to a serotonin challenge than healthy women? Yes. When given an intravenous tryptophan challenge, women with PMS showed a much larger increase in allopregnanolone than healthy women. This suggests a possible interaction between serotonin and brain hormones in women with PMS. However, the study was very small. Survey study, 2001 How do steroid hormones affect the brain and cause symptoms? Steroid hormones can rapidly change brain activity and behavior within seconds to minutes. This review discusses these fast effects in relation to premenstrual syndrome and other conditions. Survey study, 2001 Are synthetic fragrances linked to hormone problems in women? Yes. Two types of synthetic fragrances (musk xylene and musk ketone) were found in nearly all blood samples of women with hormone and ovary problems. They may disrupt how the brain controls the ovaries, but more research is needed to confirm they cause the problems. Survey study, 2001 Are hormone levels different in women with PMDD? Yes. Women with PMDD had significantly lower melatonin and progesterone levels and higher prolactin levels during the late luteal phase compared to women without PMDD. Non-randomised trial, 2001 Do people with PMDD have different breathing patterns? Yes. PMDD patients showed greater variation in their breathing patterns than women without PMDD. Study, 2001 Does estrogen or progesterone affect magnesium levels in brain blood vessels? Yes. High levels of estrogen and progesterone both decrease magnesium in brain blood vessel cells. Low progesterone increases magnesium. This may explain why migraines happen more often before the period. Case-control study, 2000 How does estrogen affect thinking and brain performance? When estrogen is high, women with psychosis performed worse on a fine motor test, but normal women did not improve. This suggests estrogen affects the brain differently in women with psychosis. Survey study, 2000 Why do some women get cold sores around their period? Women with recurrent cold sores have lower protective immune proteins and higher inflammation proteins throughout their cycle. This immune weakness suggests the virus reactivates more easily around the period. Survey study, 2000 Why do women get more anxious when hormone levels drop? Falling estrogen and progesterone levels may trigger anxiety and mood disorders by affecting how brain receptors that control anxiety and mood work. The exact mechanism is not yet fully understood. Survey study, 2000 Is leptin, a hormone involved in mood and reproduction, different in women with PMS? Yes. Women with PMS have higher leptin levels throughout their cycle, and their leptin increases much more before their period, which may contribute to mood symptoms. Lab study, 2000 Does the menstrual cycle change how your brain responds to sexual images? Yes. During ovulation, the brain showed a larger electrical response to sexual images compared to other image types, but only when women were emotionally processing the images. Study, 2000 How do sex hormones affect spatial thinking during the menstrual cycle? Sex hormones affect how well women perform on spatial thinking tests. Women score higher during the menstrual phase and lower during the midluteal phase. Testosterone helps with spatial thinking, while estradiol makes it harder. Non-randomised trial, 1999 Does your menstrual cycle phase affect how alert and focused you stay during sleep deprivation? Yes, women in the follicular phase were less alert and performed worse on thinking tasks during sleep deprivation, especially at times when body temperature naturally dips. This is a small study without a comparison group. Cohort study, 1999 Does PMDD affect mood, memory and thinking differently across the menstrual cycle? Mood got worse in the luteal (premenstrual) phase for women with PMDD, but memory and thinking problems in that phase happened in both PMDD and non-PMDD women equally, based on this very small study. Survey study, 1999 Does the menstrual cycle affect spatial memory in women? Yes. Women performed better on a spatial memory test during non-menstrual phases of their cycle compared to during menstruation. Survey study, 1998 Does trouble digesting fructose cause depression? This small study found that people who couldn't absorb fructose well had higher depression scores, especially women. But the study can't prove fructose malabsorption causes depression. Survey study, 1998 Are PMS symptoms connected to hormone levels? High levels of estradiol and LH in the phase after ovulation were linked to more severe PMS symptoms. Symptoms develop after ovulation and disappear within 4 days of menstruation starting. Review, 1998 What are neurosteroids and how do they work in the brain? Neurosteroids are hormones made in the brain that affect brain function through a special mechanism and are important in both normal and abnormal brain conditions. Randomised trial, 1998 Does tibolone improve PMS symptoms? Yes. Tibolone 2.5 mg/day significantly improved all PMS symptom categories by the third month (P < 0.05). Survey study, 1998 How common is PMS in women of