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Review, 2006

When mood changes seem tied to your cycle, is it actually PMDD?

No. Many mood and anxiety symptoms tied to the menstrual cycle are not genuine PMDD. When true PMDD occurs, its impact on quality of life is similar to major depressive disorder.

Early or limited evidence Women (review article examining research on women and depression)

What they did

A review of research on gender differences in depression, including how depression presents differently in women and men, and how women respond to antidepressants.

What they found

Mood and anxiety symptoms that seem related to the menstrual cycle do not often represent genuine premenstrual dysphoria. However, when premenstrual dysphoric disorder does occur, its impact on quality of life is similar to that of major depressive disorder. SSRIs (a type of antidepressant) may be more effective in the presence of estrogen.

What it means for you

Not every mood dip around your period is PMDD. Many menstrual-related mood changes are normal. But true PMDD is serious and has quality of life impact as significant as major depression and deserves treatment. If SSRIs are used for PMDD, they may work better during high-estrogen phases of your cycle.

About the study

Original title
Gender differences in depression and response to psychotropic medication
Authors
Gorman JM
Journal
Gender medicine
Year
2006
Study design
Review
What was tested
None - review article

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