--- title: Anxiolytics and other psychotropics: 100 studies, explained | Niyora description: 100 studies on anxiolytics and other psychotropics and PMS or PMDD, each summarised in plain English: what was tested, who took part, what they found and what url: https://niyora.com/research/topics/treatment-anxiolytics/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Anxiolytics and other psychotropics # Anxiolytics and other psychotropics: what the research says 100 studies on anxiolytics and other psychotropics in PMS and PMDD, each explained in plain English. 7 of them use the strongest designs: randomised trials and systematic reviews. Review 24 Randomised trial 20 Survey study 19 Case report 9 Non-randomised trial 7 Study 6 Review, 2015 What treatments work best for PMDD and PMS? SSRIs are the first-line treatment for PMDD. Only calcium supplement has strong evidence among supplements, though other psychiatric medications and hormonal treatments also work. Systematic review, 2007 What treatments work for premenstrual syndrome? Many treatments have been studied for PMS, but researchers face a major challenge: there is no standard way to measure symptom severity, making it difficult to know which treatments truly work. Randomised trial, 2004 What medications work for PMDD when taken only during the second half of the menstrual cycle? SSRIs including sertraline, fluoxetine, and paroxetine are the most proven treatment for PMDD when taken during the luteal phase. Symptom reduction is similar to taking them continuously, but with less medication exposure and lower costs. Review, 2003 How do menstrual cycle hormones affect the brain and cause mood disorders like PMDD? A hormone called allopregnanolone acts on brain receptors. Changes in this hormone during the cycle may cause mood and behavioral symptoms in up to 20% of people through three mechanisms: direct effects, building tolerance, and withdrawal effects. Review, 2002 What treatments work best for PMS and PMDD? Ovulation suppression and SSRIs (selective serotonin reuptake inhibitor antidepressants) are the two most effective treatments. SSRIs work particularly well for PMDD and can be taken only during the luteal phase of the cycle. Study, 1997 What medications work best for treating PMS? SSRIs like fluoxetine and benzodiazepines like alprazolam have clear benefits for PMS. GnRH agonists also work well but cause too many side effects for routine use, and other drugs can treat specific symptoms like headaches or fluid retention. Randomised trial, 1995 Does progesterone or the anti-anxiety drug alprazolam work better for severe PMS? Alprazolam was significantly better than both progesterone and placebo, with 37% of women experiencing a 50% reduction in symptoms. Progesterone was no better than placebo. Non-randomised trial, 2020 What treatments help premenstrual syndrome? Both medications and non-drug treatments help PMS. Non-drug options including herbs, supplements, exercise, and therapy are recommended as they have fewer side effects. Systematic review, 2019 Do lithium and valproate levels change during the menstrual cycle? In women with bipolar disorder, lithium levels decreased during the luteal phase (before the period) despite stable doses, linked to worsening mood symptoms. In healthy women, lithium levels were not affected by the menstrual cycle. Case-control study, 2015 Does lamotrigine reduce menstrual cycle-related mood changes in women with bipolar disorder? Women with treated bipolar disorder showed greater mood and sleep changes across the menstrual cycle compared to healthy women. Women taking lamotrigine had less mood fluctuation and were more similar to healthy women than those not taking lamotrigine. Randomised trial, 2013 Is buspirone as good as fluoxetine for treating PMS? Both medicines helped reduce PMS symptoms, and there was no clear difference between them. However, larger and more rigorous studies are needed to confirm this. Survey study, 2012 What non-hormonal medications and therapies help severe PMS and PMDD? SSRIs (a type of antidepressant) are well-established for severe PMS and PMDD, taken either continuously or during the luteal phase. Cognitive-behaviour therapy, calcium, and chasteberry may also help, though the strength of evidence varies. Cohort study, 2011 Does premenstrual symptom worsening change how bipolar disorder develops over time? Yes. Women with bipolar disorder who reported premenstrual symptom worsening had more mood episodes and relapsed sooner, though other patterns in their illness may partly explain this. Review, 2010 Can neurosteroids help with anxiety and brain disorders? The review suggests neurosteroids might help with anxiety, epilepsy, and depression, but clinical evidence is limited. Case-control study, 2007 Are there genes that increase the risk of PMDD? Genetic variations in the ESR1 gene (which codes for estrogen receptor alpha) appear linked to PMDD mood symptoms, suggesting genetic factors contribute to who develops the condition. This was found in a study of women with PMDD and unaffected controls. Review, 2006 How do brain hormones affect PMDD and mood problems during the menstrual cycle? Probably yes. Brain hormones that change during the menstrual cycle may trigger mood problems in PMDD by working similarly to anti-anxiety drugs. PMDD affects 2-6% of reproductive women. Review, 2006 What treatments work for premenstrual disorders? Several treatments work. Three SSRIs are FDA-approved for PMDD. Exercise, diet changes, and therapy also help some women, but no single treatment works for everyone. Review, 2004 How well does alprazolam work for anxiety and panic attacks? Alprazolam is more effective than placebo and works as well as some other medications for anxiety. It works within the first week but can impair thinking and driving skills. Cohort study, 2004 Do women with bipolar disorder on mood-stabilizing medication experience premenstrual symptom worsening? No, women with bipolar disorder on mood-stabilizing treatment (lithium or valproate) experienced significantly less premenstrual symptom worsening than healthy women, suggesting the medication may protect against it. Review, 2003 What role do hormones play in PMS and how should we treat it? Female hormones trigger PMS by affecting brain chemistry, especially the serotonin and GABA systems. SSRIs and medications that stop ovulation are the most effective treatments. Review, 2002 What treatments work for PMDD? PMDD affects 2 to 10 percent of women of reproductive age. Try lifestyle changes first, and if that does not work, SSRIs taken just during the luteal phase are very effective with minimal side effects. Randomised trial, 2001 Do women with PMS have different brain receptors that change with hormones? No. Receptor density did not differ significantly between women with PMS and controls, and did not change when estradiol or progesterone were given. Randomised trial, 2000 Does having used benzodiazepines before make withdrawal symptoms worse when stopping them? No. Analysis of data from three clinical trials found that prior benzodiazepine use did not increase symptoms when stopping the medication, either in people with PMS or anxiety disorder. Randomised trial, 1999 How many women with severe PMS improve from taking a placebo pill? About 20% show significant lasting improvement (at least 50% reduction in symptoms), 42% partially improve, and 39% don't improve. If you improve for at least 2 consecutive months, you are likely to keep improving. Randomised trial, 1999 Does menstrual cycle phase affect how women respond to triazolam? No. The effects of triazolam on mood and performance were stable across all three phases of the menstrual cycle. Review, 1999 How should severe premenstrual dysphoric disorder be diagnosed and treated? Diagnosis requires ruling out other conditions and tracking daily symptoms. Treatment with serotonin-blocking antidepressants or alprazolam during the luteal phase provides substantial relief. Randomised trial, 1999 Does the drop in progesterone or stress during the menstrual cycle cause chocolate and sweets cravings? This study found no clear evidence either way. Neither progesterone nor a tranquilizer reduced chocolate or sweets craving in women with severe PMS. Randomised trial, 1998 Which medication works best for severe PMS: fluoxetine, propranolol, alprazolam, or pyridoxine? Fluoxetine at 10 mg reduced symptoms by 65.4%, the most of any drug tested. Propranolol reduced symptoms by 58.7%, alprazolam by 55.6%, and pyridoxine by 45.3%. Placebo also helped significantly, reducing symptoms by 39.4-46.1%. Randomised trial, 1998 Does alprazolam improve mood and task performance in women with PMDD? No. Alprazolam did not improve premenstrual mood and actually worsened mood in the follicular phase. It also impaired task performance. Review, 1997 Which antidepressants are most effective for premenstrual dysphoric disorder? Selective antidepressants that work on serotonin are consistently the most effective. Most studies used daily treatment, but intermittent dosing needs more research. Review, 1994 What medications work for PMS and are they safe? Three classes of drugs have proven effective: benzodiazepines (especially alprazolam), SSRIs (especially fluoxetine), and GnRH agonists. However, all have significant side effects that doctors must weigh against benefits. Randomised trial, 1994 Does alprazolam help women with late luteal phase dysphoric disorder? Yes, but only for women whose symptoms happen only in the luteal phase. It reduced tension, irritability, and anxiety in that group but not in women who also had anxiety or depression at other times of the month. Randomised trial, 1993 Does alprazolam