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Review, 2002

Are women more likely to get depression, especially due to hormonal changes?

Yes. Women have 1.7 to 2.7 times higher risk of depression in their lifetime compared to men, and hormonal changes around puberty, periods, and menopause increase that risk.

Early or limited evidence Women across reproductive life stages from puberty through menopause.

What they did

Reviewed evidence on depression rates and risk in women across different stages of reproductive life: puberty, menstruation, pregnancy, postpartum period, and menopause.

What they found

Women have lifetime major depression rates 1.7 to 2.7 times higher than men. Puberty marks the start of increased depression risk in women. Most women report premenstrual physical or emotional symptoms, with some severe enough to diagnose as PMDD. Pregnancy does not increase depression risk, but women with past depression history are at risk for relapse if antidepressants are stopped. Postpartum period increases depression incidence. Women going through perimenopause, especially those with past psychiatric history, report depressive symptoms.

What it means for you

Women are biologically at higher risk for depression throughout their reproductive years due to hormonal changes. Women with a history of depression need to be careful about stopping antidepressant medication during life transitions like pregnancy or perimenopause.

1.7 to 2.7 times

Higher lifetime depression rate in women compared to men

About the study

Original title
Epidemiology of depression throughout the female life cycle
Authors
Burt VK, Stein K
Journal
The Journal of clinical psychiatry
Year
2002
Study design
Review

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