---
title: Allopregnanolone and Dynamic GABA-A Receptor Plast | PMS & PMDD trial
description: Recruiting now. Clinical trial on Premenstrual Dysphoric Disorder (PMDD) run by Johns Hopkins University in United States.
url: https://niyora.com/research/trials/allopregnanolone-and-dynamic-gaba-a-receptor-plasticity-in-nct06704594/
---

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- Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder

Recruiting now

# BLOOM: Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder

Status Recruiting now Registry ID NCT06704594 Type Interventional (tests a treatment) Phase Phase 4 Conditions Premenstrual Dysphoric Disorder (PMDD) What is tested sertraline 50 mg daily (drug); Placebo Oral Tablet (drug) Sponsor Johns Hopkins University Where United States Participants 288 (planned) Start 2025-05-14 Completion 2029-07-01 Last update 2026-05-07

## About the study

Premenstrual dysphoric disorder (PMDD) is a severe affective disorder impacting millions of women worldwide, thought to be due to altered sensitivity to hormone fluctuations across the menstrual cycle. Neuroactive steroid hormones (NAS) and the gamma-aminobutyric acid (GABA)-A receptor (GABAAR) are thought to play a role in PMDD. This research will assess the blood levels of GABAergic NAS, expression of associated enzymes, and expression of GABAAR subunits across the premenstrual (luteal) phase of the menstrual cycle in healthy controls and individuals with PMDD. Within the PMDD group, the investigators will assess how these measures are affected by a low-dose antidepressant medication versus placebo. The results will provide a comprehensive view of the changes in these systems across the menstrual cycle and will add to the investigator's understanding of the mechanisms that underlie PMDD, as well as therapeutic mechanisms of PMDD treatment.

Summary from ClinicalTrials.gov.

[See how to take part](https://clinicaltrials.gov/study/NCT06704594)

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