---
title: Unique Effects of Perimenstrual Estradiol or Proge | PMS & PMDD trial
description: Completed. Clinical trial on Suicidal Ideation run by University of Illinois at Chicago in United States.
url: https://niyora.com/research/trials/unique-effects-of-perimenstrual-estradiol-or-progesterone-nct03498313/
---

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- Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality

Completed

# CLEAR-2: Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality

Status Completed Registry ID NCT03498313 Type Interventional (tests a treatment) Phase Phase 4 Conditions Suicidal Ideation What is tested Transdermal Estradiol + Placebo (drug); Oral Micronized Progesterone + Placebo (drug); Placebos (drug) Sponsor University of Illinois at Chicago Where United States Participants 60 Start 2018-07-27 Completion 2021-05-09 Last update 2022-09-14 Results posted Yes

## About the study

This within-person, crossover, 3-condition, placebo-controlled study compares the impact of three perimenstrual conditions on severity of suicidal symptoms in females with past-month suicidality but minimal risk of imminent suicide attempt. The three conditions are (1) perimenstrual withdrawal from estradiol only (during progesterone stabilization), (2) perimenstrual withdrawal from progesterone only (during estradiol stabilization), and (3) perimenstrual withdrawal from both estradiol and progesterone during placebo.

Summary from ClinicalTrials.gov.

[See the full record](https://clinicaltrials.gov/study/NCT03498313)

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