Survey study, 2014
Is a gene called COMT a risk factor for PMS?
No, not directly. A gene called COMT does not appear to be linked to PMS overall, though women with joint pain may have a connection to a specific type of this gene.
What they did
Compared blood samples from 53 women with PMS and 53 healthy women, looking for differences in a gene called COMT.
What they found
There was no significant difference in the COMT gene between women with PMS and healthy women overall. However, women who reported joint pain as a PMS symptom were more likely to carry a particular version of the COMT gene called Met/Met.
What it means for you
The COMT gene does not seem to cause PMS, though it might relate to joint pain. The study was small, so conclusions are limited and more research is needed.
53
women in each group
p=0.61
COMT difference between PMS and control groups
p=0.04
COMT Met/Met variant and joint pain
About the study
- Original title
- Is catechol-o-methyltransferase gene polymorphism a risk factor in the development of premenstrual syndrome?
- Authors
- Deveci EO, Incebiyik A, Selek S et al.
- Journal
- Clinical and experimental reproductive medicine
- Year
- 2014
- Study design
- Survey study
- Participants
- 53
- What was tested
- None
- Open access
- Yes
- Read the paper
- doi.org/10.5653/cerm.2014.41.2.62
Topics
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