Review, 1994
Can GnRHa hormone therapy treat premenstrual syndrome long-term?
GnRHa treats PMS but causes about 8.2% bone loss in 6 months that may not fully reverse, creating a challenge for longer-term use.
What they did
Reviewed scientific literature on long-term GnRHa hormone therapy for conditions including PMS, endometriosis, fibroids, and others.
What they found
GnRHa is used for PMS and related conditions. A 6-month course causes up to 8.2% decrease in lumbar bone density, which may not entirely reverse 6 months after stopping treatment.
What it means for you
GnRHa can help PMS but the bone loss is a concern, especially for treatment lasting more than 6 months. Adding hormones back ('add-back' therapy) might reduce side effects, but researchers say more studies are needed.
8.2%
Decrease in lumbar bone density after 6 months of GnRHa
About the study
- Original title
- Long-term gonadotrophin-releasing hormone agonist therapy: the evolving issue of steroidal 'add-back' paradigms
- Authors
- Adashi EY
- Journal
- Human reproduction (Oxford, England)
- Year
- 1994
- Study design
- Review
- What was tested
- Long-term GnRHa therapy with and without steroid add-back regimens
- Read the paper
- doi.org/10.1093/oxfordjournals.humrep.a138715
Topics
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