help premenstrual syndrome symptoms? No. Alprazolam did not reduce PMS symptoms compared to placebo on most measures, with only a small statistical improvement in depression that was not clinically meaningful. Review, 1993 Can GnRH agonists plus hormone replacement help severe PMS? Evidence suggests that GnRH agonists combined with estrogen-progestin replacement can substantially reduce severe PMS symptoms, particularly in women who do not respond to fluoxetine or alprazolam. Review, 1993 What are the medication options for treating PMS? PMS can be treated with hormonal medications that alter the menstrual cycle, mood drugs, diuretics for fluid retention, and pain relievers for headaches. Treatment should start with simpler measures and consider side effects. Review, 1990 Is buspirone an effective treatment for anxiety? Yes, buspirone works as well as benzodiazepine anxiety medications and significantly better than placebo for generalized anxiety disorder and chronic anxiety. It also has antidepressant effects, and it is safer because it does not cause dependence, though it works more slowly. Review, 1990 What treatments for PMS actually work? Most PMS treatments are based on weak research. The most effective approach involves accurate diagnosis, stress control, a healthy diet and exercise, and possibly the medication alprazolam. Progesterone has been shown not to work. Randomised trial, 1990 Does alprazolam help premenstrual dysphoria? Yes. Alprazolam was significantly superior to placebo in treating late luteal phase dysphoric disorder based on physicians' ratings and patients' reports. Survey study, 1989 What does research say about what causes PMS and what treatments work? A review of PMS research found no definitive cause and no universally effective treatment. Lifestyle approaches like diet, exercise, and support help many women, while some medications like alprazolam and mefenamic acid help some, but progesterone therapy is ineffective. Randomised trial, 1987 Does alprazolam help premenstrual syndrome? Yes, according to this study, alprazolam was significantly more effective than placebo at relieving many PMS symptoms including mood and physical symptoms. Side effects were uncommon, making it potentially acceptable for women who don't respond to other treatments. Review, 1983 What causes PMS symptoms and how should it be treated? The four days before a period are when most PMS happens, causing irritability, depression, anxiety and fatigue. Treatments include vitamin B6, antidepressants, anti-anxiety medication and therapy, though evidence is mixed. Survey study, 2026 What substances do people use to manage premenstrual symptoms? People most commonly use cannabis, alcohol, and psychedelics to manage premenstrual mood symptoms. People with PMDD use cannabis much more often than others, but we don't yet know how well these substances actually work. Survey study, 2026 Among women with bipolar I disorder, who is more likely to also have PMDD? About one-third (36.5%) of women with bipolar I disorder have PMDD. Those at higher risk have seasonal mood patterns, a history of suicide attempts, and a family history of mental illness. Case report, 2024 Can lithium help treat PMDD when other medications are not an option? Yes, based on one case. A woman with PMDD and a family history of bipolar disorder responded well to lithium treatment. Study, 2024 Can PMDD cause psychosis that returns with each menstrual cycle? Yes. A woman experienced psychotic symptoms starting 5 days before her period and ending when her period began, and this pattern repeated every month for 5 years. Treatment with medications reduced the severity but did not completely stop the symptoms. Lab study, 2024 Can the natural compound rutin help with depression from PMDD? In laboratory studies with rats, rutin reduced depression symptoms, improved memory, and reduced brain cell damage. It is unknown whether rutin would help women with PMDD because this was not tested in people. Survey study, 2023 How common are PMS and PMDD in deaf and hard-of-hearing women with mood disorders? Among 380 deaf or hard-of-hearing women with mood disorders, 71.05% had moderate to severe PMS and 16% had PMDD. Women with severe PMS consumed more processed foods and experienced more digestive problems. Review, 2022 Can blocking a natural brain steroid help PMDD? Maybe. An early study showed that blocking a steroid called allopregnanolone improved negative mood in women with PMDD compared with placebo, but more research is needed. Survey study, 2021 Can a menstrual cycle trigger psychiatric episodes in teenagers? A 15-year-old girl's monthly episodes of confusion and dissociation lasting 5-6 days improved when her period started, but doctors couldn't determine whether hormones, the menstrual cycle, or a psychiatric condition caused it. Case report, 2020 Can PMDD