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Menstrual cycle and mood: what the research says

1534 studies on menstrual cycle and mood in PMS and PMDD, each explained in plain English. 68 of them use the strongest designs: randomised trials and systematic reviews.

Survey study 623Study 224Randomised trial 138Cohort study 125Case-control study 102Review 93
Cohort study, 2026

What genetic factors are linked to premenstrual symptoms?

One genetic location on chromosome 12 was clearly associated with PMS. The genetic factors linked to PMS are also linked to depression.

Systematic review, 2026

Do brain wave patterns change across the menstrual cycle?

Yes. Brain wave patterns shift across the cycle. Certain waves decrease and others increase around ovulation in a pattern that suggests sharper thinking and better emotional well-being. These changes could help detect hormone-sensitive mood disorders.

Randomised trial, 2026

Does aerobic or resistance exercise reduce anxiety in women with PMS?

Both aerobic and resistance exercise reduced anxiety and improved emotional control in women with PMS. Resistance exercise was superior to aerobic exercise for reducing anxiety.

Study, 2026

How do women with PMDD process emotions differently in their brains?

Women with PMDD show increased activity in emotion-processing brain networks, especially during the luteal phase, and this baseline difference even appears in the follicular phase and relates to symptom severity.

Systematic review, 2026

Can digital tools help diagnose PMDD?

Digital tools show promise for diagnosing PMDD by helping you track symptoms, but most need more testing and better integration with healthcare systems before they're widely used.

Systematic review, 2026

Why do some women experience mood changes linked to their menstrual cycle?

Evidence shows these women have normal hormone levels but heightened sensitivity in their brains and cells to hormone changes. This explains PMDD and some postpartum and perimenopausal mood problems, and has led to new treatments.

Cohort study, 2026

Does sleeping longer improve mood and fitness in elite athletes?

Yes. Sleeping longer was linked to better mood and fitness across all athletes, regardless of menstrual cycle status. Sleeping less than 8 hours was linked to below-average mood and fitness.

Case-control study, 2026

Do women with PMS handle emotions differently at different times of the cycle?

Yes. Women with PMS tend to use emotion coping strategies that make symptoms worse (like dwelling on negative thoughts) and fewer strategies that help (like accepting difficult thoughts). These patterns change across the menstrual cycle.

Survey study, 2025

Does PMDD or PMS affect quality of life?

Women with PMDD had noticeably lower quality of life scores. Women with only PMS had quality of life similar to those without these conditions. The study accounted for smoking, obesity, education, and other factors.

Randomised trial, 2025

Does mood, well-being, and sexual function change across the menstrual cycle?

No, there were no meaningful changes in sexual function, mood, or well-being across menstrual cycle phases in healthy young women. Being in a stable relationship predicted better sexual function overall, but cycle phase did not.

Systematic review, 2025

How do cognition and behavior change across the menstrual cycle in people with PMDD?

Evidence that cognitive abilities change is limited and inconsistent. A negative attention bias (focusing on negative things) appears central to PMDD.

Systematic review, 2025

Do people with PMDD and severe PMS have difficulties with emotion regulation?

People with PMDD and severe PMS may have difficulties identifying emotions and choosing how to handle them, particularly using rumination (replaying upset thoughts) in the late-luteal phase. Evidence remains limited.

Randomised trial, 2025

Does taking an antidepressant only during the second half of your cycle reduce anger and aggression in PMDD?

Yes. Taking escitalopram 20 mg during the second half of the menstrual cycle significantly reduced PMDD symptoms including irritability and anger, and reduced aggressive responses to provocation.

Survey study, 2025

Is premenstrual syndrome inherited from your family?

A study found that genes play a small role in who gets PMS symptoms. One genetic change was linked to PMS, and this same genetic pattern is also linked to depression.

Systematic review, 2025

Does how well women think change throughout their menstrual cycle?

No. Across 3,943 women in 102 studies with 730 comparisons, there was no clear evidence that thinking, memory, creativity, problem-solving, coordination, spatial ability, or verbal ability changed across the menstrual cycle.

Randomised trial, 2025

Does the menstrual cycle phase affect how much alcohol impairs women's memory?

Yes, women's working memory was less impaired by alcohol during the late follicular phase (when estradiol is high) compared to the early follicular phase (when estradiol is low), suggesting higher estradiol may protect against alcohol's cognitive effects.

Cohort study, 2025

How common is PMS in Chinese teenage girls, and what factors are linked to it?

About 1 in 4 Chinese girls (24.6%) has PMS. Higher stress, anger, alcohol use, menstrual cycles of 24 days or less, and period pain are all linked to increased PMS likelihood.

Review, 2025

How do stress hormone levels change during the menstrual cycle and how does this affect health?

Cortisol levels are higher in the first two phases of the cycle and lower in the final phase. Higher cortisol is linked to PMS symptoms, miscarriage, and reduced fertility, while birth control medications may help stabilize cortisol.

Systematic review, 2025

Does alcohol use affect menstrual health in teenage girls?