reproductive age and what factors increase the risk? 30.4% had PMS, with most having mild to moderate symptoms. Women with higher stress, depression symptoms, painful periods, and higher education level had higher rates. Lab study, 1998 Do magnesium and calcium levels change during the menstrual cycle? Yes, clearly. Magnesium is highest early in the cycle and drops around ovulation and when progesterone is high. The ratio of calcium to magnesium increases during ovulation and the luteal phase. Survey study, 1997 Do women with PMS or menstrual migraine respond differently to stress? Women with PMS or menstrual migraine responded normally to a stress test, but had higher baseline blood pressure and overall arousal before and after the test. Non-randomised trial, 1997 Does progesterone affect the hormones that cause fluid retention in PMS? In a small study of 6 women, oral progesterone therapy during the luteal phase increased certain hormones (ANF) and decreased sensitivity to fluid-retaining hormones (vasopressin), which may explain how progesterone helps PMS bloating, though confirmation in larger studies is needed. Non-randomised trial, 1997 Does estrogen help asthma symptoms that worsen before periods? Yes. Taking estradiol significantly improved asthma symptoms and breathing difficulty in women with premenstrual asthma, though this very small study needs confirmation. Cohort study, 1997 Does estrogen reduce asthma symptoms before a period? Yes, in 14 women with asthma, extra estrogen significantly improved asthma symptoms and breathing difficulty. However, this is very preliminary evidence from a tiny study with no control group. Interview study, 1997 What are young undergraduate women's experiences of their menstrual cycle? Young women experienced some premenstrual symptoms but considered them minor compared to the stereotype. None had thought about positive experiences, though managing menstruation was seen as bothersome. Cohort study, 1996 Can hormones trigger PMS symptoms in women without ovaries or a uterus? Not clearly. Some individual women showed links between progesterone and symptoms, but results overall were not statistically significant. Women don't respond uniformly to hormones. Randomised trial, 1996 Do women with PMS have lower brain opioid activity than women without PMS? This small study found that women with PMS lacked the normal rise in a brain-opioid-linked hormone response seen in women without PMS, suggesting reduced opioid activity may be involved in PMS. Review, 1996 How does estrogen affect mood and memory? Yes. Estrogen affects mood and memory by changing levels of brain chemicals that control emotion and behavior. Low estrogen is linked to PMS, depression after childbirth, and postmenopausal depression, though human studies remain limited. Survey study, 1996 Does how women react to jealousy change during the menstrual cycle? Yes. Women showed stronger physical signs of emotional reaction to jealousy during the preovulatory phase, especially when imagining emotional rather than sexual betrayal. Non-randomised trial, 1996 Do women with PMS have different hormone levels? Women with PMS have lower vasopressin levels throughout their cycle, suggesting a biological difference. However, this very small study needs larger confirmation studies. Survey study, 1996 Are PMS symptoms connected to steroid hormone levels? Women with PMS had higher estradiol and lower progesterone than control women. Symptom peaks occurred 1 day after pregnenolone sulfate peaked or 3 to 4 days after other steroid peaks. Higher luteal estradiol and certain other steroids related to worse symptoms. Review, 1996 Do PMS, postpartum depression, and menopause share a common cause related to the brain? The hypothesis suggests that when brain estrogen levels fall below a critical threshold, mood and neurological symptoms develop. This could explain why PMS, postpartum depression, and menopause involve similar symptoms, though the mechanism remains unproven. Survey study, 1996 How do estrogen and progesterone receptors in breast tissue change during the menstrual cycle and with age? Hormone receptor levels stay mostly the same throughout the menstrual cycle, but estrogen receptors decrease during the mid-cycle compared to around menstruation. Cohort study, 1995 Does calcium metabolism work differently in women with PMS? Yes. Women with PMS have higher parathyroid hormone (PTH) at midcycle compared to healthy women, suggesting a calcium regulation problem. The study was very small. Survey study, 1995 How do women cope with menstrual cycle symptoms and which methods work best? Women use four types of coping strategies. Active-cognitive (thinking-based) and active-behavioral (action-based) methods were most helpful, though how often a strategy was used didn't predict how helpful it was. Cohort study, 1995 Do hormone release patterns differ in women with PMS? Hormone levels were similar between PMS and non-PMS women, but the timing between luteinizing hormone and progesterone pulses was unexpectedly different in PMS women on symptom-onset day. The