Randomised trial, 2002
Do different doses of medroxyprogesterone affect mood in women on hormone replacement therapy?
Both doses caused mood symptoms, but the higher dose improved mood in women with a prior PMS history. This small randomized trial suggests lower doses do not help.
What they did
A randomized double-blind crossover study of 36 postmenopausal women in northern Sweden. Women received 2 mg estradiol continuously and either 10 mg or 20 mg medroxyprogesterone acetate for 12 days of each cycle, for 5 cycles. Mood and physical symptoms were tracked daily.
What they found
Physical symptoms did not differ between doses. Both groups had more negative mood with the 10 mg dose. Women with previous PMS had better positive mood with the 20 mg dose.
What it means for you
In women on hormone replacement therapy, the higher dose of this progestin may be better for mood, especially if you have a PMS history. The study was small and included only postmenopausal women in Sweden.
36
Number of women
10 mg and 20 mg
Medroxyprogesterone doses tested
5 cycles
Treatment duration (28 days per cycle)
About the study
- Original title
- The impact of different doses of medroxyprogesterone acetate on mood symptoms in sequential hormonal therapy
- Authors
- Björn I, Bixo M, Nöjd KS et al.
- Journal
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Year
- 2002
- Study design
- Randomised trial
- Participants
- 36
- What was tested
- Medroxyprogesterone acetate at 10 mg or 20 mg doses
- Read the paper
- doi.org/10.1080/gye.16.1.1.8
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