Skip to content

Menstrual psychosis: what the research says

32 studies on menstrual psychosis in PMS and PMDD, each explained in plain English. 0 of them use the strongest designs: randomised trials and systematic reviews.

Case report 23Survey study 4Study 2Review 2Non-randomised trial 1
Survey study, 2026

Should PMDD be recognized in Indian law as affecting criminal responsibility?

The analysis concludes that PMDD should be legally recognized in India as affecting judgment and behavior. Modern medicine recognizes PMDD as serious, but Indian criminal law currently does not acknowledge it.

Case report, 2026

Can hormonal therapy treat psychotic symptoms tied to the menstrual cycle?

This case describes a 26-year-old woman whose psychotic symptoms appeared with her menstrual cycle. Antipsychotic medication initially helped, but low-dose hormonal birth control led to lasting improvement.

Study, 2024

Can PMDD cause psychosis that returns with each menstrual cycle?

Yes. A woman experienced psychotic symptoms starting 5 days before her period and ending when her period began, and this pattern repeated every month for 5 years. Treatment with medications reduced the severity but did not completely stop the symptoms.

Case report, 2023

What is menstrual psychosis?

Menstrual psychosis is a rare condition causing severe psychiatric symptoms that repeat with the menstrual cycle. This case shows that psychiatry and gynecology doctors must work together to diagnose and treat it properly.

Case report, 2022

How is menstrual psychosis with unusual physical symptoms treated?

In this case, a 28-year-old woman with premenstrual dysphoric disorder developed severe psychotic symptoms a week before menstruation, which improved rapidly with medication and resolved when her period started.

Case report, 2022

Can aripiprazole prevent menstrual psychosis?

In this case, a previously healthy adolescent girl experienced psychotic symptoms that appeared before her menstrual period and resolved when her period started. The medication aripiprazole prevented these episodes, but they returned when she stopped taking it.

Survey study, 2022

Can women get psychosis linked to their menstrual cycle?

Yes, menstrual psychosis exists but is extremely rare, with only 30 cases reported worldwide. Estrogen's effect on the brain may play a role.

Case report, 2022

What is cyclic menstrual psychosis in adolescents?

This case describes a 14-year-old girl with psychotic symptoms including confusion, delusional ideas and physical restlessness that occurred in a repeating cycle linked to her menstruation. The symptoms went away when her period began.

Survey study, 2021

Can a menstrual cycle trigger psychiatric episodes in teenagers?

A 15-year-old girl's monthly episodes of confusion and dissociation lasting 5-6 days improved when her period started, but doctors couldn't determine whether hormones, the menstrual cycle, or a psychiatric condition caused it.

Case report, 2020

Can psychosis happen connected to your menstrual cycle?

Yes. A condition called menstrual psychosis can cause psychotic symptoms during the premenstrual period. These symptoms usually go away within days after your period starts.

Case report, 2020

Do psychotic symptoms connected to your menstrual cycle always come back every month?

Yes. Menstrual psychosis causes psychotic symptoms that start suddenly, last a short time, and happen in a rhythm with the menstrual cycle. Between episodes, women recover completely.

Case report, 2020

What causes severe psychiatric symptoms that recur with the menstrual cycle, and how should they be treated?

Menstrual psychosis is a rare condition where severe psychiatric symptoms occur cyclically with menstruation. Hormonal therapy is more effective than antipsychotic medications alone.

Case report, 2020

Can psychosis get worse before your period if you have PCOS?

A woman with PCOS and schizoaffective disorder had psychotic episodes that happened right before her period and improved when bleeding started. This suggests a link between PCOS and menstrual-cycle-linked psychosis.

Case report, 2020

How do psychotic symptoms connected to the menstrual cycle look in different parts of the world?

In a study of 4 women in Oman with menstrual psychosis, all had psychotic and mood symptoms timed to their menstrual cycle. All had normal intelligence but had problems with thinking speed, memory, and planning skills.

Case report, 2018

Can medication stop psychotic symptoms that come every month with your period?

Yes. A young woman with psychotic and mood symptoms during every menstrual cycle improved significantly with treatment using two medications combined with psychiatric and medical care.

