Skip to content

Vitex agnus-castus (chasteberry): what the research says

89 studies on vitex agnus-castus (chasteberry) in PMS and PMDD, each explained in plain English. 22 of them use the strongest designs: randomised trials and systematic reviews.

Randomised trial 29Review 14Systematic review 12Survey study 11Study 8Non-randomised trial 7
Randomised trial, 2025

Which is more effective for PMS - Vitagnus, soy, or both together?

The abstract provided is incomplete and does not show the full results, so we cannot determine which treatment was most effective.

Randomised trial, 2023

Can herbal medicine prevent or treat PMS and menstrual disorders?

Yes, several herbs may help prevent PMS and menstrual disorders, but research quality is mixed and better studies are needed.

Randomised trial, 2020

What is the best dose of Vitex for treating PMS?

A dose of 20 mg daily was most effective for reducing PMS symptoms. Higher dose (30 mg) was no better, and lower dose (8 mg) was less effective.

Systematic review, 2020

Does Vitex agnus-castus help cyclic breast pain?

Vitex appears moderately effective for reducing cyclic breast pain compared to placebo, works as well as some medications, and is safe with minimal side effects.

Guideline, 2019

How should doctors treat PMS and PMDD?

Treatment should be tailored to each woman's symptoms and life stage. Options include therapy, herbs, antidepressants, birth control to stop ovulation, and water pills.

Review, 2018

Does Vitex agnus castus supplement help treat PMS symptoms?

This paper is a protocol (a plan) for a systematic review. The research hasn't been completed yet, so there are no findings on whether Vitex works for PMS.

Review, 2017

What causes PMDD and what are the best treatments?

PMDD involves an abnormal response to normal hormone changes affecting the serotonin system and brain circuits that control emotion. SSRIs are the first-line treatment, with several other options available.

Systematic review, 2017

Does Vitex agnus castus help treat premenstrual syndrome?

The meta-analysis found a large pooled effect of Vitex agnus castus compared to placebo, but the included studies have significant quality problems, publication bias, and very different results from each other, so we cannot confidently say it truly works.

Systematic review, 2017

Is Vitex agnus castus safe and effective for treating PMS and PMDD?

All 8 included trials showed Vitex agnus castus was better than comparison treatments and was well tolerated, but the studies used different definitions of PMS, different outcome measures, and different Vitex preparations, making confident conclusions difficult.

Review, 2015

What do we know about PMS and PMDD and how are they treated?

PMS affects 30 to 40 percent of reproductive-age women and PMDD affects 3 to 8 percent. Serotonergic antidepressants are the most effective treatment, but oral contraceptives, lifestyle changes, cognitive behavioral therapy, and herbal supplements are also available options.

Systematic review, 2014

Do acupuncture and herbal medicine help PMS or PMDD symptoms?

Both acupuncture and herbal medicine significantly improved PMS and PMDD symptoms, with most treatments providing over 50% improvement. They appear safe, though the evidence is limited.

Systematic review, 2013

Does Vitex (chaste tree) help PMS and PMDD symptoms?

Most studies found Vitex better than placebo for PMS. For PMDD, results were mixed: one study showed it equal to fluoxetine, while another found fluoxetine more effective. Side effects were mild.

Randomised trial, 2012

Does Vitex agnus castus work for PMS, and what dose is best?

Yes, Vitex at 20 mg daily significantly reduced PMS symptoms compared to placebo. A 30 mg dose did not work better, making 20 mg the optimal dose.

Randomised trial, 2010

Does Vitex agnus castus (chasteberry) reduce PMS symptoms in Chinese women?

Yes, Vitex extract significantly improved all 17 PMS symptoms compared to placebo over 3 menstrual cycles, especially mood and sleep problems.

Randomised trial, 2010

What treatments work for premenstrual syndrome?

Several treatments reduce PMS symptoms according to controlled studies: SSRIs, some birth control pills, hormone injections, calcium, chasteberry, and cognitive-behavioral therapy. However, about 40% of women don't respond to current treatments.