Yes. Alcohol use is linked to irregular periods, PMS, period pain, and early or unintended pregnancy in teenage girls, though more research is needed to prove alcohol directly causes these problems.

Cohort study, 2025

Do women with a history of PMS or PMDD have more depression during pregnancy and after birth?

Women with PMS or PMDD history had higher depression scores throughout pregnancy and postpartum, with PMDD carrying higher risk than PMS.

Randomised trial, 2024

Does curcumin reduce depression, anxiety, and stress in women with PMS and dysmenorrhea?

Yes, curcumin significantly reduced depression, anxiety, and stress and improved mental health and quality of life compared to placebo. This was a larger, high-quality study.

Randomised trial, 2024

Does estradiol prevent thinking problems before the period in women with suicidal thoughts?

Yes. Estradiol prevented drops in working memory and verbal fluency that otherwise happened before the period.

Review, 2024

What do brain wave patterns show about PMS and PMDD?

Preliminary evidence suggests women with these conditions may have different brain wave patterns, but we need more research to be sure.

Systematic review, 2024

What are the best treatments for PMDD and PMS?

SSRIs (antidepressants) and combined oral contraceptives (birth control pills) have the strongest evidence. For difficult cases, GnRH agonists and surgery work. Some alternatives like acupuncture and yoga show promise but need better quality research.

Case-control study, 2024

Are stomach symptoms worse before your period and linked to mood?

Yes. Digestive symptoms like bloating and constipation are much more common in the week before menstruation in women with and without PMS. These symptoms are linked to worsening mood in both groups.

Systematic review, 2023

What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy?

Hormonal treatments have been tested 56 times for premenstrual mood disorder, 21 times for menstrual migraine, and 8 times for catamenial epilepsy. Combined oral contraceptives were a frequent focus.

Cohort study, 2023

Are PMS symptoms linked to genetic factors for psychiatric disorders?

Yes. Women with PMS were more likely to have genetic factors for depression, bipolar disorder, ADHD, schizophrenia, and autism spectrum disorder. This was a large, well-designed study, so we can be confident in these findings.

Case-control study, 2023

Does the serotonin system work differently in PMDD across the menstrual cycle?

Yes. Women with PMDD showed an 18 percent increase in serotonin transporter binding during the premenstrual phase while controls showed a 10 percent decrease. This increase correlated with depression severity.

Systematic review, 2023

Is PMDD linked to depression?

PMDD and depression are strongly linked. Nearly all studies found that people with PMDD were more likely to have depression, and people with depression were more likely to have PMDD.

Systematic review, 2023

How common are menstrual cycle problems and PMS or PMDD in female athletes?

Menstrual cycle problems are common in female athletes, with dysmenorrhoea affecting about 32%. More athletes report symptoms during their period than in the days before.

Systematic review, 2022

What are the best treatments for PMDD and PMS?

SSRIs (antidepressants) and combined oral contraceptives (birth control pills) have the strongest evidence. For difficult cases, GnRH agonists and surgery work. Some alternatives like acupuncture and yoga show promise but need better quality research.

Systematic review, 2022

Do mental health disorders get worse during the menstrual cycle?

Yes, several mental health disorders like depression, panic attacks, eating disorders and borderline personality disorder clearly worsen around menstruation. The evidence is less clear for anxiety or bipolar disorder.

Survey study, 2022

What causes PMS and PMDD and what new treatments are being studied?

PMS and PMDD involve changes in hormone sensitivity, serotonin levels, genetic factors, and inflammation. New treatments under research target progesterone receptors and inflammatory pathways.

Systematic review, 2022

Do athletes' feelings and performance change across the menstrual cycle?

Some feelings change across the cycle, especially motivation and mood. However, the research methods vary a lot, so we cannot be very confident about most findings.

Systematic review, 2021

Does substance use change across the menstrual cycle, especially in women with PMS or PMDD?

Yes. Women use more nicotine before and during their period, especially those with PMDD or PMS, and alcohol use also increases during these phases.

Study, 2021

How much does the menstrual cycle affect mood and body signs compared to daily, weekly, and seasonal changes?

The menstrual cycle causes the biggest changes in mood and body measurements compared to daily, weekly, or seasonal changes. Mood, vital signs, and sexual behavior vary most; sleep and exercise stay fairly steady.

Systematic review, 2021

Does damask rose help reduce menstrual pain, headache, fatigue, anxiety, and bloating?

Damask rose significantly reduced menstrual-related headache, fatigue, and bloating, but did not clearly reduce menstrual pain or anxiety. More research on pain and anxiety is needed.

Randomised trial, 2021

Does ulipristal acetate (a progesterone blocker) treat PMDD?

Yes. Women taking 5 mg daily improved by 41% versus 22% on placebo. Half achieved remission with the medication compared to 21.1% on placebo.

Survey study, 2020

What symptoms best predict whether PMDD will seriously affect daily life?

Four premenstrual symptoms is the optimal number for predicting clinically significant impairment. Psychological symptoms like difficulty concentrating were the strongest predictors, more so than core mood symptoms.

