Review, 1993
Can GnRH agonists plus hormone replacement help severe PMS?
Evidence suggests that GnRH agonists combined with estrogen-progestin replacement can substantially reduce severe PMS symptoms, particularly in women who do not respond to fluoxetine or alprazolam.
What they did
Review of research on GnRH agonist treatment for PMS, examining how these drugs work and the evidence for their use combined with hormone replacement.
What they found
GnRH agonists reduce progesterone levels which may be central to PMS development. When combined with estrogen-progestin replacement, they appear to substantially improve PMS symptoms while protecting against the side effects of low estrogen.
What it means for you
This approach may work well for severe PMS but has not been directly compared to other treatments in controlled trials. An accurate diagnosis must be made first, and doctors should consider fluoxetine and alprazolam before using this approach.
About the study
- Original title
- Applications of gonadotropin-releasing hormone analogues in the treatment of premenstrual syndrome
- Authors
- Mortola JF
- Journal
- Clinical obstetrics and gynecology
- Year
- 1993
- Study design
- Review
- What was tested
- GnRH agonists with estrogen and progestin replacement
- Read the paper
- doi.org/10.1097/00003081-199309000-00032
Topics
Related studies
Systematic review, 2007
What treatments work for premenstrual syndrome?
Review, 2002
What treatments work best for PMS and PMDD?
Study, 1997
What medications work best for treating PMS?
Review, 2006
What treatments work for premenstrual disorders?
Review, 2003
What role do hormones play in PMS and how should we treat it?
Review, 2002
What treatments work for PMDD?