Randomised trial, 2010

Does Vitex agnus castus reduce moderate-to-severe PMS in Chinese women?

Yes, Vitex extract significantly reduced PMS symptoms by the 3rd cycle, with 60 percent or greater symptom reduction in the treatment group compared to placebo, especially for mood and water retention.

Systematic review, 2009

Which herbs, vitamins and minerals help treat PMS?

Only calcium has good evidence to work for PMS. Chasteberry and vitamin B6 may help, but most of the 62 products people try lack proper research.

Randomised trial, 2009

Does Vitex agnus castus reduce PMS symptoms in Chinese women?

Yes, Vitex agnus castus significantly reduced PMS symptoms better than placebo. Symptoms improved in both groups, but the herbal medicine group improved more, though the large placebo improvement (50%) means some benefit may not be from the herb itself.

Randomised trial, 2006

Do herbal remedies help with PMS, pregnancy nausea, or hot flushes?

Preliminary evidence suggests chaste tree helps PMS, ginger helps pregnancy nausea, and black cohosh helps hot flushes, but the evidence is not strong enough to be certain.

Randomised trial, 2006

What herbs and dietary supplements have evidence for treating premenstrual syndrome?

A review of research found that calcium, vitamin B6, and chasteberry have the strongest evidence from clinical trials for treating premenstrual syndrome.

Randomised trial, 2001

Does agnus castus (Vitex) fruit extract reduce premenstrual syndrome symptoms?

Yes. Women taking agnus castus had significantly greater symptom improvement than placebo, with 52% having at least 50% symptom reduction compared to 24% on placebo.

Randomised trial, 1997

Does Vitex agnus castus work better than vitamin B6 for premenstrual tension syndrome?

Both reduced symptoms by similar amounts (47-48%), but more women on Vitex reported excellent results and had no remaining complaints, suggesting Vitex may work better for PMTS.

Survey study, 2025

Can a chatbot help monitor PMS symptoms over time?

Yes. A Telegram chatbot successfully tracked PMS symptoms across multiple menstrual cycles. Some women with PMS also met the criteria for fibromyalgia.

Review, 2025

Do yoga and dietary changes help with PMS symptoms?

Yes, both yoga and specific dietary supplements improve PMS symptoms and quality of life. Combining yoga and diet changes together appears to work better than either alone.

Non-randomised trial, 2025

Does Mabelle Cycle help restore regular periods in women with stress-related problems?

Yes, more women taking Mabelle Cycle restored regular periods compared to those in the control group. After three months, 62.5% of those taking Mabelle Cycle had restored cycles versus 27.5% in the control group.

Survey study, 2025

How are PMS and PMDD diagnosed and treated?

PMS and PMDD are diagnosed by tracking symptoms for at least two cycles and noting if they occur in the luteal phase. SSRIs are first-line treatment. Cognitive behavior therapy, exercise, acupuncture, and the herb Vitex agnus castus may also help.

Cohort study, 2024

Does Vitex supplement improve menstrual cycle problems and quality of life?

Yes, after 3 months of treatment, most women showed improvement in irregular periods, pain, and breast tenderness. Quality of life improved for all participants.

Survey study, 2023

Can diet help reduce PMS symptoms?

A review of past studies found that calcium, vitamin B6, and chasteberry fruit likely help PMS symptoms, while saffron, ginger, and high vitamin D have weaker evidence.

Review, 2023

Can herbs and supplements help with PMS symptoms?

Herbs like chaste berry and supplements like calcium and magnesium may help with PMS. Evidence is strongest when combined with lifestyle changes and therapy, though more research is needed.

Review, 2021

Do herbal products help with PMS?

Chaste tree shows effectiveness for PMS, but more research is needed. Evidence for other herbs is still developing.

Study, 2020

Does Tazalok work better than Vitex for treating PMS?