Systematic review, 2019

Do women take more health-related risks at certain times in their menstrual cycle?

Women show higher sexual activity and better risk awareness during ovulation, but no consistent pattern for alcohol or cigarette smoking across the cycle.

Survey study, 2018

Does the menstrual cycle affect emotions and thinking ability?

The menstrual cycle affects emotions consistently, especially in the luteal phase and stronger in women with PMDD. It has only small and inconsistent effects on cognitive tasks like memory and attention.

Randomised trial, 2017

Does the combined oral contraceptive pill affect mood?

Yes, but effects vary by cycle phase. The pill causes small increases in anxiety and irritability between periods but improves depression in the days before menstruation.

Randomised trial, 2017

Does calcium reduce PMS symptoms?

Yes. Women taking 500 mg of calcium daily for two months had significantly less severe PMS symptoms than those taking placebo, especially mood and water retention problems.

Randomised trial, 2015

Which birth control pill better reduces PMS and menstrual symptoms: nomegestrol acetate or drospirenone?

Nomegestrol acetate reduced more PMS and menstrual symptoms than drospirenone pills in this large study of 3522 women, though drospirenone was better for emotional arousal.

Review, 2015

What do we know about PMS and PMDD and how are they treated?

PMS affects 30 to 40 percent of reproductive-age women and PMDD affects 3 to 8 percent. Serotonergic antidepressants are the most effective treatment, but oral contraceptives, lifestyle changes, cognitive behavioral therapy, and herbal supplements are also available options.

Systematic review, 2014

Do acupuncture and herbal medicine help PMS or PMDD symptoms?

Both acupuncture and herbal medicine significantly improved PMS and PMDD symptoms, with most treatments providing over 50% improvement. They appear safe, though the evidence is limited.

Systematic review, 2014

Do estrogen and progesterone change how the brain processes emotions and decisions?

Yes. These hormones affect which brain areas activate when women process emotions and make decisions, particularly in areas involved in mood and choice-making. The specific pattern varies by hormone level and person.

Review, 2013

What treatments work best for PMDD?

A combination of lifestyle changes, medicines, and cognitive behavioral therapy works best. This approach reduces symptoms and improves daily functioning and quality of life.

Systematic review, 2012

Does the menstrual cycle cause negative mood, especially before your period?

Most studies found no link between the menstrual cycle and negative mood. Only 14.9 percent found negative mood linked specifically to the premenstrual phase, challenging the widespread belief in a premenstrual mood syndrome.

Systematic review, 2012

What medications work best for PMDD?

The abstract does not include findings or results, so no conclusion can be drawn from it.

Randomised trial, 2011

Does phone support reduce stress during IVF waiting?

No, the stress scale showed no difference, but women perceived the support as helpful and wanted more.

Review, 2009

What causes PMDD and what are the treatment options?

PMDD affects an estimated 5-8% of women and causes severe mood and physical symptoms. The cause involves individual sensitivity to hormonal changes. Treatments include serotonin antidepressants, medications that stop ovulation, and certain newer birth control pills.

Review, 2008

What medications are FDA-approved for treating PMDD?

Three selective serotonin reuptake inhibitors (SSRIs, a type of antidepressant) and a low-dose birth control pill containing drospirenone are FDA-approved for PMDD. SSRIs can be taken just during the two weeks before menstruation.

Randomised trial, 2005

Does stopping ovulation help irritable bowel syndrome that gets worse during the menstrual cycle?

Yes, stopping ovulation with leuprolide acetate significantly improved bowel symptoms related to the menstrual cycle. Adding tibolone (a hormone) did not improve bowel symptoms further but did improve quality of life more than leuprolide alone.

Randomised trial, 2005

Does paroxetine taken only during the luteal phase help premenstrual dysphoric disorder?

Yes. Both doses of paroxetine CR (12.5 mg and 25 mg) taken during the luteal phase were significantly better than placebo.

Randomised trial, 2004

Does the antidepressant paroxetine CR reduce PMDD mood symptoms?

Yes. In this large trial, both a lower and a higher dose of paroxetine CR significantly improved mood symptoms compared with placebo, with the higher dose working somewhat better.

Review, 2003

Are SSRIs safe and effective for treating PMDD?

Yes. SSRIs taken daily or intermittently are considered the first-line effective treatment for PMDD and are well tolerated.

Randomised trial, 2000

Does sertraline improve how women with PMDD feel and function?

Yes. Sertraline was clearly better than placebo at improving how women with PMDD functioned and their quality of life, and improvements appeared by the second month of treatment.

Randomised trial, 1999

Does calcium reduce PMS symptoms?

Yes, this large study of 497 women found that calcium supplementation reduced PMS symptoms during the luteal and menstrual phases. This is strong evidence from a well-designed trial.

Randomised trial, 1998

Does taking calcium supplements reduce PMS symptoms?

Yes. In this large trial, women who took calcium carbonate had much lower PMS symptom scores than women who took a placebo, with symptoms down 48% versus 30% by the third month.