---
title: Examining the Impact of Phytoestrogens Supplementa | PMS & PMDD trial
description: By invitation. Clinical trial on Apparently Healthy and Not Receiving Hormonal Therapy run by University of Jordan in Jordan.
url: https://niyora.com/research/trials/examining-the-impact-of-phytoestrogens-supplementation-on-nct07310485/
---

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- Examining the Impact of Phytoestrogens Supplementation on the Gene Expression, and Premenstrual Syndrome in Primenopausal Women

By invitation

# Examining the Impact of Phytoestrogens Supplementation on the Gene Expression, and Premenstrual Syndrome in Primenopausal Women

Examining the Impact of Phytoestrogens Supplementation on the Gene Expression and Premenstrual Syndrome in Perimenopausal Women Aged 40-55 in Jordan

Status By invitation Registry ID NCT07310485 Type Interventional (tests a treatment) Phase NA Conditions Apparently Healthy and Not Receiving Hormonal Therapy What is tested SDG lignans (dietary_supplement); Placebo (dietary_supplement) Sponsor University of Jordan Where Jordan Participants 50 (planned) Start 2025-11-01 Completion 2026-08-31 Last update 2026-09-04

## About the study

This randomized, double-blind, placebo-controlled clinical trial investigated the effects of flaxseed-derived phytoestrogen supplementation on selected gene-expression markers and premenstrual syndrome (PMS) severity among perimenopausal women aged 40-55 years in Jordan. Participants received either a flaxseed lignan extract providing 100 mg of lignans daily or a matched placebo for 12 weeks. Gene expression and PMS severity were assessed at baseline and at the end of the intervention to examine the potential effects of phytoestrogen supplementation on selected molecular markers and menstrual-related symptoms.

Summary from ClinicalTrials.gov.

[See how to take part](https://clinicaltrials.gov/study/NCT07310485)

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