Randomised trial, 1990
Does synthetic diosmin help premenstrual breast pain?
Yes, synthetic diosmin significantly reduced breast pain over one year and the improvement lasted. However, this study had no placebo group, so we cannot tell if the benefit is from the drug itself or other factors.
What they did
120 women with premenstrual and vascular breast pain received synthetic diosmin. Another 120 women were not treated (controls). Both groups were observed for one year to track changes in breast pain.
What they found
Women treated with diosmin had a significant decrease in breast pain that was maintained throughout the year.
What it means for you
Diosmin may help premenstrual breast pain, but the main limit is that there was no placebo group, so we cannot know if the improvement is from the drug itself or from attention, time, or expectation. The study also lacks details about how pain was measured.
120
Women treated
120
Control group
1 year
Duration
About the study
- Original title
- [Randomized study of the use of synthetic diosmin in premenstrual and vascular dysplastic mastodynia]
- Authors
- Meggiorini ML, Cascialli GL, Luciani S et al.
- Journal
- Minerva ginecologica
- Year
- 1990
- Study design
- Randomised trial
- Participants
- 120
- What was tested
- Synthetic diosmin for one year
- Read the paper
- https://pubmed.ncbi.nlm.nih.gov/2290601/
Topics
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