Randomised trial, 2004
Does paroxetine controlled-release help PMDD symptoms?
Yes, paroxetine CR was more effective than placebo for PMDD symptoms and caused less nausea than regular paroxetine in the first week. This summary reviews multiple well-designed trials.
What they did
Reviews multiple placebo-controlled trials of paroxetine CR in patients with depression, anxiety, panic disorder, and PMDD. Treatment duration was 12 weeks for most conditions, or three menstrual cycles for PMDD given either continuously or intermittently.
What they found
In PMDD trials, paroxetine CR was superior to placebo on the Visual Analogue Scale-Mood score. Recipients experienced significantly less nausea than those on immediate-release paroxetine in the first week. The adverse-event profile was typical of SSRIs.
What it means for you
Paroxetine CR may reduce PMDD mood symptoms with fewer side effects like nausea. This is a review of multiple studies rather than one single trial, so specific sample sizes from individual studies are not detailed here.
12 weeks
Treatment duration for depression and anxiety
3 cycles
Treatment duration for PMDD (menstrual)
4-5 hours
Paroxetine CR release time in body
About the study
- Original title
- Paroxetine controlled release
- Authors
- Bang LM, Keating GM
- Journal
- CNS drugs
- Year
- 2004
- Study design
- Randomised trial
- What was tested
- Paroxetine CR vs placebo
- Read the paper
- doi.org/10.2165/00023210-200418060-00003
Topics
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