After 3 months, Tazalok improved hormone levels more than Vitex, with bigger improvements in depression and pain. Since women were not randomly assigned to groups, we cannot be completely certain about these differences.

Randomised trial, 2019

Does chasteberry (Vitex agnus-castus) help premenstrual breast pain and related symptoms?

Yes, according to multiple placebo-controlled studies reviewed here, chasteberry extracts reduced premenstrual breast pain and other premenstrual symptoms, likely by lowering prolactin, and side effects were mild and infrequent.

Systematic review, 2019

Does chasteberry help premenstrual syndrome?

Yes, based on 3 high-quality trials, women taking chasteberry were 2.57 times more likely to experience symptom improvement compared to placebo. However, evidence is limited because only 3 rigorous studies met quality criteria.

Systematic review, 2018

Can herbal remedies help ease PMS symptoms?

A review pulling together 18 Iranian studies found several herbs may help ease PMS symptoms, but it didn't measure how strong or reliable each herb's effect actually was.

Systematic review, 2017

Does the herb Vitex agnus-castus help with PMS and related problems?

A review of 43 studies concludes that Vitex agnus-castus can help treat PMS and PMDD, ease pain after menstruation, and support infertility treatment, but it is a summary of past findings rather than a measured result.

Systematic review, 2017

Does the herb chaste-berry (Vitex agnus-castus) really reduce PMS symptoms?

A pooled analysis of 14 trials found a large average benefit of chaste-berry over placebo for PMS symptoms, but the underlying studies had a high risk of bias and very inconsistent results, so this cannot be taken as a firm conclusion.

Guideline, 2013

What do experts agree is the best way to treat PMS and PMDD?

A group of international experts agreed that treatment should start with careful diagnosis, and that the main options work either by calming brain serotonin activity or by stopping ovulation, with some other approaches worth more study.

Survey study, 2012

What non-hormonal medications and therapies help severe PMS and PMDD?

SSRIs (a type of antidepressant) are well-established for severe PMS and PMDD, taken either continuously or during the luteal phase. Cognitive-behaviour therapy, calcium, and chasteberry may also help, though the strength of evidence varies.

Randomised trial, 2012

Does Vitex agnus castus help women with PMS?

Yes, Vitex significantly improved PMS symptoms compared to placebo in both mild and moderate cases.

Systematic review, 2011

Do herbal treatments help PMS and PMDD?

Vitex agnus castus seems to reduce symptoms better than placebo. Ginkgo biloba and crocus sativus might help, but evening primrose oil and St. John's Wort do not.

Randomised trial, 2006

Which dietary supplements and herbs work for PMS?

Calcium and vitamin B6 have the best evidence for PMS. Evening primrose oil and magnesium have conflicting results. Other supplements like Vitex need more and better research.

Review, 2003

Do complementary and alternative medicine treatments work for PMS and PMDD?

Some treatments like exercise, mind-body approaches, and certain herbs and supplements have good evidence of working. Many other approaches lack conclusive evidence.

Randomised trial, 2003

Does chaste tree help premenstrual symptoms?

Chaste tree extract has been shown in controlled studies to help breast tenderness before the period and may help other premenstrual symptoms. It works by reducing prolactin, a hormone linked to breast tissue.

Randomised trial, 2001

Does agnus castus help with PMS?

Yes, agnus castus was safe and effective for treating PMS in a randomized, blinded trial of 170 women, though this is based on one study.

Review, 2001

What is the best treatment approach for PMS and PMDD?

About 5 percent of women have premenstrual symptoms severe enough to affect their daily lives. Start with lifestyle changes, then serotonin-based antidepressants if needed, preferably taken during just the luteal phase.

Non-randomised trial, 2000

Does Vitex agnus castus (chaste tree) help premenstrual syndrome symptoms?

In a large study without a control group, 93% of 1,634 women reported decreased PMS symptoms after three months of Vitex, with good tolerance and minimal side effects, though the lack of a control group limits certainty about the effect.

