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Randomised trial, 2026

Does pumpkin seed extract reduce PMS symptoms in teenage girls?

Yes. Taking 500 mg of pumpkin seed extract twice daily for 10 days significantly reduced PMS symptoms more than taking it once daily or placebo.

Moderate study design 42 adolescent girls in Indonesia with PMS

What they did

RCT with 42 adolescent girls in Indonesia with PMS, randomly divided into three groups for 10 days. One group received pumpkin seed extract 500 mg twice daily, another received 500 mg once daily, and a control group received placebo tablets 500 mg once daily.

What they found

The group taking pumpkin seed extract 500 mg twice daily had the most significant symptom reduction with a mean score of 23.07 (p=0.000).

What it means for you

Pumpkin seed extract might work as a natural treatment for teenage PMS. However, this is a small study in one country and we don't know if it works the same in other groups of girls or populations.

42

adolescent girls studied

500mg 2x/day

effective dose

10 days

treatment duration

About the study

Original title
Effectiveness of Pumpkin Seed (Cucurbita moschata) Extract in Reducing Premenstrual Syndrome Symptoms in Adolescent Girls
Authors
Eka Apriadi Farkhati Nafi’ah, Sri Sumarn, Sri Endang Windiarti
Journal
Journal Midwifery Jurusan Kebidanan Politeknik Kesehatan Gorontalo
Year
2026
Study design
Randomised trial
Participants
42
What was tested
Pumpkin seed extract 500 mg twice daily for 10 days
Open access
Yes
Original abstract

Premenstrual Syndrome (PMS) is a common condition among adolescent girls, characterized by physical and emotional complaints that can interfere with daily activities. In Indonesia, the prevalence of PMS is reported to reach approximately 85% among women of reproductive age, with 60–75% experiencing moderate to severe PMS. This study aimed to evaluate the effectiveness of pumpkin seed extract (Cucurbita moschata) in reducing PMS symptoms in adolescent girls. A quantitative approach was applied using a true experimental design with a pre-test and post-test control group design. The study population consisted of adolescent girls experiencing PMS in the Poltekkes Kemenkes Semarang area. A total of 42 respondents were selected using randomized clinical trial sampling and divided into three groups: intervention 1 (pumpkin seed extract 500 mg, twice daily), intervention 2 (500 mg, once daily), and a control group receiving 500 mg amylum tablets once daily for 10 days. The results showed that administration of pumpkin seed extract at a dose of 500 mg twice daily for 10 days produced the most significant reduction in PMS symptoms (p = 0.000; mean = 23.07). Pumpkin seed extract has potential as an effective natural therapy to alleviate PMS symptoms in adolescent girls.

Reproduced under CC-BY-SA.

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