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Review, 2006

How do reproductive hormones affect mood in women with PMDD?

Reproductive hormones regulate emotional processing and mood through specific brain circuits. The key question is why normal hormone levels destabilize mood in some women but not others.

Moderate study design Literature review - not a primary study

What they did

Literature review examining how reproductive hormones affect emotional processing, mood regulation, and PMDD in particular.

What they found

The paper identifies brain circuits and component processes involved in how reproductive hormones regulate mood. It emphasizes differences in how sensitive individual women are to the mood effects of reproductive hormones.

What it means for you

Understanding how hormones affect mood-regulating brain circuits could lead to better PMDD treatments. This summarizes existing research rather than presenting new original findings.

About the study

Original title
Gonadal steroid regulation of mood: the lessons of premenstrual syndrome
Authors
Rubinow DR, Schmidt PJ
Journal
Frontiers in neuroendocrinology
Year
2006
Study design
Review
What was tested
None - literature review of current knowledge

Topics