Survey study, 2022
How can animal models help us understand and treat PMDD?
This review discusses how animal models are used to study PMDD. It concludes that PMDD is complex and involves multiple hormone systems, and effective animal models must capture this complexity to develop new treatments.
What they did
This was a review analyzing current knowledge about premenstrual disorders, the hormone systems involved (particularly those controlling the ovaries and stress responses), and the animal models used in PMDD research.
What they found
The review found that ovarian hormones play a role in PMDD, and several points in how these hormones are made, broken down, and affect the brain could be abnormal in PMDD. The review discusses various animal models used to study PMDD and identifies gaps in how well they represent human PMDD.
What it means for you
Understanding PMDD requires studying hormone systems in animal models. Because PMDD in humans involves many factors working together, animal models need to be sophisticated to accurately represent the condition and lead to useful treatments.
~80%
women worldwide with mild premenstrual disorders
3-8%
women with severe PMDD
About the study
- Original title
- Can animal models resemble a premenstrual dysphoric condition?
- Authors
- Erika EC, López-Rubalcava C
- Journal
- Frontiers in neuroendocrinology
- Year
- 2022
- Study design
- Survey study
- What was tested
- Not applicable - review article
- Read the paper
- doi.org/10.1016/j.yfrne.2022.101007
Topics
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