Survey study, 2009
Can estrogen therapy help depression that worsens during hormonal cycle changes?
High-dose estrogen has shown some success for depression linked to hormonal fluctuations, though standard antidepressants often do not work. Recognizing that depression follows the menstrual cycle or other hormonal changes is key to diagnosis.
What they did
Literature review of hormone-related depression, discussing history of treatment approaches and the relationship between mood changes and the menstrual cycle, postpartum period, and perimenopause.
What they found
The relationship between mood changes and the menstrual cycle is well recognized. Historically, removing the ovaries was attempted to prevent hormone fluctuation, but this caused long-term harm like osteoporosis and heart disease. High-dose estrogen has been explored with some success. Diagnosis is based on symptoms worsening during hormone fluctuation (premenstrual phase, after birth, perimenopause). Some women feel well for only a minority of days in the month, and the problem can become chronic. Standard antidepressant medication is often not successful, though commonly prescribed.
What it means for you
For women whose depression clearly follows hormonal patterns, estrogen therapy may work better than standard antidepressants, though this is a specialized treatment. This literature review reflects existing evidence, not a new study. High-dose estrogen has side effects and complexity requiring specialist care.
About the study
- Original title
- Are oestrogens useful for the treatment of depression in women?
- Authors
- Studd J, Panay N
- Journal
- Best practice & research. Clinical obstetrics & gynaecology
- Year
- 2009
- Study design
- Survey study
- What was tested
- Estrogen therapy (high-dose) compared to standard antidepressant medications
- Read the paper
- doi.org/10.1016/j.bpobgyn.2008.11.001
Topics
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