be mistaken for bipolar disorder? Yes. PMDD and bipolar disorder have similar mood symptoms, which can lead to wrong diagnosis and treatment. A woman given lithium for bipolar disorder stayed sick, but recovered when she started antidepressant medication, which is the correct treatment for PMDD. Survey study, 2020 How common are PMS and PMDD in women with mood and anxiety disorders? PMS affected 47.5% and PMDD affected 13.0% of women with mood or anxiety disorders. Both were significantly linked to diet, menstrual patterns, and medication use. Survey study, 2018 How do women respond differently to psychiatric medications and why do we need sex-specific treatments? Women respond differently to psychiatric medications than men because of biological differences in brain receptors and hormones. Sex-specific treatments are important for conditions like PMDD and postpartum depression. Case report, 2017 Can mood symptoms like mania and psychosis change across the menstrual cycle in bipolar disorder? In one detailed case, yes: a woman with bipolar I disorder had psychosis-like symptoms when estrogen was low and hypomania when estrogen was high, and a targeted treatment approach for this pattern worked for her. Randomised trial, 2017 Does yoga help with PMS symptoms? This text only gives the background and reasoning for a yoga trial. It does not include the trial's actual methods or results, so no answer about whether yoga worked can be given from this excerpt. Case-control study, 2016 Do women with PMDD respond differently to allopregnanolone across the menstrual cycle? Yes, women with PMDD show an opposite pattern of brain response to injected allopregnanolone across the cycle compared to healthy women, with stronger effects in the luteal phase, suggesting altered sensitivity to this hormone. Randomised trial, 2015 Does quetiapine help women with PMS/PMDD who don't respond well to antidepressants? This very small pilot study suggests quetiapine as an add-on to antidepressants may help reduce mood-related symptoms like anxiety and irritability, but the evidence is weak because only 20 women were studied. Survey study, 2014 Does allopregnanolone, a progesterone metabolite, cause mood problems in PMDD? Theory suggests it might. In women with PMDD, allopregnanolone levels increase during the menstrual cycle and appear linked to mood changes. Paradoxically, this brain chemical normally calms the brain. Case report, 2013 Can mood disorder symptoms happen only during the second half of the menstrual cycle? One woman had cycles of high mood followed by low mood that happened only during the second half of her menstrual cycle, repeating each month. Case report, 2013 Can high testosterone levels be connected to PMDD, bipolar disorder, and certain medications? In one woman with bipolar disorder and PMDD on quetiapine and lithium, initial testosterone was 88.5 ng/dL. When hormone levels were normalized, testosterone returned to normal. This is one case only. Case report, 2013 Does lamotrigine help when antidepressants don't work well enough for severe PMDD? One woman with severe PMDD significantly improved when lamotrigine was added to her antidepressant. This is one person's experience, so we can't be sure it would work for everyone. Case report, 2013 Can severe mood changes around a period be an early sign of bipolar disorder? In one teenage girl, a psychotic episode tied to her period turned out to be the first sign of bipolar disorder. This is a single case, so it cannot tell us how common this is. Case report, 2013 Does olanzapine help premenstrual psychosis? One girl with recurrent premenstrual psychosis was successfully treated with olanzapine. This is one case of a very rare condition, so we need much more research. Survey study, 2013 Do women with epilepsy have more PMDD, and does the medication matter? Overall, PMDD rates are similar in women with and without epilepsy. But women with certain types of epilepsy, especially temporal lobe epilepsy, have more PMDD, and lamotrigine may reduce the risk. Survey study, 2012 How do changes in brain chemicals during your cycle affect seizures? This lab study in mice found that a brain chemical that normally decreases before your period protects against seizures. When it drops, seizures become more likely. Survey study, 2011 Why do some women experience negative mood with hormone changes? The paper proposes that negative mood in PMDD may result from how a brain chemical reacts to receptors. This is a theoretical explanation based on research patterns, not a definitive finding from a new study. Cohort study, 2011 Does having epilepsy increase the risk of PMDD, and what makes it worse? The study suggests epilepsy and certain antiepileptic drugs may influence PMDD severity in women with epilepsy, but findings are preliminary. Specific medications like carbamazepine and