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Case report, 2022

How is menstrual psychosis with unusual physical symptoms treated?

In this case, a 28-year-old woman with premenstrual dysphoric disorder developed severe psychotic symptoms a week before menstruation, which improved rapidly with medication and resolved when her period started.

Early or limited evidence One 28-year-old woman with a history of premenstrual dysphoric disorder.

What they did

Doctors described one 28-year-old woman with a history of PMDD who developed psychotic symptoms with unusual body positions and reduced responsiveness starting a week before her menstruation.

What they found

The woman was treated with lorazepam and olanzapine (antipsychotic medications), and her psychotic symptoms resolved rapidly when her menstruation began. She was then followed in the community and continued to do well without continuing antipsychotic medication.

What it means for you

This case shows that severe psychotic symptoms can occur in the week before menstruation in women with PMDD, and that they can resolve when menstruation starts. The woman did not need to continue antipsychotics long-term. The main limitation is that this is one person, so we cannot know how common this pattern is or whether this outcome applies to others.

28

woman's age in years

a week

when symptoms started before menstruation

About the study

Original title
A case of pre-menstrual psychosis with catatonic symptoms
Authors
Brian O'Mahony
Journal
Psychiatry Research Case Reports
Year
2022
Study design
Case report
What was tested
Lorazepam and olanzapine (antipsychotic medications).
Open access
Yes
Original abstract

This case report discusses the case of a 28-year-old woman, with a history of Premenstrual Dysphoric Disorder, who presented with polymorphic psychosis, with catatonic features, which started a week prior to menstruation. She was treated with lorazepam and olanzapine and her psychotic symptoms resolved rapidly, upon menstruation. She was subsequently treated in the community and continues to do well without antipsychotic therapy. Not recognised in either ICD or DSM criteria, menstrual psychosis is nonetheless well described in the literature. Menstrual psychosis with catatonia appears to be an extremely rare condition and, as such, its pathology and most appropriate treatment is not well described.

Reproduced under CC-BY.

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