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Survey study, 1995

Is premenstrual syndrome related to depression?

The evidence suggests yes. Women with PMS are more likely to have had depression, and antidepressants help both conditions.

Early or limited evidence Review of existing literature (not a new study of people)

What they did

Reviewed the diagnosis, frequency, cause, and treatment of PMS. Also examined the relationship between menopause and depression.

What they found

Several findings suggest PMS and depression are linked: women with PMS have higher rates of prior depression, they share similar brain chemistry problems, and they respond to the same antidepressants. The link between menopause and depression is not as clear, although women already at risk for depression may experience more symptoms during the menopause transition.

What it means for you

PMS and depression may be related through shared brain chemistry. However, this conclusion is based on a review of existing studies, not new research. Future studies should examine whether hormone treatments affect depression in menopausal women.

About the study

Original title
Hormones and depression: what are the facts about premenstrual syndrome, menopause, and hormone replacement therapy?
Authors
Pearlstein TB
Journal
American journal of obstetrics and gynecology
Year
1995
Study design
Survey study
What was tested
None

Topics