---
title: CREST: Samphire Guided Care Program on Wellbeing,  | PMS & PMDD trial
description: Recruiting now. Study on Premenstrual Syndrome and Premenstrual Dysphoric Disorder run by Samphire Group, Inc. in United States.
url: https://niyora.com/research/trials/crest-samphire-guided-care-program-on-wellbeing-work-nct07679074/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Clinical trials](https://niyora.com/research/trials/)
- CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life

Recruiting now

# CREST: CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life

A 12-Week Prospective Cohort Study Evaluating the Efficacy of the Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life in Individuals With Menstrual and Pelvic Health Conditions

Status Recruiting now Registry ID NCT07679074 Type Observational (no treatment given) Conditions Premenstrual Syndrome, Premenstrual Dysphoric Disorder, Dysmenorrhea, Endometriosis What is tested Lutea Transcranial Direct Current Stimulation (tDCS) Device (device); Samphire Guided Care Program (behavioral) Sponsor Samphire Group, Inc. Where United States Participants 50 (planned) Start 2026-06-01 Completion 2027-03-01 Last update 2026-07-01

## About the study

This study evaluates the feasibility and efficacy of the Samphire Guided Care (SGC) program * a 12-week structured digital health program combining clinician-led onboarding, at-home neuromodulation using the Lutea tDCS device, neuromodulation coach support, and app-based symptom tracking - on work productivity, employee wellbeing, and quality of life in individuals experiencing mood and cognitive symptoms associated with menstruation, perimenopause, or menopause.

Summary from ClinicalTrials.gov.

[See how to take part](https://clinicaltrials.gov/study/NCT07679074)

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