Survey study, 2025
Are specific genetic variations linked to PMS and PMDD?
Yes, specific genetic variations in the estrogen receptor 1 gene were linked to different PMS symptoms like anxiety and sleep problems, suggesting genetics may affect how sensitive women are to hormones. Sample size is not provided in the abstract.
What they did
Cross-sectional study examining six genetic variations (SNPs) in the ESR1 gene in women with premenstrual symptoms. Researchers looked at associations between these genetic variations and symptom severity, and interactions between the variations.
What they found
Specific genetic variations were linked to distinct symptom profiles including anxiety, difficulty concentrating, and sleep disturbances. Interactions between genetic variations revealed both risk-enhancing and protective effects. Findings suggest premenstrual symptoms may stem from genotype-linked reduced sensitivity to ovarian hormones.
What it means for you
Genetics may influence which PMS symptoms a woman experiences and their severity by affecting how her body responds to hormones. The study does not provide sample size in the abstract, limiting our understanding of how reliable these findings are.
6
Single nucleotide polymorphisms (SNPs) studied
3
Symptom types linked to genetic variants
ESR1
Gene investigated
About the study
- Original title
- Genetic contributions to premenstrual symptoms: revisiting the role of the ESR1 gene
- Authors
- Lahnsteiner A, Hidalgo-Lopez E, Noachtar I et al.
- Journal
- medRxiv
- Year
- 2025
- Study design
- Survey study
- What was tested
- None
- Open access
- Yes
- Read the paper
- doi.org/10.1101/2025.01.13.25320449
Topics
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