Case-control study, 1988
Is monoamine oxidase B activity different in women with PMS?
No, there were no significant differences between women with PMS and controls in monoamine oxidase B activity. This suggests this enzyme is not involved in PMS, though the study was small.
What they did
Case-control study measuring platelet monoamine oxidase B activity, estradiol, and progesterone throughout one menstrual cycle in women with PMS and control subjects.
What they found
No significant differences were noted between women with PMS and control subjects in monoamine oxidase B activity, estradiol, or progesterone levels. The study indicates that well-screened women with PMS are biochemically similar to normal controls on these measures.
What it means for you
This enzyme does not appear to be involved in PMS. The main limitations are the small sample size and that this is just one enzyme among many that affect mood and brain function.
13
Women with premenstrual syndrome
19
Control women
1
Menstrual cycles tracked per woman
About the study
- Original title
- Platelet monoamine oxidase B activity in women with premenstrual syndrome
- Authors
- Rapkin AJ, Buckman TD, Sutphin MS et al.
- Journal
- American journal of obstetrics and gynecology
- Year
- 1988
- Study design
- Case-control study
- Participants
- 19
- What was tested
- None
- Read the paper
- doi.org/10.1016/0002-9378(88)90590-x