Case-control study, 1988
Are hormone levels different between women with menstrually related mood disorder and healthy women?
No significant differences were found in hormone levels or patterns between the two groups, suggesting that PMS is not caused by simple hormone deficiency.
What they did
Blood samples were collected across the menstrual cycle from women with menstrually related mood disorder and control women. Multiple hormones were measured.
What they found
No differences were observed between groups in levels or patterns of progesterone, estradiol, FSH, LH, testosterone-estradiol-binding globulin, DHEA sulfate, dihydrotestosterone, prolactin, or cortisol.
What it means for you
PMS does not appear to be caused by abnormal hormone levels alone, which questions some proposed hormone-based treatments. The abstract does not specify the sample size, which is a significant limitation to understanding the study's strength.
2
Diagnostic groups
9
Hormones measured
About the study
- Original title
- Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects
- Authors
- Rubinow DR, Hoban MC, Grover GN et al.
- Journal
- American journal of obstetrics and gynecology
- Year
- 1988
- Study design
- Case-control study
- What was tested
- Hormone measurement across menstrual cycle
- Read the paper
- doi.org/10.1016/0002-9378(88)90765-x
Topics
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