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Systematic review, 2003

Does vitamin B6 help with premenstrual syndrome?

Yes, a meta-analysis of 6 controlled trials found that vitamin B6 is effective for treating PMS.

Moderate study design Women with PMS (from 6 controlled trials)

What they did

Meta-analysis of 6 controlled clinical trials testing pyridoxine (vitamin B6) for PMS symptoms.

What they found

Results were divided into two categories. Category 1 showed relative risk of 1.18 with 95% confidence interval 1.06 to 1.30. Category 2 showed relative risk of 3.34 with 95% confidence interval 2.12 to 5.25. Both showed pyridoxine was more effective than control treatment.

What it means for you

Vitamin B6 appears to help PMS symptoms. However, this analysis is from 2003 and includes only 6 trials, which is a small amount of evidence. The abstract does not explain what Category 1 and Category 2 represent, which makes it difficult to understand what these results mean in practice.

6

controlled trials analyzed

1.18

relative risk Category 1 (95% CI 1.06-1.30)

3.34

relative risk Category 2 (95% CI 2.12-5.25)

About the study

Original title
Effectiveness of Pyridoxine in the Treatment of Premenstrual Syndrome: Meta-analysis of Controlled Trials
Authors
Long-Yan Lin, Li‐Hsing Ho, Ching‐Yi Lin
Journal
中山醫學雜誌
Year
2003
Study design
Systematic review
What was tested
Pyridoxine (vitamin B6)

Topics