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Survey study, 2006

Do oral contraceptives improve mood in women with premenstrual dysphoric disorder?

This theoretical review proposes that birth control pills affect mood by changing brain chemicals called neurosteroids, but researchers still disagree on whether the pills improve or worsen mood in PMDD.

Early or limited evidence Women with and without PMDD

What they did

A literature review presenting a theoretical model of how oral contraceptives might affect mood through changes in neurosteroids (brain chemicals derived from hormones). The authors review research on estrogen, progesterone, and their effects on brain function and PMDD.

What they found

The review proposes that progestins (synthetic progesterone in birth control pills) may affect mood by changing neurosteroid levels. However, the authors note that despite numerous studies, there is no consensus on the effects of oral contraceptives on mood.

What it means for you

Birth control pills may affect mood through brain chemical changes, but more research is needed to understand exactly how and whether they help or harm mood in women with PMDD. This is a theoretical framework for future research, not new research findings.

About the study

Original title
Oral contraceptives and mood in women with and without premenstrual dysphoria: a theoretical model
Authors
Kurshan N, Neill Epperson C
Journal
Archives of women's mental health
Year
2006
Study design
Survey study
What was tested
None

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