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Survey study, 2007

Why does migraine get worse around menstruation and how can it be treated?

Migraine in some women worsens around menstruation, probably because of declining estrogen after hormone levels drop. Treatment with triptans, NSAIDs, or other drugs can help acute attacks, and prevention strategies are available.

Early or limited evidence Women with menstrual migraine (review article)

What they did

Review of research on menstrual migraine, its causes, and treatment options.

What they found

Many women have increased migraine frequency around menstruation, and these attacks may be more severe than migraines at other times of the cycle. Menstrual migraine is probably caused by declining estrogen levels after exposure to high estrogen. Acute treatment options include 5-HT1B/1D agonists (triptans), ergots, NSAIDs, or combination painkillers. Women with frequent or severe menstrual migraine may benefit from perimenstrual prophylaxis (prevention around the period).

What it means for you

If your migraines get worse around your period, this is likely linked to hormone changes. The same treatments for other migraines can help, and you may benefit from taking preventive medicine around the time you expect an attack. Main limit: this is a review of existing knowledge, not new research data.

About the study

Original title
Menstrual migraine: a review of hormonal causes, prophylaxis and treatment
Authors
Ashkenazi A, Silberstein S
Journal
Expert opinion on pharmacotherapy
Year
2007
Study design
Survey study
What was tested
Not an intervention study; review of treatment options

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