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Randomised trial, 2006

Which dietary supplements and herbs work for PMS?

Calcium and vitamin B6 have the best evidence for PMS. Evening primrose oil and magnesium have conflicting results. Other supplements like Vitex need more and better research.

Moderate study design Women with PMS (from multiple randomized controlled trials reviewed)

What they did

Systematic review of published randomized controlled trials of dietary supplements and herbal remedies used for PMS. The researchers reviewed studies on calcium, magnesium, vitamin B6, evening primrose oil, Vitex agnus castus, ginkgo biloba, and St. John's Wort.

What they found

Substantial evidence supports calcium and vitamin B6 for PMS. Magnesium and evening primrose oil produced conflicting results across trials. Insufficient data exist for ginkgo biloba, Vitex, and St. John's Wort, though preliminary data seem supportive.

What it means for you

If you are considering supplements for PMS, calcium and B6 have the strongest evidence. Other supplements need larger and better-designed studies. The main limitation is that most research is preliminary or has methodological issues.

About the study

Original title
Dietary supplements and herbal remedies for premenstrual syndrome (PMS): a systematic research review of the evidence for their efficacy
Authors
Sarah Elise Canning, Mitch G. Waterman, Louise Dye
Journal
Journal of Reproductive and Infant Psychology
Year
2006
Study design
Randomised trial
What was tested
Various dietary supplements and herbal remedies (reviewed from published studies)

Topics