lamotrigine appear to affect PMDD differently. Cohort study, 2010 How do anxiety disorders differ across different life stages? The provided summary focuses on anxiety in children and risk factors. The section about women and hormones is cut off in the provided text, so no conclusion about menstrual-related anxiety can be drawn. Survey study, 2009 Why do some women feel depressed or anxious when progesterone increases before their period? A literature review suggests progesterone is converted to chemicals that affect the brain's GABA system. At levels before the period, these chemicals paradoxically cause anxiety instead of calming it. Women with PMDD have changes in their GABA system that make them more sensitive. Lab study, 2007 Can antidepressants reduce anxious-like behavior during low-hormone phases in female rats? Yes. Fluoxetine, desipramine, nomifensine, diazepam, and progesterone all reduced anxious-like burying behavior during the low-hormone phase. Chlorpromazine had no effect. Lab study, 2006 Can a hormone that usually reduces anxiety instead cause anxiety after your body adapts to its being blocked? Yes. When a hormone precursor was blocked, the hormone THP (which normally calms anxiety) instead increased anxiety in female mice. This effect involved changes to specific brain receptors. Survey study, 2004 How does the menstrual cycle affect sleep problems in women? Sleep problems in women are connected to hormone changes during the menstrual cycle, pregnancy, and menopause. Medical systems recognize premenstrual insomnia and oversleeping as sleep disorders linked to the cycle. Randomised trial, 2001 Do buspirone and nefazodone help premenstrual dysphoria? Buspirone reduced premenstrual irritability and overall symptoms more than placebo. Nefazodone did not work better than placebo. Both had good tolerability with no excess sexual side effects. Survey study, 2001 How common is premenstrual dysphoric disorder and how is it related to other psychiatric conditions? About 75-85% of women report some premenstrual symptoms, but only 10-15% seek care and 2-5% experience serious disruption to work or social life. PMS may worsen other psychiatric conditions. Survey study, 2001 Does short-term progesterone exposure change anxiety and brain chemistry in female rats? Yes. Even 2-3 days of progesterone exposure changed brain cell receptors in a way linked to increased anxiety, and rats showed more anxiety-like behavior. Survey study, 2000 Why do women get more anxious when hormone levels drop? Falling estrogen and progesterone levels may trigger anxiety and mood disorders by affecting how brain receptors that control anxiety and mood work. The exact mechanism is not yet fully understood. Study, 2000 Are physical PMS symptoms linked to progesterone and other hormones? Symptoms peaked 1-3 days before menstruation, delayed 3-6 days after hormone peaks. Progesterone was more linked to symptoms than desoxycorticosterone. Review, 2000 Do antidepressants work differently for women, and can they help PMDD? This expert review suggests newer antidepressants (SSRIs) may work better than older ones in women and may help premenstrual dysphoric disorder (PMDD), including when taken only in part of the cycle, but it is an opinion piece summarising other research, not a new trial. Randomised trial, 1999 Does alprazolam (an anti-anxiety medicine) affect how much women with PMDD eat? Yes. Alprazolam increased food intake during the premenstrual phase, especially fatty foods. Women who restrict eating were most affected, eating 26% more calories on the highest dose than on placebo. Non-randomised trial, 1999 Does taking sertraline only in the second half of the cycle help PMDD? In this very small study, half of the women who completed treatment (3 out of 6) showed significant improvement in PMDD symptoms with luteal-phase sertraline dosing. Lab study, 1998 How does progesterone dropping affect the brain's anxiety-control system? When progesterone suddenly drops, the brain's anxiety-calming system becomes much less effective. This might explain anxiety symptoms that some women experience before their period. Review, 1998 What treatments actually help with PMS? This review says treatment depends on your symptoms, and that birth control pills, water pills (diuretics), antidepressants, talk therapy and nutritional supplements have helped some women, while high-dose vitamin B6, progesterone, alprazolam and GnRH agonist drugs are generally not recommended. Survey study, 1997 How are anxiety symptoms and anxiety disorders linked to PMDD? PMDD appears linked to anxiety disorders. Women with PMDD often have anxiety histories, and treatments that work for anxiety also help PMDD, though this is a review of existing research rather than new original findings. Non-randomised trial, 1997 Do women with PMS respond differently to sedatives