---
title: RESist Against Irritability Superiority Trial | PMS & PMDD trial
description: Status unknown. Clinical trial on Irritable Mood run by University Hospital, Montpellier in France.
url: https://niyora.com/research/trials/resist-against-irritability-superiority-trial-nct05528926/
---

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- RESist Against Irritability Superiority Trial

Status unknown

# RESIST: RESist Against Irritability Superiority Trial

Parent Training for the Treatment of Irritability in Children and Adolescents: a Multisite Randomized Controlled, 3-parallel-group, Evaluator-blinded, Superiority Trial

Status Status unknown Registry ID NCT05528926 Type Interventional (tests a treatment) Phase NA Conditions Irritable Mood What is tested Non-Violent Resistance (other); Parent Management Training (other); Treatment As Usual (drug) Sponsor University Hospital, Montpellier Where France Participants 270 (planned) Start 2023-04-25 Completion 2026-09-01 Last update 2023-08-14

## About the study

Irritability is defined as developmentally inappropriate proneness to anger. Irritability is a symptom of several mental health conditions in children and adolescents such as attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), conduct disorder (CD), depressive disorders, anxiety disorders.Irritability has been associated with poor functional outcomes across the lifespan and was found to be specifically associated with concurrent and longitudinal emotional disorders, suicidality and impaired academic and socio-professional functioning. Children with high irritability also have distinct physiological profiles with hyper-reactivity to stress and perceived threats. Despite the high prevalence and health issues related to irritability, there is little treatment research on this topic. Developing evidence-based non-pharmacological treatment options for children suffering from severe, chronic irritability is therefore a particularly important target for clinical research.

Summary from ClinicalTrials.gov.

[See the full record](https://clinicaltrials.gov/study/NCT05528926)

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