Survey study, 2020
Do low progesterone and genetics explain PMS?
Women with PMS have significantly lower progesterone in the luteal phase, especially those with swelling or severe symptoms. A genetic variant (PROGINS) was not significantly different between women with and without PMS.
What they did
Cross-sectional study. Researchers measured progesterone in blood twice during the menstrual cycle (in the follicular and luteal phases) in 50 women with PMS and 25 without. They also tested for a genetic variant (PROGINS T1T2).
What they found
Women with PMS, especially those with edematous (swelling) and severe forms, had low progesterone in the luteal phase. The PROGINS genetic variant showed no significant differences between women with and without PMS.
What it means for you
Low progesterone may play a role in PMS, particularly in swelling and severe types. The genetic variant studied does not appear to be a major factor. This is a very small study with only 50 women with PMS, limiting confidence in the findings.
50
women with PMS
25
women without PMS (control)
p<0.05
low progesterone in luteal phase
About the study
- Original title
- Evaluation of progesterone and progesterone receptor gene PROGINS polymorphism in the development of some forms of premenstrual syndrome
- Authors
- Lyudmyla V. Pakharenko
- Journal
- Reproductive health of woman
- Year
- 2020
- Study design
- Survey study
- Participants
- 50
- What was tested
- None. This measured progesterone levels and tested for a genetic variant.
- Open access
- Yes
- Read the paper
- doi.org/10.30841/2708-8731.1.2020.471241
Original abstract
One of the most common neuroendocrine syndromes in gynecology is premenstrual syndrome (PMS). The article is devoted to study of pro-gesterone level and frequency of polymorphic variants T1T2 of progesterone receptor gene PROGINS, as well as their possible relationship in patients with various forms of PMS. The object of the study were 50 women of reproductive age with diagnosis of PMS, including 25 women with edematous form of the disease, 25 – with neuropsychical form. Mild form of disease had 25 women, severe form – also 25 persons. Control group consisted of 25 women without diagnosis of PMS. Progesterone level was determined in blood serum twice in the first and second phase of menstrual cycle. Polymorphism T1T2 of progesterone gene receptor PROGINS was studied using polymerase chain reaction.We found hypoprogesteronemia of luteal phase of menstrual cycle in women with PMS, especially pronounced in persons with edematous and severe forms of the disease (p 0.05)
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