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Randomised trial, 2017

Does the birth control pill change how bad premenstrual symptoms feel?

Yes, women using cyclic hormonal contraception had slightly smaller swings in mood and physical symptoms around their period compared with women not using it, though the pill did not get rid of the symptom pattern entirely.

Moderate study design Women enrolled in a premenstrual syndrome clinical trial, split into those using and not using cyclic hormonal contraception

What they did

Researchers studied daily symptom diaries from two groups of women in a premenstrual syndrome study: one group of 103 pill users and 387 non-users who asked to join, and another of 41 pill users and 211 non-users who were randomly assigned. They compared symptom changes across four windows of days around the start of a period.

What they found

In both groups, hormonal contraception use affected how much symptoms changed around the period (p < 0.01), and the timing window also mattered (p < 0.0001). Overall, symptom changes were bigger in women not using hormonal contraception. Depression (p = 0.04), anger or irritability (p < 0.01), and physical symptoms (p < 0.01) rose more in the non-hormonal group. Symptoms worsened as the period got closer for everyone, with the biggest group difference in the window 4 days before to 2 days after the period started.

What it means for you

Cyclic hormonal contraception seems to slightly soften premenstrual symptom swings, especially mood and physical symptoms, but it does not remove the premenstrual pattern altogether. The days just before and just after a period starts seem to be when the difference between pill users and non-users is clearest.

103 vs 387

Screened cohort using hormonal contraception vs not

41 vs 211

Randomized cohort using hormonal contraception vs not

day -4 to day 2

Window with largest symptom change difference

About the study

Original title
The Influence of Cyclic Hormonal Contraception on Expression of Premenstrual Syndrome
Authors
Yonkers KA, Cameron B, Gueorguieva R et al.
Journal
Journal of women's health (2002)
Year
2017
Study design
Randomised trial
What was tested
Cyclic hormonal contraception (the birth control pill) compared with no hormonal contraception
Open access
Yes

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