Case report, 2018

Can psychotic symptoms happen only during and just after menstruation?

Yes, in this case a woman had psychotic symptoms including hallucinations and paranoia that started with her period and went away about 10 days later. This pattern repeated every menstrual cycle for 7 years. Very few cases like this have been reported.

Case report, 2018

Do oral contraceptives help psychotic symptoms that start before menstruation?

In one adolescent with psychosis starting just before her period, symptoms improved after her period ended and after she started taking oral contraceptives and olanzapine. We can't know from this single case whether the contraceptives, the medication, or the natural end of menstruation helped most.

Case report, 2017

Can mood symptoms like mania and psychosis change across the menstrual cycle in bipolar disorder?

In one detailed case, yes: a woman with bipolar I disorder had psychosis-like symptoms when estrogen was low and hypomania when estrogen was high, and a targeted treatment approach for this pattern worked for her.

Case report, 2015

Do hormones from the menstrual cycle affect schizophrenia symptoms?

Yes. Women with schizophrenia often have worsening psychotic symptoms and depression or anxiety at certain times in their menstrual cycle. Doctors can manage this by adjusting medications.

Case report, 2013

Can psychotic episodes happen in a pattern linked to the menstrual cycle?

Yes. Psychotic episodes linked to menstruation may remit between cycles and become much less common after menopause.

Case report, 2013

Can severe mood changes around a period be an early sign of bipolar disorder?

In one teenage girl, a psychotic episode tied to her period turned out to be the first sign of bipolar disorder. This is a single case, so it cannot tell us how common this is.

Case report, 2012

Do antipsychotic medications help psychosis that only happens around menstruation?

In this case, a 30-year-old woman had psychotic symptoms around her menstrual cycle. Despite trying three different antipsychotic medications at different doses over 10 years, her symptoms kept coming back on a menstrual cycle pattern. The medications did not prevent these episodes.

Non-randomised trial, 2012

Do schizophrenia symptoms get worse before menstruation?

Many women with schizophrenia do experience worse symptoms before their period, but no treatment studies have been done so doctors must decide case-by-case how to help.

Review, 2011

What is menstrual psychosis and how is it connected to the menstrual cycle?

Menstrual psychosis is a rare illness that looks like manic depressive (bipolar) disorder but comes on in a pattern linked to the menstrual cycle. The review suggests this link involves the hypothalamus, but this is based on case evidence, not a controlled study.

Case report, 2009

Can birth control pills prevent psychotic episodes that happen before menstruation?

Yes. Birth control pills prevented psychotic episodes in one woman who had them before her period.

Case report, 2008

Can metformin help psychosis that happens with the menstrual cycle?

Maybe. One woman with polycystic ovary syndrome (PCOS) and menstrual-linked psychosis had significant improvement when metformin restored her normal menstrual cycle.

Survey study, 2005

Can menstruation trigger severe mental illness like psychosis?

Yes. Medical case reports show that menstruation can trigger psychotic episodes in some women, particularly around the time of the period or repeatedly in cycles tied to the menstrual cycle.

Case report, 2003

Can a teenage girl have psychotic episodes linked to her menstrual cycle?

Yes. A 16-year-old girl had three psychotic episodes over 5 months, suggesting a pattern linked to menstruation.

Case report, 2003

What causes psychosis linked to the menstrual cycle in adolescents?

Two cases showed acute psychosis in the days before menstruation that came and went with each cycle. One improved with a hormonal contraceptive, and the other improved on its own. The link may involve anovulation, which means not having regular ovulation.

Review, 2002

Can PMS or premenstrual psychosis be used as a legal defense?

A small subset of women experience psychotic symptoms during the premenstrual phase. This defense has largely failed in US courts but has been used in Great Britain to support claims of diminished capacity.

Study, 1998

Is there a specific type of psychosis linked to the menstrual cycle in teenagers?

Yes. Periodic menstruation-linked psychosis of adolescence appears to have a distinct presentation and requires different treatment than other forms of psychosis.

Case report, 1998

Can drops in estrogen before your period cause psychotic episodes?

A case report and literature review propose that sudden drops in estrogen before menstruation may trigger psychotic episodes in vulnerable women, but this is a theory that needs more testing.