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Review, 1999

Are SSRIs effective for treating PMDD?

Yes, SSRIs are effective in treating PMDD and many related conditions in women, according to this review of depression treatment.

Early or limited evidence Review article about women; not a specific study population

What they did

Review of how depression is diagnosed and treated differently in women compared to men, including medication effects specific to women and treatment of mood-related conditions.

What they found

SSRIs effectively treat PMDD and many related conditions that often occur alongside depression. Women may reach higher blood concentrations of antidepressants and may require lower doses than men. The review states there is no increased birth defect risk from SSRIs or tricyclic antidepressants taken during pregnancy.

What it means for you

This indicates SSRIs are a proven treatment for PMDD available to women. Women's bodies process antidepressants differently, so dosing needs to be individualized. This is based on existing research rather than new data.

About the study

Original title
Depression in women: diagnostic and treatment considerations
Authors
Bhatia SC, Bhatia SK
Journal
American family physician
Year
1999
Study design
Review
What was tested
SSRIs (selective serotonin reuptake inhibitors), tricyclic antidepressants, and psychotherapy

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