study is very small and findings need confirmation in larger studies. Survey study, 1995 Is depression being missed in women's health care? Depression is twice as common in women as in men and occurs in as many as 21% of women over their lifetime. Doctors often miss it because depression hides behind complaints about other gynecologic problems. Non-randomised trial, 1995 Does cognitive behaviour therapy help premenstrual dysphoric symptoms? Both cognitive behaviour therapy and a comparison treatment improved anxiety, depression, negative thoughts and physical symptoms. It's unclear how much came from the therapy itself since both groups improved similarly. Survey study, 1994 Do brain chemicals linked to mood (serotonin, dopamine, noradrenaline) look different in women with PMS? Overall levels of these brain chemicals in spinal fluid were not different between women with PMS and women without, but some patterns in how the chemicals related to each other and to hormones did differ. With only 13 women per group, the authors call this preliminary. Case-control study, 1994 Does cognitive-behavioral coping skills training reduce premenstrual symptoms? Yes. Women who received coping skills training showed clear reductions in premenstrual symptoms and negative thinking right after treatment and at 9-month follow-up. Cohort study, 1994 Do women with PMS have lower magnesium levels? Yes, women with PMS have lower magnesium in their red blood cells. This difference appears throughout the menstrual cycle, not just before the period. Study, 1994 Does PMS affect how fast and accurately women do attention tasks? Women responded more slowly to easier attention tasks before menstruation, but accuracy wasn't affected. After the task, women felt lower in energy and mood before menstruation. Survey study, 1993 Does the menstrual cycle affect how well women do at computer tasks? No, computer task performance and thinking ability showed no change across different phases of the menstrual cycle. Survey study, 1993 Does cognitive ability change during different phases of the menstrual cycle? No. Women performed equally well on verbal and spatial thinking tests regardless of menstrual cycle phase. Study, 1993 Does the ability to think clearly change with the menstrual cycle? Yes. When women were tested in their premenstrual phase versus their preovulatory phase, they showed more difficulty suppressing irrelevant information and following instructions. The difficulty was more pronounced in women who reported worse premenstrual symptoms. Cohort study, 1992 Do glucose and fructose levels in cervical mucus change during the menstrual cycle? Yes. A small study of 9 women found that glucose and fructose levels in cervical mucus were lower before ovulation than at other cycle phases. Study, 1992 Do women with severe premenstrual symptoms have different mental performance during their cycle? Women with severe symptoms had slower thinking and response times overall, but neither group showed large changes in mental performance related to their menstrual phase. Case report, 1992 Is severe overeating linked to the premenstrual period in women with PMS? Yes. This woman experienced uncontrollable binge eating only during her premenstrual period, especially in the 3 to 5 days before her period. Case-control study, 1992 Are prostaglandin hormone levels different in women with PMS? Yes. Women with PMS have lower levels of one prostaglandin during the luteal phase and higher levels of several others at different times of the cycle. Cohort study, 1992 Do standard depression tests detect mood changes linked to PMS? The Beck Depression Inventory detected mood changes in women with PMS, while another test did not. This suggests PMS depression is mainly about negative thinking rather than physical symptoms. Randomised trial, 1991 Does cognitive-behavioral therapy work better than medication or relaxation for PMS? Yes. Cognitive-behavioral therapy showed significant improvement after the first month that continued throughout and persisted at 3-month follow-up. Medication and relaxation showed quick improvement that faded after 2 months. Survey study, 1991 What is the best treatment for PMS? No single medication works for everyone. Treatment works best when combined approaches including diet, exercise, stress management, and sometimes medication are matched to each woman's specific symptoms. Study, 1991 Do women with PMS have different blood fatty acids than healthy women? Yes. Women with PMS have higher amounts of linoleic acid but lower amounts of what their body should make from it. This suggests their bodies may not process this fatty acid correctly. Survey study, 1991 How do stress hormones affect the menstrual cycle and PMS? Stress hormones in the brain can suppress the hormones needed for normal menstruation and ovulation. Changes in certain brain chemicals during the cycle may be linked to PMS symptoms, but evidence comes mainly from animal studies and theory rather than clinical trials. Study, 1991 Do hormone and brain chemical levels change between phases of the menstrual cycle