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Cohort study, 2023

Is the mid-luteal phase a vulnerable time for mood problems?

The study found weak evidence for this. Women had more depression-like symptoms in the mid-luteal phase, but stress was a stronger predictor of mood changes than menstrual cycle phase.

Moderate study design Naturally cycling women in a non-clinical sample

What they did

A 35-day longitudinal study tracked naturally cycling women's daily stress and three types of mood symptoms: anxious worry, anxious arousal, and depression-like symptoms. Statistical models examined whether mood changes were linked to menstrual phase, stress, or both.

What they found

Depression-like symptoms increased in the mid-luteal phase. Stress was linked to anxious worry and depression-like symptoms across all phases, not just the mid-luteal. These associations were not stronger in the mid-luteal phase. Stress was a better predictor of mood changes than menstrual phase.

What it means for you

While the mid-luteal phase may bring more depression-like symptoms, stress appears to be more important than cycle phase for mood changes. The study measured three different mood types, which was useful because they respond differently to stress and the cycle.

35

days of daily tracking

3

types of mood symptoms measured

About the study

Original title
Examining a window of vulnerability for affective symptoms in the mid-luteal phase of the menstrual cycle
Authors
Guevarra DA, Louis CC, Gloe LM et al.
Journal
Psychoneuroendocrinology
Year
2023
Study design
Cohort study
What was tested
None
Open access
Yes

Topics