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Survey study, 2015

Does a chemical in your body change before menstruation, and does smelling it affect your feelings?

A chemical called 2-heptanone increases to about twice the level before menstruation. When people smelled this chemical for longer periods (180 seconds), they were less interested in smelling it again compared to shorter exposures. The connection to PMS or mood is unclear.

Early or limited evidence 24 women providing urine samples; 141 volunteers (men and women) in a lab smelling a chemical

What they did

The study had two parts. First, 24 women provided urine samples around ovulation and 12 days later. Second, 141 volunteers smelled 2-heptanone chemical for 5, 60, or 180 seconds and said if they wanted to smell it again. Women with anxiety, mood disorders, or PMDD were excluded from part 1.

What they found

2-heptanone levels in urine were approximately 2-fold higher before menstruation compared to around ovulation. When volunteers smelled 2-heptanone for 180 seconds, they were less willing to smell it again compared to those who smelled it for only 5 or 60 seconds. Men and women responded similarly to the chemical.

What it means for you

A chemical change happens before menstruation, which may be part of the body's normal cycle, but we don't know what it means for PMS or mental health. This study measured responses in a lab setting rather than tracking actual mood or PMS symptoms in daily life, so the practical importance remains unclear. Research directly connecting this chemical to PMS would help clarify its significance.

approx. 2-fold

2-heptanone increase before menstruation

180 seconds

exposure duration reducing interest in smelling again

141

volunteers who smelled the chemical

About the study

Original title
2-Heptanone Produces Sensorial-Emotional Changes, Depending on Length of Exposure / La 2-heptanona produce cambios sensorio-emocionales, dependiendo del tiempo de exposición
Authors
Ana Gloria Gutiérrez-García, Carlos M. Contreras, Ma. Remedios Mendoza-López
Journal
Revista Costarricense de Psicología
Year
2015
Study design
Survey study
Participants
141
What was tested
exposure to 2-heptanone for different durations
Open access
Yes

Topics