in women with PMS? Some hormone and brain chemical levels did differ between the symptom-free and symptomatic phases of the cycle, but with only 8 women studied this is very early, exploratory work and not strong evidence. Case-control study, 1991 Does PMS change how women remember everyday events? Yes. Women with PMS remember negative events better when they are in a bad mood, while women without PMS remember positive events better. Women with PMS have more negative moods overall. Survey study, 1991 Does mental and physical performance get worse during the menstrual cycle? No, most aspects of thinking and physical performance did not get worse during the menstrual or premenstrual phases. Women did report feeling more alert before their period and performed slightly better on one word-matching task premenstrually. Review, 1991 Can serotonin drugs treat PMS? The abstract mentions that tryptophan, a serotonin precursor, has been used to self-treat PMS, but doesn't provide evidence that serotonin drugs work for PMS specifically. Review, 1991 What treatments are available for late luteal phase dysphoric disorder? Many treatments exist, including medications, vitamins, and hormones. However, non-drug approaches like diet, exercise, and psychotherapy have received less research attention. Survey study, 1990 Does PMS come from a broken stress hormone system? Women with PMS had a few small differences in their stress hormone (cortisol) responses compared to women without PMS, but their overall daily cortisol output was normal. This suggests only mild, temporary hormone shifts that the body seems able to correct on its own. Case report, 1990 Can fear of menstruation that stops periods be treated with therapy? This single case shows that a woman whose periods had stopped due to fear of menstruation was helped by cognitive therapy (talking about her thoughts and beliefs), which increased her confidence and brought her periods back. Study, 1990 Do thinking and movement skills change during the menstrual cycle? Yes, some skills change across the cycle. Tasks measuring speed of hand movements, speaking speed, and spatial thinking varied, possibly due to hormone level changes. Survey study, 1989 Does thyroid disease cause behavioral and emotional problems, especially in women? This review discusses that thyroid regulation problems happen more often in women than men and are often linked to behavioral and emotional symptoms, though it does not present new research findings. Study, 1989 Do women with PMS think differently from women without PMS? No. Women with PMS do not show the changes in thinking that typically happen with depression, even though they have significant mood symptoms. Study, 1989 Is neurotensin involved in causing PMS? No. Women with PMS had similar neurotensin levels in their spinal fluid compared to healthy women. This brain chemical does not appear to be abnormal in PMS. Survey study, 1989 Do mood disorders affect premenstrual depression and attention across the cycle? Only 8 of 16 women with a mood disorder history actually had premenstrual depression when tracked daily. Those who did showed worse mood premenstrually, but both groups showed the same attention patterns in both phases. Study, 1989 How does prolactin change during a full day and night across the menstrual cycle? Prolactin goes up and down in irregular episodes throughout day and night. The pattern of these ups and downs changes depending on time of day and whether someone is asleep or awake. Study, 1989 Does how the brain is organized for different tasks change across the menstrual cycle? Yes. The brain's organization for recognizing faces changes across the cycle, but organization for recognizing words stays the same. During menstruation the right side dominates for faces, but during the premenstrual phase the left side becomes more involved. Lab study, 1989 Do women with PMS have thyroid problems? No. Women with PMS have similar thyroid hormone and prolactin levels to healthy women in both the follicular and luteal phases of their cycle. Study, 1989 Does the menstrual cycle change how the two sides of the brain handle visual tasks? This small, preliminary study found some signs that brain response patterns for certain visual tasks shift across the cycle, but the pattern was mixed, so it is not a firm conclusion. Survey study, 1989 Do women's beliefs about PMS affect their memory of their symptoms? Yes. Women who believed PMS causes distress remembered their menstrual symptoms as worse than their daily records actually showed. Physical symptoms varied by cycle phase, but mood symptoms did not. Study, 1988 Do women's body chemistry responses to an opiate drug differ between menstruation and ovulation? Yes. Growth hormone response was weaker during menstruation than at ovulation. Prolactin was about 1.5 times higher at ovulation. Other hormones and mood did not clearly differ. Cohort study, 1988 Does beta-endorphin explain why some women get PMS? No clear relationship was found. Beta-endorphin levels did not differ between women with high versus low PMS symptoms, though