Survey study, 2026
Can blood tests help identify which women have moderate-to-severe PMS?
Yes. Four blood markers related to inflammation were higher in women with moderate-to-severe PMS compared to mild PMS, and a combined score from these markers predicted moderate-to-severe PMS.
What they did
Researchers enrolled 80 women aged 18-40 with PMS and tracked their symptom severity over two menstrual cycles. They divided women into mild PMS (32 women) and moderate-to-severe PMS (44 women) groups. During the late menstrual phase (days 21-28), they took blood samples and measured four markers related to inflammation and blood cells.
What they found
All four blood markers were higher in women with moderate-to-severe PMS compared to mild PMS. A combined score from these markers correlated strongly with symptom severity scores and predicted which women had moderate-to-severe PMS.
What it means for you
Blood tests might be a simple, cost-effective way to identify which women have moderate-to-severe PMS and need more intensive treatment. However, the study was small, done in one location, and the authors note that findings need to be tested in other populations before they can be widely used.
44
Moderate-to-severe PMS
32
Mild PMS
80
Women studied
About the study
- Original title
- A composite hematological inflammatory panel (NLR, PLR, MPV, CRP) as a predictor of moderate-to-severe Premenstrual Syndrome: A prospective observational study
- Authors
- T. Nischala, R Vel Murugan
- Journal
- International Journal of Drug Delivery Technology
- Year
- 2026
- Study design
- Survey study
- Participants
- 44
- What was tested
- None
- Open access
- Yes
- Read the paper
- doi.org/10.25258/ijddt.16.50s.121