---
title: Comparison of Fluoxetine, Calcium and Placebo for  | PMS & PMDD trial
description: Completed. Clinical trial on Premenstrual Syndrome run by Donaghue Medical Research Foundation in United States.
url: https://niyora.com/research/trials/comparison-of-fluoxetine-calcium-and-placebo-for-the-nct00965562/
---

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- Comparison of Fluoxetine, Calcium and Placebo for the Treatment of Moderate to Severe Premenstrual Syndrome (PMS)

Completed

# Comparison of Fluoxetine, Calcium and Placebo for the Treatment of Moderate to Severe Premenstrual Syndrome (PMS)

A Double-blind, Parallel Comparison of Fluoxetine, Calcium and Placebo for the Treatment of Moderate to Severe Premenstrual Syndrome (PMS)

Status Completed Registry ID NCT00965562 Type Interventional (tests a treatment) Phase NA Conditions Premenstrual Syndrome What is tested Fluoxetine (drug); Calcium (drug); Placebo (drug) Sponsor Donaghue Medical Research Foundation Where United States Participants 49 Start 2000-09 Completion 2010-10 Last update 2015-03-23 Results posted Yes

## About the study

The purpose of this study is to compare the efficacy of calcium carbonate to fluoxetine in the treatment of moderate to severe PMS. Second, to compare each active agent to a placebo control. Third, to evaluate the efficacy of each treatment for specific symptom clusters (i.e. affective and somatic). Fourth, to determine whether the addition of calcium to on going fluoxetine treatment leads to additional therapeutic benefit.

Summary from ClinicalTrials.gov.

[See the full record](https://clinicaltrials.gov/study/NCT00965562)

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