Randomised trial, 1988
Does stopping ovulation with buserelin help premenstrual tension syndrome?
Yes, buserelin (which stops ovulation) worked significantly better than placebo and eliminated the monthly symptom pattern. This shows the menstrual cycle is the cause of these symptoms.
What they did
26 women with PMS received buserelin nasal spray (400 micrograms once daily) or placebo in a double-blind crossover design. 23 women completed the study. Women rated their symptoms daily for 2 baseline cycles, then for up to 6 treatment cycles or 6 months. Blood samples for hormone levels were taken weekly.
What they found
Both placebo and buserelin were better than the woman's own baseline symptoms. Buserelin was significantly better than placebo. Women on placebo still had symptoms that changed monthly at the end of treatment, but women taking buserelin no longer had this monthly pattern.
What it means for you
Stopping ovulation clearly helps PMS and eliminates the monthly pattern of symptoms. Small study with 26 women. The study proves the menstrual cycle is involved in causing these symptoms.
26
women enrolled (23 completed)
400 micrograms
buserelin dose daily
6 months
study duration
About the study
- Original title
- Induced anovulation as treatment of premenstrual tension syndrome. A double-blind cross-over study with GnRH-agonist versus placebo
- Authors
- Hammarbäck S, Bäckström T
- Journal
- Acta obstetricia et gynecologica Scandinavica
- Year
- 1988
- Study design
- Randomised trial
- Participants
- 26
- What was tested
- GnRH-agonist buserelin nasal spray 400 micrograms daily versus placebo
- Read the paper
- doi.org/10.3109/00016348809004191
Topics
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