Randomised trial, 2024
Is Ganyushu Granule effective and safe for premenstrual syndrome?
Yes, both high-dose and low-dose Ganyushu Granule reduced PMS symptoms better than placebo starting from the second cycle, with high-dose showing the fastest improvement and no serious side effects.
What they did
Randomized controlled trial from June 2018 to March 2021 with 240 women with PMS and liver depression/qi stagnation. Women were divided into three groups: high-dose Ganyushu Granule (78 women), low-dose Ganyushu Granule (82 women), and placebo (80 women). Treatment was taken 3 times daily for up to 3 menstrual cycles.
What they found
Starting from the 2nd cycle, both high and low-dose groups had lower PMS diary scores than placebo (P<0.05). The high-dose group had lower tension scores after the 1st cycle and the best Chinese medicine syndrome improvement after the 2nd cycle. No serious adverse reactions were reported in any group.
What it means for you
Ganyushu Granule appears to safely reduce PMS symptoms, with higher doses working faster. The study was conducted only in China for one specific PMS pattern, so results may not apply to all women or other countries.
240
total participants
3
treatment groups
3
menstrual cycles
About the study
- Original title
- Efficacy and Safety of Ganyushu Granule in Treatment of Premenstrual Syndrome with Gan (Liver) Depression and Qi Stagnation Syndrome: A Randomized, Double-Blind, Multicenter, Phase-II Clinical Trial
- Authors
- Teng XX, Xu LW, Lin J et al.
- Journal
- Chinese journal of integrative medicine
- Year
- 2024
- Study design
- Randomised trial
- Participants
- 240
- What was tested
- High-dose or low-dose Ganyushu Granule or placebo, 3 times daily for up to 3 menstrual cycles
- Read the paper
- doi.org/10.1007/s11655-024-3755-z
Topics
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