Review, 2005
Can controlling hormones during the luteal phase improve fertility treatment outcomes?
Yes. Lowering the hormone FSH during the luteal phase reduced size variation among egg follicles and improved their coordination during fertility treatment.
What they did
Three clinical studies tested whether suppressing FSH (a hormone) during the luteal phase could reduce variation in egg follicle sizes. Researchers used physiological doses of estradiol and GnRH antagonist during the luteal phase and measured follicle characteristics on day 3 of the cycle and during ovarian stimulation.
What they found
Luteal FSH suppression by either estradiol or GnRH antagonist reduced follicle size variation and improved uniformity of early follicles. This coordination effect persisted during ovarian stimulation and improved ovarian response to both GnRH agonist and antagonist protocols.
What it means for you
This is a specialized finding for women undergoing fertility treatment. It shows that hormone timing can improve how many eggs mature together during treatment. This does not apply to PMS or PMDD but to fertility procedures.
3
Clinical studies conducted testing this approach
Day 3
When follicle characteristics were measured
Luteal
Phase when hormone suppression was given
About the study
- Original title
- Hormonal manipulations in the luteal phase to coordinate subsequent antral follicle growth during ovarian stimulation
- Authors
- Fanchin R, Méndez Lozano DH, Schonäuer LM et al.
- Journal
- Reproductive biomedicine online
- Year
- 2005
- Study design
- Review
- What was tested
- FSH suppression during luteal phase using physiological estradiol or GnRH antagonist
- Read the paper
- doi.org/10.1016/s1472-6483(10)61115-7
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