one correlation was weak and did not reach statistical significance. Survey study, 1987 What happens to hormones and follicles when estrogen is blocked in the menstrual cycle? Blocking estrogen with antibodies increased FSH and LH hormones and caused larger follicles to grow. This was tested in monkeys, not people. Case-control study, 1987 Do women with premenstrual tension have lower beta-endorphin? Yes. Women with symptoms had lower blood beta-endorphin during the early luteal phase (10.7 vs 14.6 pg/ml). This suggests a hormonal difference but doesn't prove it causes symptoms. Study, 1986 Does the body's nervous system react differently to stress in women with PMS? The study found that women with PMS had different heart rate patterns during different phases of the cycle, with higher rates during the premenstrual phase. However, this was a very small study, so we can't be very sure about these findings. Non-randomised trial, 1986 Does what a woman is told about PMS change how severe her symptoms feel? Women told PMS comes from societal myths reported less negative mood and fewer symptoms compared to other groups. All women actually showed better task persistence and more positive interactions with their children during the premenstrual phase compared to mid-cycle. Lab study, 1986 Does alcohol affect you differently at different times in your menstrual cycle? No clear difference. Women's bodies processed alcohol similarly at different cycle phases, and alcohol's effects on memory, balance, and attention were not significantly different by cycle phase. Case-control study, 1985 Are hormone levels and ovulation timing different in women with premenstrual tension? Yes. Women with premenstrual tension tend to ovulate earlier in their cycle and have higher stress hormone (cortisol) levels than women without symptoms. Case-control study, 1985 Do women with PMS show different hormone patterns and ovulation timing after the corpus luteum is removed? Yes. Women with PMS took longer to ovulate after corpus luteum removal (21 days versus 19 days in controls) and had lower FSH levels, suggesting their hormonal feedback system is more sensitive. Case report, 1985 What is PMS and how should doctors treat it? PMS is a cyclical condition with physical and psychological symptoms that occur 7-14 days before menstruation. About 30 percent of women experience PMS in a severe form at some point in their lives. Survey study, 1984 Which hormones cause premenstrual pain? Higher levels of vasopressin (a hormone that makes the uterus contract) may cause premenstrual pain. Severe period pain may result from both vasopressin and prostaglandins working together. Study, 1980 Is progesterone deficiency the cause of premenstrual syndrome? Progesterone deficiency is probably not the cause. The study found higher progesterone levels in women with PMS during the postovulatory phase, suggesting the problem is not too little progesterone. Study, 1980 How do birth control pills affect renin levels in the body and uterus? Birth control pills lower renin in the bloodstream but raise related substances in the uterus. The highest activity of these substances occurs before menstruation. Study, 1980 How does a hormone-like substance called PGFM change through the menstrual cycle? PGFM levels rise sharply at two points in the cycle: just before ovulation and just before the period starts. Between these peaks, levels stay much lower. Cohort study, 1979 Are menstrual symptoms caused by beliefs about the menstrual cycle? This is a theoretical review arguing that some menstrual symptoms may originate from biased beliefs and selective processing of menstrual cycle information, not just from physical changes. It is not original research. Randomised trial, 1976 Does bromocriptine help premenstrual syndrome and infertility? Yes, bromocriptine improved PMS symptoms and was associated with pregnancies in women treated for infertility, likely by lowering the hormone prolactin. Survey study, 1976 Does premenstrual anxiety and depression affect how well women think? Women reported more anxiety and depression before their period, but this mood change did not affect how well they performed on thinking tests. Survey study, 1975 Is there a link between estrogen and progesterone levels and PMS symptoms? There was a significant link between estrogen levels and anxiety, irritability, and depression symptoms, but no clear link with progesterone levels. This is a very small early study, so we cannot be very sure. Study, 1975 Does physical and mental work capacity change during the menstrual cycle? Physical exertion feels harder during menstruation and reaction time is slightly slower. Heart rate and oxygen use do not change. Overall mental work capacity does not clearly change. Study, 1931 What types of health problems happen before menstruation? Women experience a range of premenstrual problems from mild discomfort including fatigue and difficulty concentrating to severe pain requiring bed rest to serious symptoms like convulsions. Show more studies Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