Randomised trial, 1998

Does Vitex agnus castus help cyclical breast pain?

Yes. The extract reduced breast pain faster than placebo and was well tolerated.

Non-randomised trial, 2026

Is Pilates exercise or Vitex agnus supplement more effective at reducing PMS symptoms?

Yes, both reduced PMS symptoms after 2 months (p<0.001), but Pilates was significantly more effective than Vitex agnus (p<0.001). The study lacked randomization and did not compare to standard PMS treatments.

Randomised trial, 2026

Do seed cycling capsules with chasteberry reduce PMS symptoms over two months?

Yes, women reported significant improvements in PMS symptoms including pain, cramping, bloating, mood, and sleep. However, this was an open-label study without a control group, so we cannot be sure the improvements are from the product rather than expectation.

Survey study, 2025

Can a plant-based supplement reduce PMS symptoms?

Yes, a multi-ingredient plant-based supplement taken daily for three months significantly reduced anger, irritability, mood problems, and other PMS symptoms in most women. Without a control group, some improvement might be due to placebo effect or natural changes over time.

Review, 2025

Do herbal remedies help with menstrual and menopausal symptoms?

Several herbs have been traditionally used and may help with menstrual pain, irregular cycles, mood changes, and heavy bleeding. More rigorous testing is needed to confirm these effects, and you should talk to your doctor before using herbs, especially if you take other medicines.

Survey study, 2025

Which Kampo medicines do Japanese doctors use for PMS and PMDD?

19.5% of Japanese gynecologists prefer Kampo medicine for PMS/PMDD. Different doctors choose different types based on their experience and whether they work in a clinic or hospital.

Study, 2025

Could ginkgo biloba, soy, and other nutrients help hormone-related mood problems like PMS and PMDD?

This paper presents a theoretical model suggesting ginkgo biloba, soy isoflavones, and supporting nutrients might together support hormone, blood vessel, and brain chemical balance in conditions such as PMS and PMDD. It is not a new study in women, so we cannot know how well it works.

Survey study, 2024

What do pharmacy students know about using herbs for PMS?

Pharmacy students had moderate knowledge (58.9% correct answers) about these herbs, and about 83% believed the herbs could help PMS symptoms. However, this study only surveyed opinions. It did not test whether these herbs actually work.

Randomised trial, 2024

Does a supplement with Rhodiola, Vitex, and vitamin B6 reduce PMS?

The supplement improved mood and antioxidant protection in women taking it, but the study could not tell if this was better than placebo because both groups improved similarly.

Review, 2024

Can herbal remedies and lifestyle changes help manage premenstrual syndrome?

A review suggests that herbs like Chaste Tree, Evening Primrose Oil, Dong Quai, and Ginger, combined with diet and exercise, may help relieve PMS, though individual responses vary and clinical evidence is limited.

Review, 2024

What methods can help relieve PMS symptoms?

Diet changes, physical activity (especially yoga and Pilates), relaxation techniques, cognitive-behavioral therapy, and SSRI medications can all reduce PMS severity. Non-drug methods appear to be low-cost alternatives to medication.

Survey study, 2024

Does Vitex agnus castus help PMS, and what causes PMS?

Risk factors for PMS include delayed menarche (2.5 times increased risk) and painful periods (2.1 times increased risk). Treatment with Vitex agnus castus extract showed 2.8 times higher symptom remission than no treatment.

Non-randomised trial, 2023

Does a supplement with Vitex, vitamin B6, and magnesium reduce PMS symptoms?

Yes. The supplement was more effective than standard therapy alone at reducing PMS symptoms and improving quality of life, with the best results when combined with standard treatment.

Study, 2023

Can a herbal supplement called chasteberry help with PMS and period pain?

This review of past studies suggests chasteberry is safe and has a positive effect on PMS and period pain, though it is a summary of other people's research rather than a new trial.