Case-control study, 2021
Are there genetic differences between different types of PMDD?
Yes. Different PMDD subtypes show distinct genetic patterns that could eventually help diagnose which type a woman has and predict which treatments might work.
What they did
Case-control study examining genetic material from white blood cells in 127 Chinese women with two clinical subtypes of PMDD and 108 Chinese controls. Researchers used genome sequencing to look for copy number variation (areas where people have extra or missing DNA). Machine learning was used to see if genetic patterns could predict PMDD subtype.
What they found
Genetic patterns divided PMDD patients into two groups that matched the two clinical subtypes with 89.8% consistency. Machine learning could predict whether a genetic sample came from a woman with depression-type PMDD, invasion-type PMDD, or a control with over 80% accuracy. Certain genetic features related to steroid hormone production appeared protective against PMDD.
What it means for you
Genetic variation may explain why different women with PMDD experience different symptom patterns. This could eventually help doctors identify which type a woman has and choose better treatments. The study was limited to a Chinese population with two specific subtypes, so results may not apply to all women.
127
Chinese women with PMDD studied
108
Chinese controls
89.8%
consistency between genetic patterns and clinical subtypes
About the study
- Original title
- Copy number variation profile-based genomic subtyping of premenstrual dysphoric disorder in Chinese
- Authors
- Xue H, Wu Z, Long X et al.
- Journal
- bioRxiv
- Year
- 2021
- Study design
- Case-control study
- Participants
- 127
- Read the paper
- doi.org/10.1101/2021.02.08.430168
Topics
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