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Case-control study, 2014

Does past abuse affect pain sensitivity differently in women with menstrual mood disorders?

Yes. Women with menstrual mood disorders who experienced abuse showed greater pain sensitivity and lower stress hormone levels, suggesting abuse affects this group differently.

Moderate study design 126 women: 63 with menstrually related mood disorders (34 with abuse history) and 63 without (31 with abuse history)

What they did

126 women (63 with menstrually related mood disorders, 63 without) were tested for pain sensitivity using cold water and arm blood flow restriction. Researchers also measured their stress hormones in blood.

What they found

Women with menstrual mood disorders and abuse history showed increased sensitivity to both pain tests and lower cortisol levels. Higher cortisol was linked to less pain sensitivity in all women. Norepinephrine predicted pain sensitivity only in women with menstrual mood disorders.

What it means for you

Women with menstrual mood disorders and past abuse show distinctly different pain responses and stress hormone patterns, which might explain why they experience more pain. This could help identify who needs specialized treatment, though this is an observational study and larger trials are needed to confirm these associations.

126

total women studied

63

women with menstrual mood disorders

34

with abuse history in mood disorder group

About the study

Original title
Menstrually related mood disorders and a history of abuse: moderators of pain sensitivity
Authors
Fleischman DS, Bunevicius A, Leserman J et al.
Journal
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
Year
2014
Study design
Case-control study
Participants
126
What was tested
Pain sensitivity testing and stress hormone measurement
Open access
Yes

Topics