than women without PMS? Yes, women with PMS had reduced sensitivity to benzodiazepines throughout their menstrual cycle compared to controls, with effects most noticeable in the luteal phase. This is a small uncontrolled study, so we cannot be fully certain of these results. Randomised trial, 1997 Do women with PMS respond differently to sedative medications? Yes, women with PMS showed reduced sensitivity to benzodiazepine medication, particularly during the premenstrual phase, compared to other women. Non-randomised trial, 1994 Is there a blood cell marker linked to PMS symptoms? Possibly, but we cannot be confident. A small pilot study found a link between a cell transport mechanism and premenstrual symptom severity in the week before the period, but the groups were too small to confirm this. Cohort study, 1993 Is low serotonin sensitivity a permanent trait in PMDD? Women with PMDD showed blunted serotonin responses during their follicular phase, suggesting low serotonin sensitivity may be a constant trait rather than only occurring before the period. Non-randomised trial, 1993 Does low-dose valproate help premenstrual syndrome? In this small trial, only 3 of 8 women with premenstrual syndrome (38%) reported good response to low-dose valproate, while 5 reported no response. The medication worked much better for mood disorders than for PMS. Review, 1993 What mood disorders affect women and how should they be treated? Yes. Premenstrual depression is strongly linked to major depression and responds well to serotonin-boosting antidepressants. SSRIs are especially useful because they have few side effects and are safe even in overdose. Review, 1991 What treatments are available for late luteal phase dysphoric disorder? Many treatments exist, including medications, vitamins, and hormones. However, non-drug approaches like diet, exercise, and psychotherapy have received less research attention. Study, 1990 Does the menstrual cycle change how much lithium stays in your blood? No. The menstrual cycle does not appear to affect blood lithium levels. Study, 1988 Can PMS be linked to mental health problems? PMS may be connected to psychiatric disorders. Better understanding of how they are linked could help with treating both conditions. Randomised trial, 1985 What are the best methods for studying premenstrual syndrome? Good PMS research should use well-defined patient groups, confirm reports with daily monitoring, consider different types of biological changes, exclude placebo responders before testing treatments, and use double-blind placebo-controlled crossover designs. Review, 1985 What causes PMS and what is the best treatment? Multiple theories explain PMS including psychological, nutritional, and hormonal causes, but none are proven. No definitive treatment exists. Treatment must be individualized based on clinical response. Case report, 1985 Does blood lithium level change with menstrual cycle mood changes? Yes. This single woman showed that her blood lithium level changed in sync with her mood swings: highest during depression, lowest during hypomania, even though she took the same dose every day. Non-randomised trial, 1985 What are the treatments for premenstrual symptoms? As of 1985, PMS causes were unknown and controlled studies had failed to confirm proposed theories. This paper reviews treatment approaches and offers clinical management suggestions. Non-randomised trial, 1984 Does lithium help with premenstrual tension? Case reports suggested it might help, but well-designed research studies found no benefit. Survey study, 1983 Do the treatments doctors use for premenstrual tension actually work? Doctors have tried many treatments for PMS including hormones, vitamins, and psychotherapy, but the results are mixed and conflicting. Without understanding the cause of PMS, there is no single universally accepted effective treatment. Interview study, 1980 What causes premenstrual tension syndrome? The authors propose that high prolactin levels, possibly combined with low estrogen or progesterone, may cause premenstrual symptoms. This is a theory, not a tested finding. Study, 1980 Does lithium carbonate help women with severe premenstrual tension? Lithium did not reduce physical symptoms and did not work for most women's behavioral symptoms. Measurement tools showed improvement, but this benefit had no real practical value, and side effects were common. Review, 1971 Could hormone-driven changes in brain chemicals explain premenstrual mood swings? This 1971 review suggests that shifting levels of ovarian hormones (estrogen, progesterone, aldosterone) during the cycle may affect mood by altering brain chemicals called monoamines, but this is a theory built from combining older human and animal studies, not a new trial in women with PMS. Show more studies Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