---
title: Neurocognitive Mechanisms of Perimenstrual Estroge | PMS & PMDD trial
description: Stopped early. Clinical trial on Suicide run by University of Illinois at Chicago in United States.
url: https://niyora.com/research/trials/neurocognitive-mechanisms-of-perimenstrual-estrogen-effects-nct06191289/
---

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- Neurocognitive Mechanisms of Perimenstrual Estrogen Effects on Suicidality

Stopped early

# CLEAR-4: Neurocognitive Mechanisms of Perimenstrual Estrogen Effects on Suicidality

Clarifying the Endocrinology of Acute Risk 4 (CLEAR-4): Neurocognitive Mechanisms of Perimenstrual Estrogen Effects on Suicidality

Status Stopped early Registry ID NCT06191289 Type Interventional (tests a treatment) Phase Phase 2 Conditions Suicide What is tested Transdermal Estradiol (drug); Placebo (other) Sponsor University of Illinois at Chicago Where United States Participants 11 Start 2024-03-16 Completion 2024-12-01 Last update 2025-10-29

## About the study

This within-person, crossover, 2-condition, placebo-controlled study compares the impact of two perimenstrual conditions on severity of suicidal symptoms in females with past-month suicidality but minimal risk of imminent suicide attempt. The two conditions are (1) perimenstrual administration of estradiol and (2) natural perimenstrual withdrawal from estradiol during placebo.

Summary from ClinicalTrials.gov.

[See the full record](https://clinicaltrials.gov/study/NCT06191289)

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